Surgery

James Howe, MD

Portrait

Director, Division of Surgical Oncology and Endocrine Surgery
Co-Director, Neuroendocrine Cancer Clinic
Professor of Surgery  - Surgical Oncology and Endocrine Surgery

Contact Information

Primary Office: 4644 JCP
Iowa City, IA 52242
Primary Office Phone: 319-356-1727

Email: james-howe@uiowa.edu

Education

MD, University of Vermont College of Medicine

Fellowship, Surgical Research Fellow, Washington University, St. Louis, MO
Residency, General Surgery, Barnes Hospital, St. Louis, MO
Fellowship, Clinical, Surgical Oncology, Memorial Sloan-Kettering Center

Licensure and Certifications

Iowa Medical License, Iowa Board of Medicine
Certified, Advanced Trauma Life Support
Board Certified, General Surgery, American Board of Surgery
Qualifying Examination, American Board of Surgery
Recertification Examination, American Board of Surgery

Research Summary

I am a Surgical Oncologist and Endocrine Surgeon who specializes in taking care of patients with cancers of the pancreas, liver, GI tract, soft tissue sarcoma, melanoma, thyroid, parathyroid, and adrenal glands; I am co-director of the neuroendocrine cancer clinic, Division Director of Surgical Oncology and Endocrine Surgery, and Professor of Surgery at the University of Iowa. My area of research expertise is in Familial Cancer Syndromes, genetic linkage, gene discovery, and gene expression studies. My postdoctoral training at Washington University under Helen Donis-Keller, Ph.D. and Samuel Wells, M.D., was directed at the identification of the gene for Multiple Endocrine Neoplasia Type 2. As a faculty member, my focus has been the genetics of Juvenile Polyposis, which led to the discovery of the 2 predisposing genes. More recently, I have developed a large clinical practice and research interest in the genetics of neuroendocrine tumors (NETs). Our current research focus is the study of gene expression profiles in pancreatic and small bowel NETs to identify new targets for imaging and treatment, and collection of families to search for predisposing genes.

Selected Publications

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Carr J, Boese E, Spanheimer P, Dahdaleh F, Martin M, Calva D, Schafer B, Thole D, Braun T, O’Dorisio T, O'Dorisio M, Howe J.  Differentiation of Small Bowel and Pancreatic Neuroendocrine Tumors by Gene Expression Profiling.  Surgery .  2013. 152:998-1007.

Dahdaleh F, Calva D, O’Dorisio  , Carr  J, Liao  J, Mezhir J, Howe J.  Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution.  Annals of Surgical Oncology.  2012. 19:966-972.
[PubMed]

Howe J.  Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution.  2011 September. 

Howe J, Dahdaleh F, Lorenzen  , Carr  , Liao J, O’Dorisio  .  The Value of Preoperative Imaging in Ileal Neuroendocrine Tumors.  SSO.  2011 September. 

Howe J.  Genetic Alterations of the E2F Regulatory Binding Site of the BMPR1A Promoter Causes Juvenile Polyposis.  2010 October 5. 

Howe J.  Germline Mutations in Regulatory Binding Sites of the BMPR1A Promoter Predispose to Juvenile Polyposis.  2010 October 5. 

Howe J.  SMAD4 Transcription is Regulated by p53.  2010 October 5. 

Howe J, O’Dorisio,  T, Krutzik S, Woltering  , Lindholm E, Joseph  , Gandolfi A, Wang Y, Boudreaux J, Vinik A, Go V, Halfdanarson T, O’Dorisio M, Mamikunian  .  Development of highly sensitive and specific carboxyl-terminal human Pancreastatin assay to monitor neuroendocrine tumor behavior. .  Pancreas.  2010. 39:611-6.

Calva D, Dahdeleh  , Chinnathambi  , Nagy  , Larsen Haidle  , Weigel R, Woodfield G, Howe J.  Discovery of the BMPR1A Promoter and Germline Mutations that cause Juvenile Polyposis. .  Human Molecular Genetics .  2010. 19:4654-62.
[PubMed]

Howe J, Fang S, Guidroz J, O’Malley Y, Lal G, Sugg  , Weigel  R, Jensen  C.  Expansion of a Cell Population Expressing Stem Cell Markers in Parathyroid Glands from Patients with Hyperparathyroidism.  Annals of Surgery .  2010. 251:107-13.

Date Last Modified: 09/30/2013 - 11:52:46