Surgery

James Howe, MD

Portrait

Director, Division of Surgical Oncology and Endocrine Surgery
Co-Director, Neuroendocrine Cancer Clinic
Professor of Surgery  - Surgical Oncology and Endocrine Surgery

Contact Information

Primary Office: 4644 JCP
Iowa City, IA 52242
Primary Office Phone: 319-356-1727

Email: james-howe@uiowa.edu

Education

MD, University of Vermont College of Medicine

Fellowship, Surgical Research Fellow, Washington University, St. Louis, MO
Residency, General Surgery, Barnes Hospital, St. Louis, MO
Fellowship, Clinical, Surgical Oncology, Memorial Sloan-Kettering Center

Licensure and Certifications

Iowa Medical License, Iowa Board of Medicine
Certified, Advanced Trauma Life Support
Board Certified, General Surgery, American Board of Surgery
Qualifying Examination, American Board of Surgery

Research Summary

I am a Surgical Oncologist and Endocrine Surgeon who specializes in taking care of patients with cancers of the pancreas, liver, GI tract, soft tissue sarcoma, melanoma, thyroid, parathyroid, and adrenal glands; I am co-director of the neuroendocrine cancer clinic, Division Director of Surgical Oncology and Endocrine Surgery, and Professor of Surgery at the University of Iowa. My area of research expertise is in Familial Cancer Syndromes, genetic linkage, gene discovery, and gene expression studies. My postdoctoral training at Washington University under Helen Donis-Keller, Ph.D. and Samuel Wells, M.D., was directed at the identification of the gene for Multiple Endocrine Neoplasia Type 2. As a faculty member, my focus has been the genetics of Juvenile Polyposis, which led to the discovery of the 2 predisposing genes. More recently, I have developed a large clinical practice and research interest in the genetics of neuroendocrine tumors (NETs). Our current research focus is the study of gene expression profiles in pancreatic and small bowel NETs to identify new targets for imaging and treatment, and collection of families to search for predisposing genes.

All Publications

Carr J, Boese E, Spanheimer P, Dahdaleh F, Martin M, Calva D, Schafer B, Thole D, Braun T, O’Dorisio T, O'Dorisio M, Howe J.  Differentiation of Small Bowel and Pancreatic Neuroendocrine Tumors by Gene Expression Profiling.  Surgery .  2013. 152:998-1007.

Howe J.  Inhibition of Ubiquitination Restores Protein Levels in Patients Affected with Juvenile Polyposis.  2012 February 16. 

Howe J, Dahdaleh  F, Howe J, Carr J, Wang D.  BMPR1A Mutations in Juvenile Polyposis Affect Cellular Localization.  7th Annual Academic Surgical Congress .  2012 February. 

Howe J, Dahdaleh F, Carr J.  Germline Mutations in SMAD4 Lead to Increased Invasive Potential.  7th Annual Academic Surgical Congress .  2012 February. 

Howe J, Wang D, Dahdaleh F, Carr  .  Inhibition of Ubiquitination Restores Protein Levels in Patients Affected with Juvenile Polyposis.  7th Annual Academic Surgical Congress.  2012 February. 

Howe J, Liao J, Milhem M, Mezhir J, Hoshi  , Carr J.  Sentinel Lymph Node Biopsy for Melanoma: Natural History of 234 Consecutive Patients Treated at a Midwestern Hospital .  Midwestern Melanoma Partnership .  2012 February. 

Dahdaleh F, Calva D, O’Dorisio  , Carr  J, Liao  J, Mezhir J, Howe J.  Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution.  Annals of Surgical Oncology.  2012. 19:966-972.
[PubMed]

Howe J, Carr J, Spanheimer  , Dahdaleh F, Weigel R, Sugg  , Lal  , Liao J.  200 Consecutive Adrenalectomies from a Midwestern Institution in the Laparoscopic Era.  SSO.  2011 September. 

Howe J.  Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution.  2011 September. 

