Internal Medicine

Kevin P. Campbell, PhD

Portrait

Director
Professor of Molecular Physiology and Biophysics
Professor of Neurology, Internal Medicine

Contact Information

Primary Office: 4269B CBRB
Iowa City, IA 52242
Primary Office Phone: 319-335-8767

Email: kevin-campbell@uiowa.edu
Web: Lab Website

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Research in my laboratory is focused on two main topics: the mechanism of muscular dystrophies and development of therapeutic strategies to treat muscular dystrophy. Alterations in the dystrophin-glycoprotein complex cause several forms of muscular dystrophy, including those with abnormal central nervous system development and function. We are investigating the structure and function of the dystrophin-glycoprotein complex in skeletal, cardiac, and smooth muscle as well as non-muscle tissues including brain and peripheral nerve. In particular, we are interested in the following projects: (1) the post-translational processing of dystroglycan required for its function and steps targeted in muscular dystrophy, (2) the functional role of members of the sarcoglycan-sarcospan complex, (3) the function of dystroglycan within the central and peripheral nervous system including neuronal migration, peripheral nerve conduction, and synaptic plasticity. Muscular dystrophy research my lab utilizes a variety of biochemical tools and modern genetic approaches, including human patient samples, spontaneous mutant or gene targeted mice, viral gene transfer and stem cell therapy. These approaches are geared at understanding disease mechanisms and forming the basis of therapeutic studies in vivo. We have also uncovered a pathway for muscle membrane repair that is responsible for at least two different forms muscular dystrophy not associated with the dystrophin-glycoprotein complex. Current investigations include (1) the function of dysferlin in membrane repair (2) the membrane repair machinery in skeletal muscle (3) the role of membrane repair in other forms of muscular dystrophy.

Date Last Modified: 07/31/2013 - 10:51:40