Urology

Moshe Wald, MD

Portrait

Associate Professor of Urology

Contact Information

Office: 3251 RCP
Iowa City, IA 52242
Office Phone: 319-356-8922

Email: moshe-wald@uiowa.edu
Web: UI Health Care Profile

Education

MD, Hebrew University and Hadassah School of Medicine, Jerusalem
BSc, Medical Sciences, Hebrew University and Hadassak School of Medicine, Jerusalem

Fellowship, University of Illinois at Chicago, Andrology
Fellowship, University of Iowa Hospitals and Clinics, Andrology and Male Infertility
Residency, Bnai-Zion Medical Center, Haifa, Israel, Urology

Research Summary

Dr. Walds' research focuses on the mechanisms that lead to vasectomy failure, and on the possible use of growth factors and biodegradable grafts for reconstructive surgery of the male reproductive tract, as part of the treatment of obstructive azoospermia. Recently he has focused on platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-�, found to be increased in vasectomy sites. His experimental model also demonstrated the presence of microscopic tubules between the two edges of severed vasa deferentia, thus suggesting a possible mechanism for vasectomy failure. Previous studies have evaluated possible biomedical applications of biodegradable polymer grafts, specifically focusing on their use in guiding and accelerating peripheral nerve growth. Techniques have been developed for micropatterning biodegradable polymer substrates and incorporating nanospheres with growth factors into them, to provide physical and chemical guidance, respectively, for the regrowing elements. Current work is focusing on the role of biodegradable grafts, with or without micropatterning and/or incorporation of selected growth factors, in bridging long obstructive segments of the male reproductive tract, and serving as scaffolds for the regrowing elements. Dr. Wald is also involved in the development of computational models for the prediction of assisted reproductive techniques outcomes, as well as the outcomes of other urological conditions. He has recently developed a computational model for the prediction of in- vitro fertilization (IVF)/intra cytoplasmic sperm injection (ICSI), using surgically retrieved sperm, and is currently working of a model that could predict the outcomes of intrauterine insemination (IUI), another common assisted reproductive technique. These models can be deployed in the JavaScript language for ready availability on the world- wide web and in PalmOS for usage of handheld computers, allowing clinicians to simply enter the input data and receive an immediate outcome prediction. As such, these models could be a useful tool for decision making in various clinical situations.

Selected Publications

Rosevear H, Krishnamachari Y, Ariza C, Mallapragada S, Salem A, Griffith T, Deyoung B, Wald M.  Effect of combined locally delivered growth factors and systemic sildenafil citrate on microrecanalization in biodegradable conduit for vas deferens reconstruction.  Urology.  2012. 79:967.e1-4.
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Holoch P, Wald M.  Current options for preservation of fertility in the male.  Fertil Steril.  2011. 96:286-90.
[Link]

Holoch P, Mallapragada S, Ariza C, Griffith T, Deyoung B, Wald M.  Micro-recanalization in a biodegradable graft for reconstruction of the vas deferens is enhanced by sildenafil citrate.  Asian J Androl.  2010. 12:814-8.
[Link]

Adams C, Wald M.  Risks and complications of vasectomy.  Urol Clin North Am.  2009. 36:331-6.
[Link]

Rosevear H, Mishail A, Sheynkin Y, Wald M.  Unusual scrotal pathology: an overview.  Nat Rev Urol.  2009. 6:491-500.
[Link]

Date Last Modified: 07/31/2013 - 10:51:40