Psychiatry

James B. Potash, MD, MPH

Portrait

Paul W. Penningroth Chair, Professor and Head, Department of Psychiatry
Professor of Psychiatry

Contact Information

Office: 2887 John Pappajohn Pavilion
Iowa City, IA 52242
Office Phone: 319-356-1144

Lab: B002J Medical Laboratories
Iowa City, IA 52242
Phone: 319-335-7225

Email: james-potash@uiowa.edu
Web: James B. Potash Laboratory, Molecular Psychiatry Division

Education

BA, English, Yale College, New Haven, CT
Post-baccalaureate, pre-med, Goucher College, Baltimore, MD
MPH, Epidemiology and International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD
MD, Johns Hopkins School of Medicine, Baltimore, MD

Internship, Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD
Assistant Resident, Psychiatry, Johns Hopkins Hospital, Baltimore, MD
Chief Resident, Psychiatry, Johns Hopkins Hospital, Baltimore, MD

Licensure and Certifications

Iowa Board of Medical Examiners
Psychiatry, American Board of Psychiatry and Neurology

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

I am interested in the genetic variation and DNA methylation variation that confer susceptibility to depression and bipolar disorder. Family, twin, and adoption studies have made it abundantly clear that these disorders are substantially heritable, but only a very small proportion of that heritability has thus far been explained molecularly. Similarly, the environment clearly plays a role in the etiology of depression, but the molecular basis of that role remains undefined. I have an R01 grant from the NIMH to perform next-generation exome sequencing in about 3,000 bipolar disorder cases and controls, and examine the data searching for rare variants associated with this illness. I also have an R01 grant from the NIMH to assess genome-wide DNA methylation variation in a mouse model of stress and depression. Both of these projects involve bench work including DNA sequencing, bisulfite pyrosequencing, and gene expression assays. They further involve bioinformatics and statistical genetics assessment of large data sets.

All Publications

Battle A, Mostafavi S, Zhu X, Potash J, Weissman M, McCormick C, Haudenschild C, Beckman K, Shi J, Mei R, Urban A, Montgomery S, Levinson D, Koller D,  .  Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals.  Genome Res.  2013 October 3. 
[PubMed]

Seifuddin F, Pirooznia M, Judy J, Goes F, Potash J, Zandi P.  Systematic review of genome-wide gene expression studies of bipolar disorder.  BMC Psychiatry.  2013 August 15. 

Manchia M, Adli M, Akula N, Ardau R, Aubry J, Backlund L, Banzato C, Baune B, Bellivier F, Bengesser S, Biernacka J, Brichant-Petitjean C, Bui E, Calkin C, Cheng A, Chillotti C, Cichon S, Clark S, Czerski P, Dantas C, Zompo M, Depaulo J, Detera-Wadleigh S, Etain B, Falkai P, Frisen L, Frye M, Fullerton J, Gard S, Garnham J, Goes F, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn J, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, Kuo P, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband S, Lopez Jaramillo C, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell P, Mondimore F, Monteleone P, Nallet A, Neuner M, Novak T, O'Donovan C, Osby U, Ozaki N, Perlis R, Pfennig A, Potash J, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau G, Rybakowski J, Schalling M, Schofield P, Schubert O, Schweizer B, Seemuller F, Grigoroiu-Serbanescu M, Severino G, Seymour L, Slaney C, Smoller J, Squassina A, Stamm T, Steele J, Stopkova P, Tighe S, Tortorella A, Turecki G, Wray N, Wright A, Zandi P, Zilles D, Bauer M, Rietschel M, McMahon F, Schulze T, Alda M.  Assessment of response to lithium maintenance treatment in bipolar disorder: a consortium on lithium genetics (ConLiGen) report.  PLoS ONE.  2013 June 19. 8(6):e65636.

Mahon P, Zandi P, Potash J, Nestadt G, Wand G.  Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults.  Psychopharmacology.  2013 May. 227(2):231-241.
[PubMed]

Akhter A, Fiedorowicz J, Zhang T, Potash J, Joseph Cavanaugh J, Solomon D, Coryell W.  Seasonal variation of manic and depressive symptoms in individuals with bipolar disorder.  Bipolar Disord.  2013 April. 

Gamazon E, Badner J, Cheng L, Zhang C, Zhang E, Cox N, Gershon E, Kelsoe J, Greenwood T, Nievergelt C, McKinney R, Shilling P, Schork N, Smith E, Bloss C, Nurnberger J, Edenberg H, Foroud T, Koller D, Scheftner W, Lawson W, Nwulia E, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze T, Berrettini W, Potash J, Zandi P, Mahon P, McInnis M, Zollner S, Zhang P, Craig D, Szelinger S, Barrett T, Liu C.  Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants.  Mol Psychiatry.  2013 March. 18(3):340-346.

Chen D, Jiang X, Akula N, Shugart Y, Wendland J, Steele C, Kassem L, Park J, Chatterjee N, jamain S, Cheng A, Leboyer M, Muglia P, Schulze T, Cichon S, Nothen M, Rietschel M,  B, McMahon F, Kelsoe J, Greenwood T, Nievergelt C, McKinney R, Shilling P, Schork N, Smith E, Bloss C, Nurnberger Jr J, Edenberg H, Foroud T, Koller D, Gershon E, Liu C, Badner J, Scheftner W, Lawson W, Nwulia E, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Chen D, Berrettini W, Potash J, Zandi P, Mahon P, McInnis M, Zollner S, Zhang P, Craig D, Szelinger S, Barrett T, Schulze T.  Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.  2013 February. 18(2):195-205.
[PubMed]

Chen Y, Carter H, parla J, Kramer M, Goes F, Pirooznia M, Zandi P, McCombie W, Potash J, Karchin R.  A hybrid likelihood model for sequence-based disease association studies.  PLoS Genetics.  2013. 19(1):e1003224.

