Anatomy and Cell Biology

Jeffrey Murray, MD

Portrait

Adjunct Professor of Pediatric Dentistry
Professor, Dows Institute of Dental Research
Professor of Pediatrics  - Neonatology
Professor of Anatomy and Cell Biology, Biology, Epidemiology, Preventive Medicine

Contact Information

Lab: 2182 ML
Iowa City, IA 52242
Phone: 319-335-6897

Email: jeff-murray@uiowa.edu
Web: Murray Laboratory

Education

BS, Biology, Massachusetts Institute of Technology, Cambridge, Massachussetts
MD, Tufts Medical School, Boston, Massachussetts

Residency, Pediatrics, New England Medical Center Hospital, Boston, Massachussetts
Fellowship, Medical Genetics, University of Washington, Seattle Washington

Licensure and Certifications

Iowa Medical License
American College of Medical Genetics, Clinical Genetics
American Board of Medical Genetics, Clinical Genetics
American Board of Pediatrics

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Current projects include strategies to identify and characterize genes and environmental components in complex human disorders. We focus on conditions that affect infants and children including a common birth defect- cleft lip and palate, prematurity and two traits of young children- myopia and language development. Many of our studies are carried out using large population and epidemiologic studies of children particularly from the Philippines, Japan, Denmark, Norway, Argentina and Brazil, and we work in close collaboration with investigators in these countries. Studies of cleft lip involve using epidemiolgic databases coupled to large scale genetic evaluation (genotyping and DNA sequencing) to find how variation in normal genes affects exposure (such as smoking or poor nutrition) to induce fetal developmental abnormalities. For prematurity, a problem that affects 10% of all infants and leads to death and significant medical problems (mental retardation, blindness, deafness), we study cases and families to find genes and examine environmental triggers such as infection, stress and smoking. Our work involves collaborations with many other disciplines such as embryologists, biostatisticians and clinicians. Our lab has particular expertise in analyzing DNA from very large datasets and tying this into basic science and clinical care. In some cases we also carry out clinical trials targetted at prevention or improved treatment of these conditions. Graduate students play an active role in implementation of the studies and are often involved at many different levels of the collaboration from bench techniques to overseas coordination of sample collection.

Date Last Modified: 10/13/2014 - 14:09:57