Physical Therapy and Rehabilitation Science

Kathleen A. Sluka, PT, PhD, FAPTA

Portrait

Professor of Physical Therapy and Rehabilitation Science

Contact Information

Primary Office: 1-248 Medical Education Building
Iowa City, IA 52242
Primary Office Phone: 319-335-9791

Email: kathleen-sluka@uiowa.edu
Web: Neurobiology of Pain Laboratory

Education

BS, Physical Therapy, Georgia State University, Atlanta, GA
PhD, Anatomy, University of Texas Medical Branch, Galveston, TX

Licensure and Certifications

Physical Therapy State Board of Iowa

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Dr. Sluka's laboratory studies the peripheral and central mechanisms of chronic musculoskeletal pain, and non-pharmacological treatment for chronic pain. These studies involve the use of animal models of muscle pain developed and characterized in Dr. Sluka's laboratory, as well as projects in human subjects. We use a variety of techniques to address these questions including cell culture, molecular biology, genetic manipulations, behavioral pharmacology, and standard clinical trial methodology. Our overall goals are to improve the management of pain for people with a variety of musculoskeletal pain conditions by discovering the underlying mechanisms that lead to the development of chronic pain, discovering new therapies for pain management, and improving the use of currently available treatment for pain.

All Publications

Gereau 4th R, Sluka K, Maixner W, Savage S, Price T, Murinson B, Sullivan M, Fillingim R.  A Pain Research Agenda for the 21st Century.  J Pain.  2014 October 29. 
[PubMed]

Sato K, Johanek L, Sanada L, Sluka K.  Spinal cord stimulation (SCS) improves decreased physical activity induced by nerve injury.  Behav Neurosci.  2014 October. 128(5):625-32.
[PubMed]

Rakel B, Zimmerman M, Geasland K, Embree J, Clark C, Noiseux N, Callaghan J, Herr K, Walsh D, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) for the Control of Pain during Rehabilitation Following Total Knee Arthroplasty (TKA): A Randomized, Blinded, Placebo-Controlled Trial.  Pain.  2014 September 27. 
[PubMed]

Noehren B, Dailey D, Rakel B, Vance C, Zimmerman M, Crofford L, Sluka K.  Effect of Transcutaneous Electrical Nerve Stimulation on Pain, Function, and Quality of Life in Fibromyalgia: A Double-Blind Randomized Clinical Trial.  Phys Ther.  2014 September 11. 
[PubMed]

Glass N, Segal N, Sluka K, Torner J, Nevitt M, Felson D, Bradley L, Neogi T, Lewis C, Frey-Law L.  Examining sex differences in knee pain: the Multicenter Osteoarthritis Study.  Osteoarthritis Cartliage.  2014 August. 22(8):1100-6.
[PubMed]

Dailey D, Keffala V, Sluka K.  Cognitive and physical fatigue tasks enhance pain, cognitive fatigue and physical fatigue in people with fibromyalgia.  Arthritis Care Res (Hoboken).  2014 July 29. 
[PubMed]

Noiseux N, Callaghan J, Clark C, Zimmerman M, Sluka K, Rakel B.  Preoperative predictors of pain following total knee arthroplasty.  J Arthroplasty.  2014 July. 29(7):1383-7.
[PubMed]

Gong W, Johanek L, Sluka K.  Spinal cord stimulation reduces mechanical hyperalgesia and restores physical activity levels in animals with noninflammatory muscle pain in a frequency-dependent manner.  Anesth Analg.  2014 July. 119(1):186-95.
[PubMed]

da Silva M, Bobinski F, Sato K, Kolker S, Sluka K, Santos A.  IL-10 Cytokine Released from M2 Macrophages Is Crucial for Analgesic and Anti-inflammatory Effects of Acupuncture in a Model of Inflammatory Muscle Pain.  Mol Neurobiol.  2014 June 25. 
[PubMed]

Gong W, Kolker S, Usachev Y, Walder R, Boyle D, Firestein G, Sluka K.  Acid-Sensing Ion Channel 3 decreases phosphorylation of ERK and induces synoviocyte cell death by increasing intracellular calcium.  Arthritis Res Ther.  2014 June 12. 16(3):R121.
[PubMed]

Sanada L, Sato K, Machado N, Carmo Ede C, Sluka K, Fazan V.  Cortex glial cells activation, associated with lowered mechanical thresholds and motor dysfunction, persists into adulthood after neonatal pain.  Int J Dev Neurosci.  2014 June. 35:327-48.
[PubMed]

Rakel B, Vance C, Zimmerman M, Petsas-Blodgett N, Amendola A, Sluka K.  Mechanical Hyperalgesia and Reduced Quality of Life Occur in People with Mild Knee Osteoarthritis Pain.  Clin J Pain.  2014 May 23. 
[PubMed]

Vance C, Dailey D, Rakel B, Sluka K.  Using TENS for pain control: the state of the evidence.  Pain Manag.  2014 May. 
[PubMed]

Hoeger Bement M, St Marie B, Nordstrom T, Christensen N, Mongoven J, Koebner I, Fishman S, Sluka K.  An interprofessional consensus of core competencies for prelicensure education in pain management: curriculum application for physical therapy.  Phys Ther.  2014 April. 94(4):451-65.
[PubMed]

Sato K, Johanek L, Sanada L, Sluka K.  Spinal cord stimulation reduces mechanical hyperalgesia and glial cell activation in animals with neuropathic pain.  Anesth Analg.  2014 February. 118(2):464-72.
[PubMed]

