Physical Therapy and Rehabilitation Science

Kathleen A. Sluka, PT, PhD, FAPTA

Portrait

Professor of Physical Therapy and Rehabilitation Science

Contact Information

Primary Office: 1-248 Medical Education Building
Iowa City, IA 52242
Primary Office Phone: 319-335-9791

Email: kathleen-sluka@uiowa.edu
Web: Neurobiology of Pain Laboratory

Education

BS, Physical Therapy, Georgia State University, Atlanta, GA
PhD, Anatomy, University of Texas Medical Branch, Galveston, TX

Licensure and Certifications

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Pain, fibromyalgia, arthritis, immunology, ion channels, second messengers, glutamate, serotonin, fatigue. My research focuses on the peripheral and central neuronal mechanisms in the development and maintenance of musculoskeletal pain. We use animal models of acute and chronic musculoskeletal pain that produce behavioral signs such as limping and guarding of the limb and an increased response to noxious stimuli, hyperalgesia. Our laboratory is currently focusing on the acid sensing ion channels (ASICs) in the peripheral nervous system, and in synoviocytes lining the joint. We are also focusing on the supraspinal mechanisms underlying musculoskeletal pain including interactions between hyperalgesia and fatigue. Supraspinally we are examining brainstem and cortical sites involved in injury-induced pain behaviors with particular attention to the role of NMDA receptor subunits, phosphorylation of these subunits, and the serotonin system. We have extended these studies and are examining the effects of regular physical activity (excercise) on the development of chronic muscle pain. We are examining central nervous system and immune system contributions to the analgesia produced by regular physical activity. A third area of research has focused on deciphering the neurobiological mechanisms behind how transcutaneous electrical nerve stimulation (TENS) reduces pain. TENS is commonly used clinically as a non-invasive, adjunct therapy for pain control. Currently, we are translating findings from our animal laboratory to human subjects. We are currently performing a two-site clinical trial studying the efficacy of TENS in people with fibromyalgia.

All Publications

Gregory N, Sluka K.  Anatomical and Physiological Factors Contributing to Chronic Muscle Pain.  Taylor B, Finn D.  2014. 

Sluka K.  Preoperative predictors of pain following total knee arthroplasty.  ABJS 66th Annual Meeting: The Association of Bone and Joint Surgeons, New York, NY.  2014. 

Gregory N, Harris A, Robinson C, Dougherty P, Fuchs P, Sluka K.  An Overview of Animal Models of Pain: Disease Models and Outcome Measures..  J Pain.  2013 September. 
[PubMed]

Gardner S, Blodgett N, Hillis S, Borhart E, Mallory L, Abbott L, Pezzella P, Jensen M, Sommer T, Sluka K, Rakel B.  HI-TENS Reduces Moderate-to-Severe Pain Associated with Wound Care Procedures: A Pilot Study..  Biol Res Nurs.  2013 August 15. 
[PubMed]

Gregory N, Gibson-Corley K, Frey Law L, Sluka K.  Fatigue-enhanced hyperalgesia in response to muscle insult: induction and development occur in a sex-dependent manner..  Pain.  2013 July 29. 

Santos C, Francischi J, Lima-Paiva P, Sluka K, Resende M.  Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin.  Int J Neurosci.  2013 July. 123(7):507-515.
[PubMed]

Sabharwal R, Rasmussen L, Sluka K, Chapleau M.  Voluntary Wheel-Running Improves Neuro-Cardiovascular Regulation and Prevents Hyperalgesia in a Mouse Model of Chronic Widespread Pain.  International Union of Physiological Sciences, Birmingham, UK.  2013 July. 

Sluka K, Bjordal J, Marchand S, Rakel B.  What Makes Transcutaneous Electrical Nerve Stimulation Work? Making Sense of the Mixed Results in the Clinical Literature.  Phys Ther.  2013 July. 
[PubMed]

Pratt D, Fuchs P, Sluka K.  Assessment of avoidance behaviors in mouse models of muscle pain.  Neuroscience.  2013 June. 
[PubMed]

Correa J, Costa L, De Oliveira N, Sluka K, Liebano R.  Effects of the carrier frequency of interferential current on pain modulation in patients with chronic nonspecific low back pain: a protocol of a randomised controlled trial.  BMC Musculoskelet Disord.  2013 June. 14(1):195.
[PubMed]

Whitley P, Zhou A, Sluka K.  A Model for Back Pain Prediction and Mitigation in Military Pilots and Vehicle Occupants.  Submitted as poster. 84th Annual Scientific Meeting of the Aerospace Medical Association, Chicago, IL.  2013 May. 

Sluka K, Rasmussen L, Edgar M, O'Donnell J, Walder R, Kolker S, Boyle D, Firestein G.  Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis.  Arthritis Rheum.  2013 May. 65(5):1194-1202.
[PubMed]

Sato K, Sluka K.  Comparison of TENS, spinal cord stimulation and acupuncture in inflammatory, neuropathic and non-inflammatory pain models in rats.  American Pain Society Annual Meeting, New Orleans.  2013 May. 

Leung A, Kolker S, Allen L, Gregory N, Sluka K.  Regular physical activity results in a phenotypic switch in resident macrophages in muscle and prevents development of chronic pain through release of IL-10.  American Pain Society Annual Meeting, New Orleans.  2013 May. 

Liebano R, Vance C, Rakel B, Lee J, Cooper N, Marchand S, Walsh D, Sluka K.  Transcutaneous electrical nerve stimulation and conditioned pain modulation influence the perception of pain in humans.  Eur J Pain.  2013 May. 
[PubMed]

Sato K, DaSilva M, Sluka K.  Comparison of TENS, spinal cord stimulation and acupuncture in inflammatory, neuropathic and non-inflammatory pain models in rats..  Journal of Pain.  2013 April. 14(4 supplement):S90.

Fishman S, Young H, Chou R, Sluka K.  Core Competencies for Pain Management: Results of an Interprofessional Consensus Summit.  Pain Med.  2013 April. 
[PubMed]

Rakel B, Vance C, Zimmerman B, Petsas B, Amendola A, Sluka K.  Mild to moderate knee osteoarthritis causes peripheral and central pain sensitization and reduced quality of life..  Journal of Pain.  2013 April. 14(4 supplement):S27.

Sanada L, Sato K, Carmo E, Machado N, Sluka K, Fazan V.  Noxious stimuli in the nonatal period in rats can cause important peripheral nervous system alteration that persist on adults in sex-dependent manner..  Journal of Pain.  2013 April. 14(4 supplement):S56.

Rakel B, Noiseux N, Zimmerman B, Callaghan J, Clark C, Sluka K.  Predictors of pain following total knee arthroplasty..  Journal of Pain.  2013 April. 14(4 supplement):S15.

Leung A, Kolker S, Gregory N, Allen L, Sluka K.  Regular physical activity reduces chronic pain and may prevent the transition from acute to chronic pain..  Journal of Pain.  2013 April. 14(4 supplement):S40.

Sato K, King E, Johanek L, Sluka K.  Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.  Eur J Pain.  2013 April. 17(4):551-561.
[PubMed]

Alves I, da Cruz K, Mota C, de Santana D, Gaujac D, de Carvalho V, Reis L, Sluka K, Quintans-Junior L, Antoniolli A, Desantana J, Badauê-Passos D, de Santana-Filho V.  Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats..  Eur J Pain.  2013 March 27. 
[PubMed]

Alves I, Sluka K.  Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats.  Eur J Pain.  2013 March. 

Sluka K, O'Donnell J, Danielson J, Rasmussen L.  Regular physical activity prevents development of chronic pain and activation of central neurons.  J Appl Physiol.  2013 March. 114(6):725-733.
[PubMed]

Boyan B, Tosi L, Coutts R, Enoka R, Sluka K.  Addressing the gaps: sex differences in osteoarthritis of the knee.  Biol Sex Differ.  2013 February. 4(1):4.
[PubMed]

Boyan B, Hart D, Enoka R, Sluka K.  Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee.  Biol Sex Differ.  2013 February. 4(1):3.
[PubMed]

Sluka K, Mense S.  Animal Models of Muscle Pain.  IASP Press.  2013. 

Sluka K.  Effects of physical activity on laboratory pain: Studies on animals.  2013. 

Sluka K, Arendt-Nielsen L.  Widespread Chronic Pain: Underlying Mechanisms and Clinical Implications.  Taylor B, Finn D.  2013. 