Howe J, Dahdaleh F, Lorenzen  , Carr  , Liao J, O’Dorisio  .  The Value of Preoperative Imaging in Ileal Neuroendocrine Tumors.  SSO.  2011 September. 

Howe J, O’Dorisio  , Carr  J, Mezhir J, Dahdaleh  F, Liao J, Calva  .  Comparison of Clinicopathologic Factors in 113 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution. .  Ann Surg Oncol.  2011. 18:S24.

Howe J, Calva  D, Wang,  , Carr  J, Dahdaleh  .  Germline mutations in SMAD4 after downstream BMP and TGF-Beta signaling,.  Journal of the American College of Surgeons .  2011. 213:S27.

Dahdaleh F, Carr J, Wang D, Calva D, Howe J.  Reduced BMP signaling due to BMPR1A germline in Juvenile Polyposis.  Journal of the American College of Surgeons.  2011. 213:S132.

Howe J, Dahdaleh F, Carr J, Calva D.  Sp1 regulates the transcription of BMPR1A.  Journal of Surgical Research .  2011. 171:15-20.
[PubMed]

Howe J, Weigel  R, Lal  G, Sugg  S, Spanheimer  .  Surveillance and Intervention After Thyroid Lobectomy..  Ann Surg Oncol.  2011. 

Howe J.  Genetic Alterations of the E2F Regulatory Binding Site of the BMPR1A Promoter Causes Juvenile Polyposis.  2010 October 5. 

Howe J.  Germline Mutations in Regulatory Binding Sites of the BMPR1A Promoter Predispose to Juvenile Polyposis.  2010 October 5. 

Howe J.  SMAD4 Transcription is Regulated by p53.  2010 October 5. 

Howe J, O’Dorisio,  T, Krutzik S, Woltering  , Lindholm E, Joseph  , Gandolfi A, Wang Y, Boudreaux J, Vinik A, Go V, Halfdanarson T, O’Dorisio M, Mamikunian  .  Development of highly sensitive and specific carboxyl-terminal human Pancreastatin assay to monitor neuroendocrine tumor behavior. .  Pancreas.  2010. 39:611-6.

Calva D, Dahdeleh  , Chinnathambi  , Nagy  , Larsen Haidle  , Weigel R, Woodfield G, Howe J.  Discovery of the BMPR1A Promoter and Germline Mutations that cause Juvenile Polyposis. .  Human Molecular Genetics .  2010. 19:4654-62.
[PubMed]

Howe J, Fang S, Guidroz J, O’Malley Y, Lal G, Sugg  , Weigel  R, Jensen  C.  Expansion of a Cell Population Expressing Stem Cell Markers in Parathyroid Glands from Patients with Hyperparathyroidism.  Annals of Surgery .  2010. 251:107-13.

Calva  , Howe J.  Familial Juvenile Polyposis Syndrome .  2010.  Available from: http://www.juvenilepolyposis.com

Howe J, Weigel R, Dahdaleh F, Woodfield G, Calva D.  Genetic Alterations of the E2F Regulatory Binding Site of the BMPR1A Promoter Causes Juvenile Polyposis.  Journal of the American College of Surgeons .  2010. 211:S55.

Howe J, Calva  , Dahdaleh F.  Germline Mutations in Regulatory Binding Sites of the BMPR1A Promoter Predispose to Juvenile Polyposis.  Journal of the American College of Surgeons.  2010. 211:S119.

Howe J, Lal  G, Fairchild  T, Weigel  R, Sugg  S, Menda  .  PET-CT scans in recurrent or persistent differentiated thyroid cancer: is there added utility beyond conventional imaging? .  Surgery .  2010. 148:1082-9.

Howe J, Dahdaleh F, Calva D, Woodfield  , Weigel  .  SMAD4 Transcription is Regulated by p53 .  Journal of the American College of Surgeons .  2010. 311:S119.

Howe J, Lal  , Nowell  , Liao J, Sugg S, Weigel  .  Determinants of survival in patients with calciphylaxis – a multivariate analysis.  Surgery .  2009. 146:1028-34.

