Psychiatry

Thomas Wassink, MD

Portrait

Professor of Psychiatry
Professor of Pediatrics

Contact Information

Office: 1-191 Medical Education Building
Iowa City, IA 52242
Office Phone: 319-335-7743

Email: thomas-wassink@uiowa.edu
Web: Thomas Wassink Laboratory, Molecular Psychiatry Division

Education

BA, English Literature, Northwestern University, Chicago, IL
MD, University of Illinois at Chicago, Chicago, IL

Residency, Psychiatry, Evanston Hospital (Northwestern University), Evanston, IL
Fellowship, Mental Health Clinic Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

Psychiatry certification, American Board of Psychiatry and Neurology
National Board of Medical Examiners

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

My laboratory's goal is to identify genes that underlie susceptibility to a variety of psychiatric disorders, with our primary focus being autism. We use a variety of approaches in this endeavor, including positional cloning, sophisticated cytogenetic analyses, various microarray platforms, and candidate disease gene screening. We perform these studies in DNA obtained from numerous independent samples of families with multiple autistic individuals. We are also equipped to assess the function and expression of identified disease genes using an array of molecular and animal model techniques. Extensive additional resources and expertise are available to us here at Iowa through our collaborations with the Center for Statistical Genetics, the UIHC Cytogenetics laboratory, and the Center for Bioinformatics and Computational Biology. We are also actively investigating the genetics of panic disorder and schizophrenia. The panic disorder work uses traditional positional cloning methods and a sample of moderate to large panic disorder pedigrees. The schizophrenia genetics research is performed in association with the Department of Psychiatry's Mental Health Clinical Research Center. We collect DNA from individuals with schizophrenia, their families, and psychiatrically normal control subjects. All of these individuals participate in protocols that gather data from a wide variety of research domains, including functional and structural brain imaging, cognitive testing, disease phenomenology, longitudinal progression of disease, etc. The goal with the schizophrenia sample, therefore, is to investigate relationships between genetic information and these other types of data.

Selected Publications

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Rudd D, Axelsen M, Epping E, Andreasen N, Wassink T.  A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model.  Am J Med Genet B Neuropsychiatr Genet.  2014. 165B(8):619-26.
[PubMed]

 , Black D, Coryell W, Potash J, Wassink T, Wray N.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.  Nat Genet.  2013. 45(9):984-94.
[PubMed]

Brauns S, Gollub R, Roffman J, Yendiki A, Ho B, Wassink T, Heinz A, Ehrlich S.  DISC1 is associated with cortical thickness and neural efficiency.  Neuroimage.  2011 August 15. 57(4):1591-600.
[Link]

Nopoulos P, Epping E, Wassink T, Schlaggar B, Perlmutter J.  Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating.  Behav Brain Funct.  2011. 7(1):45.
[Link]

Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams B, Sykes N, Pagnamenta A, Almeida J, Bacchelli E, Bailey A, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton P, Bourgeron T, Brennan S, Brian J, Carson A, Casallo G, Casey J, Chu S, Cochrane L, Corsello C, Crawford E, Crossett A, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez B, Folstein S, Fombonne E, Freitag C, Gilbert J, Gillberg C, Glessner J, Goldberg J, Green J, Guter S, Hakonarson H, Heron E, Hill M, Holt R, Howe J, Hughes G, Hus V, Igliozzi R, Kim C, Klauck S, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere C, Lamb J, Laskawiec M, Leboyer M, Le Couteur A, Leventhal B, Lionel A, Liu X, Lord C, Lotspeich L, Lund S, Maestrini E, Mahoney W, Mantoulan C, Marshall C, McConachie H, McDougle C, McGrath J, McMahon W, Melhem N, Merikangas A, Migita O, Minshew N, Mirza G, Munson J, Nelson S, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr J, Parrini B, Paton T, Pickles A, Piven J, Posey D, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter M, Bierut L, Rice J, Salt J, Sansom K, Sato D, Segurado R, Senman L, Shah N, Sheffield V, Soorya L, Sousa I, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson A, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent J, Volkmar F, Wallace S, Wang K, Wang Z, Wassink T, Wing K, Wittemeyer K, Wood S, Yaspan B, Zurawiecki D, Zwaigenbaum L, Betancur C, Buxbaum J, Cantor R, Cook E, Coon H, Cuccaro M, Gallagher L, Geschwind D, Gill M, Haines J, Miller J, Monaco A, Nurnberger J, Paterson A, Pericak-Vance M, Schellenberg G, Scherer S, Sutcliffe J, Szatmari P, Vicente A, Vieland V, Wijsman E, Devlin B, Ennis S, Hallmayer J.  A genome-wide scan for common alleles affecting risk for autism.  Hum Mol Genet.  2010 October 15. 19(20):4072-82.
[Link]