Sluka K, Berkley K, O'Connor M.  Mechanical contributors to sex differences in idiopathic knee osteoarthritis.  Biol Sex Differ.  2012 December. 3(1):28.
[PubMed]

Sluka K, Berkley K, O'Connor M.  Neural and psychosocial contributions to sex differences in knee osteoarthritic pain.  Biol Sex Differ.  2012 December. 3(1):26.
[PubMed]

Lu Y, Whiteis C, Sluka K, Chapleau M, Abboud F.  Responses of Glomus Cells to Hypoxia and Acidosis are Uncoupled, Reciprocal, and Linked to ASIC3 Expression (Selectivity of Chemosensory Transduction)..  J Physiol.  2012 November 19. 
[PubMed]

Rakel B, Blodgett N, Zimmerman M, Logsden-Sackett N, Clark C, Noiseaux N, Callaghan J, Herr K, Geaslan K, Yang X, Sluka K.  Predictors of Postoperative Movement Pain following Total Knee Replacement.  Pain .  2012 November. 153(11):2192-2203.
[PubMed]

Lu Y, Whiteis C, Sluka K, Chapleau M, Abboud F.  Responses of Glomus Cells to Hypoxia and Acidosis are Uncoupled, Reciprocal, and Linked to ASIC3 Expression (Selectivity of Chemosensory Transduction).  J Physiol.  2012 November. 
[PubMed]

Lee J, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) Reduces Head and Neck Cancer Pain: A Randomized and Placebo-Controlled Double Blind Pilot Study..  Poster presented at the AHNS Midwest Pain Society annual meeting, Chicago, IL.  2012 October 26. 

Sato K, Sanada L, Rakel B, Sluka K.  Increasing Intensity of TENS Prevents Analgesic Tolerance in Rats.  American Pain Society.  2012 September. 

Callaghan J, Noiseux N, Clark C, Sluka K, Rakel B.  Predictors Of Pain Following Total Knee Arthroplasty.  The Knee Society and The American Association of Hip and Knee Surgeons (AAHKS), San Francisco, CA.  2012 September. 

Dailey D, Sluka K, Rakel B, Keffala V.  Abstract for IASP 2012: Pain cognitive fatigue, and physical fatigue in individuals with fibromyalgia and healthy controls.  Poster abstract presentation at 14th World Congress on Pain, Milan Italy.  2012 August. 

Sanada L, Sluka K, Sato K.  Brain microglia localization with ox-42 in young and adult rats after pain stimuli during the neonatal period..  Poster abstract presented at the 14th World Congress on Pain, Milan Italy.  2012 August. 

Gregory N, Frey Law L, Sluka K.  Characterization of a model of long lasting muscle pain induced by electrically stimulated muscle contractions. .  Poster abstract presentation at 14th World Congress on Pain, Milan Italy.  2012 August. 

Alves I, Cruz K, Dias Mota C, Reis L, Sluka K, DeSantana J, Santana-Filho V, Badaue-Passos D.  Experimental hypothyroidism during pregnancy affects nociception along the life of offspring in rats..  Poster abstract presentation at 14th World Congress on Pain, Milan Italy.  2012 August. 

Sato K, Salada L, Rakel B, Sluka K.  Increasing intensity of TENS daily prevents development of analgesic tolerance in rats.  J Pain.  2012 August. 13(9):884-890.
[PubMed]

Sato K, Johanek L, Sanada L, Sluka K.  Physical activity levels decrease after nerve injury: spinal cord stimulation (SCS) restores phsyical activity levels. .  Poster abstract presentation at 14th World Congress on Pain, Milan Italy.  2012 August. 

Kim J, Sato K, Sluka K.  The effects of TENS on below-level neuropathic pain after spinal cord injury in clip compression model in rats..  Poster abstract presentation at the 14th World Congress on Pain, Milan Italy.  2012 August. 

Rakel B, Logsden-Sackett N, Clark C, Noiseux N, Callaghan J, Herr K, Frantz R, Zimmerman M, Sluka K.  Transcutaneous electrical nerve stimulation (TENS) reduces pain and improves function post total knee replacement (TKR).  Poster abstract presentation at 14th World Congress on Pain, Milan Italy.  2012 August. 

Walder R, Radhakrishnan R, Loo L, Rasmussen L, Mohapatra D, Wilson S, Sluka K.  TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation.  Pain.  2012 August. 153(8):1664-1672.
[PubMed]

Vance C, Rakel B, Blodgett N, DeSantana J, Amendola A, Zimmerman M, Walsh D, Sluka K.  Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial.  Phys Ther.  2012 July. 92(7):898-910.
[PubMed]

Lee J, Rakel B, Dailey D, Vance C, Broderick A, Sluka K, Anderson C.  Prospective placebo-controlled randomized trial of transcutaneous electrical nerve stimulation (TENS) for relief of pain fromo radation-induced mucositis in head and neck cancer. .  American Head and Neck Society.  2012 July. 

Lee J, Rakel B, Johnston T, Angstrom W, Logsden-Sackett N, Perkhounkova Y, Yang X, Clark C, Noiseux N, Callaghan J, Sluka K.  Does rehabilitation dose predict functional recovery after total knee replacement?.  Poster at 32nd Annual Meeting of the American Pain Society, Hawaii.  2012 May. 

Malloy L, Borhart E, Gardner S, Blodgett N, Logsden-Sackett N, Sluka K, Rakel B.  High Intensity TENS reduces pain during dressing changes on open wounds: A proof of concept study.  31st Annual Scientific Meeting, American Pain Society, Honolulu, Hawaii.  2012 May. 

Sanada L, Sluka K, Sato K, Machado N, Carmo E, Fazan V.  Immunoreactivity of astrocyte markers, glial fibrillary acidic protein (GFAP) and macrophage chemoattractant protein (MCP-1), increases in after neonatal injury..  Poster at 32nd Annual Meeting of the American Pain Society, Hawaii.  2012 May. 

Sato K, Sanada L, Sluka K.  Increase intensity in TENS prevent tolerance in rats. .  Poster at 32nd Annual Meeting of the American Pain Society, Hawaii.  2012 May. 

Rakel B, Vance C, Zimmerman B, Sluka K.  Mild to moderate knee osteoarthritis causes primary and secondary hyperalgesia..  Poster at 32nd Annual Meeting of the American Pain Society, Hawaii.  2012 May. 

Lee J, Rakel B, Dailey D, Vance C, Broderick A, Sluka K.  The effectiveness of TENS for head and neck cancer pain and function: a randomized and placebo-controlled double blind pilot study..  Poster at 32nd Annual Meeting of the American Pain Society, Hawaii.  2012 May. 

Sluka K.  Do women and men with the same degree of radiographic knee osteoarthritis experience similar levels of knee pain, functional limitations or disability: The MOST Study..  Abstract accepted as a poster presentation at the World OARSI Congress, Barcelona, Spain.  2012 April. 

Oliveira L, De Melo V, Macedo F, Barreto A, Badaue-Passos D, Viana Dos Santos M, Dias D, Sluka K, DeSantana J, Santana-Filho V.  Induction of chronic non-inflammatory widespread pain increases cardiac sympathetic modulation in rats.  Auton Neurosci.  2012 April. 167(1-2):45-49.
[PubMed]

Sluka K, Danielson J, Rasmussen L, DaSilva L.  Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei.  Med Sci Sports Exerc.  2012 March. 44(3):420-427.

Gautam M, Benson C, Ranier J, Light A, Sluka K.  ASICs Do Not Play a role in maintaining hyperalgesia induced by repeated intramuscular acid injections.  Pain Res Treat.  2012. 2012(817347).

Tonelli S, Rakel B, Cooper N, Angstom W, Sluka K.  Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement..  Biol Sex Differ.  2011 November. 2:12.

Mukhopadhyay N, Schutte D, Vance C, Walder R, Sluka K, Rakel B, Govil M.  Effects of genotype on TENS effectiveness in controlling knee pain in persons with moderate osteoarthritis..  American Society of Human Genetics Meeting, Montreal Canada.  2011 October. 

Tonelli S, Rakel B, Cooper N, Sluka K.  Females with late stage knee osteoarthritis have more pain and less functional ability than males but similar physical activity..  NINR 25th Anniversary Celebration, Washington DC.  2011 October. 

Schutte D, Mukhopadhyay N, Vance C, Walder R, Sluka K, Rakel B, Govil M.  Genetic predictors of knee pain in persons with mild to moderate osteoarthritis..  American Society of Human Genetics Meeting, Montreal Canada.  2011 October. 

