Surgery

Joel Shilyansky, MD

Portrait

Robert and Hélène Soper Chair of Pediatric Surgery
Surgeon-in-Chief
Professor of Surgery  - Pediatric Surgery
Professor of Pediatrics  - Pediatric Surgery

Contact Information

Primary Office: 2967 JCP
Iowa City, IA 52242
Primary Office Phone: 319-356-1766

Email: joel-shilyansky@uiowa.edu

Education

Biology, University of Michigan Ann Arbor
BS, Biology, University of California at Los Angeles
MD, University of California at Los Angeles

Surgical Internship, Surgery, University of Michigan Medical Center
Residency, General Surgery, University of Michigan Medical Center
Fellowship, NIH Staff Fellow in Surgical Oncology, Surgery Branch, National Cancer Institute NIH, Bethesda, MD
Residency, General Surgery Residency, University of Michigan Medical Center Ann Arbor, Michigan
Residency, Chief Residency , University of Michigan Chief Residency Medical Center, Ann Arbor, Michigan
Fellowship, Pediatric Surgery, University of Toronto Hospital for Sick Children

Licensure and Certifications

Iowa Medical License
Illinois Medical License
Certified, Advanced Trauma Life Support

Research Summary

Dr. Shilyansky studies the immune response in pediatric cancer patients. Specifically the mechanism allowing cancers to avoid immune destruction are being addressed. By understanding these mechanisms vaccines that can induce anti-cancer immunity and lead to cancer regression may be developed. Dendritic cells, white blood cells that regulate the immune response, are critically important for effective anti-tumor responses. Cancer cells appear adept at inhibiting dendritic cells. Recent studies in the laboratory examined phosphatidylserine as a mechanism for inhibiting dendritic cells and for evading tumor immunity. Phosphatidylserine is a membrane phospholipid that is normally restricted to the inner surface of the cell membrane (envelope) and is exposed on the cell surface during programmed cell death (apoptosis). However, live cancer cells can express phosphatidylserine on the cell surface. Dr. Shilyansky's laboratory has demonstrated that tumor phosphatidylserine inhibits human peripheral blood derived dendritic cells. Phosphatidylserine appear to interfere with NF-kappaB and p38 MAPK activation, signaling events required for dendritic cell maturation and function. Recent work has concentrated on the in vivo mechanisms by which phosphatidylserine affects tumor immunity. Additional studies in Dr. Shilyansky's laboratory relate to cancer vaccine development and effects of ligating CD40, a critical receptor on antigen presenting cells, in tumor immunity.

All Publications

Sun  R, Skeete  D, Wetjen  K, Lilienthal  M, Liao  J, Madsen  M, Shilyansky J, Lancaster  G, Choi  K.  A pediatric cervical spine clearance protocol to reduce radiation exposure in children.  J Surg Res.  2013 July. 

Shilyansky J, Masadeh  M, Petersen  J, Krein  , Bauer  M, Phearman  L, Liao  J, Pitcher  G.  Outcome of antegrade continent enema (ACE) procedures in children and young adults.  J Ped Surg.  2013. 48(10):2128-2133.

Shilyansky J, Masadeh  M, Yin  C.  Annexin V inhibits CMS5 fibrosarcoma growth by blocking phosphatidylserine.  2012 May. 

Shilyansky J, Yan  X, Doffek  K, Yin  , Krein  M, Phillips  , Sugg  S, Johnson  B.  Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo.  2012 April 5. 

Shilyansky J, O'Malley  Y, Weigel  , Lal  , Komorowski  R, Howe  .  Invasion in Follicular Thyroid Cancer (FTC) Cell Lines is Mediated by EphA2 and pAkt.  2012 April. 

Shilyansky J, Orion  K, Krein  M, Liao  J, Shaaban  A, Pitcher  G.  Outcomes of plastic closure in gastroschisis.  2011 August. 150(2):177-85.

Shilyansky J, Doffek  K, Chen  X, Sugg  S.  Phosphatidylserine inhibits NFkB and p38 MAPK activation in human monocyte derived dendritic cells.  2011 May 31. 48(15-16):1771-1777.

