Psychiatry

Shizhong Han, PhD

Portrait

Assistant Professor of Psychiatry

Contact Information

Office: 22G General Hospital
Iowa City, IA 52242
Office Phone: 319-353-8773

Email: shizhong-han@uiowa.edu
Web: Shizhong Han Laboratory, Molecular Psychiatry Division

Education

BS, Biochemistry, Yantai University, Shandong, China
PhD, Genetics, Fudan University, Shanghai, China

PhD, Genetics, Fudan University, Shanghai, China

Research Summary

My research aims to dissect the genetic components of psychiatric disorders using cutting-edge genomic technologies, advanced statistical genetic methods and multidisciplinary approaches. In addition to gene mapping efforts for psychiatric disorders, I am also interested in developing novel statistical methods and computational tools to meet the challenges arising from big data. Specifically, my research interests include genetic study of neuroimaging-based endophenotypes to enhance the gene discovery of psychiatric disorders, using prior information (e.g., linkage evidence, gene expression studies, functional annotations, etc.) to boost the power of next-generation genetic studies, and system genetic approaches that integrate multiple layers of molecular data, such as genetic/epigenetic variations, gene expressions, and protein levels—all in a high-throughput manner. I am also interested in gene mapping studies in diverse populations, such as African-Americans, for admixture mapping or trans-racial mapping, and isolated populations for mapping rare risk variants.

All Publications

Han S, Gelernter J, Kranzler H, Yang B.  Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans..  Human genetics.  2013 April. 132(4):397-403.
[PubMed]

Molineros J, Maiti A, Sun C, Looger L, Han S, Kim-Howard X, Glenn S, Adler A, Kelly J, Niewold T, Gilkeson G, Brown E, Alarcón G, Edberg J, Petri M, Ramsey-Goldman R, Reveille J, Vilá L, Freedman B, Tsao B, Criswell L, Jacob C, Moore J, Vyse T, Langefeld C, Guthridge J, Gaffney P, Moser K, Scofield R, Alarcón-Riquelme M.  Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production..  PLoS genetics.  2013. 9(2):e1003222.
[PubMed]

Molineros J, Maiti A, Sun C, Looger L, Han S, Kim-Howard X, Glenn S, Adler A, Kelly J, Niewold T, Gilkeson G, Brown E, Alarcón G, Edberg J, Petri M, Ramsey-Goldman R, Reveille J, Vilá L, Freedman B, Tsao B, Criswell L, Jacob C, Vyse T, Langefeld C, Guthridge J, Gaffney P, Moser K, Scofield H, Alarcón-Riquelme M, Williams S, Merrill J, James J, Kaufman K, Kimberly R, Harley J, Nath S.  Admixture Mapping in Systemic Lupus Erythematosus (SLE) Identifies Multiple Common Functional Variants within IFIH1 Associated with Apoptosis, Inflammation and Autoantibody Production.  PLoS Genet.  2012 December. 

Han S, Yang B, Kranzler H, Gelernter J.  Genomewide ordered subset linkage analysis for alcohol dependence in African-Americans.  Hum Genet.  2012 December. 

Han S, Yang B, Kranzler H, Oslin D, Anton R, Farrer L, Gelernter J.  Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans..  Biological psychiatry.  2012 October. 72(8):637-44.
[PubMed]

Han S, Yang B, Kranzler H, Oslin D, Anton R, Farrer L, Gelernter J.  Linkage analysis followed by association show NRG1 associated with cannabis dependence in African-Americans.  Biol Psychiatry.  2012 October. 72(8):637-44.
[Link]

Hartz S, Short S, Saccone N, Culverhouse R, Chen L, Schwantes-An T, Coon H, Han Y, Stephens S, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel N, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen L, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer J, Teumer A, Thompson J, Vink J, Vogelzangs N, Wenzlaff A, Wheeler W, Xiao X, Yang B, Aggen S, Balmforth A, Baumeister S, Beaty T, Bennett S, Bergen A, Boyd H, Broms U, Campbell H, Chatterjee N, Chen J, Cheng Y, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gu F, Hall A, Hällfors J, Han S, Hartmann A, Hayward C, Heikkilä K, Hewitt J, Hottenga J, Jensen M, Jousilahti P, Kaakinen M, Kittner S, Konte B, Korhonen T, Landi M, Laatikainen T, Leppert M, Levy S, Mathias R, McNeil D, Medland S, Montgomery G, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos E, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma D, Caporaso N, Duan J, Edenberg H, Francks C, Gejman P, Gelernter J, Grabe H, Hops H, Jarvelin M, Viikari J, Kähönen M, Kendler K, Lehtimäki T, Levinson D, Marazita M, Marchini J, Melbye M, Mitchell B, Murray J, Nöthen M, Penninx B, Raitakari O, Rietschel M, Rujescu D, Samani N, Sanders A, Schwartz A, Shete S, Shi J, Spitz M, Stefansson K, Swan G, Thorgeirsson T, Völzke H, Wei Q, Wichmann H, Amos C, Breslau N, Cannon D, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson E, Kaprio J, Madden P, Martin N, Stevens V, Stitzel J, Weiss R, Kraft P, Bierut L.  Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.  Arch Gen Psychiatry.  2012 August. 69(8):854-60.
[Link]