Gregory N, Sluka K.  Anatomical and Physiological Factors Contributing to Chronic Muscle Pain.  Springer.  2014. 20:327-348.
[Link]

Dailey D, Rakel B, Vance C, Liebano R, Amrit A, Bush H, Lee K, Lee J, Sluka K.  Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia.  Pain.  2013 November. 154(11):2554-62.
[PubMed]

Sluka K, Mense S.  Animal Models of Muscle Pain.  IASP Press.  2013 October. 
[Link]

Gregory N, Harris A, Robinson C, Dougherty P, Fuchs P, Sluka K.  An Overview of Animal Models of Pain: Disease Models and Outcome Measures..  J Pain.  2013 September. 
[PubMed]

Gardner S, Blodgett N, Hillis S, Borhart E, Mallory L, Abbott L, Pezzella P, Jensen M, Sommer T, Sluka K, Rakel B.  HI-TENS Reduces Moderate-to-Severe Pain Associated with Wound Care Procedures: A Pilot Study..  Biol Res Nurs.  2013 August 15. 
[PubMed]

Gregory N, Gibson-Corley K, Frey Law L, Sluka K.  Fatigue-enhanced hyperalgesia in response to muscle insult: induction and development occur in a sex-dependent manner..  Pain.  2013 July 29. 154(12):2668-76.
[PubMed]

Santos C, Francischi J, Lima-Paiva P, Sluka K, Resende M.  Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin.  Int J Neurosci.  2013 July. 123(7):507-515.
[PubMed]

Sluka K, Bjordal J, Marchand S, Rakel B.  What Makes Transcutaneous Electrical Nerve Stimulation Work? Making Sense of the Mixed Results in the Clinical Literature.  Phys Ther.  2013 July. 
[PubMed]

Sluka K.  Effects of physical activity on laboratory pain: Studies on animals.  Taylor and Francis.  2013 June 5. 
[Link]

Pratt D, Fuchs P, Sluka K.  Assessment of avoidance behaviors in mouse models of muscle pain.  Neuroscience.  2013 June. 
[PubMed]

Correa J, Costa L, De Oliveira N, Sluka K, Liebano R.  Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial.  BMC Musculoskelet Disord.  2013 June. 14(1):195.
[PubMed]

Sluka K, Rasmussen L, Edgar M, O'Donnell J, Walder R, Kolker S, Boyle D, Firestein G.  Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.  Arthritis Rheum.  2013 May. 65(5):1194-1202.
[PubMed]

Liebano R, Vance C, Rakel B, Lee J, Cooper N, Marchand S, Walsh D, Sluka K.  Transcutaneous electrical nerve stimulation and conditioned pain modulation influence the perception of pain in humans.  Eur J Pain.  2013 May. 
[PubMed]

Fishman S, Young H, Chou R, Sluka K.  Core Competencies for Pain Management: Results of an Interprofessional Consensus Summit.  Pain Med.  2013 April. 
[PubMed]

Sato K, King E, Johanek L, Sluka K.  Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.  Eur J Pain.  2013 April. 17(4):551-561.
[PubMed]

Alves I, da Cruz K, Mota C, de Santana D, Gaujac D, de Carvalho V, Reis L, Sluka K, Quintans-Junior L, Antoniolli A, Desantana J, Badauê-Passos D, de Santana-Filho V.  Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats..  Eur J Pain.  2013 March 27. 
[PubMed]

Alves I, Sluka K.  Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats.  Eur J Pain.  2013 March. 

Sluka K, O'Donnell J, Danielson J, Rasmussen L.  Regular physical activity prevents development of chronic pain and activation of central neurons.  J Appl Physiol.  2013 March. 114(6):725-733.
[PubMed]

Sluka K.  Peripheral and central mechanisms of chronic musculoskeletal pain.  Pain Manag.  2013 March 1. 3(2):103-107.
[PubMed]

Boyan B, Tosi L, Coutts R, Enoka R, Sluka K.  Addressing the gaps: sex differences in osteoarthritis of the knee.  Biol Sex Differ.  2013 February. 4(1):4.
[PubMed]

Boyan B, Hart D, Enoka R, Sluka K.  Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee.  Biol Sex Differ.  2013 February. 4(1):3.
[PubMed]

DeSantana J, da Cruz K, Sluka K.  Animal models of fibromyalgia.  Arthritis Res Ther.  2013. 15(6):222.
[PubMed]

Sluka K, Arendt-Nielsen L.  Widespread Chronic Pain: Underlying Mechanisms and Clinical Implications.  Springer.  2013. 