Howe J, Chinnathambi S, Calva  D.  Discovery of the BMPR1A promoter and genetic alterations that may cause Juvenile Polyposis. .  Journal of the American College of Surgeons.  2009. 209:S49.

Howe J, Barros R, Mendes N, Reis C, de Bolos C, Carneiro F, David  , Almeida R.  Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4. .  Histochemistry and Cell Biology .  2009. 131:765-72.

Howe J, Thomas D, Bartel T, Menda  , Graham M, Juweid M.  Single photon emission computed tomography (SPECT) should be routinely performed for the detection of parathyroid abnormalities utilizing technetium 99m parathyroid scintigraphy .  Clinical Nuclear Medicine .  2009. 34:651-655.

Howe J, Dahdaleh F, Calva D.  Site Directed Mutagenesis of the SMAD4 Promoter Regulatory Binding Sites Leads to Significant Decrease in Promoter Activity.  5th Annual Academic Surgical Congress.  2009. 

Howe J, Calva D, Chinnathambi  S, Pechman B, Bair  J, Larsen Haidle  .  The Rate of Germline Mutations and Larger Deletions of SMAD4 and BMPR1A in Juvenile Polyposis.  Clinical Genetics .  2009. 75:79-85.

Howe J, Calva D, O’Dorisio T, O’Dorisio  , Lal G, Sugg S, Weigel  .  When Is Prophylactic Thyroidectomy Indicated for Patients with the RET C609Y Mutation? .  Annals of Surgical Oncology .  2009. 16:2237-2244.

Howe J, Calva D.  When Is Prophylactic Thyroidectomy Indicated For Patients with The RET C609Y Mutation? 62nd Annual Cancer Symposium of the Society of Surgical Oncology,.  Annals of Surgical Oncology.  2009. 

Howe J, Chinnathambi  , Calva D, Bair J, Pechman  , Salamon A, Tam B, Simon L.  A family with consecutive nonsense mutations in BMPR1A causing Juvenile Polyposis.  Cancer Genetics and Cytogenetics .  2008. 181(52-54).

Howe J, Bergmann  , Mathas M, Broadhurst  , Weydert  J, Wilkinson  N, Haile D, Schmidt W, Brown K.  Altered expression of iron-regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis? .  Laboratory Investigation .  2008. 

Howe J, Wilkinson N, Gay G, Patel-Parekh  L, Scott-Conner C, Donohue J.  Differences in the Pattern of Presentation and Treatment of Proximal and Distal Gastric Cancer: Results of the 2001 Gastric Patient Care Evaluation.  Annals of Surgical Oncology .  2008. 15:1644-1650.

Howe J, Lal G, Padmanabha L, Nicholson R, Smith  , Zhang  , Robinson R, O'Dorisio  .  ECM1 expression in thyroid tumors - a comparison of real-time RT-PCR and IHC.  Journal of Surgical Research .  2008. 149:62-68.

Howe J, Calva D.  Hamartomatous Polyposis Syndromes.  Surgical Clinics of North America .  2008. 88:779-817.

Howe J, Adam L, Smith B, Calva  D, Lal G.  Role for limited neck exploration in young adults with apparently sporadic hyperparathyroidism.  World Journal of Surgery.  2008. 32:1518-24.

Howe J, Nishie  A, Obuchi  , Kuehn  , Dahmoush L, Stolpen  .  Small islet cell tumor in the pancreas: diagnostic value of diffusion-weighted imaging.  Journal of Medical Imaging and Radiation Oncology.  2008. 52:374-5.

Howe J, Calva D.  The Rate of Germline Mutations and Larger Deletions of SMAD4 and BMPR1A in Juvenile Polyposis, 61st Annual Cancer Symposium of the Society of Surgical Oncology.  Annals of Surgical Oncology.  2008. 

Howe J.  Cancer Research UK Science Funding Committee.  2007 March. 