Pinto D, Pagnamenta A, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams B, Almeida J, Bacchelli E, Bader G, Bailey A, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton P, Bourgeron T, Brennan S, Brian J, Bryson S, Carson A, Casallo G, Casey J, Chung B, Cochrane L, Corsello C, Crawford E, Crossett A, Cytrynbaum C, Dawson G, de Jonge M, Delorme R, Drmic I, Duketis E, Duque F, Estes A, Farrar P, Fernandez B, Folstein S, Fombonne E, Freitag C, Gilbert J, Gillberg C, Glessner J, Goldberg J, Green A, Green J, Guter S, Hakonarson H, Heron E, Hill M, Holt R, Howe J, Hughes G, Hus V, Igliozzi R, Kim C, Klauck S, Kolevzon A, Korvatska O, Kustanovich V, Lajonchere C, Lamb J, Laskawiec M, Leboyer M, Le Couteur A, Leventhal B, Lionel A, Liu X, Lord C, Lotspeich L, Lund S, Maestrini E, Mahoney W, Mantoulan C, Marshall C, McConachie H, McDougle C, McGrath J, McMahon W, Merikangas A, Migita O, Minshew N, Mirza G, Munson J, Nelson S, Noakes C, Noor A, Nygren G, Oliveira G, Papanikolaou K, Parr J, Parrini B, Paton T, Pickles A, Pilorge M, Piven J, Ponting C, Posey D, Poustka A, Poustka F, Prasad A, Ragoussis J, Renshaw K, Rickaby J, Roberts W, Roeder K, Roge B, Rutter M, Bierut L, Rice J, Salt J, Sansom K, Sato D, Segurado R, Sequeira A, Senman L, Shah N, Sheffield V, Soorya L, Sousa I, Stein O, Sykes N, Stoppioni V, Strawbridge C, Tancredi R, Tansey K, Thiruvahindrapduram B, Thompson A, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent J, Volkmar F, Wallace S, Wang K, Wang Z, Wassink T, Webber C, Weksberg R, Wing K, Wittemeyer K, Wood S, Wu J, Yaspan B, Zurawiecki D, Zwaigenbaum L, Buxbaum J, Cantor R, Cook E, Coon H, Cuccaro M, Devlin B, Ennis S, Gallagher L, Geschwind D, Gill M, Haines J, Hallmayer J, Miller J, Monaco A, Nurnberger J, Paterson A, Pericak-Vance M, Schellenberg G, Szatmari P, Vicente A, Vieland V, Wijsman E, Scherer S, Sutcliffe J, Betancur C.  Functional impact of global rare copy number variation in autism spectrum disorders.  Nature.  2010 July 15. 466(7304):368-72.
[Link]

Hartz S, Ho B, Andreasen N, Librant A, Rudd D, Epping E, Wassink T.  G72 influences longitudinal change in frontal lobe volume in schizophrenia.  Am J Med Genet B Neuropsychiatr Genet.  2010 March 5. 153B(2):640-7.
[Link]

Davis L, Meyer K, Rudd D, Librant A, Epping E, Sheffield V, Wassink T.  Novel copy number variants in children with autism and additional developmental anomalies.  J Neurodev Disord.  2009 December. 1(4):292-301.
[Link]

Bucan M, Abrahams B, Wang K, Glessner J, Herman E, Sonnenblick L, Alvarez Retuerto A, Imielinski M, Hadley D, Bradfield J, Kim C, Gidaya N, Lindquist I, Hutman T, Sigman M, Kustanovich V, Lajonchere C, Singleton A, Kim J, Wassink T, McMahon W, Owley T, Sweeney J, Coon H, Nurnberger J, Li M, Cantor R, Minshew N, Sutcliffe J, Cook E, Dawson G, Buxbaum J, Grant S, Schellenberg G, Geschwind D, Hakonarson H.  Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes.  PLoS Genet.  2009 June. 5(6):e1000536.
[Link]

Glessner J, Wang K, Cai G, Korvatska O, Kim C, Wood S, Zhang H, Estes A, Brune C, Bradfield J, Imielinski M, Frackelton E, Reichert J, Crawford E, Munson J, Sleiman P, Chiavacci R, Annaiah K, Thomas K, Hou C, Glaberson W, Flory J, Otieno F, Garris M, Soorya L, Klei L, Piven J, Meyer K, Anagnostou E, Sakurai T, Game R, Rudd D, Zurawiecki D, McDougle C, Davis L, Miller J, Posey D, Michaels S, Kolevzon A, Silverman J, Bernier R, Levy S, Schultz R, Dawson G, Owley T, McMahon W, Wassink T, Sweeney J, Nurnberger J, Coon H, Sutcliffe J, Minshew N, Grant S, Bucan M, Cook E, Buxbaum J, Devlin B, Schellenberg G, Hakonarson H.  Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.  Nature.  2009 May 28. 459(7246):569-73.
[Link]

Date Last Modified: 11/19/2014 - 12:40:25