Surgery

Ronald Weigel, MD, PhD, MBA

Portrait

Associate Vice President for UI Health Alliance
EA Crowell, Jr Professor and Chair of Surgery
Professor of Surgery  - Surgical Oncology and Endocrine Surgery
Professor of Biochemistry, Anatomy and Cell Biology

Contact Information

Primary Office: 1509 JCP
Iowa City, IA 52242
Primary Office Phone: 319-353-7474

Email: ronald-weigel@uiowa.edu

Education

MS, Chemical Engineering, Massachusetts Institute of Technology
MD, Yale University School of Medicine
PhD, Molecular Biophysics and Biochemistry, Yale University Graduate School
MBA, The Wharton School, University of Pennsylvania

Research Assistant, Department of Chemical Engineering, Massachusetts Institute of Technology Cambridge, MA
Graduate Student, Department of Chemical Engineering, Massachusetts Institute of Technology Cambridge, MA
Internship, Duke University Medical Center
Post Doctoral, Fellowship, Department Microbiology/ Immunology, Duke University Medical Center Durham, NC
Residency, Duke University Medical Center

Licensure and Certifications

Iowa Medical License, Iowa Board of Medicine
Certified, Advanced Trauma Life Support
Board Certified, American Board of Surgery

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Biochemistry PhD
Medical Scientist Training Program

Research Summary

The Weigel laboratory has had a long-standing interest in determining mechanisms of hormone response in breast cancer. Our work has identified transcriptional mechanisms that regulate the expression of estrogen receptor- alpha in breast carcinomas. Other areas of investigation have sought to identify genes that are related to hormone response and additional mechanisms of gene regulation that are responsive to estrogen. Current Projects Regulation of ER by AP2 . We identified the AP2? transcription factor as a key regulator of hormone response in breast cancer. We are now examining mechanisms of gene regulation that involve this transcription factor. Chromatin Effects Altering AP2 Activity. We have shown that epigenetic chromatin alterations can influence activity of AP2 at certain promoters. The mechanism appears to involve altered binding of AP2 mediated through chromatin structure. Studies to determine how chromatin structure alters AP2 activity are being pursued. Interaction of AP2 and p53. We demonstrated a direct interaction between AP2 factors and the p53 tumor suppressor. The interaction of p53 and AP2 has functional effects on these two factors that appear to alter hormone response in breast cancer and cell growth in other cancer types. We are investigating the details of this interaction and the functional effects on gene regulation and cell physiology.

All Publications

Bogachek  M, Chen  Y, Kulak  M, Woodfield  G, Cyr  A, Spanheimer  P, Li  Y, Li  T, Weigel  R.  Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype.  Cancer Cell.  2014 June. 25:748-761.

Spanheimer  P, Cyr  A, Gillum  M, Woodfield  G, Askeland  R, Weigel  R.  Distinct Pathways Regulated by RET and ER in Luminal Breast Cancer Demonstrates the Biologic Basis for Combination Therapy.  Annals of Surgery.  2014 April. 259:793-799.

Spanheimer P, Park J, Askeland R, Kulak M, Cyr A, Woodfield G, Sugg S, Thomas A, Weigel R,  .  Inhibition of RET Increases the Efficacy of Antiestrogen and Is a Novel Treatment Strategy for Luminal Breast Cancer..  Clinical Cancer Research.  2014 April. 20:2115-2125.
[PubMed]

Cyr  A, Kulak  M, Park  J, Bogachek  M, Spanheimer  P, Woodfield  G, O’Malley  Y, Sugg  S, Olivier  A, Zhang  W, Domann  F, Weigel  R.  TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.  Oncogene.  2014. 

Lal  G, Gomez-Contreras  P, Kulak  M, Woodfield  G, Bair  T, Domann  F, Weigel  R.  Human melanoma cells over-express Extracellular Matrix 1 (ECM1) which is regulated by TFAP2C.  PLOS ONE;  2013. 