Shilyansky J, Ostedgaard  L, Meyerholz  D, Chen  J, Pezzulo  A, Hanfland  R, Reznikov  L, Hornick  E, Rector  , Ludwig  P, Rogan  M, Dohrn  C, Davis  G, Rokhlina  , Nassar  P, Samuel  S, Taft  , McCray  P, Karp  , Richter  S, Uc  A, Stoltz  D, Welsh  M, Zabner  J, Prather  P, Ernst  .  The F508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.  Si Transl Med .  2011 March 16. 3(74):74ra24.

Shilyansky J, Orion  K, Krein  M, Liao  J, Shaaban  , Pitcher  A.  Outcomes of plastic closure of abdominal wall defects in gastroschisis.  2011 February. 

Shilyansky J.  Pediatric Laparoscopic Nissen Fundoplication.  Springer.  2011. 

Shilyansky J, Pitcher  A, Shaaban  A, Liao  J, Krein  M, Orion  K.  Plastic closure in gastroschisis.  2010 August. 

Shilyansky J, Kirby  P, Tannous  R, Day  K.  Outcome Following Hepatic Metastasectomy of Stage IV Neuroblastoma.  2010 February. 

Shilyansky J, Stoltz D, Meyerholz  , Pezulo  A, Ramachandran  S, Roga  M, Davis  G, Hanfland R, Wohlford-Lenane  C, Dohrn  C, Bartlett  J, Nelson IV  G, Chang  E, Taft  P, Ludwig  P, Hornick  .  Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth.  2010. 2(29):29-31.

Shilyansky J, McCray  P, Welsh  M, Abu-El-Haija  M, Uc  A, Meyerholz   , Ramachandran  S, Giriyappa  R, Pezzulo  A, Taft  P, Hanfland  R, Davis  G, Rogan  M, Zabner  , Stoltz  D.  Inflammation may play a role in the destruction of pancreas in cystic fibrosis..  2010. 

Shilyansky J, Pitcher  G.  Intestinal Atresias, Webs, and Duplications.  McGraw Hill.  2010. 

Shilyansky J, Kirby  , Tannous  R, Day  K.  Hepatic Metastasectomy in Stage IV Neuroblastoma.  2009 October. 

Shilyansky J, Stoltz  , Meyerholz  D, Hanfland  R, Pezzulo  A, Rogan  M, Davis  , Taft  P, Starner  , Uc  A, Brogden  K, McCray  , Zabner  , Welsh  M.  Surgical correction of meconium ileus obstruction in neonatal CFTR-/- pigs. .  2009 October. 

Shilyansky J, Krein  M, Yin  C.  Blocking Phosphatidylserine Enhances The Efficacy of Neuroblastoma Vaccine.  2009 February. 

Shilyansky J, Yin  C, Fan  J, Ray  B.  Exposure to phosphatidylserine (PS) inhibits CD80 expression in mouse A20 B cells in vitro.  2009 February. 

Shilyansky J, Fan  .  Phosphatidylserine(PS) regulates the in vivo function of bone marrow-derived dendritic cells(BMDC) .  2009 February. 

Shilyansky J.  Berlin, Springer N Engl J Med .  2009. 360(10).

Shilyansky J, Yin  C, Krein  M.  Inhibition of phosphatidylserine on the surface of tumor cells promotes anti-tumor immunity and slows tumor growth in vivo. .  2008 February. 

Shilyansky J, Rogers  C, Stoltz  D, Meyerholz  D, Ostegaard  L, Rokhlina  T, Taft  , Rogan  M, Pezzulo  A, Karp P, Itani  O, Kabel  A, Wohlford-Lenane  C, Davis  G, Hanfland  R, Smith  T, Samuel  , Wax  D, Murphy  C, Rieke  A, Whitworth  K, Uc  A, Starner  T, Brogden  K, McCray Jr  P, Zabner  , Prather  R, Welsh  M.  Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs.  Science .  2008. 321:1837-1841.

Phillips M, Doffek K, Sugg S, Shilyansky J.  Phosphatidylserine expression on the surface of tumor cells inhibits anti-tumor immunity and promotes tumor growth in vivo.  2007 February. 

Shilyansky J, Xu H, Doffek K, Sugg S, Oldham K, Pritchard K.  Targeting heat shock protein in cancer angiogenesis.  2007 February. 

Shilyansky J.  Diarrhea From Hormone-Secreting Tumors.  Philadelphia, W.B. Saunders.  2007. 