Howe J, Larsen Haidle J, Lal G, Bair J, Song C, Pechman B, Chinnathambi S, Lynch H.  ENG Mutations in MADH4/BMPR1A Mutation Negative Patients with Juvenile Polyposis.  Clinical Genetics.  2007. 71:91-92.

Calva-Cerqueira D, Smith B, Hostetler M, Lal G, Menda Y, O'Dorisio M, Howe J.  Minimally Invasive Parathyroidectomy and Preoperative MIBI Scans: Correlation of Gland Weight and Preoperative PTH.  Journal of American College of Surgeons.  2007. 205:S38-44.

Bergmann O, Mathahs M, Broadhurst K, Weydert J, Wilkinson N, Howe J, Schmidt W, Brown K.  Upregulation of ferroportin and DMT1 expression in cirrhotic human livers: A link to hemosiderosis?.  Hepatology.  2007. 46:885-6A.

Wilkinson N, Howe J, Gay G, Patel-Parekh L, Scott-Conner C, Donohue J.  Differences in the Pattern of Presentation and Treatment of Proximal and Distal Gastric Cancer: Results of the 2001 Gastric Patient Care Evaluation.  Annals of Surgical Oncology.  2006. 

Calva D, Howe J.  Minimally Invasive Parathyroidectomy and Preoperative MIBI scans: Threshold values for gland weight and preoperative PTH.  2006. 

Howe J, Calva D.  Minimally Invasive Parathyroidectomy: Correlation of gland weight and preoperative PTH with Preoperative MIBI scans.  2006. 

Lal G, Padmanabha L, Smith B, Nicholson R, Howe J, O'Dorisio M, Domann F.  RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.  Cancer.  2006. 107:2752-2759.

Merg A, Lynch H, Lynch J, Howe J.  Hereditary Colorectal Cancer. Part I..  Current Problems in Surgery.  2005. 42:185-256.

Merg A, Lynch H, Lynch J, Howe J.  Hereditary Colorectal Cancer. Part II..  Current Problems in Surgery.  2005. 42:259-333.

Howe J.  University of Iowa Center on Aging Program.  2005 January. 

Tsoulfas G, Howe J.  Amyand's Hernia: Appendicitis in an incarcerated inguinal hernia.  Surigcal Rounds.  2004. 27:515-517.

Lynch H, Tinley S, Shaw T, Lynch J, Howe J, Attard T.  Challenging polyposis pedigrees: Differential diagnosis, surveillance, and management concerns.  Cytogenetics and Cell Genetics.  2004. 148:104-117.

Merg A, Howe J.  Genetic conditions associated with intestinal juvenile polyps.  American Journal of Medical Genetics Part C (Seminars in Medical Genetics).  2004. 129C:44-55.

Howe J, Sayed M, Ahmed A, Ringold J, Larsen-Haidle J, Merg A, Mitros F, Vaccaro C, Petersen G, Giardiello F, Tinley S, Aaltonen L, Lynch H.  The Prevalence of SMAD4 and BMPR1A Mutations in Juvenile Polyposis, and Absence of Mutations of BMPR2, BMPR1B, and ACVR1.  Journal of Medical Genetics.  2004. 41:484-491.

Haidle J, Howe J.  Juvenile Polyposis Syndrome.  Copyright, University of Washington, Seattle;  2003.  Available from: http://www.genetests.org

Juweid M, Menda Y, Howe J, Graham M.  Double-Phase (DP) SPECT versus Planar 99mTc-Sestamibi (MIBI) Imaging in the Detection of Parathyroid Adenoma (PA) or Hyperplasia (PH).  Journal of Nuclear Medicine.  2003. 44:154P.

McCarthy D, Hruban R, Argani P, Howe J, Conlon K, Brennan M, Zahurak M, Wilentz R, Cameron J, Yeo C, Kern S, Klimstra D.  The role of DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: Analysis of 140 cases.  Modern Pathology.  2003. 16:272-278.

Larsen-Haidle J, Horton V, Howe J, Bergmann H.  Juvenile Polyposis: A guide for patients and families.  UI Printing Dept..  2003 January. 

