Pathology

Mailing Address

Office: 3-530 BSB
Iowa City, IA 52242
Phone: +1 319 335 9720
Email: john-harty@uiowa.edu

Office/Lab Address

Office/Lab: 3-530 BSB
Iowa City IA, 52242
Phone: +1 319 335 9720

Office/Lab Address

Office/Lab: 3-501B BSB
Iowa City IA, 52242
Phone: +1 319 335 9919

Web: Harty Lab Website

Education

BS, Biology, University of Minnesota, 1981
PhD, Microbiology, University of Minnesota, 1989
Post-Doc, Immunology, Scripps Research Foundation, 1990
Post-Doc, Immunology, University of Washington, 1993

Appointments

Primary: Microbiology
Secondary: Pathology

Center and Program Affiliations

• Interdisciplinary Graduate Program in Immunology

Research Interests

animal models of infection, bacteria, malaria, T cells, viruses

Research Summary

In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity against liver-stage malaria infection. Current projects involve:

1. Regulation of memory T cell development

2. Effector mechanisms of CD8 T cells in whole animal models of infectious disease

3. T cell homeostasis in response to infection.

4. T cell mediated immunopathology after virus infection

5. CD8 T cell immunity against liver-stage malaria

Publications

• Nolz, J, Starbeck-Miller, G, Harty, J. Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions. Immunotherapy 3(10):1223-33, 2011. [PubMed]
• Nolz, J, Harty, J. Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection. Immunity 34(5):781-93, 2011. [PubMed]
• Butler, N, Nolz, J, Harty, J. Immunologic considerations for generating memory CD8 T cells through vaccination. Cell Microbiol 13(7):925-33, 2011. [PubMed]
• Schmidt, N, Butler, N, Harty, J. Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. J Immunol 186(10):5873-84, 2011. [PubMed]
• Schmidt, N, Harty, J. Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization. J Immunol 186(7):3836-40, 2011. [PubMed]
• Martin, M, Wirth, T, Lauer, P, Harty, J, Badovinac, V. The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells. J Immunol 187(6):2923-31, 2011. [PubMed]
• Wirth, T, Martin, M, Starbeck-Miller, G, Harty, J, Badovinac, V. Secondary CD8+ T-cell responses are controlled by systemic inflammation. Eur J Immunol 41(5):1321-33, 2011. [PubMed]
• Butler, N, Schmidt, N, Vaughan, A, Aly, A, Kappe, S, Harty, J. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe 9(6):451-62, 2011. [PubMed]
• Kashiwada, M, Pham, N, Pewe, L, Harty, J, Rothman, P. NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development. Blood 117(23):6193-7, 2011. [PubMed]
• Butler, N, Harty, J. The role of inflammation in the generation and maintenance of memory T cells. Adv Exp Med Biol 684:42-56, 2010. [PubMed]