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Research Health Science Specialist, Director of Animal ResearchProfessor of Molecular Physiology and BiophysicsProfessor of
Primary Office: 5-432 BSB51 Newton RoadIowa City, IA 52242
Email: firstname.lastname@example.orgWeb: Russo Laboratory
BA, Biology (concentrations in biochemistry and microbiology), University of CaliforniaPhD, Biochemistry, University of California
Post Doctorate, Molecular Neurobiology, Department of Medicine, UCSD
Department of Molecular Physiology and Biophysics PhDInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
My research interest is to understand how neurons respond to changes in their environment. We have focused on regulation of CGRP and its actions in the context of trigeminal-mediated disorders, especially migraine. A recent focus of the lab is a CGRP-sensitized transgenic mouse model we generated based on clinical reports that injection of CGRP is able to induce a migraine, but not in people who do not suffer from migraine. These sensitized mice overexpress the RAMP1 subunit of the CGRP receptor in the nervous system. The RAMP1 mice have elevated CGRP-induced neurogenic inflammation, mechanical allodynia, and light aversion analogous to photophobia. In collaborative projects, the lab is also studying the beneficial effects of CGRP and RAMP1 against hypertension and obesity, with overall goals to develop effective diagnostic and therapeutic strategies for neurovascular disorders.
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.
Ann Clin Transl Neurol.
2015 June. 2(6):595-608.
Reactive oxygen species induce procalcitonin expression in trigeminal ganglia glia..
2014 March 1. 54(3):472-84.
Marquez de Prado B,
Heat hyperalgesia and mechanical hypersensitivity induced by calcitonin gene-related peptide in a mouse model of neurofibromatosis 1.
Protein inhibitors of STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.
J Biol Chem.
Modulation of CGRP-induced light aversion in wildtype mice by a 5HT1B/D agonist.
J Neurosci .
CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice.
J Clin Invest.
Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glial.
Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice.
Photophobia and abnormally sustained pupil responses in a mouse model of bradyopsia.
Invest. Ophthalmol. Vis. Sci..
Date Last Modified: 04/12/2016 -
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