Andrew Russo, PhD


Research Health Science Specialist, Director of Animal Research
Professor of Molecular Physiology and Biophysics
Professor of Neurology

Contact Information

Primary Office: 5-432 BSB
51 Newton Road
Iowa City, IA 52242
Phone: 319-335-7872

Web: Russo Laboratory


BA, Biology (concentrations in biochemistry and microbiology), University of California
PhD, Biochemistry, University of California

Post Doctorate, Molecular Neurobiology, Department of Medicine, UCSD

Education/Training Program Affiliations

Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

My research interest is to understand how neurons respond to changes in their environment. We have focused on regulation of CGRP and its actions in the context of trigeminal-mediated disorders, especially migraine. A recent focus of the lab is a CGRP-sensitized transgenic mouse model we generated based on clinical reports that injection of CGRP is able to induce a migraine, but not in people who do not suffer from migraine. These sensitized mice overexpress the RAMP1 subunit of the CGRP receptor in the nervous system. The RAMP1 mice have elevated CGRP-induced neurogenic inflammation, mechanical allodynia, and light aversion analogous to photophobia. In collaborative projects, the lab is also studying the beneficial effects of CGRP and RAMP1 against hypertension and obesity, with overall goals to develop effective diagnostic and therapeutic strategies for neurovascular disorders.

Selected Publications

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Russo A, Kaiser  E, Kuburas  A, Recober  A.  Modulation of CGRP-induced light aversion in wildtype mice by a 5HT1B/D agonist.  J Neurosci .  2012. 

Russo A, Raddant A.  CGRP in migraine: Intersection of peripheral inflammation and central modulation.  2011. 13(36).

Russo A, Xie  W, Fisher  J, Lynch  T, Luo  M, Evans  T, Neff  T, Zhou  W, Zhang  Y, Ou  Y, Bunnett  N, Goodheart  M, Parekh  K, Liu  X, Engelhardt  J.  CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice.  J Clin Invest.  2011. 121:3144-3158.

Russo A, Park  K, Fletcher  J, Raddant  A.  Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glial.  2011. 31:614-624.

Russo A, Zhang  Z, Liu  X, Morgan  D, Kuburas  A, Thedens  D, Rahmouni  K.  Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice.  2011. 60:1063-1071.

Russo A, Clark  M.  Tissue-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels.  1997. 48:346-354.

Russo A, Kuburas  A, Saadi  I, Russo  E, Pelletier  L, Manie  S, Billaud  M.  Identification of a novel Ret mutation in a neuronal-like medullary thyroid carcinoma. 

Russo A, Wang  J, Saadi  I, Wang  J, Engle  J, Kuburas  A, Amendt  B.  PIAS1 and PIASy differentially regulate PITX2 transcriptional activity independent of sumoylation. 

Date Last Modified: 10/09/2015 - 15:23:31