Radiation Oncology

Michael Knudson, MD, PhD

Portrait

Associate Professor of Pathology  - Transfusion Medicine
Associate Professor of Radiation Oncology

Contact Information

Primary Office: sw247 General Hospital
Iowa City, IA 52242
Primary Office Phone: 319-337-5129

Email: c-knudson@uiowa.edu

Education

BS, The University of Iowa, Iowa City, IA
MD, The University of Iowa, Iowa City, IA
PhD, The University of Iowa, Iowa City, IA

Residency, Washington University Medical Center, St. Louis, MO

Licensure and Certifications

State of Iowa Medical License, Iowa Board of Medicine
Clinical Pathology, American Board of Pathology

Education/Training Program Affiliations

Biosciences Graduate Program
Free Radical and Radiation Biology Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Role of Bcl-2 family members in cell cycle control and apoptosis, and their role in oncogenesis.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

All Publications

Zagorodna O, Martin S, Rutkowski D, Kuwana T, Spitz D, Knudson M.  2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines.  Oncogene.  2012 May. 31(22):2738-49.
[PubMed]

Knudson M, Sevier A, Zagorodna O, Martin S, Priebe W.  2-Deoxy-D-glucose cytotoxicity relies on both glycolysis inhibitioin and ER stress induction, and is efficacious in a variety of human lymphoma models.  AACR Annual Meeting, Chicago, IL.  2012 April. 

Berquam-Vrieze K, Nannapaneni K, Brett B, Holmfeldt L, Ma J, Zagorodna O, Jenkins N, Copeland N, Meyerholz D, Knudson M, Mullighan C, Scheetz T, Dupuy A.  Cell of origin strongly influences genetic selection in a mouse model of T-ALL.  Blood.  2011 October. 118(17):4646-56.
[PubMed]

Knudson M, Zagorodna O, Martin S, Spitz D.  2-deoxyglucose caused toxicity is regulated by the Bcl-2 family and is enhanced by Bcl-2 antagonist in lymphoma cell lines.  AACR Annual Meeting, Orlando, FL, April 2011.  2011 April. 

Knudson M, Wang S, Martin S.  A tale of Two Mitophages: Parkin-Dependent and - Independent Pathways.  Keystone Symposia, Authophagy.  2011. 

Wang S, Martin S, Harris P, Knudson M.  Caspase inhibition blocks cell death and enhances mitophagy but fails to promote T-cell lymphoma.  PloS one.  2011. 6(5):e19786.
[PubMed]

Knudson M, Zagorodna O, Martin S, Spitz D.  2-Doxyglucose Caused Toxicity is Regulated by the Bcl-2 Family Members and can be Enhanced by Antagonizing Bcl-2 in Lymphomas.  17th Annual Meeting, Society for Free Radical Biology and Medicine.  2010 November. 

Knudson M, Jacobus J, Duda C, Martin III S, Coleman M, Mapuskar K, Aykin-Burns N, Spitz D.  LET and gender are critical factors in accelerating development of lymphoma in irradiated Bax transgenic C57/B6 mice.  17th Annual Meeting, Society for Free Radical Bilogy and Medicine.  2010 November. 

Du J, Martin S, Levine M, Wagner B, Buettner G, Wang S, Taghiyev A, Du C, Knudson M, Cullen J.  Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.  Clinical cancer research : an official journal of the American Association for Cancer Research.  2010 January. 16(2):509-20.
[PubMed]

Knudson M, Zagorodna O, Martin S, Spitz D.  Investigating 2DG sensitivity and ER stress in murine T cell lymphoma cells.  16th Annual Meeting, Society for Free Radical Biology and Medicine.  2009 November. 

Knudson M, Berquam-Brieze K, Nannapaneni K, Zagordna O, Mullighan C, Meyerholz D, Copeland N, Jenkins N, Scheetz T, Dupuy A.  Cell-of-Origin Determines Genetic Selection and Defines T-cell Acute Lymphocytic Leukemia Sub-types in Mouse Models.  AACR Meeting.  2009 April. 

