Psychiatry

Jeffrey Long, PhD

Portrait

Professor of Psychiatry
Professor of Biostatistics (College of Public Health)

Contact Information

Office: 1-328 Medical Education Building
Iowa City, IA 52242
Office Phone: 319-335-8524

Email: jeffrey-long@uiowa.edu

Education

BA, Psychology, University of California, Los Angeles, California
MS, Experimental Psychology, California State University, Northridge, California
PhD, Quantitative Psychology, University of Southern California, Los Angeles, CA

Research Summary

My area is applied statistics in medicine and the behavioral sciences. I am specifically interested in statistical models for use in the study of neurodegenerative diseases, especially Huntington disease. My work focuses on the long-term course of neurodegenerative diseases, which involves the application of longitudinal and time-to-event models. The work I perform is primarily associated with my role as the head statistician for Neurobiological Predictors of Huntington's Disease (PREDICT-HD), funded by the National Institute of Neurological Disorders and Stroke (NINDS). PREDICT-HD is a longitudinal observational study that focuses on identifying the earliest changes associated with disease onset. I am also a lead biostatistician in the Department of Biostatistics' Data Coordinating Center (DCC) for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT). NeuroNEXT is a NINDS-funded infrastructure to facilitate rapid development and implementation of protocols in neurological disorders. The DCC assists in the design and analysis of Phase II clinical trials. Another interest of mine is open-source (free) software for statistical analysis and report generation. This includes the R software for statistical computing and graphics, the wxMaxima computer algebra system, RStudio for interactive programming, and MiKTeX and Sweave for report writing. In addition to the professional publications below, I am the co-author (with A. Zieffler and J. Harring) of the textbook “Comparing Groups: Randomization and Bootstrap Methods using R” (New York: Wiley). I am also the author of the textbook “Longitudinal Data Analysis for the Behavioral Sciences using R” (Thousand Oaks, CA: Sage).

All Publications

Matsui J, Vaidya J, Johnson H, Magnotta V, Long J, Mills J, Lowe M, Sakaie K, Rao S, Smith M, Paulsen J.  Diffusion weighted imaging of prefrontal cortex in prodromal Huntington's disease.  Human Brain Mapping.  2014. 35:1562-1573.

Paulsen J, Long J.  Onset of Huntington disease: Can it be purely cognitive?.  Movement Disorders.  2014. 29:1342-1350.

Biglan K, Zhang Y, Long J, Geschwind M, Kang G, Killoran A, Lu W, McCusker E, Mills J, Raymond L, Testa  C, Wojcieszek J, Paulsen  J.  Redefining the diagnosis of Huntington disease: the PREDICT-HD study.  Frontiers in Aging Neurosciences.  2014. 5:1-8.

Spalletta G, Robinson R, Cravello L, Pontieri F, Pierantozzi M, Stefani A, Long J, Caltagirone C, Assogna F.  The early longitudinal course of affective and cognitive symptoms and disorders in de novo patients with Parkinson’s disease.  Journal of Neurology.  2014. In Press.

Long J, Paulsen J, Marder K, Zhang Y, Mills J.  Tracking motor impairments in the progression of Huntington's Disease.  Movement Disorders.  2014. 29:477-489.

Cutuli J, Desjardins C, Herbers J, Long J, Heistad D, Chan C, Hinz E, Masten A.  Academic achievement trajectories of homeless and highly mobile students: resilience in the context of chronic and acute risk.  Child Development.  2013. 84:841-857.
[PubMed]

Epping E, Mills J, Beglinger L, Fiedorowicz J, Craufurd D, Smith M, Groves M, Bijanki K, Downing N, Williams J, Long J, Paulsen J.  Characterization of Depression in Prodromal Huntington Disease in the Neurobiological Predictors of HD (PREDICT-HD) Study .  Journal of Psychiatric Research .  2013. 47(10):1423-1431.
[PubMed]

Paulsen J, Smith M, Long J.  Cognitive decline in prodromal Huntington Disease: Implications for clinical trials.  Journal of Neurology, Neurosurgery and Psychiarty.  2013. 84:1233-1239.