Sluka K, Berkley K, O'Connor M.  Neural and psychosocial contributions to sex differences in knee osteoarthritic pain.  Biol Sex Differ.  2012 December. 3(1):26.
[PubMed]

Lu Y, Whiteis C, Sluka K, Chapleau M, Abboud F.  Responses of Glomus Cells to Hypoxia and Acidosis are Uncoupled, Reciprocal, and Linked to ASIC3 Expression (Selectivity of Chemosensory Transduction)..  J Physiol.  2012 November 19. 
[PubMed]

Rakel B, Blodgett N, Zimmerman M, Logsden-Sackett N, Clark C, Noiseaux N, Callaghan J, Herr K, Geaslan K, Yang X, Sluka K.  Predictors of Postoperative Movement Pain following Total Knee Replacement.  Pain .  2012 November. 153(11):2192-2203.
[PubMed]

Lu Y, Whiteis C, Sluka K, Chapleau M, Abboud F.  Responses of Glomus Cells to Hypoxia and Acidosis are Uncoupled, Reciprocal, and Linked to ASIC3 Expression (Selectivity of Chemosensory Transduction).  J Physiol.  2012 November. 
[PubMed]

Sato K, Salada L, Rakel B, Sluka K.  Increasing intensity of TENS daily prevents development of analgesic tolerance in rats.  J Pain.  2012 August. 13(9):884-890.
[PubMed]

Walder R, Radhakrishnan R, Loo L, Rasmussen L, Mohapatra D, Wilson S, Sluka K.  TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation.  Pain.  2012 August. 153(8):1664-1672.
[PubMed]

Vance C, Rakel B, Blodgett N, DeSantana J, Amendola A, Zimmerman M, Walsh D, Sluka K.  Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial.  Phys Ther.  2012 July. 92(7):898-910.
[PubMed]

Oliveira L, De Melo V, Macedo F, Barreto A, Badaue-Passos D, Viana Dos Santos M, Dias D, Sluka K, DeSantana J, Santana-Filho V.  Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.  Auton Neurosci.  2012 April. 167(1-2):45-49.
[PubMed]

Sluka K, Danielson J, Rasmussen L, DaSilva L.  Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei.  Med Sci Sports Exerc.  2012 March. 44(3):420-427.

Gautam M, Benson C, Ranier J, Light A, Sluka K.  ASICs Do Not Play a role in maintaining hyperalgesia induced by repeated intramuscular acid injections.  Pain Res Treat.  2012. 2012(817347).

Tonelli S, Rakel B, Cooper N, Angstom W, Sluka K.  Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement..  Biol Sex Differ.  2011 November. 2:12.

Walder R, Gautam M, Wilson S, Benson C, Sluka K.  Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation.  Pain.  2011 October. 152(10):2348-2356.
[PubMed]

Moran F, Leonard T, Hawthorne S, Hughes C, McCrum-Gardner E, Johnson M, Rakel B, Sluka K, Walsh D.  Hypoalgesia in Response to Transcutaneous Electrical Nerve Stimulation (TENS) Depends on Stimulation Intensity..  J Pain.  2011 August. 12(8):929-935.

Pantaleao M, Laurino M, Gallego N, Cabral C, Rakel B, Vance C, Sluka K, Walsh D, Liebano R.  Adjusting pulse amplitude during transcutaneous electrical nerve stimulation (TENS) application produces greater hypoalgesia..  J Pain.  2011 May. 12(5):581-590.

Schutte D, Mukhopadhyay N, Vance C, Walder R, Sluka K, Rakel B, Govil M.  Genetic predictors of knee pain in persons with mild to moderate osteoarthritis..  Midwest Nursting Research Society Annual Conference, Dearborn MI.  2011 April. 

Liebano R, Rakel B, Vance C, Walsh D, Sluka K.  An investigation of the development of analgesic tolerance to TENS in humans.  Pain.  2011 February. 152(2):335-342.
[PubMed]

De Resende M, Da Silva L, Sato K, Arendt-Nielsen K, Sluka K.  Blockade of opioid receptors in the SRD, but not the RVM, prevents analgesia produced by DNIC in rats with muscle inflammation.  J Pain.  2011 February. 
[PubMed]

Dailey D, Rakel B, Anand A, Lee J, Sluka K.  Fatigue and Fibromyalgia.  2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Lee J, Dailey D, Vance C, Liebano R, Rakel B, Sluka K.  Psychological distress and fatigue influence pain and function in fibromyalgia patients.  Paper (presented) at the 2011 University of Iowa Health Sciences Research Week and at the 2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Lee J, Rakel B, Sluka K, Logsden-Slockett N, Yang X.  The role of biopsychosocial factors in the level of TENS amplitude achieved after Total Knee Replacement.  Paper (presented) at the 2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Dailey D, Rakel B, Vance C, Lee J, Liebano R, Anand A, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) reduces pain and improves function in people with Fibromyalgia.  Paper (accepted) for the 2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Dannecker E, Sluka K.  “Pressure and Activity-Related Allodynia in Delayed-Onset Muscle Pain”.  Clinical J Pain.  2011 January. 27(1):42-47.
[PubMed]

DaSilva L, Walder R, Davidson B, Wilson S, Sluka K.  Changes in expression of NMDA-NR1 receptor subunits in the rostral ventromedial medulla modulate pain behaviors.  Pain.  2010 October. 151(1):155-161.