Knudson M, Wang S, Martin S, Harris P, Moriarty M, Zagorodna O.  Caspase inhibition blocks cell death and enhances mitophagy, but fails to promote T cell lymphoma.  Keystone Symposia, Cell Death Pathways, Vancouver, Canada.  2009 March. 

Knudson M, Berquam-Vrieze K, Zagorodna O, Nannapaneni K, Copeland N, Jenkins N, Sheetz T, Dupuy A.  Targeting mutagenesi to discrete developmental stages produces distinct genetic models of T-ALL.  AACR meeting; San Francisco, CA.  2009 January. 

Knudson M, Zagorodna O, Martin S, Spitz D.  Investigating 2DG sensitivity and oxidative stress in murine T cell lymphoma cells.  15th Annual Meeting, Society for Free Radical Biology and Medicine.  2008 November. 

van de Wetering C, Coleman M, Spitz D, Smith B, Knudson M.  Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma.  Free radical biology & medicine.  2008 April. 44(8):1677-86.
[PubMed]

Knudson M, Brown N.  Mitochondria potential, bax "activation," and programmed cell death.  Methods in molecular biology (Clifton, N.J.).  2008. 414:95-108.
[PubMed]

Cheng N, van de Wetering C, Knudson M.  p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.  PloS one.  2008. 3(4):e1911.
[PubMed]

van de Wetering C, Horne M, Knudson M.  Chromosomal instability and supernumerary centrosomes represent precursor defects in a mouse model of T-cell lymphoma.  Cancer research.  2007 September. 67(17):8081-8.
[PubMed]

Bell A, Nolen J, Knudson M, Raife T.  Severe citrate toxicity complicating volunteer apheresis platelet donation.  Journal of clinical apheresis.  2007 February. 22(1):15-6.
[PubMed]

Knudson M, van de Wetering C, Knudson C.  Chromosomal instability and centrosome amplification represent precursor defects in a mouse model of T cell lymphoma.  AACR, Los Angeles, CA.  2007. 

Brown N, Martin S, Maurice N, Kuwana T, Knudson M.  Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells.  The Journal of biological chemistry.  2007 January. 282(4):2144-55.
[PubMed]

Gould T, Buss R, Vinsant S, Prevette D, Sun W, Knudson M, Milligan C, Oppenheim R.  Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS.  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2006 August. 26(34):8774-86.
[PubMed]

Hadzic T, Li L, Cheng N, Walsh S, Spitz D, Knudson M.  The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion.  Journal of immunology (Baltimore, Md. : 1950).  2005 December. 175(12):7965-72.
[PubMed]

Emerson D, McCormick M, Schmidt J, Knudson M.  Taurine monochloramine activates a cell death pathway involving Bax and Caspase-9.  The Journal of biological chemistry.  2005 February. 280(5):3233-41.
[PubMed]

Cheng N, Janumyan Y, Didion L, Van Hofwegen C, Yang E, Knudson M.  Bcl-2 inhibition of T-cell proliferation is related to prolonged T-cell survival.  Oncogene.  2004 May. 23(21):3770-80.
[PubMed]

Knudson M, van de Wetering C.  Mouse model of chromosome instability using Lck-Bax transgenic mice.  Mouse models of Human Cancer, Keystone Symposia, Keystone, CO.  2004 February. 

Ogg P, McDonell P, Ryckman B, Knudson M, Roller R.  The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members.  Virology.  2004 February. 319(2):212-24.
[PubMed]

Stallock J, Molyneaux K, Schaible K, Knudson M, Wylie C.  The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo.  Development (Cambridge, England).  2003 December. 130(26):6589-97.
[PubMed]

Janumyan Y, Sansam C, Chattopadhyay A, Cheng N, Soucie E, Penn L, Andrews D, Knudson M, Yang E.  Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry.  The EMBO journal.  2003 October. 22(20):5459-70.
[PubMed]

Knudson M, van de Wetering C, Luke J.  Lymphoma development in Bax transgenic mice is associated with chromosomal instability.  Cold Spring Harbor Pgrammed Cell Death.  2003 September. 