Bonner-Jackson A, Long J, Westervelt H, Tremont G, Aylward E, Paulsen J.  Cognitive reserve and brain reserve in prodromal Huntington's disease.  Journal of the International Neuropsychological Society.  2013. 19:1-12.
[PubMed]

Rao J, Harrington D, Durgerian S, Reece C,  L, Koenig K, Lowe M, Magnotta V, Long J, Johnson H, Paulsen  J, Rao S.  Disruption of response inhibition circuits in prodromal Huntington Disease. .  Cortex.  2013. 58:72-85.

Paulsen J, Long J.  Establishing a clinical trial battery for Huntington disease.  Nature Reviews Neurology.  2013. 8:250-251.

Shin T, Davidson M, Long J, Chan C, Heistad  D.  Exploring gains in reading and mathematics achievement among regular and exceptional students using growth curve modeling .  Learning and Individual Differences .  2013. 23(1):92-100.

Papp K, Snyder P, Mills J, Duff K, Westervelt H, Long J, Lourens S, Paulsen J.  Measuring executive dysfunction longitudinally and in relation to genetic burden, brain volumetrics, and depression in prodromal Huntington disease.  Archives of Clinical Neuropsychology.  2013. 28(2):156-68.

Harrington D, Liu D, Smith M, Mills J, Long J, Aylward E, Paulsen J.  Neuroanatomical correlates of cognitive functioning in prodromal Huntington disease .  Brain and Behavior .  2013. 

Leoni V, Long J, Mills J, Di Donato S, Paulsen J.  Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression.  Neurobiology of Disease.  2013. 55:37-43.

Aylward E, Harrington D, Mills J, Nopoulos P, Ross C, Long J, Liu D, Westervelt H, Paulsen J.  Regional atrophy associated with cognitive and motor function in prodromal Huntington disease.  Journal of Huntington Disease .  2013. 

Englund M, Siebenbruner J, Olivia E, Egeland B, Chung C, Long J.  The developmental significance of late adolescent substance use for early adult functioning.  Devepmental Psychology.  2013. 49(8):1554-1564.

McCusker E, Gunn D, Epping E, Loy C, Radford K, Griffith J, Mills J, Long J, Paulsen J.  Unawareness of motor phenoconversion in Huntington Disease.  Neurology.  2013. 81:1-7.

Downing N, Kim J, Williams J, Long J, Mills J, Paulsen  J.  WHODAS 2.0 in prodromal Huntington disease: measures of functioning in neuropsychiatric disease.  European Journal of Human Genetics .  2013. 

Masten M, Herbers J, Desjardins C, Cutuli J, McCormick C, Sapienza J, Long J, Zelazo P.  Executive function skills and school success in young children experiencing homelessness.  Health Education Research.  2012 November. 

Long J, Matson W, Juhl A, Leavitt B, Paulsen J.  8OHdG as a marker for Huntington disease progression.  Neurobiology of Disease.  2012. 46(3):625-34.
[PubMed]

Long J, Zhang Y, Paulsen J, Kim J, Mills J, Lu W.  Classification using manifest motor signs in Huntington disease.  2012. 

Matsui J, Vaidya J, Magnotta V, Long J, Mills J, Lowe M, Rao S, Smtih M, Paulsen J, Johnson H.  Diffusion weighted imaging of prefrontal cortex in prodromal Huntington’s disease.  2012. 

Shin T, Davidson M, Long J.  Growth curve modeling of gains in reading and mathematics achievement among regular and exceptional students.  2012. 

Desjardins C, Long J, Chan C, Hinz E, Heistad D, Masten A.  Growth patterns in school suspensions: testing crescendo effects with multilevel modeling.  2012. 

Long J.  Longitudinal Data Analysis for the Behavioral Sciences using R.  Thousand Oaks, CA: Sage Publications Inc;  2012.

Magnotta V, Matsui J, Liu D, Johnson H, Long J, Bolster B, Mueller B, Lim K, Mori S, Helmer K, Turner  J, Reading S, Lowe M, Aylward E, Flashman L, Bonett G, Paulsen J.  Multi-center reliability of diffusion tensor imaging .  Brain Connectivity 2.  2012. 2:345-355.
[PubMed]

Ramel S, Long J, Gray H, Durrwachter-Erno K, Demerath E, Rao R.  Neonatal hyperglycemia and dimenshined long-term growth in very low birth weight preterm infants.  2012. 