Gautam M, Benson C, Sluka K.  Increased response of muscle sensory neurons to decreases in PH after muscle inflammation.  Neuroscience.  2010 October. 170(3):893-900.
[PubMed]

Kolker S, Walder R, Usachev Y, Hillman J, Boyle D, Firestein G, Sluka K.  ASIC3 is expressed in Type B synoviocytes and chondrocytes modulates hyaluronan expression, and release.  Annals Rhuem Disease.  2010 May. 69(5):903-909.
[PubMed]

Da Silva L, DeSantana J, Sluka  K.  Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats..  Pain.  2010 April. 11(4):378-387.
[PubMed]

Walder R, Rasmussen L, Rainier J, Light A, Wemmie J, Sluka K.  ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury..  J Pain.  2010 March. 11(3):210-218.
[PubMed]

McNearney T, Sluka K, Ahn C, Reveille J, Fischbach M, Mayes M.  Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations.  Clin Exp Rheumatol.  2010 March. 28(2 Suppl 58):S7-11.
[PubMed]

Sluka K, Rasmussen L.  Fatiguing exercise enhances hyperalgesia to muscle inflammation.  Pain.  2010 February. 148(2):188-197.
[PubMed]

DeSantana J, DaSilva L, Sluka K.  Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.  Pain.  2010 January. 148(1):84-93.
[PubMed]

Rakel B, Cooper N, Adams H, Sluka K.  A New Transient Sham TENS Device Allows for Investigator Blinding While Delivering a True Placebo Treatment.  J Pain.  2009 November. 11(3):230-238.
[PubMed]

Sluka K.  Is it possible to develop an animal model of fibromyalgia?.  Pain.  2009 November. 146(1-2):3-4.
[PubMed]

DeSantana J, DaSilva L, DeResende M, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) at both high and low frequencies activates ventrolateral periaqueductal grey to decrease mechanical hyperalgesia in arthritic rats.  Neuroscience.  2009 November. 163(4):1233-1241.
[PubMed]

Sluka K, Winter O, Wemmie J.  Acid-sensing ion channels: A new target for pain and CNS diseases..  Curr Opin Drug Discov Devel.  2009 September. 12(5):693-704.
[PubMed]

Cowen S, McKenna J, McCrum-Gardner E, Johnson M, Sluka K, Walsh D.  An Investigation of the Hypoalgesic Effects of TENS Delivered By a Glove Electrode.  J Pain.  2009 July. 10(7):694-701.
[PubMed]

Radhakrishnan P, Sluka K.  Increased glutamate and decreased glycine release in the RVM during induction of a pre-clinical model of chronic widespread muscle pain.  N Lett.  2009 July. 457(3):141-145.
[PubMed]

Sluka K, Turk Dennis C.  Invited Commentary, Cognitive-Behavioral Therapy for Older Adults with Chronic Pain.  Physical Therapy.  2009 May. 89(5):470-473.
[PubMed]

Walsh D, Howe T, Johnson M, Sluka K.  Review: Transcutaneous electrical nerve stimulation for acute pain.  Cochrane Database of Systematic Reviews .  2009 April. 
[PubMed]

Walsh D, Johnson M, Howe T, Sluka K.  Transcutaneous electrical nerve stimulation for acute pain.  Cochrane Database of Systematic Reviews.  2009 April. 
[PubMed]

Ikeuchi M, Kolker S, Sluka K.  Acid sensing ion channel 3 expression in mice knee joint afferents and effects of carrageenan-induced arthritis.  J Pain.  2009 March. 10(3):336-342.
[PubMed]

Maeda Y, Lisi T, Vance C, Sluka K.  Release of GABA and activation of GABAA in the spinal cord mediates the effects of TENS in rats.  Br Research.  2009 March. 1136(1):43-50.
[PubMed]

Walder R, Benson C, Sluka K.  Acid-Sensing Ion Channels and Pain.  John Wiley and Sons.  2009. 

DeSantana J, Sluka K, Lauretti G.  High and low frequency TENS reduce postoperative pain intensity after laparoscopic sterilization for tubal ligation: a randomized controlled trial.  Clinical J Pain.  2009 January. 25(1):12-19.
[PubMed]

Maeda Y, Ikeuchi M, Wacnik P, Sluka K.  Increased c-fos immunoreactivity in the spinal cord and brain following spinal cord stimulation is frequency-dependent.  Brain Res .  2009 January. 1259(9):40-50.
[PubMed]

DeSantana J, Walsh D, Vance C, Rakel B, Sluka K.  Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain..  Curr Rheumatol .  2008 December. 10(6):492-499.
[PubMed]

Arendt-Nielsen L, Sluka K, Hie H.  Experimental muscle pain impairs descending inhibition.  Pain.  2008 December. 140(3):465-471.
[PubMed]

Frey Law L, Sluka K, McMullen T, Lee J, Arendt-Neilsen L, Graven-Nielsen T.  Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans.  Pain.  2008 November. 140(2):254-264.
[PubMed]

de Santana J, Sluka K.  Central mechanisms in the maintenance of chronic widespread non-inflammatory muscle pain.  Curr Pain Headache Rep.  2008 October. 12(5):338-343.
[PubMed]

Maeda Y, Wacnik P, Sluka K.  Low frequencies, but not high frequencies of bi-polar spinal cord stimulation reduce cutaneous and muscle hyperalgesia induced by nerve injury.  Pain.  2008 August. 138(1):143-152.
[PubMed]

Ikuechi M, Kolker S, Burnes L, Walder R, Sluka K.  Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice.  Pain.  2008 July. 137(3):662-669.
[PubMed]

Frey Law L, Evans S, Knudtson J, Nus S, Scholl K, Sluka K.  Massage reduces pain perception and hyperalgesia in experimental muscle pain: a randomized, controlled trial.  J Pain.  2008 May. 9(8):714-721.
[PubMed]

Burnes L, Kolker S, Danielson J, Walder R, Sluka K.  Enhanced muscle fatigue occurs in male but not female ASIC3 -/- mice.  Am J Physiol Regul Integr Comp Physiol.  2008 April. 294(4):R1347-R1355.
[PubMed]

de Santana J, Santana-Filho V, Guerra D, Sluka K, Gurgel R, da Silva Jr. W.  Hypoalgesic effect of the transcutaneous electrical nerve stimulation following inguinal herniorrhaphy: A randomized controlled trial.  J Pain.  2008 April. 9(7):623-629.
[PubMed]

De Santana J, Santana-Filho V, Sluka K.  Modulation between high- and low- frequency transcutaneous electrical nerve stimulation delays the development of analgesic tolerance in arthritic rats.  Arch Phys Med Rehabil.  2008 April. 89(4):754-760.
[PubMed]

Walder R, Sluka K.  Bilateral, long-lasting hyperalgesia due to repeated excitation of muscle nociceptors: a role for ASIC3.  IASP Press.  2008. 