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium , Potash J.  A mega-analysis of genome-wide association studies for major depressive disorder.  Mol Psychiatry.  2013. 18(4):497-511.
[PubMed]

Judy J, Seifuddin F, Pirooznia M, Mahon P, Goes F, Jancic D, Schultze T, Cichon S, Nöthen W, Rietschel M,  B, Kelsoe J, DePaulo J, Potash J, Zandi P.  Converging evidence for epistasis between ANK3 and potassium channel gene KCNQ2 in bipolar disorder.  Front Behav Psychiatr Genet.  2013. 4:87.

 , Black D, Coryell W, Potash J, Wassink T, Wray N.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.  Nature Genetics.  2013. 45(9):984-94.

Han S, Yang B, Kranzler H, Liu X, Zhao H, Farrer L, Boerwinkle E, Potash J, Gelernter J.  Integrating GWAS and human protein interaction networks identifies a gene sub-network underlying alcohol dependence.  Am J Hum Genet.  2013. 
[PubMed]

Pirooznia M, Seifuddin F, Judy J, Goes F, Potash J, Zandi P.  Metamoodics: Meta-analysis and bioinformatics resource for mood disorders.  Mol Psychiatry.  2013. 
[PubMed]

Mooney M, Wilmot B, McWeeney S, Kelsoe J, Greenwood T, Nievergelt C, McKinney R, Shilling P, Schork N, Smith E, Bloss C, Nurnberger J, Edenerg H, Foroud T, Koller D, Gershon E, Liu C, Badner J, Scheftner W, Lawson W, Nwulia E, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze T, Berrettini W, Potash J, Zandi P, Mahon P, McInnis M,  S, Zhang P, Craig D, Szelinger S, Barrett T.  The GA and the GWAS: using genetic algorithms to search for multi-locus associations.  IEEE/ACM Trans Comput Biol Bioinform.  2013. 

Mostafavi S, Battle A, Zhu X, Potash J, Weissman M, Shi J, Beckman K, Haudenschild C, McCormick C, Mei R, Gameroff M, Gindes H, Adams P, Goes F, Mondimore F, MacKinnon D, Notes L, Schweizer B, Furman D, Montgomery S, Urban A, Koller D, Levinson D.  Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing.  Mol Psychiatry.  2013. 

Stevens D, Wilcox H, MacKinnon D, Mondimore F, Schweizer B, Jancic D, Coryell W, Scheftner W, Weissman M, Levinson D, Potash J.  Post-traumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression.  Depress Anxiety.  2013 January. 30(10):940-946.
[PubMed]

Goes F, Hamshere M, Seifuddin F, Pirooznia M, Belmonte-Mahon P,  B, Breuer R, Schulze T, Nothen M, Cichon S, Rietschel M, Holmans P, Zandi P, Craddock N, Potash J.  Genome-wide association of mood-incongruent psychotic bipolar disorder.  Transl Psychiatry.  2012 October 23. 2:e180.

Meier S, Mattheisen M, Vasson E, Strohmaier J, Treutlein J, Josef F, Breuer R, Degenhardt F, Mühleisen T, Müller-Myhsok B, Steffens M,  C, McMahon F,  B, Kelsoe J, Greenwood T, Nievergelt C, Barrett T, McKinney R, Shilling P, Schork N, Smith E, Bloss C, Nurnberger J, Nurnberger H, Foroud T, Koller D, Gershon E, Liu C, Badner J, Scheftner W, Lawson W, Nwulia E, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Chen D, Schulze T, Berrettini W, Potash J, Zandi P, Mahon P, McInnis M, Szelinger S, Nöthen M, Cichon S, Schulze T, Rietschel M.  Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1.  Transl Psychiatry.  2012 September 25. 2:e165.

Willour V, Seifuddin F, Mahon P, Jancic D, Pirooznia M, Steele J, Schweizer B, Goes F, Mondimore F, MacKinnon D,  T, Lee P, Kelsoe J, Rietschel M, Gurling H, Purcell S, Smoller J, Craddock N, DePaulo Jr J, Schulze T, McMahon F, Zandi P, Potash J.  A genome-wide association study of attempted suicide.  Mol Psychiatry.  2012. 17(4):433-444.
[PubMed]

Mahon P, Eldridge H, Crocker B, Notes L, Gindes H, Postell E, King S, Potash J, Ratnanather J, Barta P.  An MRI study of amygdala in schizophrenia and psychotic bipolar disorder.  Schizophr Res.  2012. 138(2-3):188-191.