Bonner-Jackson A, Long J, Westervelt H, Tremont G, Alyward E, Paulsen J.  Protective effects of cognitive reserve on neuropsychological performance and brain structure in Huntington disease.  2012. 

Aylward E, Liu D, Nopoulos P, Ross C, Pierson R, Mills J, Long J, Paulsen J.  Striatal volume contributes to the prediction of onset of Huntington disease in incident cases.  Biological Psychiatry.  2012. 71(9):822-8.

Zeller M, Guilfoyle S, Reiter-Purtill J, Ratcliff M, Inge T, Long J.  Adolescent bariatric surgery: caregiver and family functioning across the first postoperative year.  Surgery for Obesity and Related Diseases.  2011. 7(2):145-50.
[PubMed]

Zieffer A, Harring J, Long J.  Comparing Groups: Randomization and Bootstrap Methods Using R.  New York: John Wiley & Sons.;  2011.

Zhang Y, Long J, Mills J, Warner J, Lu W, Paulsen J.  Indexing disease progression at study entry with individuals at-risk for Huntington disease.  American Journal of Medical Genetics, Part B.  2011. 156B(7):751-63.

Klimes-Dougan B, Long J, Lee C, Ronsaville D, Gold P, Martinez P.  Continuity and cascade in offspring of bipolar parents: a longitudinal study of externalizing, internalizing, and thought problems.  Development and Psychopathology.  2010. 22(4):849-66.

Rao R, Ennis K, Long J, Ugurbil K, Gruetter R, Tkac I.  Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia.  Journal of Neurochemistry.  2010. 114(3):728-38.

Long J.  Rank order correlation.  Wiley.  2010. 

Masten A, Desjardins C, McCormick C, Kuo S, Long J.  The significance of childhood competence and problems for adult success in work: a developmental cascade analysis.  Development and Psychopathology.  2010. 22(3):679-94.

Long J, Ryoo J.  Using fractional polynomials to model non-linear trends in longitudinal data.  The British Journal of Mathematical and Statistical Psychology.  2010. 63(Pt 1):177-203.
[PubMed]

Obradović J, Long J, Cutuli J, Chan C, Hinz E, Heistad D, Masten A.  Academic achievement of homeless and highly mobile children in an urban school district: longitudinal evidence on risk, growth, and resilience.  Development and Psychopathology.  2009. 21(2):493-518.
[PubMed]

Pellegrini A, Long J, Solberg D, Roseth C, Dupuis D, Bohn C, Hickey M.  Bullying and Social Status During School Transitions.  New York: Routledge.  2009. 

Reschly A, Busch T, Betts J, Deno S, Long J.  Curriculum-based measurement oral reading as an indicator of reading achievement: A meta-analysis of the correlational evidence.  Journal of School Psychology .  2009. 47:427-69.
[PubMed]

Gunnar M, Wewerka S, Frenn K, Long J, Griggs C.  Developmental changes in hypothalamus-pituitary-adrenal activity over the transition to adolescence: normative changes and associations with puberty.  Development and Psychopathology.  2009. 21(1):69-85.
[PubMed]

Masten A, Long J, Kuo S, McCormick C, Desjardins C.  Developmental models of strategic intervention.  European Journal of Developmental Sciences.  2009. 3:282-91.

Shin T, Davison M, Long J.  Effects of missing data methods in strcutural equations modeling with nonnormal longitudinal data.  Structural Equation Modeling.  2009. 16:70-98.

Long J, Loeber R, Farrington D.  Marginal and Random Intercepts Models for Longitudinal Binary Data With Examples From Criminology.  Multivariate Behavioral Research.  2009. 44(1):28-58.

Hans D, Pylipow M, Long J, Thureen P, Georgieff M.  Nutritional practices in the neonatal intensive care unit: analysis of a 2006 neonatal nutrition survey.  Pediatrics.  2009. 123(1):51-7.

Zeller M, Modi A, Noll J, Long J, Inge T.  Psychosocial functioning improves following adolescent bariatric surgery.  Obesity (Silver Spring, Md.).  2009. 17(5):985-90.