Costa J, Kreder K, Howe J.  Combined urinary and fecal diversion using a 'no anastomosis' technique.  Journal of Urology.  2002. 167:2063-2065.

Howe J, Wagner B, Shellnut J, Ringold J, Sayed M, Ahmed A, Lynch P, Amos C, Sistonen P, Aaltonen L.  Common Deletion of SMAD4 in Juvenile Polyposis is a Mutational Hotspot.  American Journal of Human Genetics.  2002. 70:1537-1362.

Sayed M, Ahmed A, Ringold J, Anderson M, Bair J, Mitros F, Lynch H, Tinley S, Petersen G, Giardiello F, Vogelstein B, Howe J.  Germline SMAD4 and BMPR1A mutations and phenotype of Juvenile Polyposis.  Annals of Surgical Oncology.  2002. 9:901-906.

Sayed M, Ahmed A, Anderson M, Bair J, Mitros F, Lynch H, Tinley S, Petersen G, Giardiello F, Vogelstein B, Howe J.  The impact of germline SMAD4 and BMPR1A mutations on the phenotype of juvenile polyposis.  Society of Surgical Oncology.  2002. 

Howe J, Anderson M, Sayed M, Ahmed A, Bair J, Mitros F, Lynch H, Vanderhoff J, Tinley S, Petersen G, Giardiello F, Vogelstein B.  The prevalence of bone morphogenetic protein (BMP) pathway gene mutations in juvenile polyposis.  2002. 

Howe J.  University of Iowa Cancer Center Translational/Collaborative Grants.  2001 October. 

Howe J, Bair J, Wagner B, Shellnut J, Amos C, Anderson M, Mitros F, Sayed M, Aaltonen L.  Common SMAD4/DPC4 deletion in Juvenile Polyposis is a mutational hotspot rather than founder mutation.  Society of Surgical Oncology.  2001. 

Howe J, Bair J, Sayed M, Anderson M, Mitros F, Petersen G, Velculescu V, Traverso G, Vogelstein B.  Germline mutations of the gene for bone morphogenetic protein receptoer 1A in juvenile polyposis.  Nature Genetics.  2001. 28:184-187.

Howe J.  PTEN Hamartoma Tumor Syndrome.  2001. 

Howe J, Pilarski R, Hampel H, Eng C.  PTEN Hamartoma Tumor Syndrome.  GeneClinics.  2001. 
[Link]

Howe J, Karnell L, Scott-Conner C.  Small Bowel Sarcoma: Analysis of survival from the National Cancer Data Base.  Annals of Surgical Oncology.  2001. 8:496-508.

Sayed M, Bair J, Anderson M, Riggins G, Petersen G, Mitros F, Summers R, Lynch H, Giardiello F, Vogelstein B, Howe J.  The frequency of SMAD4 and PTEN Mutations in Juvenile Polyposis.  Surgical Forum.  2001. 52:230-231.

Howe J.  University of Iowa Cancer Center Seed Grants.  2001. 

Howe J, Karnell L, Scott-Conner C.  Carcinoids, lymphomas, and sarcomas of the small bowel: Analysis of survival from the National Cancer Data Base.  Society of Surgical Oncology.  2000. 

Howe J.  Minimally invasive parathyroidectomy.  Surgical Clinics of North America.  2000. 80:1399-1426.

Howe J.  A new pathway for the development of colorectal cancer: Lessons learned from Juvenile Polyposis.  Cancer Research Alert.  1999. 1:8-9.

Howe J, Karnell L, Menck H, Scott-Conner C.  Adenocarcinoma of the small bowel: Prognostic factors from the National Cancer Data Base.  Cancer.  1999. 86:2693-2706.

Howe J, Karnell L, Menck H, Scott-Conner C.  Adenocarcinoma of the small bowel: Prognostic factors from the National Cancer Data Base.  Society of Surgical Oncology.  1999. 

Howe J.  Carver Medical Initiative Research Grants.  1999. 

