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Chief, Division of Endocrinology and MetabolismProfessor of Internal Medicine
- Endocrinology and MetabolismProfessor of
Email: email@example.comWeb: E. Dale Abel Laboratory
MBBS, University of the West Indies, Kingston, JamaicaPhD, Physiology, Oxford University, UK
Rhodes Scholar, University of OxfordResidency, Internal Medicine, Northwestern University, ChicagoFellowship, Endocrinology & Metabolism, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA
Endocrinology, Diabetes & Metabolism Certification American Board of Internal MedicineInternal Medicine Certification American Board of Internal Medicine
Biosciences Graduate ProgramInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Our recent studies have underscored the importance of mitochondrial oxidative stress as a major mechanism leading to cardiac dysfunction in obesity and diabetes. Recent studies have focused on: (1) The contribution of excessive myocardial insulin signaling in the myocardium in accelerating left ventricular remodeling in the hypertrophied and failing heart. (2) The regulation of myocardial autophagy by insulin signaling. (3) The mechanisms by which myocardial lipid overload alters autophagy in cardiac muscle (4) The role of altered mitochondrial dynamics in the pathophysiology of cardiac dysfunction in obesity and insulin resistant states. (5) Mechanisms for increased thrombosis in obesity and insulin resistant states.
Cardiovascular Research CenterFraternal Order of Eagles Diabetes Research Center
Date Last Modified: 08/20/2014 -
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