Judy J, Seifuddin F, Mahon P, hUO Y, Goes F, Jancic D, Schweizer B, Mondimore F, Mackinnon D, Depaulo Jr J,  E, McMahon F, Cutler D, Zandi P, Potash J, Willour V.  Association study of serotonin pathway genes in attempted suicide.  Am J Med Genet B Neuropsychiatr Genet.  2012. 159(1):112-119.
[PubMed]

Jancic D, Seifuddin F, Zandi P, Potash J, Willour V.  Association study of X chromosome SNPs in attempted suicide.  Psychiatry Res.  2012. 200(2-3):1044-1046.
[PubMed]

Goes F, McCusker M, Bienvenu O, MacKinnon D, Mondimore F, Schweizer B,  N, DePaulo Jr J, Potash J.  Comorbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of comorbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder.  Psychol Med.  2012. 42(7):1449-1159.
[PubMed]

Pirooznia M, Seifuddin F, Judy J, Mahon P, Potash J, Zandi P.  Data mining approaches for genome-wide association of mood disorders.  Psychiatr Genet.  2012. 22(2):55-61.

Nissen S, Liang S, Shehktman T, Kelso J,  B, Greenwood T, Nievergelt C, McKinney R,  P, Smith E, Schork N, Bloss C, Nurnberger Jr J, Edenberg H, Foroud T,  D, Gershon E, Liu C, Badner J, Scheftner W, Lawson W, Nwulia E, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Berrettini W, Potash J, Zandi P, Mahon P, McInnis M, Zöllner S, Zhang P, Craig D, Szelinger S, Barrett T, Schulze T.  Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin.  Am J Med Genet B Neuropsychiatr Genet.  2012. 159B(8):941-950.
[PubMed]

Badner J, Koller D, Foroud T, Edenberg H, Nurnberger J, Zandi P, Willour V, McMahon F, Potash J, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu C, Gershon E, MacMahon W, Lyon G, Robinson R, Ross J, Byerley W.  Genome wide linkage analysis of 972 bipolar pedigrees using single nucleotide polymorphisms.  Mol Psychiatry.  2012. 17(8):818-826.

Sabunciyan S, Aryee M, Irizarry R, Rongione M, Webster M, Kaufmann W, Murakami P, Lessard A, Yolken R, Feinbert A, Potash J,  G.  Genome-wide DNA methylation scan in major depressive disorder.  PLoS One.  2012. 7(4):e34451.

Seifuddin F, Mahon P, Judy J, Pirooznia M,  D, Taylor J, Goes F, Potash J, Zandi P.  Meta-analysis of genetic association studies on bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2012. 159B(1):508-518.
[Link]

Pirooznia M, Wang T, Avramopoulos D,  D, Thomas G, Huganir R, Goes F, Potash J, Zandi P.  SynaptomeDB: an ontology-based knowledgebase for synaptic genes.  Bioinformatics.  2012. 28(6):897-899.

Tighe S, Reading S, Rivkin P, Caffo B, Schweizer B, Pearlson G, Potash J, DePaulo J, Bassett S.  Total white matter hyperintensity volume in bipolar disorder patietns nad their healthy relatives.  Bipolar Disord.  2012. 14(8):888-893.
[PubMed]

Potash J.  Unipolar depression.  Cambridge University Press: Cambridge, UK.  2012. 

Lee R, Tamashiro K, Yang X, Purcell R, Huo Y, Rongione M, Potash J, Wand G.  A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice.  Psychopharmacology (Berl).  2011 November. 218(1):303-12.
[Link]

Sklar P, Ripke S, Scott L, Andreassen O, Cichon S, Craddock N, Edenberg H, Nurnberger J, Rietschel M, Blackwood D, Corvin A, Flickinger M, Guan W, Mattingsdal M, McQuillin A, Kwan P, Wienker T, Daly M, Dudbridge F, Holmans P, Lin D, Burmeister M, Greenwood T, Hamshere M, Muglia P, Smith E, Zandi P, Nievergelt C, McKinney R, Shilling P, Schork N, Bloss C, Foroud T, Koller D, Gershon E, Liu C, Badner J, Scheftner W, Lawson W, Nwulia E, Hipolito M, Coryell W, Rice J, Byerley W, McMahon F, Schulze T, Berrettini W, Lohoff F, Potash J, Mahon P, McInnis M, Zöllner S, Zhang P, Craig D, Szelinger S, Barrett T, Breuer R, Meier S, Strohmaier J, Witt S, Tozzi F, Farmer A, McGuffin P, Strauss J, Xu W, Kennedy J, Vincent J, Matthews K, Day R, Ferreira M, O'Dushlaine C, Perlis R, Raychaudhuri S, Ruderfer D, Hyoun P, Smoller J, Li J, Absher D, Thompson R, Meng F, Schatzberg A, Bunney W, Barchas J, Jones E, Watson S, Myers R, Akil H, Boehnke M, Chambert K, Moran J, Scolnick E, Djurovic S, Melle I, Morken G, Gill M, Morris D, Quinn E, Mühleisen T, Degenhardt F, Mattheisen M, Schumacher J, Maier W, Steffens M, Propping P, Nöthen M, Anjorin A, Bass N, Gurling H, Kandaswamy R, Lawrence J, McGhee K, McIntosh A, McLean A, Muir W, Pickard B, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green E, Grozeva D, Jones I, Kirov G, Moskvina V, Nikolov I, O'Donovan M, Owen M, Collier D, Elkin A, Williamson R, Young A, Ferrier I, Stefansson K, Stefansson H, Thornorgeirsson T, Steinberg S, Gustafsson O, Bergen S, Nimgaonkar V, Hultman C, Landén M, Lichtenstein P, Sullivan P, Schalling M, Osby U, Backlund L, Frisén L, Langstrom N, Jamain S, Leboyer M, Etain B, Bellivier F, Petursson H, Sigur Sson E, Müller-Mysok B, Lucae S, Schwarz M, Schofield P, Martin N, Montgomery G, Lathrop M, Oskarsson H, Bauer M, Wright A, Mitchell P, Hautzinger M, Reif A, Kelsoe J, Purcell S.  Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.  Nat Genet.  2011 October. 43(10):977-83.
[Link]