Walder R, Sluka K.  Centering on central mechanisms in the development and maintenance of chronic widespread muscle pain.  J Musculoskeletal Pain.  2008. 16(1-2):107-113.

Sluka K, Skyba D, Hoeger Bement M, Audette K, Radhakrishnana R.  Chapter 17: Second messenger pathways in pain..  Higher Education Press.  2008. 

Sluka K, Westlund K.  Neurological Regulation of Inflammation.  2008. 

Hingne P, Sluka K.  Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats.  J Pain.  2007 December. 9(3):217-225.
[PubMed]

Yokoyama T, Ushida T, Yamasaki F, Inoue S, Sluka K.  Epidural puncture can be confirmed by the Queckenstedt-test procedure in patients with cervical spinal canal stenosis.  Acta Anaesthesiol Scand.  2007 November. 52(2):265-261.
[PubMed]

Tillu D, Gebhart G, Sluka K.  Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult.  Pain .  2007 August. 136(3):331-339.
[PubMed]

Yokoyama T, Lisi T, Moore S, Sluka K.  Muscle fatigue increases the probability of developing hyperalgesia in mice.  J Pain.  2007 July. 8(9):692-699.
[PubMed]

Sluka K, Radhakrishnan R, Benson C, Price M.  ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation.  Pain.  2007 May. 129(1-2):102-112.
[PubMed]

Yokoyama T, Maeda Y, Audette K, Sluka K.  Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats.  J Pain.  2007 May. 8(5):422-429.
[PubMed]

Yokoyama T, Sadahiro T, Sluka K, Yamashita K, Tokoroyama H, Manabe M.  Tethered cord syndrome discovered in preoperative examination.  J Anesth.  2007 May. 21(2):270-272.
[PubMed]

Moss P, Sluka K, Wright A.  The initial effects of knee joint mobilization on osteoarthritic hyperalgesia.  J Manip Ther .  2007 May. 12(2):109-118.

Bement M, Sluka K.  Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model.  Neuroscience Letters.  2007 March. 418(1):22-27.
[PubMed]

Hingne P, Sluka K.  Differences in waveform characteristics have no effect on the anti-hyperalgesia produced by transcutaneous electrical nerve stimulation (TENS) in rats with joint inflammation.  J Pain.  2007 March. 8(3):251-255.
[PubMed]

Hoeger Bement M, Sluka K.  Pain: Perception and mechanisms.  Saunders-Elsevier Health Sciences.  2007. 

Sluka K.  The Neurobiology of Pain and Foundations for Electrical Stimulation for Pain Control.  AJ Robinson and L Snyder-Mackler .  2007. 

Vance C, Radhakrishnan R, Skyba D, Sluka K.  Transcutaneous electrical nerve stimulation at both high and low frequencies reduces primary hyperalgesia in rats with joint inflammation in a time-dependent manner.  Phys Ther.  2007 January. 87(1):44-51.
[PubMed]

Yokoyama T, Yamashita K, Manabe M, Sluka K.  Tracheobronchomalacia-like lung collapse during three separate trials of general anesthesia.  Anesth Analg.  2006 October. 103(4):1039-1040.
[PubMed]

Sluka K, Lisi T, Westlund K.  Increased release of serotonin in the spinal cord during low, but not high, frequency TENS in rats with joint inflammation.  Arch Phys Med Rehab.  2006 August. 87(8):1137-1140.
[PubMed]

Sluka K, Skyba D, Radhakrishnan R, Leeper B, Wright A.  Joint mobilization reduces hyperalgesia associated with chronic muscle and joint inflammation in rats.  J Pain.  2006 August. 7(8):602-607.
[PubMed]

Sluka K, Audette K.  Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia.  Mol Pain .  2006 April. 2:13.

Vadakkan K, Wang H, Ko S, Zastepa E, Petrovic M, Sluka K, Zhuo M.  Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases.  Mol Pain.  2006 February. 2:7.
[PubMed]

Moss P, Sluka K, Wright A.  IASP Press.  IASP Press.  2006. 

Sluka K, Westlund K.  Nocifensive behaviors (muscle and joint).  2006. 

Sluka K.  Opioids and muscle pain.  2006. 

Moss P, Sluka K, Wright A.  Passive joint movement produces local and widespread hypoalgesic effects in subjects with knee osteoarthritis. .  IASP Press.  2006. Chapter 73.

Sluka K, Wu G, Chung J.  Recent insights into analgesic mechanisms of acupuncture and TENS.  IASP Press.  2006. 

Sluka K.  TENS, mechanisms of action.  2006. 

