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Chair/Department Executive Officer, Department of Internal MedicineDirector, Division of Endocrinology and Metabolism, Department of Internal MedicineDirector, Fraternal Order of Eagles Diabetes Research CenterProfessor of Internal Medicine
- Endocrinology and MetabolismProfessor of
Office: SE303 GH 200 Hawkins DriveIowa City, IA 52242
Lab: 4312 PBDB 169 Newton RoadIowa City, IA 52242
Email: email@example.comWeb: E. Dale Abel Laboratory
MBBS, University of the West IndiesPhD, Physiology, Oxford University
Internship, Surgery, Medicine, OBGYN, Peds, ER, University of the West IndiesResidency, Internal Medicine, Northwestern UniversityFellowship, Endocrinology & Metabolism, Harvard Medical School, Beth Israel Deaconess Medical Center
Endocrinology, Diabetes & Metabolism Certification, American Board of Internal MedicineInternal Medicine Certification, American Board of Internal Medicine
Interdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Our recent studies have underscored the importance of mitochondrial oxidative stress as a major mechanism leading to cardiac dysfunction in obesity and diabetes. Recent studies have focused on: (1) The contribution of excessive myocardial insulin signaling in the myocardium in accelerating left ventricular remodeling in the hypertrophied and failing heart. (2) The regulation of myocardial autophagy by insulin signaling. (3) The mechanisms by which myocardial lipid overload alters autophagy in cardiac muscle (4) The role of altered mitochondrial dynamics in the pathophysiology of cardiac dysfunction in obesity and insulin resistant states. (5) Mechanisms for increased thrombosis in obesity and insulin resistant states.
Alfred P. Sloan Center for Exemplary MentoringCardiovascular Research CenterFraternal Order of Eagles Diabetes Research CenterUI Obesity Research and Education Initiative
Date Last Modified: 07/06/2016 -
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