Smith E, Koller D, Panganiban C, Szelinger S, Zhang P, Badner J, Barrett T, Berrettini W, Bloss C, Byerley W, Coryell W, Edenberg H, Foroud T, Gershon E, Greenwood T, Guo Y, Hipolito M, Keating B, Lawson W, Liu C, Mahon P, McInnis M, McMahon F, McKinney R, Murray S, Nievergelt C, Nurnberger J, Nwulia E, Potash J, Rice J, Schulze T, Scheftner W, Shilling P, Zandi P, Zöllner S, Craig D, Schork N, Kelsoe J.  Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.  PLoS Genet.  2011 June. 7(6):e1002134.
[Link]

Mahon P, Pirooznia M, Goes F, Seifuddin F, Steele J, Lee P, Huang J, Hamshere M, Depaulo J, Kelsoe J, Rietschel M, Nöthen M, Cichon S, Gurling H, Purcell S, Smoller J, Craddock N, Schulze T, McMahon F, Potash J, Zandi P.  Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2011 April. 156B(3):370-8.
[Link]

Lee R, Tamashiro K, Aryee M, Murakami P, Seifuddin F, Herb B, Huo Y, Rongione M, Feinberg A, Moran T, Potash J.  Adaptation of the CHARM DNA methylation platform for the rat genome reveals novel brain region-specific differences.  Epigenetics.  2011. 6(11):1378-1390.
[PubMed]

Goes F, Rongione M, Chen Y, Karchin R, Elhaik E, Potash J.  Exonic DNA sequencing of ERBB4 in bipolar disorder.  PLoS One.  2011. 6(5):e20242.
[Link]

Malhortra D, McCarthy S, Vacic V, Michaelson J, Burdick K, Makarov V, Yoon S, Krastoshevsky O, Krause V, Bhandari A, Gary S, Malhotra A, Leibenluft E, Potash J, Schulze T, Cichon S, Rietschel M, Nothen M, McMahon F, Kelsoe J, Gershon E, Gill M, Corvin A, Levy D, Karayiorgou M, Sebat J.  High frequencies of de novo CNVs in bipolar disorder and schizophrenia.  Neuron.  2011. 72(6):951-963.
[PubMed]

Shyn S, Shi J, Kraft J, Potash J, Knowles J, Weissman M, Garriock H, Yokoyama J, McGrath P, Peters E, Scheftner W, Coryell W, Lawson W, Jancic D, Gejman P, Sanders A, Holmans P, Slager S, Levinson D, Hamilton S.  Novel loci for major depression identified by genome-wide association study of sequenced treatment alternatives to relieve depression and meta-analysis of three studies.  Mol Psychiatry.  2011. 16(2):202-215.
[PubMed]

Tighe S, Potash J.  Predictors of lithium response in bipolar disorder.  Ther Adv Chronic Dis.  2011. 2(3):209-226.
[PubMed]

McMahon F, Akula N, Cichon S, Detera-Wadleigh S, Edenberg H, Holsboer F, Nöthen M, Nurnberger J, Potash J, Preisig M, Rietschel M, Schulze T.  Reply to “Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression”.  Nat Genet.  2011. 43(1):5.
[PubMed]

Dao D, Mahon P, Cai X, Kovacsics C, Blackwell R, Arad M, Shi J, Zandi P, O'Donnell P, Knowles J, Weissman M, Coryell W, Scheftner W, Lawson W, Levinson D, Thompson S, Potash J, Gould T.  Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans.  Biol Psychiatry.  2010 November 1. 68(9):801-10.
[Link]

Lee R, Tamashiro K, Yang X, Purcell R, Harvey A, Willour V, Huo Y, Rongione M, Wand G, Potash J.  Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice.  Endocrinology.  2010 September. 151(9):4332-43.
[Link]

Mahon P, Stuetz A, Seifuddin F, Huo Y, Goes F, Jancic D, Toolan J,  B, DePaulo Jr J, Gershon E, McMahon F, Zandi P, Potash J, Willour V.  Case-control association study of TGOLN2 in attempted suicide.  Am J Med Genet B Neuropsychiatr Genet.  2010. 153(5):1016-1023.
[PubMed]

Perlis H, Huang J, Purcell S, Fava M, Rush A, Sachs G, Sullivan P, Hamilton S, McMahon F, Potash J, Penninx B, Boomsma D, Vogelzangs N, Middeldorp C, Gurling H, Craddock N, Sklar P, Smoller J.  Genome-wide association study of suicide attempts in mood disorder patients.  Am J Psychiatry.  2010. 167(12):1499-1507.
[PubMed]

Goes F, Willour V, Zandi P, Belmonte P, MacKinnon D, Mondimore F, Schweizer B,  N, DePaulo J, Gershon E, McMahon F, Potash J.  Sex-specific association of the Reelin gene with bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2010. 153(2):549-553.
[PubMed]

Mahon P, Payne J, MacKinnon D, Mondimore F, Goes F, Schweizer B, Jancic D, Coryell W, Holmans P, Shi J, Knowles J, Scheftner W, Weissman M, Levinson D, DePaulo J, Zandi P, Potash J.  Genome-wide linkage and follow-up association study of postpartum mood symptoms.  Am J Psychiatry.  2009 November. 166(11):1229-37.
[Link]