Lisi T, Sluka K.  A new electrochemical HPLC method for analysis of enkelphalins and endomorphins.  J Neurosci Methods.  2006 January. 150(1):74-79.
[PubMed]

Sluka K, Vance C, Lisi T.  High-frequency, but not low-frequency, transcutaneous electrical nerve stimulation reduces aspartate and glutamate release in the spinal cord dorsal horn.  J Neurochem.  2005 December. 95(6):1794-1801.
[PubMed]

Skyba D, Lisi T, Sluka K.  Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injections of acidic saline.  Pain.  2005 November. 119(1-3):142-149.
[PubMed]

Ainsworth L, Budelier K, Clinesmith M, Fiedler A, Landstrom R, Leeper B, Moeller L, Mutch S, O'Dell J, Ross J, Radhakrishnan R, Sluka K.  Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation.  Pain.  2005 November. 120(1-2):182-187.
[PubMed]

Radhakrishnan R, Sluka K.  Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-induced antihyperalgesia.  J Pain.  2005 October. 6(10):673-680.
[PubMed]

Bement M, Sluka K.  Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner.  Arch Phys Med Rehabil.  2005 September. 86(9):1736-1740.
[PubMed]

Carlson E, Audette K, Altman G, Nguyen H, Sluka K, Fairbanks C.  Transcutaneous electrical nerve stimulation activates peripherally located alpha 2A adrenergic receptors.  Pain.  2005 June. 115(3):364-373.
[PubMed]

Radhakrishnan R, Sluka K.  Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats.  J Pharmacol Exp Ther .  2005 May. 313(2):921-927.
[PubMed]

Skyba D, Radhakrishnan R, Sluka K.  Characterization of a method for measuring primary hyperalgesia of deep somatic tissue.  J Pain .  2005. 6(1):41-47.
[PubMed]

Sluka K, Radhakrishnan R.  Chronic musculoskeletal pain: Preclinical models and drug discovery.  Indian Pharmaceutical Forum Proceedings.  2005. 

Skyba D, Radhakrishnan R, Hoeger Bement M, Sluka K.  AC-cAMP pathway and pain: Potential targets for drug development.  Drug Discovery Today .  2004. 1:115-119.

Radhakrishnan R, Bement M, Skyba D, Kehl L, Sluka K.  Models of muscle pain: Carrageenan model and acidic saline model.  John Wiley & Sons.  2004. 

Sluka K, Price M, Wemmie J, Welsh M.  The ASIC3, but not the ASIC1 channel is involved in chronic muscle pain.  IASP Press.  2004. 

Sluka K, Price M, Breese N, Stucky C, Wemmie J, Welsh M.  Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.  Pain.  2003 December. 106(3):229-239.
[PubMed]

Radhakrishnan R, Sluka K.  Spinal muscarinic receptors are activated during low or high frequency TENS-induced antihyperalgesia in rats.  Neuropharmacology.  2003 December. 45(8):1111-1119.
[PubMed]

Skyba D, Radhakrishnan R, Rohlwing J, Wright A, Sluka K.  Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.  Pain .  2003 November. 106(1-2):159-168.
[PubMed]

Radhakrishnan R, King E, Dickman J, Herold C, Johnston N, Spurgin M, Sluka K.  Spinal 5-HT2 and 5-HT3 receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats.  Pain .  2003 September. 105(1-2):205-213.

Radhakrishnan R, Moore S, Sluka K.  Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats..  Pain.  2003 August. 104(3):567-577.
[PubMed]

Hoeger Bemet M, Sluka K.  Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.  J Neurosci .  2003 July. 23(13):5437-5445.
[PubMed]

Lisi T, Westlund K, Sluka K.  Comparison of microdialysis and push-pull perfusion for retrieval of serotonin and norepinephrine in the spinal cord dorsal horn.  J Neurosci Meth .  2003 June. 126(2):187-194.
[PubMed]

Saito F, Moore S, Barresi R, Henry M, Messing A, Ross-Barta S, Cohn R, Williamson R, Sluka K, Sherman D, Brophy P, Schmelzer J, Low P, Wrabetz L, Feltri M, Campbell K.  Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization.  Neuron .  2003 June. 38(5):747-758.
[PubMed]

Sluka K, Walsh D.  TENS: basic science mechanisms and clinical effectiveness.  J Pain .  2003 April. 4(3):109-121.
[PubMed]

Chandran P, Sluka K.  Development of opioid tolerance with repeated TENS administration.  Pain.  2003 March. 102(1-2):195-201.
[PubMed]

Hoeger Bement M, Skyba D, Radhakrishnan R, Sluka K.  Review: Central sensitization and musculoskeletal pain.  Seminars in Pain Medicine .  2003. 1(3):139-149.

Sluka K, Chandran P.  Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS.  Pain .  2002 November. 100(1-2):183-190.
[PubMed]

Zahn P, Sluka K, Brennan T.  Excitatory amino acid release in the spinal cord caused by plantar incision in the rat.  Pain .  2002 November. 100(1-2):65-76.
[PubMed]

Sluka K, Rohlwing J, Bussey R, Eikenberry S, Wilken J.  Chronic muscle pain induced by repeated acid injection is reversed by spinally administered - and -, but not -, opioid receptor agonists.  J Pharmacol Exp Ther .  2002 September. 302(3):1146-1150.
[PubMed]

Skyba D, King E, Sluka K.  Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline.  Pain .  2002 July. 98(1-2):69-78.
[PubMed]

Sluka K.  Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway.  J Neuroscience.  2002 July. 22(13):5687-5693.
[PubMed]

Sluka K, Hoeger M, Skyba D.  Basic science mechanisms of physical therapy treatmens for pain.  IASP Press.  2002. 

