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Co-Director, Neuroendocrine Cancer ClinicDirector, Division of Surgical Oncology and Endocrine SurgeryMedical Director, University of Iowa Tumor RegistryProfessor of Surgery - Surgical Oncology and Endocrine Surgery
Primary Office: 4644 JCPIowa City, IA 52242 Primary Office Phone: 319-356-1727
Email: james-howe@uiowa.edu
Champlain Valley Union High School, Hinesberg, VT5 "O" levels, Bristol Cathedral School, Bristol, EnglandH.S. Diploma, Champlain Valley Union High School, Hinesberg, VTA.B., Biology, Dartmouth College, Hanover, NHMD, University of Vermont College of Medicine
Residency, Junior Assitant Resident, Barnes Hospital, St. Louis, MOSurgical Internship, Barnes Hospital, St. Louis, MOFellowship, Surgical Research Fellow, Washington University, St. Louis, MOResidency, Senior Assitant Resident, Barnes Hospital, St. Louis, MOResidency, Fourth Year Resident, Barnes Hospital, St. Louis, MOResidency, Chief Resident, Barnes Hospital, St. Louis, MOFellowship, Clinical, Surgical Oncology, Memorial Sloan-Kettering Center
Iowa State Medical LicenseCertified, Advanced Trauma Life SupportBoard Certified, American Board of SurgeryQualifying Examination, American Board of SurgeryRecertification Examination, American Board of Surgery
Work in the Surgical Oncology Molecular Biology lab is focused upon understanding and defining the genetic basis of Juvenile Polyposis (JP). The main objective of our current studies is to identify the third causative gene for this inherited cancer predisposition syndrome. To this end, a large Iowa JP family is being tested using a comprehensive panel of genetic markers derived from all the human chromosomes to determine the chromosomal location of this gene. When candidate genes from this region are found, they will be tested for mutations in this JP family, and a panel of over 90 different JP families. In addition to this research focus, we have also been studying how the mutations in people born with JP lead to the formation of polyps. To do this, we have taken both normal and polyp tissues obtained from surgery or endoscopy in JP patients with mutations in the three different JP genes. From these we have performed microarray analysis, which allows us to compare the level of expression of all human genes. These patterns of changes in gene expression between the different JP genes will help us to understand which genetic pathways are involved in polyp development. We are also systematically examining the effects of the DNA mutations in JP patients upon the RNA messages and protein products that result from them. To do this, we have established cell lines from the white blood cells from a large number of JP patients, which gives us a repository of renewable cells for future studies. This will help to clarify the effects of mutations in some JP patients, while in others in whom no mutations have been found by sequencing, may suggest alterative mechanisms of how the JP genes are inactivated. It will also make in vitro studies possible, which will give us a way to determine the effects of various drugs on cells, so that we may develop treatments that will suppress the development of polyps and cancers.
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Inhibition of Ubiquitination Restores Protein Levels in Patients Affected with Juvenile Polyposis. Howe J. 2012 February. BMPR1A Mutations in Juvenile Polyposis Affect Cellular Localization. Howe J, Dahdaleh F, Howe J, Carr J, Wang D. 7th Annual Academic Surgical Congress . 2012 February. Germline Mutations in SMAD4 Lead to Increased Invasive Potential. Howe J, Dahdaleh F, Carr J. 7th Annual Academic Surgical Congress . 2012 February. Inhibition of Ubiquitination Restores Protein Levels in Patients Affected with Juvenile Polyposis. Howe J, Wang D, Dahdaleh F, Carr . 7th Annual Academic Surgical Congress. 2012 February. Sentinel Lymph Node Biopsy for Melanoma: Natural History of 234 Consecutive Patients Treated at a Midwestern Hospital . Howe J, Liao J, Milhem M, Mezhir J, Hoshi , Carr J. Midwestern Melanoma Partnership . 2012 February. 200 Consecutive Adrenalectomies from a Midwestern Institution in the Laparoscopic Era. Howe J, Carr J, Spanheimer , Dahdaleh F, Weigel R, Sugg , Lal , Liao J. SSO. 2011 September. Comparison of Clinicopathologic Factors in 122 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution. Howe J. 2011 September. The Value of Preoperative Imaging in Ileal Neuroendocrine Tumors. Howe J, Dahdaleh F, Lorenzen , Carr , Liao J, O’Dorisio . SSO. 2011 September. Comparison of Clinicopathologic Factors in 113 Patients with Resected Pancreatic and Ileal Neuroendocrine Tumors from a Single Institution. . Howe J, O’Dorisio , Carr J, Mezhir J, Dahdaleh F, Liao J, Calva . Ann Surg Oncol. 2011; 18 :S24. Germline mutations in SMAD4 after downstream BMP and TGF-Beta signaling,. Howe J, Calva D, Wang, , Carr J, Dahdaleh . Journal of the American College of Surgeons . 2011; 213 :S27.
Date Last Modified: 01/08/2013 - 17:05:00