Hartz S, Short S, Saccone N, Culverhouse R, Chen L, Schwantes-An T, Coon H, Han Y, Stephens S, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel N, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen L, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer J, Teumer A, Thompson J, Vink J, Vogelzangs N, Wenzlaff A, Wheeler W, Xiao X, Yang B, Aggen S, Balmforth A, Baumeister S, Beaty T, Bennett S, Bergen A, Boyd H, Broms U, Campbell H, Chatterjee N, Chen J, Cheng Y, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gu F, Hall A, Hällfors J, Han S, Hartmann A, Hayward C, Heikkilä K, Hewitt J, Hottenga J, Jensen M, Jousilahti P, Kaakinen M, Kittner S, Konte B, Korhonen T, Landi M, Laatikainen T, Leppert M, Levy S, Mathias R, McNeil D, Medland S, Montgomery G, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos E, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma D, Caporaso N, Duan J, Edenberg H, Francks C, Gejman P, Gelernter J, Grabe H, Hops H, Jarvelin M, Viikari J, Kähönen M, Kendler K, Lehtimäki T, Levinson D, Marazita M, Marchini J, Melbye M, Mitchell B, Murray J, Nöthen M, Penninx B, Raitakari O, Rietschel M, Rujescu D, Samani N, Sanders A, Schwartz A, Shete S, Shi J, Spitz M, Stefansson K, Swan G, Thorgeirsson T, Völzke H, Wei Q, Wichmann H, Amos C, Breslau N, Cannon D, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson E, Kaprio J, Madden P, Martin N, Stevens V, Stitzel J, Weiss R, Kraft P, Bierut L.  Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers..  Archives of general psychiatry.  2012 August. 69(8):854-60.
[PubMed]

Yang B, Han S, Kranzler H, Farrer L, Elston R, Gelernter J.  Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances..  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.  2012 June. 159B(4):361-9.
[PubMed]

Yang B, Han S, Kranzler H, Farrer L, Gelernter J.  A genomewide linkage scan of cocaine dependence and major depressive episode in two populations..  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.  2011 November. 36(12):2422-30.
[PubMed]

Ma L, Han S, Yang J, Da Y.  Multi-locus test conditional on confirmed effects leads to increased power in genome-wide association studies.  PLoS One.  2011 November. 5(11).
[Link]

Han S, Yang B, Kranzler H, Oslin D, Anton R, Gelernter J.  Association of CHRNA4 polymorphisms with smoking behavior in two populations.  Am J Med Genet B Neuropsychiatr Genet.  2011 June. 156B(4):421-9.
[Link]

Han S, Yang B, Kranzler H, Oslin D, Anton R, Gelernter J.  Association of CHRNA4 polymorphisms with smoking behavior in two populations..  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.  2011 June. 156B(4):421-9.
[PubMed]

Saccone N, Culverhouse R, Schwantes-An T, Cannon D, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X, Landi M, Ma J, Short S, Stephens S, Stevens V, Sun L, Wang Y, Wenzlaff A, Aggen S, Breslau N, Broderick P, Chatterjee N, Chen J, Heath A, Heliövaara M, Hoft N, Hunter D, Jensen M, Martin N, Montgomery G, Niu T, Payne T, Peltonen L, Pergadia M, Rice J, Sherva R, Spitz M, Sun J, Wang J, Weiss R, Wheeler W, Witt S, Yang B, Caporaso N, Ehringer M, Eisen T, Gapstur S, Gelernter J, Houlston R, Kaprio J, Kendler K, Kraft P, Leppert M, Li M, Madden P, Nöthen M, Pallai S, Rietschel M, Rujescu D, Schwartz A, Amos C, Bierut L.  Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.  PLoS Genet.  2010 August. 6(8).
[Link]

Saccone N, Culverhouse R, Schwantes-An T, Cannon D, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X, Landi M, Ma J, Short S, Stephens S, Stevens V, Sun L, Wang Y, Wenzlaff A, Aggen S, Breslau N, Broderick P, Chatterjee N, Chen J, Heath A, Heliövaara M, Hoft N, Hunter D, Jensen M, Martin N, Montgomery G, Niu T, Payne T, Peltonen L, Pergadia M, Rice J, Sherva R, Spitz M, Sun J, Wang J, Weiss R, Wheeler W, Witt S, Yang B, Caporaso N, Ehringer M, Eisen T, Gapstur S, Gelernter J, Houlston R, Kaprio J, Kendler K, Kraft P, Leppert M, Li M, Madden P, Nöthen M, Pillai S, Rietschel M, Rujescu D, Schwartz A, Amos C, Bierut L.  Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD..  PLoS genetics.  2010 August. 6(8).
[PubMed]

Ma L, Han S, Yang J, Da Y.  Multi-locus test conditional on confirmed effects leads to increased power in genome-wide association studies..  PloS one.  2010. 5(11):e15006.
[PubMed]

