Psychiatry

Michael Lutter, MD, PhD

Portrait

Associate Professor of Psychiatry  - Molecular Psychiatry

Contact Information

Office: 1320 Pappajohn Biomedical Discovery Building
169 Newton Rd
Iowa City, IA 52242
Phone: 319-353-5425

Email: michael-lutter@uiowa.edu
Web: Michael Lutter Laboratory, Molecular Psychiatry Division

Education

BS, Biological Chemistry, University of Chicago
PhD, Integrative Biology, University of Texas Southwestern Medical Center
MD, Integrative Biology Graduate Program, University of Texas Southwestern Medical Center

Residency, Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX

Licensure and Certifications

ABPN
ABPN Certification: Psychiatry, American Board of Psychiatry and Neurology

All Publications

Lutter M, Croghan A, Cui H.  Animal Models of Eating Disorders in the Post-Diagnostic and Statistical Manual Era.  Biological Psychiatry.  2016. 79(1):17-24.
[PubMed]

Cui H, Lu Y, Khan M, Anderson R, McDaniel L, Wilson H, Yin T, Radley J, Pieper A, Lutter M.  Behavioral disturbances in estrogen-related receptor alpha-null mice.  Cell Reports.  2015. 11(3):344-50.
[PubMed]

Weidemann B, Voong S, Morales-Santiago F, Kahn M, Ni J, Littlejohn N, Claflin K, Burnett C, Pearson N, Lutter M.  Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System.  Scientific Reports.  2015. 5:11123.
[PubMed]

Acevedo S, Valencia C, Lutter M, McAdams C.  Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa.  Psychiatry Research.  2015. 228(3):641-8.
[PubMed]

Kumar J, Chuang J, Kuperman A, Gillman A, Mukherjee S, Zigman J, McClung C, Lutter M.  Differential effects of chronic social stress and fluoxetine on meal patterns in mice.  Appetite.  2013 December 12. 64:81-88.
[PubMed]

Cui H, Moore J, Drawbridge J, Han S, Hing B, Matthews A, McAdams C,  , Darbo B, Peiper A, Waller D, Xing C, Lutter M.  Eating disorder predisposition is associated with ESRRA and HDAC4 mutations..  Journal of Clinical Investigation.  2013 October 8. 123(11):4706-4713.
[PubMed]

Xu P, Britt J, McDaniel L, Huntington P, Hodge R, Tran S, Mason B, Lee C, Vong L, Lowell B, Malenka R, Lutter M, Pieper A.  Double Deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.  Proceeding of the National Academy of Science of the USA.  2013 June 25. 110(26):10759-10763.
[PubMed]

Cui H, Lutter M.  The expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine.  Genes, Brain and Behavior.  2013 June 20. 12(6):658-65.
[PubMed]

Mason B, Lobo M, Parada L, Lutter M.  Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight.  Obesity.  2013 March. 21(11):2372-2376.
[PubMed]

Cui H, Mason B, Lee C, Nishi A, Elmquist J, Lutter M.  Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning.  Physiology & Behavior.  2012. 106(2):201-10.
[PubMed]

Cui H, Sohn J, Gautron L, Funahashi H, Williams K, Elmquist J, Lutter M.  Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area..  The Journal of Comparative Neurology.  2012. 520(18):4168-83.
[PubMed]

Vialou V, Cui H, Perello M, Mahgoub M, Yu H, Rush A, Pranav H, Jung S, Yangisawa M, Zigman J, Elmquist J, Nestler E, Lutter M.  A role for DeltaFosB in calorie restriction-induced metabolic changes..  Biological Psychiatry.  2011. 70(2):204-7.
[PubMed]

Lutter M.  Depression in Narcolepsy.  Narcolepsy.  2011. 

