Internal Medicine

Anne E. Kwitek, PhD


Associate Director, Iowa Institute of Human Genetics
Associate Professor of Pharmacology
Associate Professor of Internal Medicine

Contact Information

Primary Office: 2-252 Bowen Science Building
Iowa City, IA 52242
Primary Office Phone: 319-384-2934

Lab: 2-200 Bowen Science Building
Iowa City, IA 52242
Phone: 319-335-6887

Web: Department of Pharmacology Faculty Profile


BS, University of Wisconsin at Stevens Point
PhD, Genetics, University of Iowa, Iowa City, IA

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Medical Scientist Training Program

Research Summary

Dr. Kwitek is an animal and human geneticist whose research revolves around dissecting the genetic components of complex disease in rat and human, with an emphasis on hypertension, diabetes, and the metabolic syndrome. Her use of genome-wide approaches such as QTL mapping, comparative genomics, transcriptomics, and high-throughput genotyping has led to the identification of loci and genes involved in diabetes and cardiovascular disease in both rat models and human populations. Her current work is focused on combining traditional positional cloning approaches with, functional genomics and in silico mapping strategies to identify genes and pathways involved in the Metabolic Syndrome.

Center, Program and Institute Affiliations

Cardiovascular Research Center
Center for Functional Genomics of Hypertension
Environmental Health Sciences Research Center
Fraternal Order of Eagles Diabetes Research Center
Iowa Initiative in Human Genetics
Obesity Initiative

Selected Publications

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Moralejo D, Fuller J, Rutledge E, Van Yserloo B, Ettinger R, Jensen R, Osborne W, Kwitek A, Lernmark A.  BB rat Gimap gene expression in sorted lymphoid T and B cells..  Life sciences.  2011 November. 89(19-20):748-54.

Moralejo D, Hansen C, Treuting P, Hessner M, Fuller J, Van Yserloo B, Jensen R, Osborne W, Kwitek A, Lernmark A.  Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats..  Physiological genomics.  2010 March. 41(1):9-20.

Fuller J, Bogdani M, Tupling T, Jensen R, Pefley R, Manavi S, Cort L, Blankenhorn E, Mordes J, Lernmark A, Kwitek A.  Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene..  Physiological genomics.  2009 June. 38(1):89-97.

Gilibert S, Bataillard A, Nussberger J, Sassard J, Kwitek A.  Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats..  Journal of hypertension.  2009 June. 27(6):1186-93.

Aneas I, Rodrigues M, Pauletti B, Silva G, Carmona R, Cardoso L, Kwitek A, Jacob H, Soler J, Krieger J.  Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR..  Physiological genomics.  2009 March. 37(1):52-7.

Rutledge E, Fuller J, Van Yserloo B, Moralejo D, Ettinger R, Gaur P, Hoehna J, Peterson M, Jensen R, Kwitek A, Lernmark A.  Sequence variation and expression of the Gimap gene family in the BB rat..  Experimental diabetes research.  2009. 2009:Article 835650.

Bilusia M, Moreno C, Barreto N, Tschannen M, Harris E, Porteous W, Thompson C, Grigor M, Weder A, Boerwinkle E, Hunt S, Curb J, Jacob H, Kwitek A.  Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension..  Croatian medical journal.  2008 October. 49(5):586-99.

Mattson D, Dwinell M, Greene A, Kwitek A, Roman R, Jacob H, Cowley A.  Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease..  American journal of physiology. Renal physiology.  2008 September. 295(3):F837-42.

Gilibert S, Kwitek A, Hubner N, Tschannen M, Jacob H, Sassard J, Bataillard A.  Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat..  Physiological genomics.  2008 April. 33(2):212-7.

Date Last Modified: 08/27/2014 - 07:53:59