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Professor of Radiation Oncology
Email: firstname.lastname@example.orgWeb: Departmental ProfileWeb: Human ToxicologyWeb: Molecular and Cellular BiologyWeb: Biosciences
BS, Chemistry, St. Anthony's College, Shillong, IndiaMS, Chmistry, Gauhati University, IndiaPhD, Chemistry, Gauhati University, India
Post Doctoral, Department of Microbiology, University of Miami, Miami, FLFellowship, Regional Research Laboratory, Jorhat, India
Biosciences Graduate ProgramFree Radical and Radiation Biology Graduate ProgramInterdisciplinary Graduate Program in Human ToxicologyInterdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between ROS-signaling and other aspects of intracellular signaling networks.
Research efforts are concentrated in identifying the molecular mechanisms involved in the regulation of the redox-sensitive G1-checkpoint following mitogenic stimuli and in asynchronously growing exponential cells. The possible role of ROS and thiol-redox reactions in regulating expression and activities of cyclins, CDKs, CKIs, CDC25, Rb, thioredoxin, and glutaredoxin are of immediate interest.
Research efforts are also ongoing identifying the cellular effects of environmental pollutants, polychlorinated biphenyls. The possible role of oxidative stress in PCB-induced DNA damage, perturbation in cellular proliferation, and cell death is currently being investigated.
Additional research interest includes investigating the possible role of intracellular redox environment in wound healing, radiosensitivity, radiation-induced cell cycle checkpoint pathways, and post-transcriptional gene regulation.
The knowledge gained from these research projects may provide novel insights into the regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to devise better treatment protocols based on redox control of the cell cycle.
Date Last Modified: 06/07/2014 -
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