Han S, Gelernter J, Luo X, Yang B.  Meta-analysis of 15 genome-wide linkage scans of smoking behavior.  Biol Psychiatry.  2010 January. 67(1):12-9.
[Link]

Han S, Gelernter J, Luo X, Yang B.  Meta-analysis of 15 genome-wide linkage scans of smoking behavior..  Biological psychiatry.  2010 January. 67(1):9-Dec.
[PubMed]

Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge J, Thomas K, Kaufman K, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi C, Gregersen P, Merrill J, James J, Gaffney P, Moser K, Jacob C, Kimberly R, Harley J, Bae S, Anaya J, Alarcón-Riquelme M, Matsuda K, Vyse T, Nath S.  Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).  Hum Mol Genet.  2009 March. 18(6):1171-80.
[Link]

Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge J, Thomas K, Kaufman K, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi C, Gregersen P, Merrill J, James J, Gaffney P, Moser K, Jacob C, Kimberly R, Harley J, Bae S, Anaya J, Alarcón-Riquelme M, Matsuda K, Vyse T, Nath S.  Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)..  Human molecular genetics.  2009 March. 18(6):1171-80.
[PubMed]

Han S, Ma L, Li D, Yang B.  Is the tail-strength measure more powerful in tests of genetic association?.  Am J Hum Genet.  2009 February. 84(2):295-8.
[Link]

Han S, Ma L, Li D, Yang B.  Is the tail-strength measure more powerful in tests of genetic association?.  American journal of human genetics.  2009 February. 84(2):295-8; author reply 298-300.
[PubMed]

Nath S, Han S, Kim-Howard X, Kelly J, Viswanathan P, Gilkeson G, Chen W, Zhu C, McEver R, Kimberly R, Alarcón-Riquelme M, Vyse T, Li Q, Wakeland E, Merrill J, James J, Kaufman K, Guthridge J, Harley J.  A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.  Nat Genet.  2008 February. 40(2):152-4.
[Link]

Nath S, Han S, Kim-Howard X, Kelly J, Viswanathan P, Gilkeson G, Chen W, Zhu C, McEver R, Kimberly R, Alarcón-Riquelme M, Vyse T, Li Q, Wakeland E, Merrill J, James J, Kaufman K, Guthridge J, Harley J.  A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus..  Nature genetics.  2008 February. 40(2):152-4.
[PubMed]

Cui S, Qu X, Han S, Yu C, Sun W, Tang Q.  Application of Dual-color Fluorescence Hybridization Chip Technique in the Monitoring of the Genetic Quality of Inbred Mice Strains.  Zool Res.  2008. 29:16-Oct.

Sawalha A, Webb R, Han S, Kelly J, Kaufman K, Kimberly R, Alarcón-Riquelme M, James J, Vyse T, Gilkeson G, Choi C, Scofield R, Bae S, Nath S, Harley J.  Common variants within MECP2 confer risk of systemic lupus erythematosus..  PloS one.  2008. 3(3):e1727.
[PubMed]

Sanghera D, Ortega L, Han S, Singh J, Ralhan S, Wander G, Mehra N, Mulvihill J, Ferrell R, Nath S, Kamboh M.  Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk..  BMC medical genetics.  2008. 9:59.
[PubMed]

Han S, Guthridge J, Harley I, Sestak A, Kim-Howard X, Kaufman K, Namjou B, Deshmukh H, Bruner G, Espinoza L, Gilkeson G, Harley J, James J, Nath S.  Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction..  PloS one.  2008. 3(3):e0001757.
[PubMed]

Huang Y, Han S, Li Y, Mao Y, Xie Y.  Different roles of MTHFR C677T and A1298C polymorphisms in colorectal adenoma and colorectal cancer: a meta-analysis..  Journal of human genetics.  2007. 52(1):73-85.
[PubMed]

Han S, Zhang H, Wang Z, Xie Y, Tang R, Mao Y, Li Y.  DNA repair gene XRCC3 polymorphisms and cancer risk: a meta-analysis of 48 case-control studies..  European journal of human genetics : EJHG.  2006 October. 14(10):1136-44.
[PubMed]

Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y.  CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis..  Human immunology.  2006 August. 67(8):618-26.
[PubMed]

Han S, Zhang S, Li R, Li Y.  The common -318C/T polymorphism in the promoter region of CTLA4 gene is associated with reduced risk of opthalmopathy in Chinese Graves' patients..  International Journal of Immunogenetics.  2006 August. 33(4):281-287.
[PubMed]

Han S, Li Y, Mao Y, Xie Y.  Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis..  Human genetics.  2005 October. 118(1):123-32.
[PubMed]

Hans S.  Integrating GWAS and protein-protein interaction network identifies a subnetwork implicated in Alcohol Dependence . 

Han S, Yang B, Kranzler H, Farrer L, Zhao H, Gelernter J.  Integrating GWAS and protein-protein interaction network identifies a subnetwork implicated in Alcohol Dependence. 

Date Last Modified: 06/07/2014 - 21:56:23