Doffek K, Yan X, Sugg S, Johnson B, Shilyansky J.  Neuroblastoma express phosphatidylserine: mechanism for immune evasion.  2007. 

Shilyansky J.  Tumors of the Digestive Tract.  Philadelphia, W.B. Saunders.  2007. 

Jacobs P, Doffek K, Sugg S, Shilyansky J.  Induction of cytolytic T lymphocytes (CTL) agaisnt pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor.  Journal of Pediatric Surgery.  2007 January. 42(1):54-61; discussion 61.

Lodge A, Yu P, Nicholl M, Brown I, Jackson C, Schreiber K, Sugg S, Schreiber H, Shilyansky J.  CD40 ligation restores cytolytic T lymphocyte (CTL) response and eliminates murine fibrosarcoma in mice lacking CD4+ T cells.  Cancer Immunology Immunotherapy.  2006 December. 55(12):1542-52.

Shilyansky J, Doffek K, Macallister D, Chen X, Sugg S.  PS inhibits DC maturation by interferring with P38 MAPK and NF-kappaB Signaling.  2006 February. 

Shilyansky J, Jacobs P, Doffek K, Sugg S.  Induction of cytolytic T lymphocytes (CTL) against pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor.  Journal of Pediatric Surgery.  2006. 

Shilyansky J, Chen X, Doffek K, Sugg S.  Neuroblastoma inhibit dendritic cell maturation by expressing phosphatidylserine on the cell surface.  2006. 

Shilyansky J.  Oncology-Neuroblastoma.  Cambridge University Press.  2006. 

Densmore J, Doffek K, Kaul S, Pritchard K, Guice K, Oldham K, Shilyansky J.  Endothelium-derived microparticles induce dendritic cell apoptosis.  2005 October. 

Cole D, Weil D, Shilyansky J, Custer M, Kawakami Y, Rosenberg S, Nishimura M.  Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.  Cancer Research.  2005. 55:748-752.

Arca M, Somers K, Derks T, Goldin A, Aiken J, Sato T, Shilyansky J, Winthrop A, Oldham K.  Use of vacuum-assisted closure system in the management of complex wounds in the neonate.  Pediatric Surgery International.  2005. 21:532-535.

Chen X, Doffek K, Gavin C, Sugg S, Shilyansky J.  Immune evasion by neuroblastoma (NB): Role of Phosphatidylserine (PS).  2004 November. 

Lodge A, Shilyansky J.  Mechanisms for restored CTL response and elimination of murine fibrosarcoma (MF) by CD40 ligation in mice lacking CD4+ T cells.  2004 November. 

Doffek K, Chen X, Gavin C, Sugg S, Shilyansky J.  Phosphatidylserine inhibits ERK1/2, NFkB and p38 MAPK but not AKT activation in response to LPS, modulating DC maturation and function.  2004 November. 

Aziz R, Lodge A, Chen X, Sugg S, Shilyansky J.  Phosphatidylserine modulates the phenotype of mouse dendritic cells.  2004 September. 

Gavin C, Doffek K, Chen X, Sugg S, Shilyansky J.  Downregulation of dendritic cell surface antigen expression and stimulatory function by apoptotic neutrophils is partly reversed by Annexin V blockade.  2004 July. 

Doffek K, Chen X, Gavin C, Sugg S, Shilyansky J.  Phosphatidylserine modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation response to LPS.  2004 July. 

Shilyansky J.  Phosphatidylserine (PS) modulated the maturation and function of human dendritic cells (DC): A possible mechanism for immune evasion by Neuroblastoma (NB).  FASEB Journal.  2004 April. 

Shilyansky J, Chen X, Doffek K, Sugg S.  Phosphatidylserine modulated the maturation and function of human dendritic cells (DC): A mechanism for immune evasion by neuroblastoma (NB).  FASEB Journal.  2004 April. 

Lodge A, Shilyansky J.  Restored cytolytic T lymphocyte (CTL) response and elimination of murine fibrosarcoma (MF) by CD40 ligation in mice lacking CD4+T cells.  FASEB Journal.  2004 April. 

Xiang B, Du L, Kappes A, Shilyansky J, Hessner M, Jiang N, Demeure M, Wilson S, Sugg S.  Altered gene expression in metastatic vs primary follicular thyroid carcinoma cell lines by cDNA microarray.  Annals of Surgical Oncology.  2004 March. 