Howe J, Ringold J, Hughes J, Summers R.  Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis.  1999. 

Howe J, Ringold J, Hughes J, Summers R.  Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis.  Surgery.  1999. 126:162-170.

Roth S, Howe J, Jarvinen H, Aaltonen L.  The Molecular Genetic Background of Juvenile Polyposis and Evidence of Heterogeneity.  1999. 

Howe J.  University of Iowa College of Medicine Grants.  1999. 

Howe J, Ringold J, Summers R, Mitros F, Nishimura D, Stone E.  A gene for familial juvenile polyposis maps to chromosome 18q21.  Gastroenterology.  1998. 

Howe J, Ringold J, Summers R, Mitros F, Nishimura D, Stone E.  A gene for familial juvenile polyposis maps to chromosome 18q21.1.  American Journal of Human Genetics.  1998. 62:1129-1136.

Howe J, Klimstra D, Moccia R, Conlon K, Brennan M.  Factors predictive of survival in ampullary carcinoma.  Annals of Surgery.  1998. 228:87-94.

Howe J.  Molecular Biology of Pancreatic Cancer.  1998. 

Howe J, Roth S, Ringold J, Summers R, Jarvinen H, Sistonen P, Tomlinson I, Houlston R, Bevan S, Mitros F, Stone E, Aaltonen L.  Mutations in the SMAD4/DPC4 gene in juvenile polyposis.  Science.  1998. 280:1086-1088.
[PubMed]

Howe J.  New Zealand Cancer Society.  1998. 

Howe J, Ringold J, Mitros F, Summers R.  Presymptomatic diagnosis of gene carriers in familial juvenile polyposis.  Surgical Forum.  1998. 49:142-144.

Howe J, Mitros F, Summers R.  The risk of gastrointestinal cancer in familial juvenile polyposis.  Annals of Surgical Oncology.  1998. 5:751-756.

Howe J, Mitros F, Summers R.  The risk of gastrointestinal carcinoma in familial juvenile polyposis.  Society of Surgical Oncology.  1998. 

Howe J.  University of Nebraska Research Initiative.  1998. 

Howe J, Klimstra D, Cordon-Cardo C.  DNA extraction from paraffin embedded tissues using a salting out procedure: A reliable method for PCR amplification of archival material.  Histology and Histopathology.  1997. 12:595-601.

Howe J, Klimstra D, Moccia R, Conlon K, Brennan M.  Factors predictive of survival in ampullary carcinoma.  Society of Surgical Oncology.  1997. 

Howe J, Klimstra D, Cordon-Cardo C, Paty P, Park P, Brennan M.  K-ras mutation in adenomas and carcinomas of the ampulla of Vater.  Clinical Cancer Research.  1997. 3:129-133.

Howe J, Guillem J.  The genetics of colorectal cancer.  Surgical Clinics of North America.  1997. 77:175-196.

Howe J, Conlon K.  The molecular genetics of pancreatic cancer.  Surgical Oncology.  1997. 6:1-18.

Howe J, Klimstra D, Cordon-Cardo C, Paty P, Park P, Brennan M.  K-ras mutation is an early event in ampullary carcinoma.  Society of Surgical Oncology.  1996. 

Howe J, Monsees B, Destouet J, Seib J, Dehner L, Kraybill W.  Needle localization breast biopsy: A multidisciplinary model for quality assurance.  Journal of Surgical Oncology.  1995. 58:233-239.

Lairmore T, Dou S, Howe J, Chi D, Carlson K, Veile R, Mishra S, Wells Jr S, Donis-Keller H.  A 1.5 Mb YAC contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.  Proceedings of the National Academy of Sciences USA.  1993. 90:492-496.

Howe J, Lairmore T, Veile R, Dou S, Taillon-Miller P, Wells Jr S, Donis-Keller H.  Development of an STS for the centromere of chromosome 10: its use in cytogenetic and physical mapping.  Human Genetics.  1993. 91:199-204.

