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Paul W. Penningroth Chair in PsychiatryChair & Departmental Executive OfficerProfessor of Psychiatry
Office: 2887 John Pappajohn PavilionIowa City, IA 52242
Office Phone: 319-356-1144
Lab: B002J Medical LaboratoriesIowa City, IA 52242
BA, English, Yale College, New Haven, CTPost-baccalaureate pre-med, pre-med, Goucher College, Baltimore, MDMPH, Epidemiology and International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MDMD, Johns Hopkins School of Medicine, Baltimore, MD
Internship, Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MDResidency, Psychiatry, Johns Hopkins Hospital, Baltimore, MDResidency, Psychiatry, Johns Hopkins Hospital, Baltimore, MDResidency, Psychiatry, Johns Hopkins Hospital, Baltimore, MD
Iowa Board of Medical ExaminersPsychiatry, American Board of Psychiatry and Neurology
Biosciences Graduate ProgramInterdisciplinary Graduate Program in GeneticsInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
I am interested in the genetic variation and DNA methylation variation that confer susceptibility to depression and bipolar disorder. Family, twin, and adoption studies have made it abundantly clear that these disorders are substantially heritable, but only a very small proportion of that heritability has thus far been explained molecularly. Similarly, the environment clearly plays a role in the etiology of depression, but the molecular basis of that role remains undefined. I have an R01 grant from the NIMH to perform next-generation exome sequencing in about 3,000 bipolar disorder cases and controls, and examine the data searching for rare variants associated with this illness. I also have an R01 grant from the NIMH to assess genome-wide DNA methylation variation in a mouse model of stress and depression. Both of these projects involve bench work including DNA sequencing, bisulfite pyrosequencing, and gene expression assays. They further involve bioinformatics and statistical genetics assessment of large data sets.
Exonic DNA sequencing of ERBB4 in bipolar disorder.
Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice.
DNA methylation signatures within the human brain.
Am J Hum Genet.
Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33.
Bipolar Disorder Phenome Group ,
Am J Psychiatry.
Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder.
Am J Psychiatry.
Date Last Modified: 04/17/2013 -
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