Kertes D, Gunnar M, Madsen N, Long J.  Early deprivation and home basal cortisol levels: a study of internationally adopted children.  Development and Psychopathology.  2008. 20(2):473-91.

Burt K, Obradović J, Long J, Masten A.  The interplay of social competence and psychopathology over 20 years: testing transactional and cascade models.  Child Development.  2008. 79(2):359-74.

Espin C, Wallace T, Campbell H, Lembke E, Long J, Ticha  R.  Validity and reliability of curriculum-based measures in written expression: Predicting the success of secondary-school students on state standards tests .  Exceptional Children .  2008. 74:174-93.

Pellegrini A, Long J, Roseth C, Bohn C, Van Ryzin M.  A short-term longitudinal study of preschoolers' (Homo sapiens) sex segregation: the role of physical activity, sex, and time.  Journal of Comparative Psychology (Washington, D.C. : 1983).  2007. 121(3):282-9.

Pellegrini T, Long J.  An observational longitudinal study of early heterosexual interaction at a middle school dance: Male and female strategies for gender integration.  Journal of Research on Adolescence.  2007. 17:613-38.

Brekke J, Hoe M, Long J, Green M.  How neurocognition and social cognition influence functional change during community-based psychosocial rehabilitation for individuals with schizophrenia.  Schizophrenia Bulletin.  2007. 33(5):1247-56.

Peer J, Kupper Z, Long J, Brekke J, Spaulding W.  Identifying mechanisms of treatment effects and recovery in rehabilitation of schizophrenia: longitudinal analytic methods.  Clinical Psychology Review.  2007. 27(6):696-714.

Long J, Harring J, Brekke J, Test M, Greenberg J.  Longitudinal construct validity of Brief Symptom Inventory subscales in schizophrenia.  Psychological Assessment.  2007. 19(3):298-308.

Obradović J, Pardini D, Long J, Loeber R.  Measuring interpersonal callousness in boys from childhood to adolescence: an examination of longitudinal invariance and temporal stability.  Journal of Clinical Child and Adolescent Psychology.  2007. 36(3):276-92.

Long J.  Ordinal level of measurement.  Newbury Park, CA: Sage.  2007. 

Siddappa A, Rao R, Long J, Widness J, Georgieff M.  The assessment of newborn iron stores at birth: a review of the literature and standards for ferritin concentrations.  Neonatology.  2007. 92(2):73-82.

deRegnier R, Long J, Georgieff M, Nelson C.  Using event-related potentials to study perinatal nutrition and brain development in infants of diabetic mothers.  Developmental Neuropsychology.  2007. 31(3):379-96.

Webb S, Long J, Nelson C.  A longitudinal investigation of visual event-related potentials in the first year of life.  Developmental Science.  2005. 8(6):605-16.

Test M, Greenberg J, Long J, Brekke J, Burke S.  Construct validity of a measure of subjective satisfaction with life of adults with serious mental illness.  Psychiatric Services (Washington, D.C.).  2005. 56(3):292-300.

Masten A, Roisman G, Long J, Burt K, Obradovic J, Riley J, Boelcke-Stennes K, Tellegen A.  Developmental cascades: linking academic achievement and externalizing and internalizing symptoms over 20 years.  Developmental Psychology.  2005. 41(5):733-46.

Long J.  Omnibus hypothesis testing in dominance-based ordinal multiple regression.  Psychological Methods.  2005. 10(3):329-51.

Pellegrini A, Long J, Mizerek E.  Sexual segregation in humans.  Cambridge: Cambridge University Press..  2005. 

Beasley T, Brand J, Long J.  The use of nonparametric procedures in the statistical analysis of microarray data.  New York: CRC Press.  2005. 

Frazier P, Tashiro T, Berman M, Steger M, Long J.  Correlates of levels and patterns of positive life changes following sexual assault.  Journal of Consulting and Clinical Psychology.  2004. 72(1):19-30.

Black L, deRegnier R, Long J, Georgieff M, Nelson C.  Electrographic imaging of recognition memory in 34-38 week gestation intrauterine growth restricted newborns.  Experimental Neurology.  2004. 190 Suppl 1:S72-83.