Carr  J, Spanheimer P, Dahdaleh  F, Lal  G, Weigel  R, Sugg  S, Liao  J, Howe  R.  Discriminating Pheochromocytomas from Other Adrenal Lesions: The Dilemma of Elevated Catecholamines.  2013. 

Spanheimer  P, Stoltze  A, Howe  J, Sugg  S, Lal  G, Weigel  R.  Do Giant Parathyroid Adenomas Represent a Distinct Clinical Entity? .  2013. 

Spanheimer  P, Askeland  R, Wu  T, Weigel  R.  High TFAP2C/Low CD44 Expression is Associated with an Increased Rate of Pathologic Complete Response Following Neoadjuvant Chemotherapy in Breast Cancer.  Journal of Surgical Research.  2013. 

Kulak  M, Cyr  A, Woodfield  G, Bogachek  M, Li  T, Price  D, Domann  F, Weigel  R.  Transcriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer.  Oncogene .  2012 September. 32:4043-4051.

Spanheimer  P, Woodfield  G, Cyr  A, Kulak  M, White-Baer  L, Bair T, Weigel  R.  Expression of the RET Proto-oncogene is Regulated by TFAP2C in Breast Cancer Independent of the Estrogen Receptor.  Annals of Surgical Oncology .  2012 August. 20:2204-2212.

O’Malley  Y, Lal  G, Howe  J, Weigel  R, Komorowski  R, Shilyansky  J, Sugg  S.  ). Invasion in Follicular Thyroid Cancer Cell Lines is Mediated by EphA2 and pAkt.  Surgery.  2012. 152:1218-24.

Lal  G, Groff  M, Howe  J, Weigel  R, Sugg  S, Lynch  C.  ). Risk of Subsequent Primary Thyroid Cancer Following Another Malignancy: Latency Trends in a Population-based Study.  Annals of Surgical Oncology.  2012. 19:1887-96.

Spanheimer  P, Weigel  R.  Concepts in Thyroid, Parathyroid and Adrenal Surgery.  Springer, New York.  2012. 

Spanheimer  P, Weigel  R.  Management of Patients with Primary Hyperparathyroidism and Concurrent Thyroid Disease: An Evolving Field.  Annals of Surgical Oncology .  2012. 19:1428-9.

Bhama  A, Smith  R, Robinson  R, Weigel  R, Sugg  S, Howe  J, Lal  G.  Preoperative Evaluation of Thyroglossal Duct Cysts: Children versus Adults – Is there a Difference? .  2012. 

Lal  G, Groff  M, Howe  J, Weigel  R, Sugg  S, Lynch  C.  Risk of Subsequent Primary Thyroid Cancer Following Another Malignancy: Latency Trends in a Population-based Study .  Annals of Surgical Oncology .  2012. 19:1887-96.

Larrieux  G, Cupp  J, Liao  J, Scott-Conner  C, Weigel  R.  The Effect of Introducing Hematoma Ultrasound Guided (HUG) Lumpectomy in a Surgical Practice.  Journal of the American College of Surgeons .  2012. 215:237-243.

The Response to Neoadjuvant Chemotherapy Predicts Clinical Outcome and Increases Breast Conservation in Advanced Breast Cancer.  American Journal of Surgery .  2012. 

Guidroz J, Larrieux G, Liao J, Sugg S, Scott-Conner C, Weigel R.  Sampling of secondary margins decreases the need for re-excision after partial mastectomy.  Surgery.  2011 October. 150(4):802-9.
[Link]

Spanheimer P, Sugg S, Lal G, Howe J, Weigel R.  Surveillance and intervention after thyroid lobectomy.  Ann Surg Oncol.  2011 June. 18(6):1729-33.
[Link]

Calva-Cerqueira  D, Dahdaleh  F, Woodfield  G, Weigel  R, Carr  J, Chinnathambi  S, Howe  J.  Discovery of SMAD4 Promoters, Transcription Factor Binding Sites, and Deletions in Juvenile Polyposis Patients.  Nucleic Acids Research.  2011. 39:5369-5378.

