Radiology

Michael K. Schultz, PhD

Portrait

Assistant Professor of Radiology  - Division of Nuclear Medicine
Assistant Professor of Internal Medicine, Radiation Oncology

Contact Information

Primary Office: B180 ML
Iowa City, IA 52242
Primary Office Phone: 319-335-8017

Email: michael-schultz@uiowa.edu

Education

BA, Russian Language, University of South Florida, Department of Linguistics, Tampa
MS, Marine Chemistry, Florida State University, Department of Oceanography, Tallahassee, FL
PhD, Chemical Oceanography, Florida State University

Fellowship, Graduate Researcher/Radiochemist (Predoctoral PhD Fellowship), National Institute of Standards and Technology, Gaithersburg, MD
Post Doctoral, Radiochemist (Postdoctoral, Targeted Radionuclide Therapy for Cancer Research), National Institute of Standards and Technology, Nuclear Medicine Program. Gaithersburg, MD

Education/Training Program Affiliations

Biosciences Graduate Program
Free Radical and Radiation Biology Graduate Program

Research Summary

Dr. Schultz's research interests involve the development of synthetic-bioactive molecular targeting vectors for imaging and therapy of cancer. Molecular targeting involves identification of G-protein coupled receptors and other cell surface antigens and the development of targeting vectors that selectively bind to these antigens. Vectors include synthetically-modified peptides, small molecules, targeted nanoparticles, and RNA "aptamers". Multimodality imaging probes are designed for use with positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and fluorescence imaging techniques. Dr. Schultz's lab focuses on identification of cell surface receptors that are unique to specific cell types (e.g., melanoma, prostate cancer and neuroendocrine tumors) and use of bioconjugate chemistry to develop targeting vectors that not only bind specifically to these cell surface antigens, but deliver a reporter signal that can be recognized by PET, SPECT, MRI, and optical technologies for in vivo imaging, as well as delivery radiation dose precisely to malignancy in vivo. Optimizing these targeting vectors includes examining molecular modifications that alter their pharmacokinetics and biodistribution for improved cancer cell targeting. Radionuclides used for imaging include fluorine-18, carbon-11, gallium-68, indium-111, copper-64, and others. These targeting vectors can also be used to precisely deliver radionuclides therapies to cancerous tumors while minimizing dose to healthy cells in vivo. To impart improved molecular targeting characteristics to peptides, small molecules, RNA aptamers, and nanoparticles, the Schultz laboratory examines a variety of bioconjugate chemistry approaches include novel methods in copper-free click chemistry approaches to organic synthesis.

Date Last Modified: 11/13/2013 - 09:00:45