Shilyansky J, Chen X, Doffek K, Sugg S.  Phosphatidylserine modulated the maturation and function of human dendritic cells: A possible mechanism for immune evasion by Neuroblastoma.  2004 March. 

Bannister K, Lodge A, Sugg S, Shilyansky J.  Role of CTLA4 in tumor immunity.  2004 March. 

Alloo J, Gerstle T, Shilyansky J, Ein S.  Appendicitis in children less than 3 years of age: A 28-year review.  Pediatric Surgery International.  2004. 19:777-779.

Nicholl M, Pitt H, Wolf P, Cooney N, Kalayoglu M, Shilyansky J, Rikkers L.  Choledochal cysts in western adults: complexities compared to children.  Journal of Gastrointestinal Surgery.  2004. 8(3):245-252.

Metzger S, Nusair S, Planer D, Barash V, Pappo P, Shilyansky J, Chajek-Shaul T.  Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development in mice bearing IL-1 {beat}-secreting tumor.  Endocrinology.  2004. 145(11):5150-5156.

Shilyansky J.  Oncogenesis.  Philadelphia, Lippincott-Raven.  2004. 

Gavin C, Jacobs P, Doffek K, Shilyansky J.  Phosphatidylserine mediates the inhibitory effects of apoptotic cells on dendritic cells.  International Proceedings of Immunology.  2004. 

Chen X, Doffek K, Sugg S, Shilyansky J.  Phosphatidylserine modulates the human dendritic cell maturation and function.  Journal of Immunology.  2004. 173:2985-2994.

Doffek K, Chen X, Gavin C, Sugg S, Shilyansky J.  PS modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation in response to LPS.  International Proceedings of Immunology.  2004. 

Nicholl M, Lodge A, Brown I, Sugg S, Shilyansky J.  Restored immune response to a MHC-II restricted antigen in tumor bearing Hosts after elimination of regulatory T-cells.  Journals of Pediatric Surgery.  2004. 39:941-946.

Nicholl M, Lodge A, Brown I, Sugg S, Shilyansky J.  Restored immune response to an MHC-II-restricted antigen in tumor-bearing hosts after elimination of regulatory T cells.  Journal of Pediatric Surgery.  2004. 39(6):941-946.

Chen X, Doffek K, Chan E, Gavin C, Sugg S, Shilyansky J.  Phosphatidylserine-dependent suppression of dendritic cell function by neuroblastoma: A novel mechanism of tumor evasion.  2003 November. 

Nicholl M, Shilyansky J.  Restored Immune response to an MHC-II restricted antigen in tumor-bearing hosts after elimination of regulatory T cells.  2003 October. 

Nicholl M, Shilyansky J.  T regulatory cells infiltrate murine fibrosarcoma and enhance tumor establishment.  2003 October. 

Nicholl M, Shilyansky J.  Treg depletion in tumor-bearing mice enhances response to tumor antigen immunization.  2003 October. 

Lodge A, Yu P, Brown I, Sugg S, Shilyansky J.  Tumor elimination requires helper T cells for persistent CTL response.  2003 October. 

Lodge A, Yu P, Brown I, Sugg S, Shilyansky J.  Helper T cells are required for persistent CTL response and tumor elimination.  2003 May. 

Chen X, Shilyansky J.  Phosphatidylserine (PS) exposure is a sufficient signal to alter the maturation and function of human dendritic cells.  2003 March. 

Shilyansky J.  immunostimulatory function of dendritic cells.  Journal of Pediatric Surgery.  2003. 38(6):901-05.

Chen X, Doffek K, Sugg S, Shilyansky J.  Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells.  Journal of Pediatric Surgery.  2003. 38(6):901-05.

Chen X, Doffek K, Shilyansky J.  Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells.  2002 November. 

Nicholl M, Shilyansky J.  Local immune privilege promotes establishment of fibrosarcoma.  2002 October. 

Chen X, Shilyansky J.  Neuroblastoma induce regulatory dendritic cells and inhibit T cell activation.  2002 October. 

Nicholl M, Shilyansky J, Ota D.  Current management of malignant large-bowel obstruction.  Contemporary Surgery.  2002. 58(8):396-400.

Shilyansky J.  Diarrhea From Hormone-Secreting Tumors.  Philadelphia, W.B. Saunders.  2002. 