Pellegrini A, Long J.  Part of the solution and part of the problem: A dominance theory view of bullying and victimization during the transition from primary school through middle school.  Mahwah, NJ: Erlbaum.  2004. 

Masten A, Burt K, Roisman G, Obradović J, Long J, Tellegen A.  Resources and resilience in the transition to adulthood: continuity and change.  Development and Psychopathology.  2004. 16(4):1071-94.

Pellegrini A, Long J.  A sexual selection theory longitudinal analysis of sexual segregation and integration in early adolescence.  Journal of Experimental Child Psychology.  2003. 85(3):257-78.

Long J, Feng D, Cliff N.  Ordinal analysis of behavioral data.  New York: John Wiley & Sons.  2003. 

Long J, Pellegrini A.  Studying the change in dominance and bullying with linear mixed models.  School Psychology Review.  2003. 32:401-417.

Pellegrini A, Long J.  A longitudinal study of bullying, dominance, and victimization during the transition from primary school through middle school.  British Journal of Developmental Psychology.  2002. 20:259-280.

Wuerker A, Long J, Haas G, Bellack A.  Interpersonal control, expressed emotion, and change in symptoms in families of persons with schizophrenia.  Schizophrenia Research.  2002. 58(3-Feb):281-92.

Brekke J, Long J, Kay D.  The structure and invariance of a model of social functioning in schizophrenia.  The Journal of Nervous and Mental Disease.  2002. 190(2):63-72.

Brekke J, Prindle C, Bae S, Long J.  Risks for individuals with schizophrenia who are living in the community.  Psychiatric Services (Washington, D.C.).  2001. 52(10):1358-66.

Beasley T, Long J, Natali M.  Validation of the Mathematics Anxiety Scale for Children: A confirmatory factor analysis measurement and evaluation in counseling and development .  2001. 34:14-26.

Brekke J, Long J.  Community-based psychosocial rehabilitation and prospective change in functional, clinical, and subjective experience variables in schizophrenia.  Schizophrenia Bulletin.  2000. 26(3):667-80.

Land H, Long J.  The structure of coping in AIDS caregivers: A factor analytically derived measure.  Journal of Applied Social Psychology.  2000. 30:463-483.

Long J.  A confidence interval for ordinal multiple regression weights.  Psychology Methods.  1999. 4:315-330.

Brekke J, Ansel M, Long J, Slade E, Weinstein M.  Intensity and continuity of services and functional outcomes in the rehabilitation of persons with schizophrenia.  Psychiatric Services (Washington, D.C.).  1999. 50(2):248-56.

Long J.  Kendall’s tau.  New York: John Wiley & Sons.  1999. 

Long J, Brekke J.  Longitudinal factor structure of the brief psychiatric rating scale in schizophrenia.  Journal of Psychological Assessment.  1999. 11:498-506.

Silverstein M, Long J.  Trajectories of adult grandparent-grandchild relationshipd: a growth curve analysis over 23 years.  Journal of Marriage and Family .  1998. 60:912-923.

Long J, Cliff N.  Confidence intervals for Kendall's tau.  British Journal of Mathematical and Statistical Psychology.  1997. 50:31-41.

Brekke J, Long J, Nesbitt N, Sobel E.  The impact of service characteristics on functional outcomes from community support programs for persons with schizophrenia: a growth curve analysis.  Journal of Consulting and Clinical Psychology.  1997. 65(3):464-75.

Collins L, Graham J, Long J, Hansen W.  Cross validation of latent class models of early substance use onset.  Multivariate Behavioral Research.  1994. 29:165-183.

Collins L, Fidler P, Wugalter S, Long J.  Goodness-of-fit testing for latent class models .  Multivariate Behavioral Research.  1993. 28:375-389.

Long J, Wugalter S, Collins L.  Monte Carlo sampling as a tool for goodness-of-fit testing with latent class models.  Dept. of Psychology, University of Southern California..  1993. 

Klimes-Dougan B, Desjardins C, James M, Narayan A, Long J, Cullen K, Gold P, Martinez P.  The development of thought problems: A longitudinal family risk study of offspring of bipolar, unipolar, and well parents.  Development and Psychopathology. 

Date Last Modified: 06/07/2014 - 21:56:23