Luke J, Van De Wetering C, Knudson M.  Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability.  Cell death and differentiation.  2003 June. 10(6):740-8.
[PubMed]

Taghiyev A, Guseva N, Harada H, Knudson M, Rokhlin O, Cohen M.  Overexpression of BAD potentiates sensitivity to tumor necrosis factor-related apoptosis-inducing ligand treatment in the prostatic carcinoma cell line LNCaP.  Molecular cancer research : MCR.  2003 May. 1(7):500-7.
[PubMed]

Knudson M, van de Wetering C, Luke J.  Paradoxical tumor development and chromosomal instability in Lck-Bax transgenic mice.  Oral presentation at American Society of Hematology, Philadelphia, PA.  2002 December. 

Knudson M, Hadjic T, Deimerley L, Spitz D.  Gluthathione is not required for murine T cell proliferation.  31st Annual Autumn Immunology Conference, Chicago, IL.  2002 November. 

Russell L, Chiarini-Garcia H, Korsmeyer S, Knudson M.  Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis.  Biology of reproduction.  2002 April. 66(4):950-8.
[PubMed]

Ross A, Amy S, Mahar P, Lindsten T, Knudson M, Thompson C, Korsmeyer S, MacGregor G.  BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.  Developmental biology.  2001 November. 239(2):295-308.
[PubMed]

Knudson M, Luke J, Deimerly L, van de Wetering C.  Chromosomal Instability Induced by High Levels of Bax.  Cold Spring Harbor Programmed Cell Death.  2001 November. 

Gibson M, Han B, Choi J, Knudson M, Korsmeyer S, Parsadanian M, Holtzman D.  BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways.  Molecular medicine (Cambridge, Mass.).  2001 September. 7(9):644-55.
[PubMed]

Rokhlin O, Guseva N, Tagiyev A, Knudson M, Cohen M.  Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis.  Oncogene.  2001 May. 20(22):2836-43.
[PubMed]

Knudson M, Johnson G, Lin Y, Korsmeyer S.  Bax accelerates tumorigenesis in p53-deficient mice.  Cancer research.  2001 January. 61(2):659-65.
[PubMed]

Knudson M, Qiao L, Johnson G.  Effect of Bcl-2 transfection on HT-29 colon adenocarcinoma cells after sulindac sulfide treatment.  The Molecular Medicine of Colorectal Cancer, Keystone Symposia, Taos, NM.  2001 January. 

Lobner D, Canzoniero L, Manzerra P, Gottron F, Ying H, Knudson M, Tian M, Dugan L, Kerchner G, Sheline C, Korsmeyer S, Choi D.  Zinc-induced neuronal death in cortical neurons.  Cellular and molecular biology (Noisy-le-Grand, France).  2000 June. 46(4):797-806.
[PubMed]

Schorr K, Li M, Bar-Peled U, Lewis A, Heredia A, Lewis B, Knudson M, Korsmeyer S, Jäger R, Weiher H, Furth P.  Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.  Cancer research.  1999 June. 59(11):2541-5.
[PubMed]

Shibata M, Liu M, Knudson M, Shibata E, Yoshidome K, Bandey T, Korsmeyer S, Green J.  Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage.  The EMBO journal.  1999 May. 18(10):2692-701.
[PubMed]

Hotchkiss R, Swanson P, Knudson M, Chang K, Cobb J, Osborne D, Zollner K, Buchman T, Korsmeyer S, Karl I.  Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.  Journal of immunology (Baltimore, Md. : 1950).  1999 April. 162(7):4148-56.
[PubMed]

Bar-Peled O, Knudson M, Korsmeyer S, Rothstein J.  Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.  Journal of neuroscience research.  1999 March. 55(5):542-56.
[PubMed]

Lentz S, Knudson M, Korsmeyer S, Snider W.  Neurotrophins support the development of diverse sensory axon morphologies.  The Journal of neuroscience : the official journal of the Society for Neuroscience.  1999 February. 19(3):1038-48.
[PubMed]