Royer  N, Miron  J, Kirby  P, Weigel  R, Lal  G.  Incidental Finding of Composite Pheochromocytoma-Ganglioneuroma: Successful Management after Emergent Appendectomy and Review of the Literature.  World Journal of Endocrine Surgery .  2011. 3:39-44.

Guidroz  J, Scott-Conner  C, Weigel  R.  Management of Pregnant Women with Breast Cancer.  Journal of Surgical Oncology.  2011. 103:337-340.

Spanheimer  P, Weigel  R.  Reply to comment on "Surveillance and intervention after thyroid lobectomy".  Annals of Surgical Oncology .  2011. 18:S309.

Guidroz  J, Weigel  R.  The Biology of Breast Cancer.  Springer, New York.  2011. 

Lal G, Fairchild T, Howe J, Weigel R, Sugg S, Menda Y.  PET-CT scans in recurrent or persistent differentiated thyroid cancer: is there added utility beyond conventional imaging?.  Surgery.  2010 December. 148(6):1082-9; discussion 1089-90.
[Link]

Calva-Cerqueira D, Dahdaleh F, Woodfield G, Chinnathambi S, Nagy P, Larsen-Haidle J, Weigel R, Howe J.  Discovery of the BMPR1A promoter and germline mutations that cause juvenile polyposis.  Hum Mol Genet.  2010 December 1. 19(23):4654-62.
[Link]

Woodfield G, Chen Y, Bair T, Domann F, Weigel R.  Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells.  Genes Chromosomes Cancer.  2010 October. 49(10):948-62.
[Link]

Gollapalli V, Liao J, Dudakovic A, Sugg S, Scott-Conner C, Weigel R.  Risk factors for development and recurrence of primary breast abscesses.  J Am Coll Surg.  2010 July. 211(1):41-8.
[Link]

Guidroz J, Johnson M, Scott-Conner C, Deyoung B, Weigel R.  The use of touch preparation for the evaluation of sentinel lymph nodes in breast cancer.  Am J Surg.  2010 June. 199(6):792-6.
[Link]

Fang S, Guidroz J, O'Malley Y, Lal G, Sugg S, Howe J, Jensen C, Weigel R.  Expansion of a cell population expressing stem cell markers in parathyroid glands from patients with hyperparathyroidism.  Ann Surg.  2010 January. 251(1):107-13.
[Link]

Lal G, Nowell A, Liao J, Sugg S, Weigel R, Howe J.  Determinants of survival in patients with calciphylaxis: a multivariate analysis.  Surgery.  2009 December. 146(6):1028-34.
[Link]

Fang S, Chen Y, Weigel R.  GATA-3 as a marker of hormone response in breast cancer.  J Surg Res.  2009 December. 157(2):290-5.
[Link]

Johnson M, Guidroz J, Smith B, Graham M, Scott-Conner C, Sugg S, Weigel R.  A single institutional experience of factors affecting successful identification of sentinel lymph node in breast cancer patients.  Surgery.  2009 October. 146(4):671-6; discussion 676-7.
[Link]

Woodfield G, Hitchler M, Chen Y, Domann F, Weigel R.  Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure.  Clin Cancer Res.  2009 June 1. 15(11):3672-9.
[Link]

Lal  G, Hashimi  S, Smith  B, Lynch  C, Zhang  L, Robinson  R, Weigel  R.  Extracellular Matrix 1 (ECM1) expression is a novel prognostic marker for poor long-term survival in breast cancer – a hospital-based cohort study in Iowa.  Annals of Surgical Oncology .  2009. 16:2280-7.

Spanheimer  P, Graham  M, Sugg  S, Scott-Conner  C, Weigel  R.  Measurement of Uterine Radiation Exposure from Lymphoscintigraphy Indicates Safety of Sentinel Lymph Node Biopsy during Pregnancy.  Annals of Surgical Oncology .  2009. 16:1143-7.