McCarthy S, Makarov V, Kirov G, Addington A, McClellan J, Yoon S, Perkins D, Dickel D, Kusenda M, Krastoshevsky O, Krause V, Kumar R, Grozeva D, Malhotra D, Walsh T, Zackai E, Kaplan P, Ganesh J, Krantz I, Spinner N, Roccanova P, Bhandari A, Pavon K, Lakshmi B, Leotta A, Kendall J, Lee Y, Vacic V, Gary S, Iakoucheva L, Crow T, Christian S, Lieberman J, Stroup T, Lehtimäki T, Puura K, Haldeman-Englert C, Pearl J, Goodell M, Willour V, Derosse P, Steele J, Kassem L, Wolff J, Chitkara N, McMahon F, Malhotra A, Potash J, Schulze T, Nöthen M, Cichon S, Rietschel M, Leibenluft E, Kustanovich V, Lajonchere C, Sutcliffe J, Skuse D, Gill M, Gallagher L, Mendell N, Craddock N, Owen M, O'Donovan M, Shaikh T, Susser E, Delisi L, Sullivan P, Deutsch C, Rapoport J, Levy D, King M, Sebat J.  Microduplications of 16p11.2 are associated with schizophrenia.  Nat Genet.  2009 November. 41(11):1223-7.
[Link]

Maheshwari M, Shi J, Badner J, Skol A, Willour V, Muzny D, Wheeler D, Gerald F, Detera-Wadleigh S, McMahon F, Potash J, Gershon E, Liu C, Gibbs R.  Common and rare variants of DAOA in bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2009 October 5. 150B(7):960-6.
[Link]

Grover D, Verma R, Goes F, Mahon P, Gershon E, McMahon F, Potash J, Gershon E, McMahon F, Potash J.  Family-based association of YWHAH in psychotic bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2009 October 5. 150B(7):977-83.
[Link]

Goes F, Willour V, Zandi P, Belmonte P, MacKinnon D, Mondimore F, Schweizer B, Gershon E, McMahon F, Potash J.  Family-based association study of Neuregulin 1 with psychotic bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2009 July 5. 150B(5):693-702.
[Link]

Potash J, Bienvenu O.  Neuropsychiatric disorders: Shared genetics of bipolar disorder and schizophrenia.  Nat Rev Neurol.  2009 June. 5(6):299-300.
[Link]

Payne J, Klein S, Zamoiski R, Zandi P, Bienvenu O, Mackinnon D, Mondimore F, Schweizer B, Swartz K, Crowe R, Scheftner W, Weissman M, Levinson D, DePaulo J, Potash J.  Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees.  Arch Womens Ment Health.  2009 February. 12(1):27-34.
[Link]

Irizarry R, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash J, Sabunciyan S, Feinberg A.  The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.  Nat Genet.  2009 February. 41(2):178-86.
[Link]

Willour V, Chen H, Toolan J, Belmonte B, Cutler D, Goes F, Zandi P, Lee R, MacKinnon D, Mondimore F, Schweizer B,  B,  N, DePaulo Jr J, Gershon E,  F, Potash J.  Family-based association of FKBP5 in bipolar disorder.  Mol Psychiatry.  2009. 14(3):261-268.
[PubMed]

Shi J, Badner J, Willour V, Potash J, Gershon E, Liu C.  Further evidence for an association of G72/G30 with schizophrenia in Chinese.  Schizophr Res.  2009. 107(2-3):324-326.
[PubMed]

Smith E, Bloss C, Badner J, Barrett T, Belmonte P, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg H, Eskin E, Foroud T, Gershon E, Greenwood T, Hipolito H, Koller D, Lawson W, Liu C, Lohoff F, McInnis M, McMahon F, Mirel D, Nievergelt C, Nurnberger J, Nwulia E, Paschall J, Potash J, Rice J, Schulze T, Scheftner W, Panganiban C, Zaitlen N, Zandi P, Zollner S, Schork N, Kelsoe J.  Genome-wide association study of bipolar disorder in European American and African American individuals.  Mol Psychiatry.  2009. 14(8):755-763.
[PubMed]

Zhang D, Cheng L, Qian Y, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg H, Foroud T, Greenwood T, Hipolito M, Koller D, Lawson W, McInnis M, McMahon F, Nurnberger J, Nwulia E, Potash J, Rice J, Schulze T, Sheftner W, Szelinger S, Zandi P, Zollner S, Schork N, Kelsoe J, Smith E, Alliey-Rodriguez N,  S, Liu C, Gershon E.  Singleton deletions throughout the genome increase risk of bipolar disorder.  Mol Psychiatry.  2009. 14(4):376-380.
[PubMed]

Shi J, Wittke-Thompson J, Badner J, Hattori E, Potash J, Willour V, McMahon F, Gershon E, Liu C.  Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.  Am J Med Genet B Neuropsychiatr Genet.  2008 October 5. 147B(7):1047-55.
[Link]

Shi J, Badner J, Hattori E, Potash J, Willour V, McMahon F, Gershon E, Liu C.  Neurotransmission and bipolar disorder: a systematic family-based association study.  Am J Med Genet B Neuropsychiatr Genet.  2008 October 5. 147B(7):1270-7.
[Link]

Zandi P, Zöllner S, Avramopoulos D, Willour V, Chen Y, Qin Z, Burmeister M, Miao K, Gopalakrishnan S, McEachin R, Potash J, Depaulo J, McInnis M.  Family-based SNP association study on 8q24 in bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2008 July 5. 147B(5):612-8.
[Link]