Walder R, Gautam M, Wilson S, Benson C, Sluka K.  Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation.  Pain.  2011 October. 152(10):2348-2356.
[PubMed]

Rakel B, Cooper N, Sluka K.  “Daily Activities are Limited by Knee Osteoarthritis and Correlate with Perceived Disability and Quality of Life,” presented at the “Bringing Science to Life: A Healthier Tomorrow,”.  NINR’s 25th anniversary Concluding Scientific Symposium, Capitol Hill in Washington, DC.  2011 October. 

Moran F, Leonard T, Hawthorne S, Hughes C, McCrum-Gardner E, Johnson M, Rakel B, Sluka K, Walsh D.  Hypoalgesia in Response to Transcutaneous Electrical Nerve Stimulation (TENS) Depends on Stimulation Intensity..  J Pain.  2011 August. 12(8):929-935.

Pantaleao M, Laurino M, Gallego N, Cabral C, Rakel B, Vance C, Sluka K, Walsh D, Liebano R.  Adjusting pulse amplitude during transcutaneous electrical nerve stimulation (TENS) application produces greater hypoalgesia..  J Pain.  2011 May. 12(5):581-590.

Schutte D, Mukhopadhyay N, Vance C, Walder R, Sluka K, Rakel B, Govil M.  Genetic predictors of knee pain in persons with mild to moderate osteoarthritis..  Midwest Nursting Research Society Annual Conference, Dearborn MI.  2011 April. 

Liebano R, Rakel B, Vance C, Walsh D, Sluka K.  An investigation of the development of analgesic tolerance to TENS in humans.  Pain.  2011 February. 152(2):335-342.
[PubMed]

De Resende M, Da Silva L, Sato K, Arendt-Nielsen K, Sluka K.  Blockade of opioid receptors in the SRD, but not the RVM, prevents analgesia produced by DNIC in rats with muscle inflammation.  J Pain.  2011 February. 
[PubMed]

Hawthorne S, Leonard T, McCrum-Gardner E, Johnson M, Rakel B, Sluka K.  An investigation of the dose response hypalgesic effects of transcutaneous electrical nerve stimulation using pressure pain threshold.  Proceedings 16th International World Confederation for Physical Therapy Congress, Amsterdam.  2011. 

Dailey D, Rakel B, Anand A, Lee J, Sluka K.  Fatigue and Fibromyalgia.  2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Lee J, Dailey D, Vance C, Liebano R, Rakel B, Sluka K.  Psychological distress and fatigue influence pain and function in fibromyalgia patients.  Paper (presented) at the 2011 University of Iowa Health Sciences Research Week and at the 2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Leonard T, Hawthorne S, McCrum-Gardner E, Johnson M, Sluka K.  Testing a novel transient placebo transcutaneous electrical nerve stimulation intervention.  Proceedings, 17th International World Confederation for Physical Therapy Congress, Amsterdam.  2011. 

Sluka K.  The Longer Someone Has Osteoarthritis Knee Pain the Less Efficient Their DNIC Response. DNIC MNRS Poster, The University of Iowa College of Nursing; College of Public Health.  Physical Therapy and Rehabilitation Science, Iowa City, Iowa.  2011. 

Lee J, Rakel B, Sluka K, Logsden-Slockett N, Yang X.  The role of biopsychosocial factors in the level of TENS amplitude achieved after Total Knee Replacement.  Paper (presented) at the 2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Dailey D, Rakel B, Vance C, Lee J, Liebano R, Anand A, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) reduces pain and improves function in people with Fibromyalgia.  Paper (accepted) for the 2011 annual meeting of the American Pain Society, Austin, TX.  2011. 

Dannecker E, Sluka K.  “Pressure and Activity-Related Allodynia in Delayed-Onset Muscle Pain”.  Clinical J Pain.  2011 January. 27(1):42-47.
[PubMed]

DaSilva L, Walder R, Davidson B, Wilson S, Sluka K.  Changes in expression of NMDA-NR1 receptor subunits in the rostral ventromedial medulla modulate pain behaviors.  Pain.  2010 October. 151(1):155-161.

Gautam M, Benson C, Sluka K.  Increased response of muscle sensory neurons to decreases in PH after muscle inflammation.  Neuroscience.  2010 October. 170(3):893-900.
[PubMed]

Kolker S, Walder R, Walder K, Usachev Y, Boyle D, Firestein G, Sluka K.  Expression of ASIC1 and ASIC3 in fibroblast-like synoviocytes contributes to pH responsiveness.  13th World Congress on Pain.  2010 September. 

Walder R, Gautam M, Wilson S, Benson C, Sluka K.  Selective Targeting of ASIC3 using miRNAs results in the inhibition of primary and secondary hyperalgesia in mice.  13th World Congress on Pain.  2010 September. 

Hawthorne S, Leonard T, Sluka K.  The effects of a novel sham TENS device upon participant blinding; Poster in placebo, TENS, blinding.  13th world congress of pain.  2010 September. 

Sluka K, Rasmussen L, Danielson J, Da Silva L.  Increased Hyperalgesia In Response To A Fatiguing Exercise Task Activities Nmda Receptors And Increases Expression Of Phosphorylated Nr1 In The Caudal Raphe Nuclei.  13th World Congress on Pain, Montreal, Canada.  2010 August. 

Kolker S, Walder R, Usachev Y, Hillman J, Boyle D, Firestein G, Sluka K.  ASIC3 is expressed in Type B synoviocytes and chondrocytes modulates hyaluronan expression, and release.  Annals Rhuem Disease.  2010 May. 69(5):903-909.
[PubMed]

Da Silva L, DeSantana J, Sluka  K.  Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats..  Pain.  2010 April. 11(4):378-387.
[PubMed]

Walder R, Rasmussen L, Rainier J, Light A, Wemmie J, Sluka K.  ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury..  J Pain.  2010 March. 11(3):210-218.
[PubMed]

McNearney T, Sluka K, Ahn C, Reveille J, Fischbach M, Mayes M.  Plasma endogenous enkephalin levels in early systemic sclerosis: clinical and laboratory associations.  Clin Exp Rheumatol.  2010 March. 28(2 Suppl 58):S7-11.
[PubMed]

Sluka K, Rasmussen L.  Fatiguing exercise enhances hyperalgesia to muscle inflammation.  Pain.  2010 February. 148(2):188-197.
[PubMed]

Walsh D, Rakel B, Sluka K.  An Investigation of the Effect of Adjusting Pulse Amplitude During TENS Application.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

Liebano R, Vance C, Walsh D, Rakel B, Sluka K.  Development of Tolerance to Repeated Low and High Frequency Transcutaneous Electrical Nerve Stimulation (TENS) in Humans.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

Rakel B, Logsden-Sackett N, Yang X, Cooper N, Tonelli S, Herr K, Frantz R, Clark C, Sluka K.  Knee Osteoarthritis Pain Correlates with Mechanical Pain Sensitivities But Does Not Influence Active Flexion or Walking Function.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

Hoeger Bement M, Vance C, Sluka K.  Managing Wound Related Pain.  FA Davis Publishers.  2010. 

Lee J, Johnston T, Yang X, Sluka K.  Pain Reduces Compliance with Recommended Therapy after Total Knee Replacement.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

Yongjun L, Whiteis  C, Chapleau M, Sluka K, Abboud F.  Sensitivity to low pH in mouse glomus type I cells correlates with ASIC3 expression.  Experimental Biology.  2010. 

Vance C, Liebano R, Lee J, Cooper N, Rakel B, Walsh D, Sluka K.  TENS and DNIC Influence the Perception of Pain in Healthy Adults.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

Hawthorne S, Leonard T, McCrum-Gardner E, Johnson M, Rakel B, Sluka K, Hughes C, Moran F, Walsh D.  The effects of novel sham TENS device upon participant blinding.  Rehabilitation & Therapy Research Society Sixth Annual Conference, Ireland.  2010. 

Dailey D, Vance C, Liebano R, Anand A, Lee J, Rakel B, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) reduces pain and improves function in people with Fibromyalgia.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

Tonelli S, Lee J, Cooper N, Sluka K, Frantz R, Herr K, Clark C, Rakel B.  Validation of the knee injury and osteoarthritis outcomes score (KOOS) using accelerometry, pain, and function measures in preoperative total knee arthroplasty (TKR) patients.  13th World Congress on Pain, Montreal, Quebec, Canada.  2010. 

