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Bariatric, Gastrointestinal, and Minimally-Invasive SurgeonProgram Director, Bariatric Surgery Fellowship ProgramDirector, UI Obesity Surgery ProgramAssociate Professor of Surgery - Gastrointestinal, Minimally-invasive and Bariatric Surgery
Primary Office: 4625 JCPIowa City, IA 52242 Primary Office Phone: 319-384-7220
Email: isaac-samuel@uiowa.edu
MD, Bangalore Medical College, Bangalore University, Karnataka State, India
Intern, Surgery and Medicine, Bangalore Medical College Hospitals, Karnataka State, IndiaResidency, Surgery and Medicine, St. Martha's and St. Philomena's Hospitals, Karnatake State, IndiaResidency, Surgery and Medicine, Tiruvella Medical Mission Hospital, Kerala State, IndiaResidency, Emergency Room, Eastbourne District, General Hospital, Eastbourne, UKResidency, General Surgery, Leeds General Infirmary, University of Leeds, UKRegistrar, General Surgery, St. Thomas' Hospital, University of London, UKFellowship, Research, General Surgery, Northwestern University, Chicago, ILResidency, General Surgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
Permanent Medical LicensePermanent Medical LicensePermanent Medical LicensePermanent Licensure, General Medical CouncilPermanent LicensureCertified, Advanced Trauma Life SupportFellow (FACS), American College of SurgeonsBoard Certified, General Surgery, American Board of SurgeryFRCS, Royal College of Surgeons, Glasgow, UK
Acute pancreatitis pathogenesis: The laboratory investigates the role of acinar cell signaling pathways such as the stress kinase (p38, JNK, ERK) pathway and the Akt/NFkB pathway as applied to a novel hypothesis for gallstone pancreatitis pathogenesis. The role of pancreatic hyperstimulation via G-protein coupled receptors (CCK receptor and cholinergic receptor) and their regulation by a novel group of proteins called RGS (regulation of G-protein signaling) proteins are also being investigated. Our long- term goal is to elucidate the pathogenesis of acute pancreatitis with a view to implement new treatment modalities. Current funding from NIH is a NIDDK K08 Career Development Award. Samuel Clinical Research: Measurement of physical activity and energy expenditure in bariatric surgery patients to improve pre-operative evaluation and long-term post-operative outcomes.
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Crosstalk Between NF-2B and AP-1 Nuclear Transcription Factor Pathways May Exacerbate Acute Pancreatic Inflammation. Samuel I, Williard D, Twait E. 2011; 5 (S1) :S-386-387. Enhanced interleukin-33 expression and mast cell activation in pancreas and lung tissues of pancreatic duct ligation-induced acute pancreatitis in rodents. Samuel I, Kempuraj D, Yuan , Theoharides . Journal of Immunology . 2011; 186 (117.16) . ERK Inhibition Substantially Improves Early Stage Mortality in Acute Pancreatitis: The First Report of AAV Vector- Mediated Gene Modulation in an Exocrine Pancreatic Disease. Samuel I, Yuan Z, Williard D, Twait E, Kempuraj D. 2011; 19 (S1) :S251-S252. Mast Cell Activation and Interleukin-33 Upregulation in Pancreas and Lung of Pancreatic Duct Ligation-Induced Acute Pancreatitis in Rodents. Samuel I, Kempuraj D, Yuan Z. Gastroenterology. 2011; 5 (S1) :S-551. Physical Activity Patterns in Morbidly Obese and Normal-Weight Women. Samuel I, Jamal M, Kwon S. American Journal of Behavioral Health . 2011; 35 (2) :155. Resolution of hyperlipidemia follows surgical weight loss in patients undergoing gastric bypass surgery: A six year analysis of data. Samuel I, Jamal , Wegner R, Heitshusen D. Surgery for Obesity and Related Disorders (SOARD) . 2011. Roux-en-Y Gastric Bypass Achieves Substantial Resolution of Migraine Headache in the Severely Obese: a 9-year analysis of 81 patients. Samuel I, Gunay Y, Jamal , Capper , Eid A, Heitshusen D. Surgery for Obesity and Related Disorders (SOARD) . 2011. Roux-en-Y gastric bypass ameliorates polycystic ovarian syndrome and dramatically improves conception rates. Samuel I, Gunay , Jamal M, Capper , Heitshusen D. 2011; 7 (3) :S-343. Systemic Inflammation With Multiorgan Dysfunction Is the Cause of Death in Murine Pancreatic Duct Ligation-Induced Acute Pancreatitis. Samuel I, Yuan Z, Meyerholz , Williard , Twait E, Kempuraj D. Gastroenterology . 2011; 5 (S1) :S-1026. A novel model of severe gallstone pancreatitis: Murine pancreatic duct ligation results in systemic inflammation and substantial mortality (Rapid Communication). Samuel I, Yuan Z, Meyerholz D, Twait E, Williard , Kempuraj D. 2010; 10 (5) :536-544.
Date Last Modified: 01/08/2013 - 17:05:00