Zandi P, Belmonte P, Willour V, Goes F, Badner J, Simpson S, Gershon E, McMahon F, DePaulo J, Potash J.  Association study of Wnt signaling pathway genes in bipolar disorder.  Arch Gen Psychiatry.  2008 July. 65(7):785-93.
[Link]

Verma R, Holmans P, Knowles J, Grover D, Evgrafov O, Crowe R, Scheftner W, Weissman M, DePaulo J, Potash J, Levinson D.  Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3.  Biol Psychiatry.  2008 June 15. 63(12):1185-9.
[Link]

Goes F, Sanders L, Potash J.  The genetics of psychotic bipolar disorder.  Curr Psychiatry Rep.  2008 April. 10(2):178-89.
[Link]

Payne J, MacKinnon D, Mondimore F, McInnis M, Schweizer B, Zamoiski R, McMahon F, Nurnberger J, Rice J, Scheftner W, Coryell W, Berrettini W, Kelsoe J, Byerley W, Gershon E, DePaulo J, Potash J.  Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees.  Bipolar Disord.  2008 February. 10(1):38-44.
[Link]

Potash J, Buervenich S, Cox N, Zandi P, Akula N, Steele J, Rathe J, Avramopoulos D, Detera-Wadleigh S, Gershon E, DePaulo J, Feinberg A, McMahon F.  Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.  Am J Med Genet B Neuropsychiatr Genet.  2008 January 5. 147B(1):59-67.
[Link]

Goes F, Sanders L, Potash J.  The genetics of psychotic bipolar disorder.  Curr Psychiatry Rep.  2008. 10(2):178-189.

Verma R, Cutler D, Holmans P, Knowles J, Crowe R, Scheftner W, Weissman M, DePaulo J, Levinson D, Potash J.  Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression.  Am J Med Genet B Neuropsychiatr Genet.  2007 December 5. 144B(8):1079-82.
[Link]

Sabunciyan S, Yolken R, Ragan C, Potash J, Nimgaonkar V, Dickerson F, Llenos I, Weis S.  Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2007 December 5. 144B(8):1083-6.
[Link]

Ladd-Acosta C, Pevsner J, Sabunciyan S, Yolken R, Webster M, Dinkins T, Callinan P, Fan J, Potash J, Feinberg A.  DNA methylation signatures within the human brain.  Am J Hum Genet.  2007 December. 81(6):1304-15.
[Link]

Goes F, Sadler B, Toolan J, Zamoiski R, Mondimore F, Mackinnon D, Schweizer B, Raymond Depaulo J, Potash J.  Psychotic features in bipolar and unipolar depression.  Bipolar Disord.  2007 December. 9(8):901-6.
[Link]

Detera-Wadleigh S, Liu C, Maheshwari M, Cardona I, Corona W, Akula N, Steele C, Badner J, Kundu M, Kassem L, Potash J, Gibbs R, Gershon E, McMahon F.  Sequence variation in DOCK9 and heterogeneity in bipolar disorder.  Psychiatr Genet.  2007 October. 17(5):274-86.
[Link]

Potash J, Toolan J, Steele J, Miller E, Pearl J, Zandi P, Schulze T, Kassem L, Simpson S, Lopez V, MacKinnon D, McMahon F.  The bipolar disorder phenome database: a resource for genetic studies.  Am J Psychiatry.  2007 August. 164(8):1229-37.
[Link]

Zandi P, Avramopoulos D, Willour V, Huo Y, Miao K, Mackinnon D, McInnis M, Potash J, Depaulo J.  SNP fine mapping of chromosome 8q24 in bipolar disorder.  Am J Med Genet B Neuropsychiatr Genet.  2007 July 5. 144B(5):625-30.
[Link]

Grover D, Woodfield A, Verma R, Zandi P, Levinson D, Potash J.  QuickSNP: an automated web server for selection of tagSNPs.  Nucleic Acids Res.  2007 July. 35(Web Server issue):W115-20.
[Link]

Mondimore F, Zandi P, MacKinnon D, McInnis M, Miller E, Schweizer B, Crowe R, Scheftner W, Weissman M, Levinson D, DePaulo J, Potash J.  A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicity.  J Affect Disord.  2007 June. 100(1-3):171-7.
[Link]

Payne J, Roy P, Murphy-Eberenz K, Weismann M, Swartz K, McInnis M, Nwulia E, Mondimore F, MacKinnon D, Miller E, Nurnberger J, Levinson D, DePaulo J, Potash J.  Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder.  J Affect Disord.  2007 April. 99(1-3):221-9.
[Link]

Willour V, Zandi P, Badner J, Steele J, Miao K, Lopez V, MacKinnon D, Mondimore F, Schweizer B, McInnis M, Miller E, Depaulo J, Gershon E, McMahon F, Potash J.  Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12.  Biol Psychiatry.  2007 March 1. 61(5):725-7.
[Link]

Holmans P, Weissman M, Zubenko G, Scheftner W, Crowe R, Depaulo J, Knowles J, Zubenko W, Murphy-Eberenz K, Marta D, Boutelle S, McInnis M, Adams P, Gladis M, Steele J, Miller E, Potash J, Mackinnon D, Levinson D.  Genetics of recurrent early-onset major depression (GenRED): final genome scan report.  Am J Psychiatry.  2007 February. 164(2):248-58.
[Link]

