Neurology

Dan Bonthius, MD, PhD

Portrait

Director, Child Neurology Residency Program
Faculty Member, Interdisciplinary Program in Molecular Biology
Faculty Member, Medical Scientist Training Program
Faculty Affiliate, Interdisciplinary Neuroscience Program
Professor of Pediatrics  - Neurology and Developmental and Behavioral Pediatrics
Professor of Neurology

Contact Information

Primary Office: 2504 JCP
Iowa City, IA 52242
Primary Office Phone: 319-356-1851

Email: daniel-bonthius@uiowa.edu

Education

BS, Zoology, The University of Iowa, Iowa City IA
MD, The University of Iowa, Iowa City IA
PhD, Neuroscience, The University of Iowa, Iowa City, IA

Fulbright Scholarship, University of Otago, New Zealand
Post Doctoral, Combined Postdoctoral Fellowship in Neuroscience and Residency in Pediatrics, University of Virginia, Charlottesville, Virginia
Residency, Pediatric Neurology, University of Iowa, Iowa City, Iowa

Licensure and Certifications

License to Practice Medicine and Surgery, Board of Medicine, Department of Health Professionals, Commonwealth of Virginia
License to Practice Medicine and Surgery, State Board of Medical Examiners, State of Iowa
Federal Licensing Examination (FLEX) Parts I and II
American Board of Psychiatry and Neurology, Certified in Neurology with Special Qualification in Child Neurology
American Board of Pediatrics

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

This laboratory investigates the biological mechanisms underlying neurologic birth defects. We are specifically interested in the brain injuries induced by lymphocytic choriomeningitis virus (LCMV) and by alcohol (fetal alcohol syndrome). In our studies of congenital LCMV infection, we utilize a rat model of the infection to study the cellular and molecular mechanisms underlying the virus-induced neuropathology. We are investigating the immune cell types and the cytokines involved in virus-induced neuronal death. In the developing brain, LCMV specifically infects certain neuronal populations and leaves others completely uninfected. We are studying the mechanisms by which LCMV spreads through the brain and are attempting to identify the metabolic and molecular characteristics of neurons that render them vulnerable to infection. Following infection with LCMV, both humans and the rats in our model system develop epilepsy. We are investigating the pathophysiology underlying this virus-induced epileptic condition. In our studies of fetal alcohol syndrome, we utilize animal models of the syndrome to study the mechanisms of alcohol-induced brain injury and the anatomical, histological and behavioral consequences of alcohol exposure. We have recently developed a mouse model of fetal alcohol syndrome, in which we utilize knock-out mice to study the importance of specific genes in influencing the pathological and behavioral effects of alcohol exposure.

Date Last Modified: 06/07/2014 - 21:56:23