DeSantana J, DaSilva L, Sluka K.  Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.  Pain.  2010 January. 148(1):84-93.
[PubMed]

Rakel B, Cooper N, Adams H, Sluka K.  A New Transient Sham TENS Device Allows for Investigator Blinding While Delivering a True Placebo Treatment.  J Pain.  2009 November. 11(3):230-238.
[PubMed]

Sluka K.  Is it possible to develop an animal model of fibromyalgia?.  Pain.  2009 November. 146(1-2):3-4.
[PubMed]

DeSantana J, DaSilva L, DeResende M, Sluka K.  Transcutaneous Electrical Nerve Stimulation (TENS) at both high and low frequencies activates ventrolateral periaqueductal grey to decrease mechanical hyperalgesia in arthritic rats.  Neuroscience.  2009 November. 163(4):1233-1241.
[PubMed]

Sluka K, Winter O, Wemmie J.  Acid-sensing ion channels: A new target for pain and CNS diseases..  Curr Opin Drug Discov Devel.  2009 September. 12(5):693-704.
[PubMed]

Cowen S, McKenna J, McCrum-Gardner E, Johnson M, Sluka K, Walsh D.  An Investigation of the Hypoalgesic Effects of TENS Delivered By a Glove Electrode.  J Pain.  2009 July. 10(7):694-701.
[PubMed]

Radhakrishnan P, Sluka K.  Increased glutamate and decreased glycine release in the RVM during induction of a pre-clinical model of chronic widespread muscle pain.  N Lett.  2009 July. 457(3):141-145.
[PubMed]

Sluka K, Turk Dennis C.  Invited Commentary, Cognitive-Behavioral Therapy for Older Adults with Chronic Pain.  Physical Therapy.  2009 May. 89(5):470-473.
[PubMed]

Dannecker E, Cook D, Sluka K.  The relationship between pain and physical function in participants with fibromyalgia syndrome: influence of measurement methodology.  American Pain Society’s 286h Annual Scientific Meeting, San Diego, CA.  2009 May. 

Walsh D, Howe T, Johnson M, Sluka K.  Review: Transcutaneous electrical nerve stimulation for acute pain.  Cochrane Database of Systematic Reviews .  2009 April. 
[PubMed]

Walsh D, Johnson M, Howe T, Sluka K.  Transcutaneous electrical nerve stimulation for acute pain.  Cochrane Database of Systematic Reviews.  2009 April. 
[PubMed]

Ikeuchi M, Kolker S, Sluka K.  Acid sensing ion channel 3 expression in mice knee joint afferents and effects of carrageenan-induced arthritis.  J Pain.  2009 March. 10(3):336-342.
[PubMed]

Maeda Y, Lisi T, Vance C, Sluka K.  Release of GABA and activation of GABAA in the spinal cord mediates the effects of TENS in rats.  Br Research.  2009 March. 1136(1):43-50.
[PubMed]

Walder R, Benson C, Sluka K.  Acid-Sensing Ion Channels and Pain.  John Wiley and Sons.  2009. 

Da Silva L, Walder R, Wilson S, Sluka K.  Changes in expression of NMDA-NR1 receptors subunits in rostral ventromedial medulla modulate muscle and cutaneous hyperalgesia mediated by repeated intramuscular injections of acidic saline.  Society for Neuroscience Annual Meeting.  2009. 

Sluka K, Rasmussen L.  Fatigue enhances response to pain through a central mechanism.  APTA Combined Sections Meeting.  2009. 

Da Silva L, Rasmussen L, Sluka K.  Fatigue Enhances the Response to Pain through NMDA Receptors in Nucleus Raphe Obscurus.  College of Rheumatology Annual Meeting.  2009. 

Walder R, Rasmussen L, Radhakrishnan R, Wilson S, Sluka K.  Thermal and Mechanical Responses in TRPV1-/- Mice with Site Specific Expression of TRPV1.  Society for Neuroscience Annual Meeting.  2009. 

DeSantana J, Sluka K, Lauretti G.  High and low frequency TENS reduce postoperative pain intensity after laparoscopic sterilization for tubal ligation: a randomized controlled trial.  Clinical J Pain.  2009 January. 25(1):12-19.
[PubMed]

Maeda Y, Ikeuchi M, Wacnik P, Sluka K.  Increased c-fos immunoreactivity in the spinal cord and brain following spinal cord stimulation is frequency-dependent.  Brain Res .  2009 January. 1259(9):40-50.
[PubMed]

DeSantana J, Walsh D, Vance C, Rakel B, Sluka K.  Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain..  Curr Rheumatol .  2008 December. 10(6):492-499.
[PubMed]

Arendt-Nielsen L, Sluka K, Hie H.  Experimental muscle pain impairs descending inhibition.  Pain.  2008 December. 140(3):465-471.
[PubMed]

Frey Law L, Sluka K, McMullen T, Lee J, Arendt-Neilsen L, Graven-Nielsen T.  Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans.  Pain.  2008 November. 140(2):254-264.
[PubMed]

Da Silva L, De Santana J, Sluka K.  Activation of NMDA receptors in the brainstem, RVM and Gi mediate hyperalgesia produced by repeated intramuscular injections of acidic saline.  Society for Neuroscience.  2008 November. 

Walder R, Rasmussen L, Rainier J, Light A, Wemmie J, Sluka K.  ASIC1 and ASIC3 Play Different Roles in the Development of Hyperalgesia Following Inflammatory Muscle Injury.  Society for Neuroscience.  2008 November. 

De Resende M, Arendt-Nielsen L, Sluka K.  Hyperalgesia modulation by an endogenous diffuse noxious inhibitory control in rats.  Society for Neuroscience.  2008 November. 

de Santana J, Sluka K.  Central mechanisms in the maintenance of chronic widespread non-inflammatory muscle pain.  Curr Pain Headache Rep.  2008 October. 12(5):338-343.
[PubMed]

McKenna J, Cowan S, Gardner E, Hunter R, Johnson M, Sluka K, Walsh D.  A comparison of the hypoalgesic effects of TENS using two different electrodes.  12th World Congress on Pain, International Association for the Study of Pain, Scotland.  2008 August. 

Frey Law L, Sluka K, McMullen T, Lee J, Arendt-Nielsen L, Graven-Nielsen T.  Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans.  12th World Congress on Pain, International Association for the Study of Pain, Scotland.  2008 August. 

Maeda Y, Ikeuchi M, Wacnik P, Sluka K.  c-fos immunoreactivity in the spinal cord and brain following spinal cord stimulation in SNI model.  12th World Congress on Pain, International Association for the Study of Pain, Scotland.  2008 August. 

Vance C, Rakel B, Blodgett N, DeSantana J, Amendola A, Walsh D, Frey Law L, Sluka K.  Effects of high and low frequency tens on knee osteoarthritis pain.  International Association for the Study of Pain, Scotland.  2008 August. 

Maeda Y, Wacnik P, Sluka K.  Low frequencies, but not high frequencies of bi-polar spinal cord stimulation reduce cutaneous and muscle hyperalgesia induced by nerve injury.  Pain.  2008 August. 138(1):143-152.
[PubMed]

Ikuechi M, Kolker S, Burnes L, Walder R, Sluka K.  Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice.  Pain.  2008 July. 137(3):662-669.
[PubMed]

Frey Law L, Evans S, Knudtson J, Nus S, Scholl K, Sluka K.  Massage reduces pain perception and hyperalgesia in experimental muscle pain: a randomized, controlled trial.  J Pain.  2008 May. 9(8):714-721.
[PubMed]

Frey Law L, Sluka K.  More Women than Men Experience Referred Pain in an Experimental Model of Muscle Pain.  American Pain Society (APS) 27th Annual Scientific Meeting, Tampa FL.  2008 May. 

Burnes L, Kolker S, Danielson J, Walder R, Sluka K.  Enhanced muscle fatigue occurs in male but not female ASIC3 -/- mice.  Am J Physiol Regul Integr Comp Physiol.  2008 April. 294(4):R1347-R1355.
[PubMed]

de Santana J, Santana-Filho V, Guerra D, Sluka K, Gurgel R, da Silva Jr. W.  Hypoalgesic effect of the transcutaneous electrical nerve stimulation following inguinal herniorrhaphy: A randomized controlled trial.  J Pain.  2008 April. 9(7):623-629.
[PubMed]

De Santana J, Santana-Filho V, Sluka K.  Modulation between high- and low- frequency transcutaneous electrical nerve stimulation delays the development of analgesic tolerance in arthritic rats.  Arch Phys Med Rehabil.  2008 April. 89(4):754-760.
[PubMed]

Frey Law L, McMullen T, Lee J, Sluka K, Graven-Nielsen T, Arendt-Nielsen L.  APTA Combined Sections Meeting.  APTA Combined Sections Meeting, Nashville, TN.  2008 February. 