Weigel R.  Textbook of Surgical Oncology.  American Journal of Surgery .  2009. 197:828.

Calva  D, O’Dorisio  T, O’Dorisio  M, Lal  G, Sugg  S, Weigel  R, Howe  J.  When Is Prophylactic Thyroidectomy Indicated For Patients With The RET C609Y Mutation? .  Annals of Surgical Oncology.  2009. 16:2237-44.

Lal  G, O’Dorisio  T, McDougall  I, Weigel  R.  Cancer of the Endocrine System.  Elsevier, Philadelphia.  2008. 

Hoballah  J, Liao  J, Salameh  M, Weigel  R.  Physician Reimbursement for General Surgical Procedures in the Last Century: 1906-2006.  Journal of the American College of Surgeons .  2008. 

Woodfield G, Horan A, Chen Y, Weigel R.  TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling.  Cancer Res.  2007 September 15. 67(18):8439-43.
[Link]

McPherson L, Woodfield G, Weigel R.  AP2 transcription factors regulate expression of CRABPII in hormone responsive breast carcinoma.  J Surg Res.  2007 March. 138(1):71-8.
[Link]

Kairys J, Daskalakis C, Weigel R.  Surgeon-performed ultrasound for preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism.  World J Surg.  2006 September. 30(9):1658-63; discussion 1664.
[Link]

Stabach P, Thiyagarajan M, Woodfield G, Weigel R.  AP2alpha alters the transcriptional activity and stability of p53.  Oncogene.  2006 April 6. 25(15):2148-59.
[Link]

Boland  G, Weigel  R.  Formation and Prevention of Postoperative Abdominal Adhesions.  Journal of Surgical Research .  2006. 132:3-12.

Weigel R, McDougall I.  The Role of Radioactive Iodine in the Treatment of Well-differentiated Thyroid Cancer.  Surgical Oncology Clinics of North America .  2006. 15:625-38.

Weigel  R.  Variability in the Adoption of Breast MRI Among Surgeons.  Journal of Surgical Oncology.  2006. 93:343-4.

Stabach P, Thiyagarajan M, Weigel R.  Expression of ZER6 in ERalpha-positive breast cancer.  J Surg Res.  2005 June 1. 126(1):86-91; discussion 1-2.
[Link]

Parikh  P, Palazzo  J, Rose  L, Daskalakis  C, Weigel  R.  GATA-3 Expression as a Predictor of Hormone Response in Breast Cancer.  Journal of the American College of Surgeons .  2005. 

Radomski  J, Cohn  H, Weigel  R.  Multiple Endocrine Neoplasia and Tumors of the Endocrine Pancreas.  Lippincott Williams & Wilkins, Philadelphia.  2005. 

Vernick  J, Weigel  R.  Pancreas.  Lippincott Williams & Wilkins, Philadelphia.  2005. 

Weigel  R.  Thyroid .  Springer-Verlag, New York.  2005. 

Aqeilan R, Palamarchuk A, Weigel R, Herrero J, Pekarsky Y, Croce C.  Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.  Cancer Res.  2004 November 15. 64(22):8256-61.
[Link]

Weigel  R, Macdonald  J, Haller  D, McDougall  I.  Cancer of the Endocrine System.  Elsevier, Philadelphia .  2004. 

Kulkarni  K, Kim  S, Weigel  R.  Utility of Very Delayed Parathyroid MIBI SPECT for Localization of Parathyroid Adenoma.  Clinical Nuclear Medicine.  2004. 29:727-729.

Chan  B, Desser  T, McDougall  I, Weigel R, Jeffrey  R.  Common and uncommon sonographic features of papillary thyroid carcinoma.  Journal of Ultrasound in Medicine.  2003. 22:1083-90.

Yu  S, Asa  S, Weigel R, Ezzat  S.  Pituitary Tumor AP-2α Recognizes A Cryptic Promoter in Intron 4 of Fibroblast Growth Factor Receptor 4.  Journal of Biological Chemistry.  2003. 278:19597-602.