Donis-Keller H, Dou S, Chi D, Carlson K, Toshima K, Lairmore T, Howe J, Moley J, Goodfellow P, Wells Jr S.  Mutations in the RET proto-oncogene are associated with MEN2A and FMTC.  Human Molecular Genetics.  1993. 2:851-856.

Howe J, Norton J, Wells Jr S.  The prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2A: Results of long term follow-up.  Surgery.  1993. 114:1070-1077.

Lairmore T, Dou S, Howe J, Chi D, Carlson K, Wells Jr S, Donis-Keller H.  A 1.5 megabase contig of YAC clones containing three loci (RET, D10S94, D10S102) tightly linked to the MEN2A gene.  American Journal of Human Genetics.  1992. 51:947.

Chi D, Lairmore T, Dou S, Howe J, Carlson K, Mishra S, Wells Jr S.  A highly informative dinucleotide repeat polymorphism at the ret proto-oncogene locus within human chromosome 10q11.2.  American Journal of Human Genetics.  1992. 51:724.

Howe J, Lairmore T, Dou S, Steinbrueck T, Veile R, Wells Jr S, Donis-Keller H.  A new RFLP marker D5S348 maps to 5p14-15.2, between D5S60 (CRI-R535) and HPRTP2.  Nucleic Acids Research.  1992. 20:1168.

Howe J, Lairmore T, Dou S, Mishra S, Veile R, Taillon-Miller P, Wells Jr S, Donis-Keller H.  Improved predictive test for MEN2 using flanking dinucleotide repeats and RFLPs.  American Journal of Human Genetics.  1992. 51:1430-1442.

Lairmore T, Howe J, Dou S, Veile R, Korte-Sarfaty J, Taillon-Miller P, Wells Jr S, Donis-Keller H.  Isolation of YAC clones from the pericentromeric region of chromosome 10 and development of new genetic markers linked to MEN2A.  Henry Ford Hospital Medical Journal.  1992. 40:210-214.

Lairmore T, Howe J, Dou S, Chi D, Carlson K, Mishra S, Wells Jr S, Donis-Keller H.  Presymptomatic genetic testing for familial medullary thyroid carcinoma.  Surgical Forum.  1992. 43:462-464.

Howe J, Lairmore T, Dou S, Mishra S, Dilley W, Donis-Keller H, Wells Jr S.  Presymptomatic identification of carriers of the MEN2A gene using flanking DNA markers.  Surgery.  1992. 112:219-226.

Howe J, Korte J, Dou S, Steinbrueck T, Donis-Keller H.  A new polymorphic marker D12S54 maps between F8VWF and KRAS2 on human chromosome 12p.  Nucleic Acids Research.  1991. 19:2518.

Lairmore T, Howe J, Dou S, Wells S, Donis-Keller H.  Characterization of the FNRB locus with YAC clones and identification of new highly informative flanking markers for predictive testing in multiple endocrine neoplasia type 2 (MEN2).  American Journal of Human Genetics.  1991. 49:348.

Howe J, Lairmore T, Dou S, Korte J, Wells Jr S, Donis-Keller H.  Confirmation of genetic homogeneity in multiple endocrine neoplasia type 2A.  Surgical Forum.  1991. 42:432-435.

Lairmore T, Howe J, Korte J, Dilley W, Aine L, Aine E, Wells S, Donis-Keller H.  Familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2B map to the same region of chromosome 10 as multiple endocrine neoplasia type 2A.  Genomics.  1991. 9:181-192.

Howe J, Donis-Keller H.  Isolation of a possible centromere junction segment from human chromosome 10.  Cold Spring Harbor, New York.  1991. 

Backdahl M, Howe J, Lairmore T, Wells Jr S.  The molecular biology of parathyroid disease.  World Journal of Surgery.  1991. 15:756-762.

Howe J, Lairmore T, Dou S, Wells S, Donis-Keller H.  Using chromosome 10 specific alphoid sequences to isolate YACs near the multiple endocrine neoplasia type 2A gene.  American Journal of Human Genetics.  1991. 49:380.