Frey Law L, McMullen T, Lee J, Sluka K, Graven-Nielsen T, Arendt-Nielsen L.  Mechanical Hyperalgesia can Occur in Referred Pain Areas.  APTA Combined Sections Meeting, Nashville, TN.  2008 February. 

De Santana J, Sluka K.  Modulating frequency of TENS reduces development of analgesic tolerance.  APTA Combined Sections Meeting.  2008 February. 

Cooper N, Adams H, Sluka K.  New TENS placebo allows for the true double-blinding.  APTA Combined Sections Meeting.  2008 February. 

Sluka K, DeSantana J.  Antinociceptive effect of transcutaneous electrical nerve stimulation (TENS) is mediated by ventrolateral periaqueductal grey (VLPAG).  World Congress on Pain, Scotland.  2008. 

Walder R, Sluka K.  Bilateral, long-lasting hyperalgesia due to repeated excitation of muscle nociceptors: a role for ASIC3.  IASP Press.  2008. 

DeSantana J, Sluka K.  Blockade of cholecystokinin receptors prevents the development of analgesic tolerance to transcutaneous electrical nerve stimulation (TENS). .  World Congress on Pain, Scotland.  2008. 

DeSantana J, Sluka K.  Blockade of NMDA receptors in the RVM reverses hyperalgesia in chronic muscle pain.  27th Annual Scientific Meeting of the American Pain Society, J Pain Supplement.  2008. 

Walder R, Sluka K.  Centering on central mechanisms in the development and maintenance of chronic widespread muscle pain.  J Musculoskeletal Pain.  2008. 16(1-2):107-113.

Sluka K, Skyba D, Hoeger Bement M, Audette K, Radhakrishnana R.  Chapter 17: Second messenger pathways in pain..  Higher Education Press.  2008. 

Sluka K, Westlund K.  Neurological Regulation of Inflammation.  2008. 

DeSantana J, Sluka K.  Pharmacological and non-pharmacological strategies for preventing analgesic tolerance to TENS.  27th Annual Scientific Meeting of the American Pain Society, J Pain Supplement.  2008. 

McNearney T, Sluka K, Reveille J, Fischbach M, Ahn C, Mayes M.  Plasma endogenous enkephalin levels in systemic sclerosis patients.  American Society for Pain Annual Meeting, Tampa, FL.  2008. 

Hingne P, Sluka K.  Blockade of NMDA receptors prevents analgesic tolerance to repeated transcutaneous electrical nerve stimulation (TENS) in rats.  J Pain.  2007 December. 9(3):217-225.
[PubMed]

Sluka K.  Central mechanisms underlying muscle pain.  2007 December. 

Sluka K.  Chronic muscle pain models and mechanisms including spinal cord.  International Muscle Pain Symposium, Aichi University, Nagoya, Japan.  2007 December. 

Walder R, Kolker S, Burnes L, Sluka K.  ASIC3 and hyaluronan are important for the development of mechanical hyperalgesia after joint inflammation.  Society for Neuroscience, San Diego, CA.  2007 November. 

Kolker S, Walder R, Sluka K.  ASIC3 and hyaluronan interactions within the mouse knee joint. .  Society for Neuroscience, San Diego, CA.  2007 November. 

Price M, Hattori T, Burnes L, Sluka K.  ASIC3 overexpression enhances thermal sensitivity in transgenic mice.  Society for Neuroscience, San Diego, CA.  2007 November. 

Yokoyama T, Ushida T, Yamasaki F, Inoue S, Sluka K.  Epidural puncture can be confirmed by the Queckenstedt-test procedure in patients with cervical spinal canal stenosis.  Acta Anaesthesiol Scand.  2007 November. 52(2):265-261.
[PubMed]

Sluka K.  The role of ASIC3 in muscle pain mini symposia. Emerging Roles of Acid-Sensing Ion Channels in Neurological and Psychiatric Disorders.  Society for Neuroscience, San Diego, CA.  2007 November. 

Tillu D, Gebhart G, Sluka K.  Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult.  Pain .  2007 August. 136(3):331-339.
[PubMed]

Yokoyama T, Lisi T, Moore S, Sluka K.  Muscle fatigue increases the probability of developing hyperalgesia in mice.  J Pain.  2007 July. 8(9):692-699.
[PubMed]

Frey Law L, Sluka K, Hunstad T, Lee J, Graven-Nielsen T.  Acidic buffer induced referred pain associated with mechanical hyperalgesia.  IASP Research Symposium 2007, Aalborg, Denmark.  2007 May. 

Sluka K, Radhakrishnan R, Benson C, Price M.  ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation.  Pain.  2007 May. 129(1-2):102-112.
[PubMed]

Kolker S, Maeda Y, Burnes L, Sluka K.  ASIC3 plays a role in development of mechanical hyperalgesia in the inflamed joint and is located in type B synoviocytes.  American Pain Society Annual Meeting, Washington DC.  2007 May. 

Maeda Y, Lisi T, Kolker S, Sluka K.  Decreased glutamate in the muscle or skin after infusion of acidic saline.  American Pain Society Annual Meeting, Washington DC.  2007 May. 

Yokoyama T, Maeda Y, Audette K, Sluka K.  Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats.  J Pain.  2007 May. 8(5):422-429.
[PubMed]

Frey Law L, Hunstad T, Lee J, Arendt-Nielsen L, Graven-Nielsen T, Sluka K.  Primary and referred experimental muscle pain produces ipsilateral mechanical hyperalgesia.  American Pain Society Annual Meeting, Washington DC.  2007 May. 

Yokoyama T, Sadahiro T, Sluka K, Yamashita K, Tokoroyama H, Manabe M.  Tethered cord syndrome discovered in preoperative examination.  J Anesth.  2007 May. 21(2):270-272.
[PubMed]

Moss P, Sluka K, Wright A.  The initial effects of knee joint mobilization on osteoarthritic hyperalgesia.  J Manip Ther .  2007 May. 12(2):109-118.

Bement M, Sluka K.  Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model.  Neuroscience Letters.  2007 March. 418(1):22-27.
[PubMed]

Hingne P, Sluka K.  Differences in waveform characteristics have no effect on the anti-hyperalgesia produced by transcutaneous electrical nerve stimulation (TENS) in rats with joint inflammation.  J Pain.  2007 March. 8(3):251-255.
[PubMed]

Sluka K, Evans S, Knudtson J, Nus S, Scholl K, Frey Law L.  Massage Reduces Pain Perception and Hyperalgesia in Experimental Muscle Pain in Human Subjects.  APTA Combined Sections Meeting.  2007 February. 

Hoeger Bement M, Sluka K.  Pain: Perception and mechanisms.  Saunders-Elsevier Health Sciences.  2007. 

Sluka K.  The Neurobiology of Pain and Foundations for Electrical Stimulation for Pain Control.  AJ Robinson and L Snyder-Mackler .  2007. 

Vance C, Radhakrishnan R, Skyba D, Sluka K.  Transcutaneous electrical nerve stimulation at both high and low frequencies reduces primary hyperalgesia in rats with joint inflammation in a time-dependent manner.  Phys Ther.  2007 January. 87(1):44-51.
[PubMed]

Sluka K, Yokoyama T, Lisi T, Moore S.  Muscle fatigue enhances mechanical hyperalgesia induced by intramuscular acid injections in mice.  Society for Neuroscience.  2006 November. 

Hingne P, Sluka K.  NMDA receptor blockade prevents analgesic tolerance to transcutaneous electrical nerve.  Society for Neuroscience.  2006 November. 

Tillu D, Gebhart G, Sluka K.  Descending facilitatory pathways from the RVM initiate bilateral hyperalgesia after muscle insult.  Society for Neuroscience.  2006 October. 

Yokoyama T, Yamashita K, Manabe M, Sluka K.  Tracheobronchomalacia-like lung collapse during three separate trials of general anesthesia.  Anesth Analg.  2006 October. 103(4):1039-1040.
[PubMed]

Sluka K, Lisi T, Westlund K.  Increased release of serotonin in the spinal cord during low, but not high, frequency TENS in rats with joint inflammation.  Arch Phys Med Rehab.  2006 August. 87(8):1137-1140.
[PubMed]

Sluka K, Skyba D, Radhakrishnan R, Leeper B, Wright A.  Joint mobilization reduces hyperalgesia associated with chronic muscle and joint inflammation in rats.  J Pain.  2006 August. 7(8):602-607.
[PubMed]

Yokoyama T, Sluka K, Yamashita K, Hosoi R, Kiyooka R, Manabe M.  Analgesic effect of jet injection of different concentrations of lidocaine for IV cannulation pain.  Annual Meeting of European Society of Anesthesiology, Madrid, Spain.  2006 June. 