Lal  , Kaulback  K, Bombonati  A, Palazzo  J, Jeffrey  R, Weigel  R.  Surgical Management of Adrenal Cysts.  American Surgeon .  2003. 69:812-4.

McFadden  D, Ferguson  M, Weigel  R, Garrison  N, Stelzner  M, Brophy  C, Dionne  D, Souba  W.  The Journal of surgical research increases its science citation index: what's the impact?.  Journal of Surgical Research .  2003. 114:107-9.

McPherson L, Loktev A, Weigel R.  Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53.  J Biol Chem.  2002 November 22. 277(47):45028-33.
[Link]

Conroy  A, Sharma  M, Holtz  A, Wu  C, Sun  Z, Weigel R.  A Novel Zinc Finger Transcription Factor with Two Isoforms that are Differentially Repressed by Estrogen Receptor-α.  Journal of Biological Chemistry .  2002. 277:9326-34.

Karwowski  J, Jeffrey  R, McDougall  I, Weigel R.  Intraoperative ultrasonograpy improves identification of recurrent thyroid cancer.  Surgery .  2002. 132:924-9.

Karwowski  J, Nowels  K, McDougall  I, Weigel R.  Needle Track Seeding of Papillary Thyroid Carcinoma from Fine Needle Aspiration Biopsy.  Acta Cytologica .  2002. 46:591-595.

Reeder  S, Desser  T, Weigel R, Jeffrey  R.  Sonography in Primary Hyperparathyroidism: Review With Emphasis on Scanning Technique.  Journal of Ultrasound in Medicine.  2002. 21:539-552.

Schuur E, Loktev A, Sharma M, Sun Z, Roth R, Weigel R.  Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.  J Biol Chem.  2001 September 7. 276(36):33554-60.
[Link]

Yang G, Levine S, Weigel R.  A spike in parathyroid hormone during neck exploration may cause a false-negative intraoperative assay result.  Arch Surg.  2001 August. 136(8):945-9.
[Link]

Wong P, Carmeci C, Jeffrey R, Weigel R.  Parathyroid crisis in a 20 year old--an unusual cause of hypercalcaemic crisis.  Postgrad Med J.  2001 July. 77(909):468-70.
[Link]

Schuur E, McPherson L, Yang G, Weigel R.  Genomic structure of the promoters of the human estrogen receptor-alpha gene demonstrate changes in chromatin structure induced by AP2gamma.  J Biol Chem.  2001 May 4. 276(18):15519-26.
[Link]

Desai D, McPherson L, Higgins J, Weigel R.  Genetic analysis of a papillary thyroid carcinoma in a patient with MEN1.  Ann Surg Oncol.  2001 May. 8(4):342-6.
[Link]

Desai D, Jeffrey R, McDougall I, Weigel R.  Intraoperative ultrasonography for localization of recurrent thyroid cancer.  Surgery.  2001 April. 129(4):498-500.
[Link]

Weigel  R.  Non-operative management of hyperparathyroidism—present and future.  Current Opinion in Oncology .  2001. 13:33-38.

McDougall  R, McDougall  I.  Recombinant Human Thyrotropin in the Management of Thyroid Cancer.  Current Opinion in Oncology .  2001. 

Weigel  R.  Thyroid.  Springer-Verlag, New York.  2001. 

Yang  G, Weigel  R.  Transcription .  Academic Press, San Diego.  2001. 

McDougall I, Weigel R.  Recombinant human thyrotropin in the management of thyroid cancer.  Curr Opin Oncol.  2001 January. 13(1):39-43.
[Link]

Ghosh M, Thompson D, Weigel R.  PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer.  Cancer Res.  2000 November 15. 60(22):6367-75.
[Link]

Schuur E, Weigel R.  Monoallelic amplification of estrogen receptor-alpha expression in breast cancer.  Cancer Res.  2000 May 15. 60(10):2598-601.
[Link]

Macdonald  J, Haller D, McDougall  I, Weigel  R.  Endocrine system.  Churchill, Livingstone, New York.  2000. 

