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Professor of Internal Medicine
- Cardiovascular MedicineProfessor of
MD, The University of Iowa
Fellowship, Cardiology, University of Iowa Hospitals and ClinicsResidency, University of Texas Southwestern Medical Center
Free Radical and Radiation Biology Graduate ProgramInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
The primary goal of Dr. Miller’s research program is to understand the molecular and cellular mechanisms by which the NADPH oxidases contribute to the pathogenesis of vascular disease and identify novel therapeutic targets. Ongoing studies are (1) examining the role of chronic inflammation in accelerating vascular injury via Nox1 NAPDH oxidase, and (2) identifying molecular mechanisms of Nox4 regulation in redox homeostasis and understanding how microRNA-mediated mediated changes in Nox4 can coordinate pathways implicated in vascular disease. Furthermore, studies are examining RNA aptamers as a novel approach for cell specific delivery of vascular therapeutics. As a practicing cardiologist, Dr. Miller is interested in confirming observations made at the bench with human disease. His findings are resulting in a better understanding of vascular disease and the development of new strategies for the treatment of atherosclerosis, stent restenosis, graft failure, and myocardial infarction.
Date Last Modified: 08/28/2015 -
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