Nancy C. Andreasen, MD, PhD


Andrew H. Woods Chair of Psychiatry
Director, Iowa Neuroimaging Consortium
Professor of Psychiatry

Contact Information

Primary Office:  
Phone: 319-356-1553

Office: T214 General Hospital
200 Hawkins Drive
Iowa City, IA 52242

Web: More information


BA, Philosophy, University of Nebraska, Lincoln, NE
BA, History, University of Nebraska, Lincoln, NE
BA, English, University of Nebraska, Lincoln, NE
MA, English, Radcliffe College, Cambridge, MA
PhD, English Literature, University of Nebraska, Lincoln, NE
MD, Psychiatry, University of Iowa College of Medicine, Iowa City, IA

Fellowship, English Literature, Oxford University, United Kingdom
Residency, Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

Medical License, Iowa Board of Medical Examiners
Board Certification, American Board of Psychiatry and Neurology

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

I have been leading multifaceted research programs to study nosology, cognitive/affective neuroscience, genet ics, and brain mechanisms of psychoses for many years. I have also done extensive work in mood disorders. We were among the first investigators to use CT and SPECT to study brain abnormalities in schizophrenia and bipolar disorder. When MR imaging became available during t he mid-l980s, we conduct ed and published t he f irst quant it at ive MR study of brain abnormalities in schizophrenia and also the first in bipolar disorder. We have invested substantial effort in developing many aspects of MR imaging, including software development that yields measures of brain components, with careful attention t o reliability and validity. As our methods have become increasingly automated, we have been careful to ensure that accuracy is not sacrificed to efficiency. We also have a strong team that uses imaging to explore issues in cognitive and affective neuroscience. We have conduct ed PET studies of many aspects of cognition and emotion, including attention, memory, language, emot ion, and social cognition. Our current work relies heavily on fMR, since it permits us t o examine large samples, and thereby to address quest ions about diversity within disease phenot ypes. I have also led a T32 program in Clinical Neurobiology t hat has t rained a large number of trainees in the tools of neuroimaging and cognitive neuroscience; nearly all of t hese have gone on t o have successf ul careers both at Iowa and at other institutions. I conducted t he first modern empirical study of the relationship between creativity and mental illness; this study was facilitated by my connect ion with the Iowa Writers’ Workshop, the oldest and best -known creative writing program in the country; it has a rotating faculty, and so I was able to study visiting writers, such as Kurt Vonnegut , John Cheever, and John Irving. I found that creative writers have a higher rate of mood disorder t han a noncreative comparison group and that creativity and mood disorders t end to run together in families. I am currently conducting a second study that examines these quest ions in a broader range of creative subject s (i.e., both artists and scientists, including many Nobel laureat es), studying their brains with structural and function MR imaging and collect ing blood f or genet ic analyses. Because this topic is of broad general interest, because pointing out a relationship between creativity and mental illness helps to reduce stigma, I have also written a book and articles on the topic for the general public.

Selected Publications

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Bijanki K, Hodis B, Magnotta V, Zeien E, Andreasen N.  Effects of age on white matter integrity and negative symptoms in schizophrenia.  Schizophrenia Research.  2015 January. 161(1):29-35.

Rudd D, Axelsen M, Epping E, Andreasen N, Wassink T.  A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model.  Am J Med Genet B.  2014 December. 165B(8):619-626.

Andreasen N.  Secrets of the Creative Brain.  The Atlantic.  2014 June 25. 

Koziol L, Budding D, Andreasen N, D'Arrigo D, Bulgheroni S, Imamizu H, Ito M, Manto M, Marvel C, Parker K, Pezzulo G, Ramnani N, Riva D, Schmahmann J, Vandervert L, Yamazaki T.  Consensus paper: The cerebellum's role in movement and cognition.  Cerebellum.  2014 January. 13(1):151-177.

Andreasen N, Liu D, Ziebell S, Vora A, Ho B.  Relapse Duration, Treatment Intensity, and Brain Tissue Loss in Schizophrenia: A Prospective Longitudinal MRI Study.  Am J Psychiatry.  2013 April. 

Parker K, Andreasen N, Liu D, Freeman J, O'Leary D.  Eyeblink conditioning in unmedicated schizophrenia patients: A positron emission tomography study.  Psychiatry Research.  2013 March. 214(3):402-409.

Onwaumeze O, Nam K, Epping E, Wassink T, Ziebell S, Andreasen N, BC H.  MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse.  Psychological Medicine.  2013. 43(3):619-631.

Fusar-Poli P, Kempton M, Ho B, Andreasen N, Borgwardt S.  Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.  Neurosci Biobehav Rev.  2013. 37(8):1680-1691.

White T, Ehrlich S, Ho B, Manoach D, Caprihan A, Schulz S, Andreasen N, Gollub R, Calhoun V, Magnotta V.  Spatial characteristics of white matter abnormalities in schizophrenia.  Schizophr Bull.  2013. 39(5):1077-1086.

Gollub R, Shoemaker J, King M, White T, Ehrlich S, Sponheim S, Clark V, Turner J, Mueller B, Magnotta V, O'Leary D, Ho B, Brauns S, Manoach D, Seidman L, Bustillo J, Laurello J, Bockholt J, Lim K, Rosen B, Schulz S, Calhoun V, Andreasen N.  The MCIC Collection: A Shared Repository of Multi-Modal, Multi-Site Brain Image Data from a Clinical Investigation of Schizophrenia.  Neuroinformatics.  2013. 11:367-388.

Date Last Modified: 08/04/2015 - 09:28:35