Durski  J, Weigel R, McDougall  I.  Recombinant Human Thyrotropin (rhTSH) in the Management of Differentiated Thyroid Cancer.  Nuclear Medicine Communications.  2000. 21:521-528.

McPherson L, Weigel R.  AP2alpha and AP2gamma: a comparison of binding site specificity and trans-activation of the estrogen receptor promoter and single site promoter constructs.  Nucleic Acids Res.  1999 October 15. 27(20):4040-9.
[Link]

Nakatani K, Thompson D, Barthel A, Sakaue H, Liu W, Weigel R, Roth R.  Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.  J Biol Chem.  1999 July 30. 274(31):21528-32.
[Link]

Nakatani K, Sakaue H, Thompson D, Weigel R, Roth R.  Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.  Biochem Biophys Res Commun.  1999 April 21. 257(3):906-10.
[Link]

Yang G, Ross D, Kuang W, Brown P, Weigel R.  Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes.  Nucleic Acids Res.  1999 March 15. 27(6):1517-23.
[Link]

Hoch  R, Thompson  D, Baker  R, Weigel R.  GATA-3 is expressed in association with estrogen receptor in breast cancer.  International Journal of Cancer .  1999. 84:122-128.

Purcell  G, Dirbas  F, Jeffrey  R, Lane  M, Desser  T, McDougall  I, Weigel R.  Parathyroid localization with high resolution ultrasound and technetium 99m-sestamibi.  Archives of Surgery.  1999. 134:824-828.

Carmeci C, Thompson D, Kuang W, Lightdale N, Furthmayr H, Weigel R.  Moesin expression is associated with the estrogen receptor-negative breast cancer phenotype.  Surgery.  1998 August. 124(2):211-7.
[Link]

Carmeci C, Jeffrey R, McDougall I, Nowels K, Weigel R.  Ultrasound-guided fine-needle aspiration biopsy of thyroid masses.  Thyroid.  1998 April. 8(4):283-9.
[Link]

Thompson D, Weigel R.  Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.  Eur J Biochem.  1998 February 15. 252(1):169-77.
[Link]

Kuang W, Thompson D, Hoch R, Weigel R.  Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line.  Nucleic Acids Res.  1998 February 15. 26(4):1116-23.
[Link]

Weigel  R.  Cancer biology.  Appleton & Lange, Stamford, CT.  1998. 

Thompson  D, Weigel R.  hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is co-expressed with estrogen receptor in breast cancer cell lines .  Biochemical and Biophysical Research Communications.  1998. 251:111-116.

Thompson  D, Carmeci  C, Weigel  R.  RT-PCR using formalin-fixed, paraffin-embedded (FFPE) archival tumour specimens.  BioTechniques Books, Natick, MA.  1998. 

Weigel  R.  The endocrine system.  Appleton & Lange, Stamford, CT.  1998. 

Lane  M, Desser  T, Weigel R, Jeffrey  R.  Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas..  American Journal of Roentgenology .  1998. 171:819-823.

Carmeci C, Thompson D, Ring H, Francke U, Weigel R.  Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer.  Genomics.  1997 November 1. 45(3):607-17.
[Link]

Thompson D, McPherson L, Carmeci C, deConinck E, Weigel R.  Identification of two estrogen receptor transcripts with novel 5' exons isolated from a MCF7 cDNA library.  J Steroid Biochem Mol Biol.  1997 June. 62(2-3):143-53.
[Link]

Carmeci C, deConinck E, Lawton T, Bloch D, Weigel R.  Analysis of estrogen receptor messenger RNA in breast carcinomas from archival specimens is predictive of tumor biology.  Am J Pathol.  1997 May. 150(5):1563-70.
[Link]

McPherson L, Baichwal V, Weigel R.  Identification of ERF-1 as a member of the AP2 transcription factor family.  Proc Natl Acad Sci U S A.  1997 April 29. 94(9):4342-7.
[Link]

Weigel  R.  Advances in the diagnosis and management of thyroid cancers .  Current Opinion in Oncology.  1996. 8:37-43.