Shilyansky J.  Tumors of the Gastrointestinal Tract.  Philadelphia, W.B. Saunders.  2002. 

Brown I, Yu P, Schreiber H, Shilyansky J.  Established tumors escape elimination, despite activation of specific T cells.  2001 November. 

Jackson C, Yu P, Brown I, Seely E, Schreiber H, Shilyansky J.  CD4+ T cells or IL-2 are required to eliminate peritoneal tumor spread.  2001 May. 

Sugg S, Niu Q, Zimmerman T, Shilyansky J.  Detection of bone marrow micrometastases in advanced breast cancer using multiple genetic markers.  Proceedings of the American Association for Cancer Research.  2001 March. 

Brown I, Yu P, Seeley E, Shilyansky J.  Tumor progression in immunocompetent mice despite the presence of activated tumor-specific T cells.  2001 March. 

Shilyansky J, Jackson C, Yu P, Brown I, Seely E, Schreiber H.  CD4+ T cells are required to prevent intraperitoneal spread of an immunogenic tumor after repeat challenges.  2000 May. 

Shilyansky J.  Pancreas.  Philadelphia, Hanley and Belfus.  2000. 

Shilyansky J, Navarro O, Superina R, Babyn P, Filler R, Pearl R.  Delayed hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event.  Journal of Pediatric Surgery.  1999. 34(1):60-64.

Shilyansky J, Roberts E, Superina R.  Distal splenorenal shunts for the treatment of severe thrombocytopenia from portal hypertension in children.  Journal of Gastrointestinal Surgery.  1999. 3(2):167-172.

Shilyansky J, Navarro O, Superina R, Babyn P, Filler R, Pearl R.  Late hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event.  1998 May. 

Ky A, Shilyansky J, Gerstle J, Filler R, Taylor G, Superina R.  Experience with papillary and solid epithelial neoplasms of the pancreas in children.  Journal of Pediatric Surgery.  1998. 33(1):42-44.

Shilyansky J, Sena L, Kreller M, Chait P, Babyn P, Filler R, Pearl R.  Non-operative management of pancreatic injuries in children.  Journal of Pediatric Surgery.  1998. 33(2):343-349.

Shilyansky J, Roberts E, Superina R.  Distal splenorenal shunts for severe thrombocytopenia from portal hypertension.  1997 July. 

Ky A, Shilyansky J, Gerstle J, Filler R, Taylor G, Superina R.  Experience with papillary and solid epithelial neoplasms of the pancreas in children.  1997 July. 

Shilyansky J, Sena L, Chait P, Gerstle J, Babyn P, Pearl R, Filler R.  Diagnosis and management of pancreatic injuries in children.  1997 May. 

Shilyansky J, Kreller M, Sena L, Babyn P, Pearl R.  Diagnosis and management of duodenal injuries in children.  Journal of Pediatric Surgery.  1997. 32(6):880-891.

Shilyansky J, Lelli Jr. J, Drongowski R, Coran A.  Efficacy of the straight endorectal pull-through in the management of familial adenomatous polyposis coli-a 16-year experience.  Journal of Pediatric Surgery.  1997. 32(8):1139-1143.

Shilyansky J, Cutz E, Filler R.  Endogenous hyperinsulinism: Diagnosis, management and long-term follow-up.  Seminars in Pediatric Surgery.  1997. 6(3):115-120.

Shilyansky J, Yang J, Custer M, Spiess P, Mixon A, Cole D, Mule J, Rosenburg S, Nishimura M.  Identificatioin of a T-cell receptor from a therapeutic murine T-cell clone.  Journal of Immunotherapy.  1997. 20(4):247-55.

Metzger S, Goldschmidt N, Barash V, Peretz T, Drize O, Shilyansky J, Shiloni E, Chajek-Shaul T.  Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphate and liver glycogen levels.  The American Journal of Physiology.  1997. 273(36):E262-267.

Shilyansky J, Fisher S, Cutz E, Perlman K, Filler R.  Is 95% pancreatectomy the procedure of choice for the treatment of persistent hyperinsulinemic hypolglycemia of the neonate?.  Journal of Pediatric Surgery.  1997. 32(2):342-346.

