Michael J. Welsh, MD


Director, Pappajohn Biomedical Institute
Professor of Internal Medicine  - Pulmonary, Critical Care and Occupational Medicine
Professor of Molecular Physiology and Biophysics, Neurosurgery

Contact Information

Web: Welsh Laboratory


MD, The University of Iowa

Residency, Internal Medicine, University of Iowa Hospitals and Clinics
Fellowship, University of California, San Francisco
Fellowship, University of Texas Medical School, Houston

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

The Welsh laboratory emphasizes research in two main areas. The first is understanding the biology of cystic fibrosis (CF), a common lethal genetic disease, and developing new treatments. Cystic fibrosis is caused by mutations in the gene that encodes the CFTR anion channel. Welsh and his colleagues are learning how the CFTR anion channel is regulated and how mutations disrupt its function. They also focus on the pathogenesis of cystic fibrosis lung disease, learning how the loss of CFTR causes the bacterial airway infections and inflammation that destroy the lung. To test key hypotheses, they developed a porcine model of cystic fibrosis that develops all the hallmarks of the human disease. Their studies of this model are providing a new understanding of the disease and are aiding the development of novel therapies. The lab also studies the molecular biology and physiology of changes in brain pH and the effect on acid sensing ion channels and neural function. They are particularly interested in understanding the bases of fear memory and how that memory might be altered to treat people with PTSD.

Date Last Modified: 10/09/2015 - 15:23:31