Weigel R, Ikeda  D, Nowels  K.  Primary squamous cell carcinoma of the breast.  Southern Medical Journal.  1996. 89:511-515.

Macdonald  J, Haller  D, Weigel  R.  Endocrine system.  Livingstone, New York.  1995. 

Weigel  R.  Inherited cancer.  Livingstone, New York.  1995. 

Weigel R, Crooks  D, Iglehart  J, deConinck  E.  Quantitative analysis of the transcriptional start sites of estrogen receptor in breast carcinoma.  Cell Growth and Differentiation.  1995. 6:707-711.

deConinck  E, McPherson  L, Weigel R.  Transcriptional regulation of estrogen receptor in breast carcinoma.  Molecular and Cellular Biology.  1995. 15:2191-2196.

Weigel R, Wells  S, Gunnells  J, Leight  G.  Surgical treatment of primary hyperaldosteronism.  Annals of Surgery.  1994. 219:347-352.

Weigel R, deConinck  E.  Transcriptional control of estrogen receptor in estrogen receptor-negative breast carcinoma.  Cancer Research.  1993. 53:3472-3474.

Weigel  R, Boyle  T, Kirk  A.  Infections.  Mosby Year Book, St. Louis, MO.  1992. 

Weigel  R.  Wound healing: biologic and clinic features.  W.B. Saunders Company, Philadelphia, PA.  1992. 

Weigel R, Nevins  J.  Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expression.  Nucleic Acids Research.  1990. 18:6107-6112.

Weigel R, Devoto  S, Nevins  J.  The adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells.  Proceedings of the National Academy of Sciences USA.  1990. 87:9878-9882.

Young  K, Weigel R, Hiebert  S, Nevins  J.  Adenovirus E1A-mediated negative control of genes activated during F9 differentiation.  Molecular and Cellular Biology.  1989. 9:3109-3113.

Weigel  R.  Gene expression during the latent and replicative states of the Epstein-Barr virus.  1986. 

Weigel R, Fischer  D, Heston  L, Miller  G.  Constitutive expression of Epstein-Barr virus-encoded RNAs and nuclear antigen during latency and after induction of Epstein-Barr virus replication.  Journal of Virology.  1985. 53:254-259.

Weigel R, Miller  G.  Latent and viral replicative transcription in vivo from the Bam K fragment of Epstein-Barr virus DNA.  Journal of Virology.  1985. 54:501-508.

Robert  M, Shedd  D, Weigel R, Fischer  D, Miller  G.  Expression of COS-1 cells of Epstein-Barr virus and nuclear antigen from a complete gene and a deleted gene.  Journal of Virology.  1984. 50:822-831.

Weigel R, Miller  G.  Major EB virus-specific cytoplasmic transcripts in a cellular clone of the HR-1 Burkitt lymphoma line during latency and after induction of viral replicative cycle by phorbol esters.  Virology.  1983. 125:287-298.

Weigel  R.  Comments on static linear and non-linear elastic properties of normal and arterialized venous tissue in dog and man.  1981. 49:1363-1364.

Weigel  R.  Covalent binding of biologically active molecules to synthetic polymers: a study of blood compatible surfaces.  1980. 

Weigel  R, Silverberg  L.  Effect of Parathyroidectomy on Polycythemia Vera.  Surgery .  137:102-3.

Weigel  R, Dracon  G, Radhakrishnan  R, Rho  Y, Sevgen  F, Dafoe  D.  Incentive Systems For Academic Productivity in a Department of Surgery. .  Journal of the American College of Surgeons .  199:300-307.

Date Last Modified: 06/07/2014 - 21:56:23