Levinson D, Evgrafov O, Knowles J, Potash J, Weissman M, Scheftner W, Depaulo J, Crowe R, Murphy-Eberenz K, Marta D, McInnis M, Adams P, Gladis M, Miller E, Thomas J, Holmans P.  Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers.  Am J Psychiatry.  2007 February. 164(2):259-64.
[Link]

Goes F, Zandi P, Miao K, McMahon F, Steele J, Willour V, Mackinnon D, Mondimore F, Schweizer B, Nurnberger J, Rice J, Scheftner W, Coryell W, Berrettini W, Kelsoe J, Byerley W, Murphy D, Gershon E, Bipolar Disorder Phenome Group , Depaulo J, McInnis M, Potash J.  Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33.  Am J Psychiatry.  2007 February. 164(2):236-47.
[Link]

Zandi P, Badner J, Steele J, Willour V, Miao K, MacKinnon D, Mondimore F, Schweizer B, McInnis M, DePaulo Jr J, Gershon E, McMahon F, Potash J.  Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates.  Mol Psychiatry.  2007. 12(7):630-639.
[PubMed]

Goodwin F, Redfield Jamison K, Potash J.  Manic-Depressive Illness.  Oxford University Press;  2007.

Mondimore F, Zandi P, Mackinnon D, McInnis M, Miller E, Crowe R, Scheftner W, Marta D, Weissman M, Levinson D, Murphy-Ebenez K, Depaulo J, Potash J.  Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees.  Am J Psychiatry.  2006 September. 163(9):1554-60.
[Link]

Oswald L, Zandi P, Nestadt G, Potash J, Kalaydjian A, Wand G.  Relationship between cortisol responses to stress and personality.  Neuropsychopharmacology.  2006 July. 31(7):1583-91.
[Link]

Potash J.  Carving chaos: genetics and the classification of mood and psychotic syndromes.  Harv Rev Psychiatry.  2006. 14(2):47-63.
[PubMed]

Potash J.  Carving chaos: genetics and the classification of mood and psychotic syndromes.  Harv Rev Psychiatry.  2006. 14(2):47-63.
[Link]

Murphy-Eberenz K, Zandi P, March D, Crowe R, Scheftner W, Alexander M, McInnis M, Coryell W, Adams P, DePaulo J, Miller E, Marta D, Potash J, Payne J, Levinson D.  Is perinatal depression familial?.  J Affect Disord.  2006 January. 90(1):49-55.
[Link]

McQueen M, Devlin B, Faraone S, Nimgaonkar V, Sklar P, Smoller J, Abou Jamra R, Albus M, Bacanu S, Baron M, Barrett T, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly M, Depaulo J, Edenberg H, Foroud T, Gill M, Gilliam T, Hamshere M, Jones I, Jones L, Juo S, Kelsoe J, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon J, McInnis M, McMahon F, Murphy D, Nothen M, Nurnberger J, Pato C, Pato M, Potash J, Propping P, Pulver A, Rice J, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi P, Laird N.  Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.  Am J Hum Genet.  2005 October. 77(4):582-95.
[Link]

MacKinnon D, Potash J, McMahon F, Simpson S, Depaulo J, Zandi P.  Rapid mood switching and suicidality in familial bipolar disorder.  Bipolar Disord.  2005 October. 7(5):441-8.
[Link]

Swift-Scanlan T, Coughlin J, Lan T, Potash J, Ingersoll R, Depaulo R, Ross C, McInnis M.  Characterization of CTG/CAG repeats on chromosome 18: a study of bipolar disorder.  Psychiatr Genet.  2005 June. 15(2):91-9.
[Link]

Payne J, Potash J, DePaulo J.  Recent findings on the genetic basis of bipolar disorder.  Psychiatr Clin North Am.  2005 June. 28(2):481-98, ix.
[Link]

Strasser H, Lilyestrom J, Ashby E, Honeycutt N, Schretlen D, Pulver A, Hopkins R, Depaulo J, Potash J, Schweizer B, Yates K, Kurian E, Barta P, Pearlson G.  Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study.  Biol Psychiatry.  2005 March 15. 57(6):633-9.
[Link]

Lin P, McInnis M, Potash J, Willour V, MacKinnon D, Miao K, DePaulo J, Zandi P.  Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.  Am J Hum Genet.  2005. 77(4):545-555.
[PubMed]

Mondimore F, Potash J.  Genetic approaches to depression: linkage studies.  Wiley VCH, Weinheim, Germany.  2005. 

Potash J, Kempf L, Hussain N.  Mood disorder with psychosis, schizoaffective disorder, and schizophrenia with mood symptoms: trouble at the borders.  Int Rev Psychiatry.  2005. 17(1):9-19.
[PubMed]

Payne J, Potash J, DePaulo Jr J.  Recent findings on the genetic basis of bipolar disorder.  Psychiatr Clin North Am.  2005. 28(2):481-498.
[PubMed]

Auger R, Potash J.  Withdrawal from baclofen delirium after suicide attempt: a case report.  Psychosomatics.  2005. 46(2):151-152.
[PubMed]

Chen Y, Akula N, Detera-Wadleigh S, Schulze T, Thomas J, Potash J, DePaulo J, McInnis M, Cox N, McMahon F.  Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33.  Mol Psychiatry.  2004. 9(2):87-92.
[PubMed]

