Anatomy and Cell Biology

John H. Fingert, MD, PhD

Portrait

Associate Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 1269B  CBRB
Iowa City, IA 52242
Primary Office Phone: 319-335-7508

Clinic: 11190 PFP
200 Hawkins Dr,
Iowa City, IA 52242

Email: john-fingert@uiowa.edu
Web: Glaucoma Genetics Laboratory
Web: Iowa Glaucoma Center

Education

BA, Engineering, Dartmouth College
BE, Bioengineering, Dartmouth College
MD, Medicine, University of Iowa
PhD, Molecular Genetics of Glaucoma, University of Iowa

Internship, Transitional, St. Lukes Hospital
Residency, Ophthalmology, University of Iowa
Fellowship, Genetics/Glaucoma, University of Iowa
Fellowship, Molecular Ophthalmology, University of Iowa Department of Ophthalmology and Visual Sciences

Licensure and Certifications

State of Iowa Medical License, Iowa Board of Medicine
NBME Diplomate, National Board of Medical Examiners

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Medical Scientist Training Program

Research Summary

I am a board-certified ophthalmologist with fellowship training in glaucoma and I have a Ph.D. in ophthalmic genetics. My training and experience has provided me with broad clinical and laboratory expertise to investigate the genetic basis of optic nerve disease. My early research resulted in the detection of the first glaucoma gene, myocilin, and more recently my laboratory has discovered one of two known normal tension glaucoma genes, TBK1. My laboratory is currently investigating the mechanisms by which defects in genes in the autophagy pathway (TBK1, OPTN, and others) lead to normal tension glaucoma using transgenic mice, induced pluripotent stem cells, and other patient-based studies. Other major projects include genetic studies of pigmentary glaucoma, exfoliative glaucoma, dominant optic atrophy, and studies of the genetic basis of quantitative features of glaucoma (eye pressure, corneal thickness, and optic nerve cupping). These projects are part of an overall mission to investigate the genetic basis of optic nerve disease and develop sight-saving therapies for this common group of blinding diseases.

Center, Program and Institute Affiliations

Carver Family Center for Macular Degeneration
Center on Aging
Institute for Clinical and Translational Science
Iowa Initiative in Human Genetics
John and Marcia Carver Nonprofit Genetic Testing Laboratory
Stephen A. Wynn Institute for Vision Research

Selected Publications

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Scheetz T, Fingert J, Wang K, Kuehn M, Knudtson K, Alward W, Boldt H, Russell S, Folk J, Casavant T, Braun T, Clark A, Stone E, Sheffield V.  A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel loci.  PLoS One.  2013 March 11. 8(3):e58657.
[Link]

Fingert J, Darbro B, Qian Q, Van Rheeden R, Miller R, Riker M, Solivan-Timpe F, Roos B, Robin A, Mullins R.  TBK1 and Flanking Genes in Human Retina.  Ophthalmic Genetics.  2013 February 20. 
[Link]

Seo S, Solivan-Timpe F, Roos B, Robin A, Stone E, Kwon Y, Alward W, Fingert J.  Identification of proteins that interact with TANK Binding kinase 1 (TBK1) and testing for mutations associated with glaucoma.  Current Eye Research.  2013 February. 38(2):310-5.
[Link]

Fingert J, Roos B, Solivan-Timpe F, Miller K, Oetting T, Wang K, Scheetz T, Stone E, Alward W.  Analysis of ASB10 variants in open angle glaucoma.  Human Molecular Genetics.  2012 October 15. 21(20):4543-4548.
[Link]

Kawase K, Allingham R, Meguro A, Mizuki N, Roos B, Solivan-Timpe F, Robin A, Ritch R, Fingert J.  Confirmation of TBK1 duplication in normal tension glaucoma.  Experimental Eye Research.  2012 March. 96(1):178-180.
[Link]

Fingert J, Robin A, Stone J, Roos B, Davis L, Scheetz T, Bennett S, Wassink T, Kwon Y, Alward W, Mullins R, Sheffield V, Stone E.  Copy number variations on chromosome 12q14 in patients with normal tension glaucoma.  Human Molecular Genetics.  2011 June 15. 20(12):2482-2494.
[Link]

Fingert J.  Primary Open Angle Glaucoma Genes.  Eye (Lond).  2011 May. 25(5):587-595.
[Link]

Kuehn M, Wang K, Roos B, Stone E, Kwon Y, Alward W, Mullins R, Fingert J.  Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort.  Mol Vis.  2011. 17:430-5.
[Link]

Mullins R, Skeie J, Folk J, Solivan-Timpe F, Oetting T, Huang J, Wang K, Stone E, Fingert J.  Evaluation of variants in the selectin genes in age-related macular degeneration.  BMC Med Genet.  2011. 12(1):58.
[Link]

Sundaresan P, Kumar S, Thompson S, Fingert J.  Reduced frequency of known mutations in a cohort of LHON patients from India.  Ophthalmic Genet.  2010 December. 31(4):196-9.
[Link]

Date Last Modified: 07/22/2014 - 13:16:32