Lairmore T, Howe J, Veile R, Dou S, Korte-Sarfaty J, Wells Jr S, Donis-Keller H.  YAC-walking and isolation of new highly polymorphic markers from the region of the MEN type 2 locus.  1991. 

Howe J, Mishra S, Korte J, Wells S, Donis-Keller H.  Isolation of new markers for presymptomatic genetic testing in multiple endocrine neoplasia type 2A.  Surgical Forum.  1990. 41:447-450.

Howe J, Korte J, Mishra S, Wells S, Donis-Keller H.  New YAC derived polymorphic markers linked to the MEN 2A locus on chromosome 10.  American Journal of Human Genetics.  1990. 47:A184.

Howe J.  Archives of Surgery. 

Howe J.  Contemporary Surgery. 

Howe J.  Current Clinical Trials in Breast and GI Oncology at UIHC.  The Virtual Hospital;  Available from: http://www.vh.org/Providers/Lectures/ClinTrials/ProtocolOutline.html

Howe J, Weigel R, Calva D, Dahdeleh F, Chinnathambi  , Woodfield G.  Discovery of the SMAD4 Promoter and Characterization of Regulatory Protein Binding Sites .  Nucleic Acids Research. 

Howe J.  DNA and Cell Biology. 

Howe J.  Endocrine. 

Howe J.  European Journal of Clinical Investigation. 

Howe J.  Gastroenterology. 

Howe J.  Gastroenterology & Hepatology. 

Howe J.  Genes, Chromosomes, and Cancer. 

Howe J.  Genetic Susceptibility to Cancer, Oncology and Tumor Biology. 

Howe J.  Genetic Susceptibility to Cancer, Oncology and Tumor Biology, Surgical Council on Resident Education (SCORE).  General Surgery Resident Curriculum Portal; 

Howe J, Wang D, Dahdaleh F, Carr  J.  Germline Mutations in SMAD4 Disrupt Bone Morphogenetic Protein Signaling..  Journal of Surgical Research (in press).. 

Howe J.  Gut. 

Howe J.  International Journal of Cancer. 

Howe J.  Journal of Clinical Endocrinology and Metabolism. 

Howe J.  Journal of Cllinical Oncology. 

Howe J.  Journal of Medical Genetics. 

Howe J.  Journal of Molecular Diagnostics. 

Howe J.  Journal of Surgical Oncology. 

Howe J.  Journal of Surgical Research. 

Howe J.  Journal of the American College of Surgeons. 

Howe J, Calva D, Carr J, Dahdaleh  F.  Juvenile Polyposis and Other Intestinal Polyposis Syndromes with Microdeletions of Chromosome 10q22-23.  Clinical Genetics . 

Howe J, Carr  J.  Midwest Melanoma Symposium. 

Howe J.  Molecular Cancer Research. 

Howe J.  Nature Clinical Practice Gastroenterology and Hepatology. 

Howe J.  Nature Medicine. 

Howe J.  Nature Reviews Cancer. 

Howe J.  Recent Patents on DNA and Gene Sequence. 

Lal  G, Groff  M, Howe J, Weigel  R, Sugg  S, Lynch  C.  Risk of Subsequent Primary Thyroid Cancer after Another Malignancy: Latency Trends in a Population-based Study.  Ann Surg Oncol. 
[PubMed]

Howe J.  Southern Medical Journal. 

Howe J.  Surgical Laparoscopy, Endoscopy, and Percutaneous Techniques. 

Jesseph F, Fitzek M, Fitzek C, Shahnazi K, Ko A, Howe J, Thornton A.  Surgical Organ Displacement for Proton Radiotherapy .  JACS. 

Howe J, Thornton A, Ko  A, Jesseph  J, Fitzek M, Chang  A, Shahnazi  .  Surgical Organ Displacement for Proton Radiotherapy .  JACS. 

Howe J.  The Oncologist. 

Howe J.  World Journal of Surgery. 

Date Last Modified: 06/07/2014 - 21:56:23