Mendoza S, Rubio R, Bartelt R, Kim J, Stevens J, Kurriger G, Lisi T, Lim T, Sluka K.  Anterior annular laceration induces more consistent pain behaviors in rats when compared to posterior annular laceration.  The 33rd Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS), Bergen, Norway.  2006 June. 

Yagi-Chaves S, Yokoyama T, Sluka K, Yamashita K, Kiyooka R, Manabe M.  Infusion of 1% glucose and magnesium during surgery maintains serum magnesium concentration and prevents catabolism.  Annual Meeting of European Society of Anesthesiology, Madrid, Spain.  2006 June. 

Yokoyama T, Kiyooka R, Sluka K, Hosoi R, Yamashita K, Manabe M.  Oral intake of amino acid reduces hypothermia during anesthesia in rats.  Annual Meeting of European Society of Anesthesiology, Madrid, Spain.  2006 June. 

Yokoyama T, Sluka K.  Pregabalin reduces primary and secondary hyperalgesia in a rat model of chronic noninflammatory muscle pain..  Annual Meeting of European Society of Anesthesiology, Madrid Spain.  2006 June. 

Yokoyama T, Sluka K.  The 33rd Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS), Bergen, Norway.  Annual Meeting of European Society of Anesthesiology, Madrid, Spain.  2006 June. 

Hingne P, Sluka K.  Differences in waveform characteristic has no effect on the antihyperalgesia produced by TENS in rats with joint inflammation.  The American Pain Society’s 25th Annual Scientific Meeting, San Antonio, TX.  2006 May. 

Yokoyama T, Audette K, Sluka K.  Pregabalin reduces primary and secondary hyperalgesia in a rat model of chronic muscle inflammation.  The American Pain Society’s 25th Annual Scientific Meeting, San Antonio, TX.  2006 May. 

Sluka K, Audette K.  Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia.  Mol Pain .  2006 April. 2:13.

Vance C, Radhakrishnan R, Skyba D, Sluka K.  Effects of TENS on acute and chronic primary hyperalgesia induced by knee joint inflammation in rats.  Combined Sections Meeting, San Diego, CA.  2006 February. 

Vadakkan K, Wang H, Ko S, Zastepa E, Petrovic M, Sluka K, Zhuo M.  Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases.  Mol Pain.  2006 February. 2:7.
[PubMed]

Ainsworth L, Budelier K, Leeper B, Ross J, Sluka K.  Low or high frequency TENS reduces chronic inflammatory muscle hyperalgesia in the rat.  Combined Sections Meeting, San Diego, CA.  2006 February. 

Moss P, Sluka K, Wright A.  IASP Press.  IASP Press.  2006. 

Sluka K, Westlund K.  Nocifensive behaviors (muscle and joint).  2006. 

Sluka K.  Opioids and muscle pain.  2006. 

Moss P, Sluka K, Wright A.  Passive joint movement produces local and widespread hypoalgesic effects in subjects with knee osteoarthritis. .  IASP Press.  2006. Chapter 73.

Sluka K, Wu G, Chung J.  Recent insights into analgesic mechanisms of acupuncture and TENS.  IASP Press.  2006. 

Sluka K.  TENS, mechanisms of action.  2006. 

Lisi T, Sluka K.  A new electrochemical HPLC method for analysis of enkelphalins and endomorphins.  J Neurosci Methods.  2006 January. 150(1):74-79.
[PubMed]

Sluka K, Vance C, Lisi T.  High-frequency, but not low-frequency, transcutaneous electrical nerve stimulation reduces aspartate and glutamate release in the spinal cord dorsal horn.  J Neurochem.  2005 December. 95(6):1794-1801.
[PubMed]

Radhakrishnan R, Gehlmann K, Sluka K.  Changes in nuclear protein expression in the RVM in an animal model of non-inflammatory musculoskeletal Pain.  Society for Neuroscience.  2005 November. 

Skyba D, Lisi T, Sluka K.  Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injections of acidic saline.  Pain.  2005 November. 119(1-3):142-149.
[PubMed]

McKim R, Sluka K, Radhakrishnan R, Wemmie J, Bonthius D, Pantazis N.  Nitric oxide (NO) mediates formalin-induced peripheral and centrally mediated nociception.  Society for Neuroscience, Washington, DC.  2005 November. 

Ainsworth L, Budelier K, Clinesmith M, Fiedler A, Landstrom R, Leeper B, Moeller L, Mutch S, O'Dell J, Ross J, Radhakrishnan R, Sluka K.  Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation.  Pain.  2005 November. 120(1-2):182-187.
[PubMed]

Radhakrishnan R, Sluka K.  Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-induced antihyperalgesia.  J Pain.  2005 October. 6(10):673-680.
[PubMed]

Bement M, Sluka K.  Low-intensity exercise reverses chronic muscle pain in the rat in a naloxone-dependent manner.  Arch Phys Med Rehabil.  2005 September. 86(9):1736-1740.
[PubMed]

Sluka K, Radhakrishnan R, Audette K, Price M, Yeomans D, Wilson S, Welsh M.  ASIC3 mediates mechanical but not heat hyperalgesia after muscle inflammation.  11th World Congress on Pain, Sydney, Australia.  2005 August. 

Skyba D, Sluka K.  Enhanced glutamate release in the spinal cord in a model of chronic musculoskeletal pain.  11th World Congress on Pain, Sydney, Australia.  2005 August. 

Moss P, Wright A, Sluka K.  Passive joint movement produces local and widespread hypoalgesic effects in subjects with knee osteoarthritis.  11th World Congress on Pain, presentations/ abstracts, Sydney, Australia.  2005 August. 

Sluka K.  Recent insights into analgesic mechanisms of acupuncture and TENS, Invited speaker.  11th World Congress on Pain, Sydney, Australia.  2005 August. 

Carlson E, Audette K, Altman G, Nguyen H, Sluka K, Fairbanks C.  Transcutaneous electrical nerve stimulation activates peripherally located alpha 2A adrenergic receptors.  Pain.  2005 June. 115(3):364-373.
[PubMed]

Radhakrishnan R, Sluka K.  Acetazolamide, a carbonic anhydrase inhibitor, reverses inflammation-induced thermal hyperalgesia in rats.  J Pharmacol Exp Ther .  2005 May. 313(2):921-927.
[PubMed]

Lisi T, Vance C, Sluka K.  High frequency TENS reduces glutamate release and low frequency increases GABA release in the spinal dorsal horn.  Combined Sections Meeting, APTA, New Orleans, LA.  2005 February. 

Skyba D, Radhakrishnan R, Sluka K.  Characterization of a method for measuring primary hyperalgesia of deep somatic tissue.  J Pain .  2005. 6(1):41-47.
[PubMed]

Sluka K, Radhakrishnan R.  Chronic musculoskeletal pain: Preclinical models and drug discovery.  Indian Pharmaceutical Forum Proceedings.  2005. 

Lisi T, Sluka K.  A new HPLC method to measure enkephalins and endomorphins.  Society for Neuroscience, San Diego, CA.  2004 October. 

Radhakrishnan R, Sluka K.  Carbonic anhydrase inhibition reverses inflammation-induced secondary hyperalgesia in rats.  Society for Neuroscience, San Diego, CA.  2004 October. 

Skyba D, Radhakrishnan R, Sluka K.  Characterization of a method for measuring primary hyperalgesia of deep somatic tissue.  Society for Neuroscience, San Diego, CA.  2004 October. 

Skyba D, Radhakrishnan R, Hoeger Bement M, Sluka K.  AC-cAMP pathway and pain: Potential targets for drug development.  Drug Discovery Today .  2004. 1:115-119.

Radhakrishnan R, Bement M, Skyba D, Kehl L, Sluka K.  Models of muscle pain: Carrageenan model and acidic saline model.  John Wiley & Sons.  2004. 

Sluka K, Price M, Wemmie J, Welsh M.  The ASIC3, but not the ASIC1 channel is involved in chronic muscle pain.  IASP Press.  2004. 