Chuang J, Perello M, Sakata I, Osborne-Lawrence S, Savitt J, Lutter M, Zigman J.  Ghrelin mediates stress-induced food-reward behavior in mice..  The Journal of Clinical Investigation.  2011. 121(7):2684-92.
[PubMed]

Scott M, Marcus J, Pettersen A, Birnbaum S, Mochizuki T, Scammell T, Nestler E, Elmquist J, Lutter M.  Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.  Behavioural Brain Research.  2011. 222(2):289-94.
[PubMed]

Chuang J, Krishnan V, Yu H, Mason B, Cui H, Cui H, Wilkinson M, Zigman J, Elmquist J, Nestler E, Lutter M.  A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress.  Biological Psychiatry.  2010. 67(11):1075-82.
[PubMed]

Drerup J, Hayashi K, Cui H, Mettlach G, Long M, Marvin M, Sun X, Goldberg M, Lutter M, Bibb J.  Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35..  Biological Psychiatry.  2010. 68(12):1163-71.
[PubMed]

Chuang J, Cui H, Mason B, Mahgoub M, Bookout A, Yu H, Perello M, Elmquist J, Repa J, Zigman J, Lutter M.  Chronic social defeat stress disrupts regulation of lipid synthesis.  Journal of Lipid Research.  2010. 51(6):1344-53.
[PubMed]

Perello M, Sakata I, Birnbaum S, Chuang J, Osborne-Lawrence S, Rovinsky S, Woloszyn J, Yanagisawa M, Lutter M, Zigman J.  Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner..  Biological Psychiatry.  2010. 67(9):880-6.
[PubMed]

Perello M, Chuang J, Scott M, Lutter M.  Translational neuroscience approaches to hyperphagia.  The Journal of Neuroscience.  2010. 30(35):11549-54.
[PubMed]

Lutter M, Elmquist J.  Depression and metabolism: linking changes in lPrinciples of Scholarly Integrityeptin and ghrelin to mood.  F1000 Biology Reports 2009.  2009 August 26. 1:63.

Lutter M, Nestler E.  Hedonic and homeostatic signals interact in the regulation of food intake.  Journal of Nutrition.  2009 March. 139(3):629-32.

Lutter M, Elmquist J.  Depression and metabolism: linking changes in leptin and ghrelin to mood..  F1000 Biology Reports.  2009. 1:63.
[PubMed]

Lutter M.  Molecular Neuropharmacology: A Foundation for Clinical Neuroscience.  Neurodegeneration.  2009. 

Lutter M, Krishnan V, Russo S, Jung S, McClung C, Nestler E.  Orexin signaling mediates the antidepressant-like effect of calorie restriction..  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience.  2008. 28(12):3071-5.
[PubMed]

Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky S, Anderson J, Jung S, Birnbaum S, Yanagisawa M, Elmquist J, Nestler E, Zigman J.  The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress..  Nature Neuroscience.  2008. 11(7):752-3.
[PubMed]

Krishnan V, Han M, Graham D, Berton O, Renthal W, Russo S, Laplant Q, Graham A, Lutter M, Lagace D, Ghose S, Reister R, Tannous P, Green T, Neve R, Chakravarty S, Kumar A, Eisch A, Self D, Lee F, Tamminga C, Cooper D, Gershenfeld H, Nestler E.  Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.  Cell.  2007. 131(2):391-404.
[PubMed]

Elmquist J, Zigman J, Lutter M.  Molecular Determinants of Energy Homeostasis..  The American Journal of Psychiatry.  2006. 163(7):1137.
[PubMed]

Gonzalvez F, Pariselli F, Dupaigne P, Budihardjo I, Lutter M, Antonsson B, Diolez P, Manon S, Martinou J, Goubern M, Wang X, Bernard S, Petit P.  tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak.  Cell Death and Differentiation.  2005. 12(6):614-26.
[PubMed]

Lutter M, Perkins G, Wang X.  The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites.  BMC Cell Biology.  2001. 2:22.
[PubMed]

Lutter M, Fang M, Luo X, Nishijima M, Xie X, Wang X.  Cardiolipin provides specificity for targeting of tBid to mitochondria.  Nature Cell Biology.  2000. 2(10):754-61.
[PubMed]

Frazer J, Jackson D, Gaillard J, Lutter M, Liu Y, Banchereau J, Capra J, Pascual V.  Identification of centerin: a novel human germinal center B cell-restricted serpin.  European Journal of Immunology.  2000. 30(10):3039-48.
[PubMed]

Budihardjo I, Oliver H, Lutter M, Luo X, Wang X.  Biochemical pathways of caspase activation during apoptosis.  Annual Review of Cell and Developmental Biology.  1999. 15:269-90.
[PubMed]

Budihardjo I, Oliver H, Lutter M, Luo X, Wang X.  Biochemical pathways of caspase activation during apoptosis.  Annual Review of Cell and Developmental Biology.  1999. 15:269-90.
[PubMed]

Date Last Modified: 04/13/2016 - 15:29:35