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Professor of PsychiatryProfessor of
Biostatistics (College of Public Health)
Office: 1-328 Medical Education BuildingIowa City, IA 52242
Office Phone: 319-335-8524
BA, Psychology, University of California, Los Angeles, California MS, Experimental Psychology, California State University, Northridge, CaliforniaPhD, Quantitative Psychology, University of Southern California, Los Angeles, CA
My area is applied statistics in medicine and the behavioral sciences. I am specifically interested in statistical models for use in the study of neurodegenerative diseases, especially Huntington disease. My work focuses on the long-term course of neurodegenerative diseases, which involves the application of longitudinal and time-to-event models.
The work I perform is primarily associated with my role as the head statistician for Neurobiological Predictors of Huntington's Disease (PREDICT-HD), funded by the National Institute of Neurological Disorders and Stroke (NINDS). PREDICT-HD is a longitudinal observational study that focuses on identifying the earliest changes associated with disease onset.
I am also a lead biostatistician in the Department of Biostatistics' Data Coordinating Center (DCC) for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT). NeuroNEXT is a NINDS-funded infrastructure to facilitate rapid development and implementation of protocols in neurological disorders. The DCC assists in the design and analysis of Phase II clinical trials.
Another interest of mine is open-source (free) software for statistical analysis and report generation. This includes the R software for statistical computing and graphics, the wxMaxima computer algebra system, RStudio for interactive programming, and MiKTeX and Sweave for report writing.
In addition to the professional publications below, I am the co-author (with A. Zieffler and J. Harring) of the textbook “Comparing Groups: Randomization and Bootstrap Methods using R” (New York: Wiley). I am also the author of the textbook “Longitudinal Data Analysis for the Behavioral Sciences using R” (Thousand Oaks, CA: Sage).
Diffusion weighted imaging of prefrontal cortex in prodromal Huntington's disease.
Human Brain Mapping.
Onset of Huntington disease: Can it be purely cognitive?.
et al .
Prediction of manifest Huntington disease with clinical and imaging measures: A 12-year prospective observational study.
The Lancet Neurology.
2014. Biglan K,
Redefining the diagnosis of Huntington disease: the PREDICT-HD study.
Frontiers in Aging Neurosciences.
The early longitudinal course of affective and cognitive symptoms and disorders in de novo patients with Parkinson’s disease.
Journal of Neurology.
2014. In Press.
Tracking motor impairments in the progression of Huntington's Disease.
Cognitive decline in prodromal Huntington Disease: Implications for clinical trials.
Journal of Neurology, Neurosurgery and Psychiarty.
Cognitive reserve and brain reserve in prodromal Huntington's disease.
Journal of the International Neuropsychological Society.
Di Donato S,
Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression.
Neurobiology of Disease.
Unawareness of motor phenoconversion in Huntington Disease.
Date Last Modified: 06/07/2014 -
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