Sluka K, Price M, Breese N, Stucky C, Wemmie J, Welsh M.  Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.  Pain.  2003 December. 106(3):229-239.
[PubMed]

Radhakrishnan R, Sluka K.  Spinal muscarinic receptors are activated during low or high frequency TENS-induced antihyperalgesia in rats.  Neuropharmacology.  2003 December. 45(8):1111-1119.
[PubMed]

Audette K, Sluka K.  Activation of peripheral a2 adrenergic receptors reduces hyperalgesia and mediates TENS antihyperalgesia following knee joint inflammation in mice.  Society for Neuroscience.  2003 November. 

Radhakrishnan R, Price M, Welsh M, Sluka K.  Differential roles of ASIC3 and TRPV1 receptors in inflammatory muscle hyperalgesia.  Society for Neuroscience.  2003 November. 

Skyba D, Radhakrishnan R, Rohlwing J, Wright A, Sluka K.  Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.  Pain .  2003 November. 106(1-2):159-168.
[PubMed]

Hoeger M, Sluka K.  Quantification of p-NR1 in chronic muscle pain and colocalization of p-NR1 and p-CREB with spinothalamic tract cells.  Society for Neuroscience.  2003 November. 

Skyba D, Hoeger-Bement M, Buttjer M, Hanfelt C, Lander R, Stelk C, Sluka K.  Spinal administration of 8-bromo-cAMP produces NMDA receptor-dependent hyperalgesia.  Society for Neuroscience.  2003 November. 

Radhakrishnan R, King E, Dickman J, Herold C, Johnston N, Spurgin M, Sluka K.  Spinal 5-HT2 and 5-HT3 receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats.  Pain .  2003 September. 105(1-2):205-213.

Radhakrishnan R, Moore S, Sluka K.  Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats..  Pain.  2003 August. 104(3):567-577.
[PubMed]

Hoeger Bemet M, Sluka K.  Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.  J Neurosci .  2003 July. 23(13):5437-5445.
[PubMed]

Lisi T, Westlund K, Sluka K.  Comparison of microdialysis and push-pull perfusion for retrieval of serotonin and norepinephrine in the spinal cord dorsal horn.  J Neurosci Meth .  2003 June. 126(2):187-194.
[PubMed]

Saito F, Moore S, Barresi R, Henry M, Messing A, Ross-Barta S, Cohn R, Williamson R, Sluka K, Sherman D, Brophy P, Schmelzer J, Low P, Wrabetz L, Feltri M, Campbell K.  Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization.  Neuron .  2003 June. 38(5):747-758.
[PubMed]

Sluka K, Walsh D.  TENS: basic science mechanisms and clinical effectiveness.  J Pain .  2003 April. 4(3):109-121.
[PubMed]

Chandran P, Sluka K.  Development of opioid tolerance with repeated TENS administration.  Pain.  2003 March. 102(1-2):195-201.
[PubMed]

Hoeger M, Sluka K.  Low intensity exercise reverses chronic muscle hyperalgesia in rats and is prevented with naloxone.  American Physical Therapy Association Combined Sections Meeting.  2003 February. 

Hoeger Bement M, Sluka K.  Chronic muscle hyperalgesia is reversed by low intensity exercise which is prevented by naloxone.  American Pain Society 22nd Annual Scientific Meeting.  2003. 

Sluka K, Radhakrishnan R.  Knee joint afferents, but not cutaneous afferents, are required for the antihyperalgesia produced by TENS.  American Pain Society 22nd Annual Scientific Meeting.  2003. 

Sodhi S, Lisi T, Westlund K, Sluka K.  Low frequency TENS increases serotonin (5-HT) in dorsal horn of inflamed rats.  American Pain Society 22nd Annual Scientific Meeting.  2003. 

Hoeger Bement M, Skyba D, Radhakrishnan R, Sluka K.  Review: Central sensitization and musculoskeletal pain.  Seminars in Pain Medicine .  2003. 1(3):139-149.

Radhakrishnan R, Sluka K.  Role of spinal cholinergic receptors in TENS-induced antihyperalgesia.  American Pain Society 22nd Annual Scientific Meeting.  2003. 

Sluka K, Chandran P.  Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS.  Pain .  2002 November. 100(1-2):183-190.
[PubMed]

Zahn P, Sluka K, Brennan T.  Excitatory amino acid release in the spinal cord caused by plantar incision in the rat.  Pain .  2002 November. 100(1-2):65-76.
[PubMed]

Sluka K, Rohlwing J, Bussey R, Eikenberry S, Wilken J.  Chronic muscle pain induced by repeated acid injection is reversed by spinally administered - and -, but not -, opioid receptor agonists.  J Pharmacol Exp Ther .  2002 September. 302(3):1146-1150.
[PubMed]

Skyba D, Sluka K.  American Pain Society Abstracts.  International Association for the Study of Pain.  2002 August. 

Skyba D, Sluka K.  Changes in GluR1 expression in the dorsal horn of the rat spinal cord in chronic muscle-induced hyperalgesia..  International Association for the Study of Pain.  2002 August. 

Hoeger H, Sluka K.  Increased phosphorylation of CREB and reversal by blockade of adenylate cyclase in a chronic muscle pain model in the rat.  International Association for the Study of Pain.  2002 August. 

Wright A, Sluka K.  Knee joint mobilization reduces hyperalgesia induced by capsaicin injection into the ankle joint.  International Association for the Study of Pain.  2002 August. 

Sluka K.  Pain and Physical Therapy. Mechanisms, Movement Measurement and Management Professional Development.  International Association for the Study of Pain.  2002 August. 

Sluka K, Price M, Wemmie J, Welsh M.  The DRASIC, but not ASIC1, channel is required for development of chronic muscle pain.  International Association for the Study of Pain.  2002 August. 

Skyba D, King E, Sluka K.  Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline.  Pain .  2002 July. 98(1-2):69-78.
[PubMed]

Sluka K.  Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway.  J Neuroscience.  2002 July. 22(13):5687-5693.
[PubMed]

Skyba D, Rohlwing J, Wright A, Sluka K.  Joint manipulation reduces secondary mechanical hyperalgesia induced by intraarticular injection of capsaicin.  American Pain Society Abstracts.  2002 March. 

King E, Nguyen H, Fairbanks C, Sluka K.  Adrenergic receptors are activated by transcutaneous electrical nerve stimulation.  International Association Study of Pain.  2002. 

Sluka K, Hoeger M, Skyba D.  Basic science mechanisms of physical therapy treatmens for pain.  IASP Press.  2002. 

Lisi T, Westlund K, Sluka K.  Comparison of push-pull versus microdialysis for measurement of catecholamines.  Society for Neuroscience.  2002. 

Radhakrishnan R, Dickman J, Richtsmeier C, Schardt N, Spurgin M, Sluka K.  Involvement of 5-HT receptor subtypes in TENS-induced analgesia.  Society for Neuroscience.  2002. 

Sluka K, Moore S, Lisi T, Radhakrishnan K.  Long-term hyperalgesia and histological changes in rats injected with carrageenan into joint or muscle.  Society for Neuroscience.  2002. 

Price M, McIlwrath S, Xie J, Cheng C, Qioa J, Tarr D, Sluka K, Brennan T, Lewin G, Welsh M.  The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice.  Neuron .  2001 December. 32(6):1071-1083.
[PubMed]

Skyba D, Sluka K.  Changes in amino acid concentration in the dorsal horn of the rat lumbar spinal cord after repeated intramuscular injection of acidic saline.  Soc Neurosci Abstr.  2001 November. 

Lisi T, Sluka K.  Release of aspartate and glutamate in the dorsal horn is decreased during treatment with TENS.  Soc Neurosci Abstr.  2001 November. 

Price M, McIlwrath S, Xie J, Cheng C, Qiao J, Sluka K, Brennan T, Johnson W, Lewin G, Welsh M.  The DRASIC channel subunit functions in detection of touch and acid.  Soc Neurosci Abstr.  2001 November. 

Welsh M, Price M, Sluka K.  The mammalian DEG/ENaC Na+ channels BNC1 and DRASIC are essential molecular components of cutaneous sensation.  J Physiol.  2001 November. 

Hoeger H, Sluka K.  The role of the cAMP pathway in a chronic muscle pain model in rats.  Soc Neurosci Abstr.  2001 November. 

Kalra A, Urban M, Sluka K.  Blockade of opioid receptors in the rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).  J Pharmacol Exp Ther .  2001 July. 298(1):257-263.
[PubMed]

Skyba D, King E, Sluka K.  Effects of an NMDA receptor antagonist on the development and maintenance of mechanical hyperalgesia induced by intramuscular injection of acidic saline. .  American Physical Therapy Association Annual Conference and Exposition, Anaheim, CA.  2001 June. 

