Physiology

Michael Henry, PhD

Portrait

Associate Professor of Molecular Physiology and Biophysics
Associate Professor of Pathology

Contact Information

Primary Office: 6-510 BSB
Iowa City, IA 52242
Primary Office Phone: 319-335-7886

Email: michael-henry@uiowa.edu
Web: Henry Laboratory

Education

BS, Genetics, University of Georgia
PhD, Biology, Massachusetts Institute of Technology

Fellowship, National Science Foundation
Fellowship, Physiology and Biophysics, University of Iowa College of Medicine

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Molecular Physiology and Biophysics PhD
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

The long term research goals of my laboratory are to understand the molecular and cellular basis of prostate cancer progression and metastasis in order to develop new methods for the diagnosis and treatment of this disease. Current efforts are focused on the role of a cell-matrix receptor dystroglycan and epithelial-mesenchymal transition in this process. We approach this problem using both cell-based and animal models of disease progression. Emerging interests include how physiological and environmental components interact with central genetic pathways related to disease progression.

Center, Program and Institute Affiliations

Cardiovascular Research Center
Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Holden Comprehensive Cancer Center

Selected Publications

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Barnes J, Henry M.  Cellular and Molecular Biology of Cancer Cell Extravasation.  Springer.  2012. 

Norian L, Kresowik T, Rosevear H, James B, Rosean T, Lightfoot A, Kucaba T, Schwarz C, Weydert C, Henry M, Griffith T.  Eradication of Metastatis Renal Cell Carcinoma after Adenovirus-Encoded TNF-Related Apoptosis-Inducing Ligand (TRAIL)/CpG Immunotherapy.  PLoS One.  2012. 7(2):e31085.

Miller M, Esser A, Weydert C, Meier M, Smith B, Vessella , Lynch C, Cohen M, Henry M.  Glycosylation of alpha-dystroglycan in prostate cancer: Prognostic implications and regulation by LARGE2.  103rd AACR Annual Meeting.  2012. 

Nauseef J, Barnes J, Henry M.  Resistance to fluid shear stress is a conserved biophysical property of malignant cells.  103rd AACR Annual Meeting.  2012. 

Tang X, Sun Z, Runne C, Madsen J, Domann F, Henry M, Lin F, Chen S.  A critical role of GBy in tumorigenesis and metastasis of breast cancer.  J. Biol. Chem..  2011. 286:13244-54.

Haverkamp J, Charbonneau B, Myerholtz D, COHEN M, Snyder P, Svensson R, Henry M, Wang H, Ratliff T.  Characterization of an inducible mouse model of abacterial prostatitis.  Prostate.  2011. 71:1139-50.

Yong T, Sun A, Henry M, Meyers S, Davis J.  Down Regulation of CSL Inhibits Cell Proliferation in Prostate and Breast Cancer Cells.  J. Cell. Biochem..  2011. 112:2340-51.

Nauseef J, Henry M.  Epithelial-to-mesenchymal transition in prostate cancer: Paradigm or puzzle?.  Nature Reviews Urology.  2011. 8:428-39.

Svensson R, Haverkamp J, Thedens D, COHEN M, Ratliff T, Henry M.  Slow disease progression in a C57BL/6 Pten deficient mouse model of prostate cancer.  Am. J. Pathol..  2011. 179:502-12.

Barnes J, Nauseef J, Henry M.  Resistance to fluid shear stress is a conserved biophysical property of malignant cells.  PLoS One. 

Date Last Modified: 06/04/2015 - 08:10:57