Price M, McIlwrath S, Xie J, Cheng C, Qioa J, Tarr D, Sluka K, Brennan T, Lewin G, Welsh M.  The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice.  Neuron .  2001 December. 32(6):1071-1083.
[PubMed]

Kalra A, Urban M, Sluka K.  Blockade of opioid receptors in the rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).  J Pharmacol Exp Ther .  2001 July. 298(1):257-263.
[PubMed]

King E, Sluka K.  The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on the treatment of secondary mechanical hyperalgesia in an animal model of inflammation.  J Pain .  2001 April. 2:128-133.
[PubMed]

Wright A, Sluka K.  Non-pharmacological treatments for musculoskeletal pain.  Clin J Pain .  2001 March. 17(1):33-46.
[PubMed]

Ma Y, Sluka K.  Reduction in inflammation-induced sensitization of dorsal horn neurons by transcutaneous electrical nerve stimulation in anesthetized rats.  Exp Brain Res .  2001 February 8. 137(1):94-102.
[PubMed]

Sluka K, Wright A.  Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint.  Europ J Pain .  2001. 5(1):81-87.
[PubMed]

Sluka K.  The basic science mechanisms of TENS and clinical implications.  APS Bulletin .  2001. 1:10-13.

Patterson S, Sluka K, Arnold M.  A novel transverse push-pull micro-probe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn.  J Neurochem .  2001 January. 76(1):234-246.
[PubMed]

Sluka K, Kalra A, Moore S.  Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia.  Muscle & Nerve .  2001 January. 24(1):37-46.
[PubMed]

Gopalkrishnan P, Sluka K.  Effect of varying frequency and intensity of TENS on primary hyperalgesia in rats.  Arch Phys Med Rehabil .  2000 July. 81(7):984-990.
[PubMed]

Sluka K, Judge M, McColley M, Reveiz P, Taylor B.  Low frequency TENS is less effective than high frequency TENS at reducing inflammation induced hyperalgesia in morphine tolerant rats.  Europ J Pain .  2000. 4(2):185-193.
[PubMed]

Sluka K.  Systemic morphine in combination with TENS produces an increased analgesia in rats with acute inflammation.  J Pain.  2000. 1(3):204-211.
[PubMed]

Sluka K, Deacon M, Stribal A, Strissel S, Terpstra A.  Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats.  J Pharm Exp Ther .  1999 May. 289(2):840-846.
[PubMed]

Sluka K, Christy M, Peterson W, Rudd S, Troy S.  Reduction of pain-related behaviors with either cold or heat treatment in an animal model of acute arthritis.  Arch Phys Med Rehabil .  1999 March. 80(3):313-317.
[PubMed]

Sluka K.  Blockade of N- and P/Q-type calcium channels reduces the secondary heat hyperalgesia induced by acute inflammation.  J Pharmacol Exp Ther .  1998 October. 287(1):232-237.
[PubMed]

Rees H, Sluka K, Urban L, Walpole C, Willis W.  The effects of SDZ NKT 343, a potent NK1 receptor antagonist on cutaneous responses of primate spinothalamic tract neurons sensitized by intradermal injection of capsaicin.  Brain Res.  1998 August. 121(3):355-358.
[PubMed]

Sluka K, Willis W.  Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor.  Brain Res .  1998 July. 798(1-2):281-286.
[PubMed]

Sluka K, Bailey K, Bogush J, Olson R, Ricketts A.  Treatment with either high or low frequency TENS reduces the secondary hyperalgesia observed after injection of kaolin and carrageenan into the knee joint.  Pain .  1998 July. 77(1):97-102.
[PubMed]

Willis W, Sluka K, Rees H, Westlund K.  A contribution of dorsal root reflexes to peripheral inflammation.  Oxford University Press.  1998. 

Sluka K.  Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin.  Br J Pharm .  1997 November. 122(6):1165-1173.
[PubMed]

Sluka K, Rees H, Chen P, Tsuruoka M, Willis W.  Capsaicin induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor.  Brain Res .  1997 October 24. 772(1-2):82-86.
[PubMed]

Sluka K.  Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats.  Pain .  1997 June. 71(2):157-164.
[PubMed]

Sluka K, Rees H, Chen P, Tsuruoka M, Willis W.  Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation & the desensitization to heat of spinothalamic tract neurons to induced intradermal injection of capsaicin in the primate.  Exp Brain Res .  1997 June. 115(1):15-24.
[PubMed]

Sluka K, Willis W.  The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.  Pain .  1997 June. 71(2):165-178.
[PubMed]

Sluka K, Milton M, Westlund K, Willis W.  Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation.  Br J Pharm .  1997 April. 120(7):1263-1273.
[PubMed]

Sluka K, Rees H.  The neuronal response to pain.  Physiother Theory and Practice .  1997. 13(1):3-22.

Rees H, Sluka K, Lu X, Westlund K, Willis W.  Dorsal root reflexes in articular afferents occur bilaterally in a chronic model of arthritis in rats.  J Neurophysiol .  1996 December. 76(6):4190-4193.
[PubMed]

Sluka K.  Pain mechanisms involved in musculoskeletal disorders.  J Orthop Sports Phys Ther .  1996 October. 24(4):240-254.
[PubMed]

Chen P, Sluka K, Rees H, Willis W.  α-2 noradrenergic receptor antagonist, idazoxan, blocks anterior pretectal nucleus induced antinociception in rats.  International Association for the Study of Pain, 8th World Congress on Pain.  1996 August. 