Chen Y, Akula N, Detera-Wadleigh S,  T, Thomas J, Potash J, DePaulo Jr J, McInnis M.  Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis.  Mol Psychiatry.  2004. 9(2):191-196.
[PubMed]

Schulze T, Buervenich S, Badner J, Thomas C, Detera-Wadleigh S, Dick D, Foroud T, Cox N, MacKinnon D, Potash J, Berrettini W, Byerley W, DePaulo Jr J, Gershon E, Kelsoe J, McInnis M, Murphy D, Reich T, Scheftner W, Nurnberger Jr J, McMahon F.  Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the NIMH genetics initiative pedigrees.  Biol Psychiatry.  2004. 56(1):18-23.
[PubMed]

McInnis M, Dick D, Willour V, Avramopoulos D, MacKinnon D, Simpson S, Potash J, Edenberg H, Bowman E, McMahon F, Smiley C, Chellis J, Huo Y, Diggs T, Meyer E, Miller M, Matteini A, Rau N, DePaulo J, Gershon E, Badner J, Rice J, Goate A, Detera-Wadleigh S, Nurnberger J, Reich T, Zandi P, Foroud T.  Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees.  Biol Psychiatry.  2003 December 1. 54(11):1265-73.
[Link]

Willour V, Zandi P, Huo Y, Diggs T, Chellis J, MacKinnon D, Simpson S, McMahon F, Potash J, Gershon E, Reich T, Foroud T, Nurnberger J, DePaulo J, McInnis M.  Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21.  Am J Med Genet B Neuropsychiatr Genet.  2003 August 15. 121B(1):21-7.
[Link]

Zandi P, Willour V, Huo Y, Chellis J, Potash J, MacKinnon D, Simpson S, McMahon F, Gershon E, Reich T, Foroud T, Nurnberger J, DePaulo J, McInnis M.  Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X.  Am J Med Genet B Neuropsychiatr Genet.  2003 May 15. 119B(1):69-76.
[Link]

Potash J, Zandi P, Willour V, Lan T, Huo Y, Avramopoulos D, Shugart Y, MacKinnon D, Simpson S, McMahon F, DePaulo J, McInnis M.  Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder.  Am J Psychiatry.  2003 April. 160(4):680-6.
[Link]

McInnis M, Lan T, Willour V, Zandi P, McMahon F, Simpson S, Addington A, MacKinnon D, Potash J, Mahoney A, Chellis J, Swift-Scanlan T, Chen H, Koskela R, Stine O, Jamison K, Holman P, Folstein S, Ranade K, Friddle C, Botstein D, Marr T, Beaty T, DePaulo J.  Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p13, and 13q14.  Mol Psychiatry.  2003. 8(e):288-298.
[PubMed]

Chen H, Wang N, Huo Y, Sklar P, MacKinnon D, Potash J, McMahon F, Antonarakis S, DePaulo J, Ross C, McInnis M.  Trapping and sequence analysis of 1138 putative exons from human chromosome 18.  Mol Psychiatry.  2003. 8(6):619-623.
[PubMed]

Potash J, Chiu Y, MacKinnon D, Miller E, Simpson S, McMahon F, McInnis M, DePaulo J.  Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees.  Am J Med Genet B Neuropsychiatr Genet.  2003 January 1. 116B(1):90-7.
[Link]

MacKinnon D, Zandi P, Cooper J, Potash J, Simpson S, Gershon E, Nurnberger J, Reich T, DePaulo J.  Familial bipolar disorder and panic disorder in the NIMH Genetics Initiative Bipolar Disorder Study.  Am J Psychiatry.  2002. 159(1):30-35.
[PubMed]

Swift-Scanlan T, Lan T, Coughlin J, Potash J, DePaulo J, McInnis M.  Genetic analysis of the (CTG)n NOTCH4 polymorphism in 65 multiplex bipolar pedigrees.  Psychiatr Genet.  2002. 12(1):43-47.
[PubMed]

MacKinnon D, Zandi P, Cooper J, Potash J, Simpson S, Gershon E, Nurnberger J, Reich T, DePaulo J.  Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder.  Am J Psychiatry.  2002 January. 159(1):30-5.
[Link]

Potash J, Willour V, Chiu Y, Simpson S, MacKinnon D, Pearlson G, DePaulo Jr J, McInnis  M.  The familial aggregation of psychotic symptoms in bipolar disorder pedigrees.  Am J Psychiatry .  2001 August. 158(8):1258-1264.
[PubMed]

Chen H, Ross C, Wang N, Huo Y, MacKinnon D, Potash J, Simpson S, McMahon F, DePaulo J, McInnis M.  NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.  Eur J Hum Genet.  2001. 9(12):922-930.
[PubMed]

DePaulo J, Phillips A, Potash J, McInnis M, McMahon F.  The current status and prospects for genetic studies of bipolar disorder.  Clin Neurosci Res.  2001. 1(1-2):153-157.

Potash J, Kane H, Chiu Y, Simpson S, MacKinnon D, McInnis M, McMahon F, DePaulo Jr J.  Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships.  Am J Psychiatry.  2000. 157(12):2048-2050.
[PubMed]

Potash J, DePaulo Jr J.  Searching high and low: a review of the genetics of bipolar disorder.  Bipolar Disord.  2000. 2(1):8-26.
[PubMed]

Esrey S, Potash J, Shiff C, Roberts L.  Effects of improved water supply and sanitation onascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma.  Bull World Health Org.  1991. 69(5):609-621.

Date Last Modified: 06/07/2014 - 21:56:23