Shilyansky J, Kreller M, Sena L, Babyn P, Pearl R.  Diagnosis and management of duodenal injuries in children.  1996 August. 

Shilyansky J, Fisher S, Cutz E, Perlman K, Filler R.  Is 95% Pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycemia of the neonate?.  1996 May. 

Shilyansky J, Lelli Jr. J, Drongowski R, Coran A.  The ileal endorectal pull-through procedure in the management of familial adenomatous polyposis coli -- A 16-year experience.  1996 May. 

Cole D, Weil D, Shilyansky J, Custer M, Kawakami Y, Rosenberg S.  Characterization of the functional specificity of a cloned T cell receptor heterodimer recognizing the MART-1 melanoma antigen.  Proceedings of the American Association for Cancer Research.  1995. 36:A2839.

Cole D, Weil D, Shilyansky J, Custer M, Kawakami Y, Rosenberg S, Nishimura M.  Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.  Cancer Research.  1995. 55(4):748-52.

Shilyansky J, Nishimura M, Kawakami Y, Yannelli J, Rosenberg S.  T cell receptor usage by melanoma specific clonal and highly ologoclonal tumor infiltrating lymphocyte lines.  1994 March. 

Shilyansky J, Wilson W, Temeck B, Pass H.  Pulmonary artery-bronchial fistula during lymphoma treatment.  Journal of Cardiovascular Surgery.  1994. 108(4):790-91.

Nishimura M, Kawakami Y, Charmley P, O'Neil B, Shilyansky J, Yannelli J.  T-cell receptor repertoire in tumor infiltrating lymphocytes: Analysis of melanoma specific long term lines.  Journal of Immunotherapy.  1994. 16(2):85-94.

Shilyansky J, Nishimura M, Yannelli J, Kawakami Y, Jacknin L, Charmley P.  T-cell receptor usage by melanoma specific clonal and highly oligoclonal tumor infiltrating lymphocyte lines.  Proceedings of the National Academy of Sciences.  1994. 91(7):2829-2833.

Shilyansky J, Nishimura M, Yang J, Custer M, Spiess P, Mule J, Rosenberg S.  Derivation of a therapeutic monoclonal tumor infiltrating lymphocyte line and the identification and cloning of the T cell receptor genes responsible for tumor recognition.  1993 October. 

Shilyansky J, Nishimura M, Kawakami Y, Tannelli J, Rosenberg S.  Analysis of TCR expression by melanoma specific tumor infiltrating lymphocytes.  Cellular Immunity and Immunotherapy of Cancer.  1993 March. 

Nishimura M, Kawakami Y, Charmley , O'Neil B, Shilyansky J, Yannelli J.  T-Cell receptor V gene usage in melanoma specific tumor infiltrating lymphocytes.  1993 March. 

Shilyansky J, Nishimura M, Yannelli J, Kawakami Y, O'Neil B, Mule J, Rosenberg S.  T-cell receptor variable gene usage in melanoma specific TIL clones and lines.  1993 March. 

Kawakami Y, O'Neil B, Nishimura M, Restifo N, Topalian S, Hom S, Yannelli J, Shilyansky J.  T-Cell recognition of human melanoma antigens.  Molecular and Cellular Immunology.  1993 March. 

Shilyansky J, Nishimura M, Yang J, Custer M, Spiess P, Mule J, Rosenberg S.  Murine sarcoma-specific tumor infiltrating lymphocyte (TIL) clone utilizing a unique T-cell receptor rearrangement successfully treats established lung metastases.  Surgical Forum.  1993. 44:521-523.

Shiloni E, Karp S, Custer M, Shilyansky J, Restifo N, Rosenberg S.  Retroviral transformation of interferon- cDNA into a non-immunogenic MHC Class-I deficient murine fibrosarcoma: Generation of T-cells capable of treating established parental metastatic tumor.  Cancer Immunology and Immunotherapy.  1993. 37:286-92.

Kawakami Y, Nishimura M, Restifo N, Topalian S, O'Neil B, Shilyansky J.  T-cell recognition of human melanoma antigens.  Journals of Immunotherapy.  1993. 14:88-93.

Foglia R, Shilyansky J, Fonkalsrud E.  Emergency lung biopsy in immunocompromised pediatric patients.  Annals of Surgery.  1989. 21(1):90-92.

Date Last Modified: 06/07/2014 - 21:56:23