Willis W, Sluka K, Rees H, Westlund K.  Cooperative mechanisms of neurotransmitter action in central nervous sensitization.  Prog Brain Res.  1996. 110:151-166.
[PubMed]

Willis W, Sluka K, Rees H, Westlund K.  Cooperative mechanisms of neurotransmitter actions in central sensitization.  Towards the Neurobiology of Chronic Pain, Progress in Brain Research.  1996. 110:151-166.

Sluka K, Rees H, Westlund K, Willis W.  Fiber types contributing to dorsal root reflexes induced by joint inflammation in cats and monkeys.  J Neurophysiol .  1995 September. 74(3):981-989.
[PubMed]

Rees H, Sluka K, Westlund K, Willis W.  The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat.  J Physiol .  1995 April. 484:437-445.
[PubMed]

Sluka K, Willis W, Westlund K.  The role of dorsal root reflexes in neurogenic inflammation.  Pain Forum .  1995. 4:141-149.

Sluka K, Jordan H, Willis W, Westlund K.  Differential effects of NMDA and non-NMDA receptor antagonists on release of amino acids after development of acute arthritis.  Brain Res .  1994 November 21. 664(1-2):77-84.
[PubMed]

Sluka K, Willis W, Westlund K.  Arthritis induced release of excitatory amino acids is prevented by spinal administration of a GABAA and not by a GABAB receptor antagonist in rats.  J Pharm Exp Ther .  1994 October. 271(1):76-82.
[PubMed]

Sluka K, Jordan H, Westlund K.  Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist.  Pain .  1994 October. 59(1):95-100.

Sluka K, Jordan H, Westlund K.  Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist..  Pain.  1994 October. 59(1):95-100.
[PubMed]

Sluka K, Lawand N, Westlund K.  Joint inflammation is reduced by dorsal rhizotomy and not by sympathectomy or spinal cord transection.  Annals Rheum Dis .  1994 May. 53(5):309-314.
[PubMed]

Sluka K, Lawand N, Westlund K.  Joint inflammation is reduced by dorsal rhizotomy and not by sympathectomy or spinal cord transection. .  Annals Rheum Dis.  1994 May. 53(5):309-314.
[PubMed]

Rees H, Sluka K, Westlund K, Willis W.  Dorsal root reflexes augment peripheral inflammation.  NeuroReport .  1994 March. 5(7):821-824.
[PubMed]

Sluka K, Willis W, Westlund K.  Central control of peripheral joint inflammation and heat hyperalgesia.  IASP Press.  1994. 

Sluka K, Westlund K.  Behavioral and immunohistochemical changes in an experimental arthritis model in rats.  Pain .  1993 December. 55(3):367-377.
[PubMed]

Sluka K, Westlund K.  Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation.  Pain .  1993 November. 55(2):217-225.
[PubMed]

Sluka K, Willis W, Westlund K.  Joint inflammation and hyperalgesia are reduced by spinal bicuculline.  NeuroReport .  1993 November. 5(2):109-112.
[PubMed]

Sluka K, Westlund K.  Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists.  Brain Res .  1993 November. 627(1):89-103.
[PubMed]

Sluka K, Westlund K.  An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn.  Neurosci Lett .  1993 January. 149(1):99-102.
[PubMed]

Sluka K, Westlund K.  An experimental arthritis in rat: dorsal horn aspartate and glutamate increases.  Neurosci Lett .  1992 October 12. 145(2):141-144.
[PubMed]

Sluka K, Westlund K.  Spinal projections of the locus coeruleus and the nucleus subcoeruleus in the Harlan and the Sasco Sprague-Dawley rat.  Brain Res .  1992 May. 579(1):67-73.
[PubMed]

Dougherty P, Sluka K, Sorkin L, Westlund K, Willis W.  Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids.  Brain Res Rev .  1992 April. 17(1):1-13.
[PubMed]

Westlund K, Sun Y, Sluka K, Dougherty P, Sorkin L, Willis W.  Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerve.  Brain Res Rev .  1992 April. 17(1):15-27.
[PubMed]

Sluka K, Dougherty P, Sorkin L, Willis W, Westlund K.  Neural changes in acute arthritis in monkeys. III Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord.  Brain Res Rev .  1992 April. 17(1):29-38.
[PubMed]

Sorkin L, Westlund K, Sluka K, Dougherty P, Willis W.  Neural changes in acute arthritis in monkeys. IV. Time course of amino acid release into the lumbar dorsal horn.  Brain Res Rev.  1992 April. 17(1):39-50.
[PubMed]

Sluka K.  Global Year Against Musculoskeletal Pain – Exercise http://www.youtube.com/watch?v=CB9FP-EP_EE&feature=channel . 

Sluka K.  Global Year Against Musculoskeletal Pain – Introduction http://www.youtube.com/watch?v=VtV8BZFI12g&feature=channel . 

Sluka K.  Global Year Against Musculoskeletal Pain – Myths http://www.youtube.com/watch?v=nTQQ57P5TxE . 

Sluka K, Skyba D, Hoeger Bement M, Audette K, Radhakrishnan R.  Second messenger pathways in pain.  Higher Education Press. 

Date Last Modified: 11/26/2014 - 13:40:54