Perez G, Robles R, Knudson M, Flaws J, Korsmeyer S, Tilly J.  Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency.  Nature genetics.  1999 February. 21(2):200-3.
[PubMed]

Johnson M, Xiang H, London S, Kinoshita Y, Knudson M, Mayberg M, Korsmeyer S, Morrison R.  Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons.  Journal of neuroscience research.  1998 December. 54(6):721-33.
[PubMed]

Moley K, Chi M, Knudson M, Korsmeyer S, Mueckler M.  Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways..  Nature medicine.  1998 December. 4(12):1421-4.
[PubMed]

Mosinger Ogilvie J, Deckwerth T, Knudson M, Korsmeyer S.  Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice.  Investigative ophthalmology & visual science.  1998 August. 39(9):1713-20.
[PubMed]

Deckwerth T, Easton R, Knudson M, Korsmeyer S, Johnson E.  Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation.  Experimental neurology.  1998 July. 152(1):150-62.
[PubMed]

Xiang H, Kinoshita Y, Knudson M, Korsmeyer S, Schwartzkroin P, Morrison R.  Bax involvement in p53-mediated neuronal cell death.  The Journal of neuroscience : the official journal of the Society for Neuroscience.  1998 February. 18(4):1363-73.
[PubMed]

White F, Keller-Peck C, Knudson M, Korsmeyer S, Snider W.  Widespread elimination of naturally occurring neuronal death in Bax-deficient mice.  The Journal of neuroscience : the official journal of the Society for Neuroscience.  1998 February. 18(4):1428-39.
[PubMed]

Knudson M, Tung S, Korsmeyer  S.  Molecular regulation of testicular cell death.  Serono Symposia USA, Inc., Springer-Verlag New York.  1998. 

Perez G, Knudson M, Leykin L, Korsmeyer S, Tilly J.  Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.  Nature medicine.  1997 November. 3(11):1228-32.
[PubMed]

Miller T, Moulder K, Knudson M, Creedon D, Deshmukh M, Korsmeyer S, Johnson E.  Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.  The Journal of cell biology.  1997 October. 139(1):205-17.
[PubMed]

Knudson M, Xiang H, Kinoshita Y, Korsmeyer S, Sxhwartzkroin P, Morrison R.  Bax involvement in p53 mediated neuronal cell death.  Cold Spring Harbor Meeting on Programmed Cell Death.  1997 September. 

Knudson M, Jay H, Korsmeyer S.  Bcl-2 but not Bax accelerates oncogenesis in p53 deficient mice.  Cold Spring Harbor Meeting on Programmed Cell Death.  1997 September. 

Knudson M, Korsmeyer S.  Bcl-2 and Bax function independently to regulate cell death.  Nature genetics.  1997 August. 16(4):358-63.
[PubMed]

Knudson M, Tung K, Korsmeyer S.  Bax dependent aptoptosis is critical for normal testicular development and spermatogenesis.  Germ cell differenetiation, Keystone Symposia, Frisco, CO.  1997 March. 

McCurrach M, Connor T, Knudson M, Korsmeyer S, Lowe S.  bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis.  Proceedings of the National Academy of Sciences of the United States of America.  1997 March. 94(6):2345-9.
[PubMed]

Yin C, Knudson M, Korsmeyer S, Van Dyke T.  Bax suppresses tumorigenesis and stimulates apoptosis in vivo.  Nature.  1997 February. 385(6617):637-40.
[PubMed]

Deckwerth T, Elliott J, Knudson M, Johnson E, Snider W, Korsmeyer S.  BAX is required for neuronal death after trophic factor deprivation and during development.  Neuron.  1996 September. 17(3):401-11.
[PubMed]

Knudson M, Tung K, Flaws J, Brown G, Tilly J, Korsmeyer S.  Oocyte survival by spermatocyte cell death in bax deficient mice.  Cell Death in Reproductive Physiology, Serono Symposium, Chicago, IL.  1996 April. 

Knudson M, Elliot J, Korsmeyer S, Snider W.  Bax is required for motorneuron death following axotomy and during development.  Society for Neuroscience Annual Meeting.  1996. 

Knudson M, White F, Korsmeyer S, Snider W.  Expression of Bax is required for programmed cell death in developing mouse lumbar dorsal root ganglia and spinal cord.  Society for Neuroscience Annual Meeting.  1996. 

Knudson M, Tung K, Tourtellotte W, Brown G, Korsmeyer S.  Bax-deficient mice with lymphoid hyperplasia and male germ cell death.  Science (New York, N.Y.).  1995 October. 270(5233):96-9.
[PubMed]

Knudson M, Tung S, Brown G, Korsmeyer S.  Bax deficient mice demonstrate lymphoid hyperplasia but male germ cell death.  Cold Spring Harbor Programmed Cell Death.  1995 September. 

Knudson M, Chao D, Korsmeyer S.  Effect of bax on thymocyte development and cell death.  Apoptosis (Programmed Cell Death), Keystone Symposia, Tamarron, Co.  1995 March. 

Knudson M, Stang K, Jorgensen A, Campbell K.  Biochemical characterization of ultrastructural localization of a major junctional sarcoplasmic reticulum glycoprotein (triadin).  The Journal of biological chemistry.  1993 June. 268(17):12637-45.
[PubMed]

Knudson M, Stang K, Moomaw C, Slaughter C, Campbell K.  Primary structure and topological analysis of a skeletal muscle-specific junctional sarcoplasmic reticulum glycoprotein (triadin).  The Journal of biological chemistry.  1993 June. 268(17):12646-54.
[PubMed]

Mickelson J, Knudson M, Kennedy C, Yang D, Litterer L, Rempel W, Campbell K, Louis C.  Structural and functional correlates of a mutation in the malignant hyperthermia-susceptible pig ryanodine receptor.  FEBS letters.  1992 April. 301(1):49-52.
[PubMed]

McPherson P, Kim Y, Valdivia H, Knudson M, Takekura H, Franzini-Armstrong C, Coronado R, Campbell K.  The brain ryanodine receptor: a caffeine-sensitive calcium release channel.  Neuron.  1991 July. 7(1):17-25.
[PubMed]

Knudson M, Mickelson J, Louis C, Campbell K.  Distinct immunopeptide maps of the sarcoplasmic reticulum (SR) Ca2+ release channel in malignant hyperthermia (MH).  VII International Congress on Neuromuscular Diseases.  1990 September. 

Knudson M, Mickelson J, Louis C, Campbell K.  Distinct immunopeptide maps of the sarcoplasmic reticulum Ca2+ release channel in malignant hyperthermia.  The Journal of biological chemistry.  1990 February. 265(5):2421-4.
[PubMed]

Knudson M, Stang K, Campbell K.  Identification and localization of a 94 kDa glycoprotein to the triad junction.  Soc Neurosci Abstr.  1990. 

Knudson M, Campbell K.  Albumin is a major protein component of transverse tubule vesicles isolated from skeletal muscle.  The Journal of biological chemistry.  1989 June. 264(18):10795-8.
[PubMed]

Knudson M, Ma J, Campbell K, Coronado R.  Flickery block of the purified ryanodine receptor ruthenium red, tetraamine palladium and tetraamine platinum.  Biophys J.  1989. 

Knudson M, Ma J, Campbell K, Coronado R.  Mechanism of ryanodine activiation in the purified ryanodine receptor channel.  Biophysical J.  1989. 

Fill M, Ma J, Knudson M, Imagawa T, Campbell K, Coronado R.  Role of the ryanodine receptor of skeletal muscle in excitation-contraction coupling.  Annals of the New York Academy of Sciences.  1989. 560:155-62.
[PubMed]

Knudson M, Chaudhari N, Sharp A, Powell J, Beam K, Campbell K.  Specific absence of the alpha 1 subunit of the dihydropyridine receptor in mice with muscular dysgenesis.  The Journal of biological chemistry.  1989 January. 264(3):1345-8.
[PubMed]

Ma J, Fill M, Knudson M, Campbell K, Coronado R.  Ryanodine receptor of skeletal muscle is a gap junction-type channel.  Science (New York, N.Y.).  1988 October. 242(4875):99-102.
[PubMed]

Knudson M, Campbell K, Leung A, Sharp A.  Ca2+ channels in skeletal muscle excitation-contraction coupling.  University of Toronto Symposium on Cellular Variations in Ca2+ signalling.  1988 August. 

Knudson M, Coronado R, Campbell K, Fill M, Ma J.  Purified Ryanodine Receptor of Muscles Sarcoplasmic Reticulum; Similarities to Gap Junction Channels.  University of Toronto Symposium on Cellular Variations in Ca2+ signalling.  1988 August. 

Beam K, Knudson M.  Calcium currents in embryonic and neonatal mammalian skeletal muscle.  The Journal of general physiology.  1988 June. 91(6):781-98.
[PubMed]

Beam K, Knudson M.  Effect of postnatal development on calcium currents and slow charge movement in mammalian skeletal muscle.  The Journal of general physiology.  1988 June. 91(6):799-815.
[PubMed]

Knudson M, Hoffman E, Kahl S, Kunkel L, Campbell K.  Evidence for the association of dystrophin with the transverse tubular system in skeletal muscle.  The Journal of biological chemistry.  1988 June. 263(17):8480-4.
[PubMed]

Knudson M, Hoffman E, Campbell K, Kunkel L.  Biochemistry and Physiology of Duchenne Muscular Dystrophy.  J Cell Biochem Suppl.  1988. 

Knudson M, Chandhari N, Beam K, Campbell K.  Characterization of proteins involved in excitation-contraction coupling in mice with muscular dysgenesis.  Biophys J.  1988. 

Knudson M, Imagawa T, Kahl S, Gaver M, Leung A, Sharp A, Jay S, Campbell K.  Evidence for physical association between junctional sarcoplasmic reticulum ryanodine receptor and junctional transverse tubular dihydropyridine receptor.  Biophys J.  1988. 

Knudson M, Ma J, Campbell K, Coronado R.  The purified ryanodine receptor of muscle sarcoplasmic reticulum: similarities to gap junction channels.  42nd Annual Meeting of the Society of General Physiologist.  1988. 

Knudson M, Fill M, Ma J, Campbell K, Imagawa T, Stefani E, Coronado R.  Voltage-dependence of purified ryanodine receptor incorporated into planar lipid bilayers.  Biophys J.  1988. 

Campbell K, Knudson M, Imagawa T, Leung A, Sutko J, Kahl S, Raab C, Madson L.  Identification and characterization of the high affinity [3H]ryanodine receptor of the junctional sarcoplasmic reticulum Ca2+ release channel.  The Journal of biological chemistry.  1987 May. 262(14):6460-3.
[PubMed]

Knudson M, Imagawa T, Leung A, Kahl S, Campbell K.  Immunoaffinity purification of ryanodine receptor from rabbit skeletal muscle.  Biophy J.  1987. 

Hoffman E, Knudson M, Campbell K, Kunkel L.  Subcellular fractionation of dystrophin to the triads of skeletal muscle.  Nature.  1987. 330(6150):754-8.
[PubMed]

Beam K, Knudson M, Powell J.  A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells.  Nature.  1986. 320(6058):168-70.
[PubMed]

Knudson M, Jay S, Beam K.  Developmental increase in skeletal muscle slow calcium current.  Biophys J.  1986. 

Knudson M, Imagawa T, Leung A, Kahl S, Sutko J, Campbell K.  Immunoprecipitation of (3H)ryanodine receptor from skeletal muscle sarcoplasmic reticulum.  Biphys J.  1986. 

Knudson M, Beam K.  Calcium currents in developing mammalian skeletal muscle cells.  Society for Neuroscience Annual Meeting.  1985. 

Knudson M, Beam K, Powell J.  Slow calcium channels are absent in muscle cells of mice with a genetic defect in excitation-contraction coupling.  39th Annual Meeting of the Society of General Physiologist.  1985. 

Date Last Modified: 06/12/2014 - 07:35:42