Chandran P, Sluka K.  Systemic administration of clonidine in combination with TENS produces an increased antihyperalgesia in rats.  American Physical Therapy Association Annual Conference and Exposition, Anaheim, CA.  2001 June. 

King E, Sluka K.  The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on the treatment of secondary mechanical hyperalgesia in an animal model of inflammation.  J Pain .  2001 April. 2:128-133.
[PubMed]

Wright A, Sluka K.  Non-pharmacological treatments for musculoskeletal pain.  Clin J Pain .  2001 March. 17(1):33-46.
[PubMed]

Ma Y, Sluka K.  Reduction in inflammation-induced sensitization of dorsal horn neurons by transcutaneous electrical nerve stimulation in anesthetized rats.  Exp Brain Res .  2001 February 8. 137(1):94-102.
[PubMed]

Sluka K, Bussy B, Eikenberry S, Lewallen Rohlwing J, Wilken J.  Intrathecal morphine reduces mechanical hyperalgesia induced by repeated intramuscular injections of pH 4.0 saline.  American Pain Society Abstracts.  2001. 

Sluka K, Wright A.  Knee joint mobilization reduces secondary mechanical hyperalgesia induced by capsaicin injection into the ankle joint.  Europ J Pain .  2001. 5(1):81-87.
[PubMed]

Chandran P, Sluka K.  Systemic administration of clonidine in combination with TENS produces an increased antihyperalgesia in rats.  American Pain Society Abstracts.  2001. 

Sluka K.  The basic science mechanisms of TENS and clinical implications.  APS Bulletin .  2001. 1:10-13.

Patterson S, Sluka K, Arnold M.  A novel transverse push-pull micro-probe: in vitro characterization and in vivo demonstration of the enzymatic production of adenosine in the spinal cord dorsal horn.  J Neurochem .  2001 January. 76(1):234-246.
[PubMed]

Sluka K, Kalra A, Moore S.  Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia.  Muscle & Nerve .  2001 January. 24(1):37-46.
[PubMed]

Wright A, Sluka K.  Evidence of manipulation-induced analgesia in an animal model of inflammatory pain. International Federation of Orthopaedic Manipulative Therapists (IFOMT) .  Perth Western Australia.  2000 November. 

Gopalkrishnan P, Sluka K.  Effect of varying frequency and intensity of TENS on primary hyperalgesia in rats.  Arch Phys Med Rehabil .  2000 July. 81(7):984-990.
[PubMed]

Kalra A, Urban M, Sluka K.  Blockade of mu-opioid receptors in the rostral ventral medulla (RVM) prevents antihyperalgesia produced by low frequency but not high frequency TENS.  APTA Annual Conference.  2000. 

Sluka K.  Development and time course of secondary heat and mechanical hyperalgesia following capsaicin or carrageenan injection of muscle, joint and skin.  Soc Neurosci Abstr.  2000. 

Skyba D, King E, Sluka K.  Effects of NMDA and non-NMDA receptor antagonists on the development and maintenance of mechanical hyperalgesia induced by intramuscular injection of acidic saline.  Soc Neurosci Abstr.  2000. 

Sluka K, Judge M, McColley M, Reveiz P, Taylor B.  Low frequency TENS is less effective than high frequency TENS at reducing inflammation induced hyperalgesia in morphine tolerant rats.  Europ J Pain .  2000. 4(2):185-193.
[PubMed]

Sluka K, Judge M, McColley M, Reveiz P, Taylor B.  Low frequency, but not high frequency, TENS is less effective in reducing hyperalgesia in morphine tolerant rats with arthritis.  APTA Annual Conference.  2000. 

Sluka K.  Systemic morphine in combination with TENS produces an increased analgesia in rats with acute inflammation.  J Pain.  2000. 1(3):204-211.
[PubMed]

Ma Y, Sluka K.  TENS (transcutaneous electrical nerve stimulation) activates off-cells located in the rostral ventral medulla (RVM) in rats.  Soc Neurosci Abstr.  2000. 

Sluka K, Deacon M, Stribal A, Strissel S, Terpstra A.  Spinal blockade of opioid receptors prevents the analgesia produced by TENS in arthritic rats.  J Pharm Exp Ther .  1999 May. 289(2):840-846.
[PubMed]

Sluka K, Christy M, Peterson W, Rudd S, Troy S.  Reduction of pain-related behaviors with either cold or heat treatment in an animal model of acute arthritis.  Arch Phys Med Rehabil .  1999 March. 80(3):313-317.
[PubMed]

Sluka K, Kalra A, Moore S.  A new model of chronic muscle pain.  Soc Neurosci Abstr.  1999. 

Sluka K.  Combined effects of TENS and systemic morphine on primary hyperalgesia in inflamed rats.  9th World Congress on Pain, Vienna, Austria.  1999. 

Ma Y, Sluka K.  High and low frequency TENS reduces inflammation-induced sensitization of wide dynamic range and high threshold dorsal horn neurons in rats.  Soc Neurosci Abstr.  1999. 

Kalra A, Urban M, Sluka K.  The role of the rostral ventral medulla (RVM) in TENS antihyperalgesia.  Soc Neurosci Abstr.  1999. 

Patterson S, Sluka K, Arnold M.  Transverse push pull microprobe for sampling extracellular fluid in the dorsal horn of the spinal cord.  Soc Neurosci Abstr.  1999. 

Sluka K.  Blockade of N- and P/Q-type calcium channels reduces the secondary heat hyperalgesia induced by acute inflammation.  J Pharmacol Exp Ther .  1998 October. 287(1):232-237.
[PubMed]

Rees H, Sluka K, Urban L, Walpole C, Willis W.  The effects of SDZ NKT 343, a potent NK1 receptor antagonist on cutaneous responses of primate spinothalamic tract neurons sensitized by intradermal injection of capsaicin.  Brain Res.  1998 August. 121(3):355-358.
[PubMed]

Sluka K, Willis W.  Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor.  Brain Res .  1998 July. 798(1-2):281-286.
[PubMed]

Sluka K, Bailey K, Bogush J, Olson R, Ricketts A.  Treatment with either high or low frequency TENS reduces the secondary hyperalgesia observed after injection of kaolin and carrageenan into the knee joint.  Pain .  1998 July. 77(1):97-102.
[PubMed]

Willis W, Sluka K, Rees H, Westlund K.  A contribution of dorsal root reflexes to peripheral inflammation.  Oxford University Press.  1998. 

Sluka K, Deacon M, Stibal A, Strissel S, Terpstra A.  Analgesia produced by high and low frequency transcutaneous electrical nerve stimulation (TENS) is blocked by opioid receptor antagonists in arthritic rats.  Soc Neurosci Abstr.  1998. 

Patterson S, Sluka K, Arnold M.  Capsaicin induced hyperalgesia is reversed by adenosine precursors delivered to the spinal cord.  Soc Neurosci Abstr.  1998. 

Kostarczyk E, Sluka K, Gebhart G.  Referred pain induced by capsaicin injection in the rat gastric artery.  American Gastrointestinal Association.  1998. 

Zahn P, Sluka K, Brennan T.  Spinal excitatory amino acid (EAA) release in a rat model for postoperative pain.  Soc Neurosci Abstr.  1998. 

Gopalkrishnan P, Sluka K.  TENS reduces primary hyperalgesia and dorsal horn neuron sensitization in rats.  Soc Neurosci Abstr.  1998. 

Sluka K.  Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin.  Br J Pharm .  1997 November. 122(6):1165-1173.
[PubMed]

Sluka K, Rees H, Chen P, Tsuruoka M, Willis W.  Capsaicin induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor.  Brain Res .  1997 October 24. 772(1-2):82-86.
[PubMed]

Sluka K.  Mecanismos del dolor implicados en los trastornos musculoesqueleticos.  Focus on Inflammatory Diseases & Pain Treatment.  1997 October. 2(2):39-40.

Sluka K.  Blockade of calcium channels can prevent the onset of secondary hyperalgesia and allodynia induced by intradermal injection of capsaicin in rats.  Pain .  1997 June. 71(2):157-164.
[PubMed]

Sluka K, Rees H, Chen P, Tsuruoka M, Willis W.  Inhibitors of G-proteins and protein kinases reduce the sensitization to mechanical stimulation & the desensitization to heat of spinothalamic tract neurons to induced intradermal injection of capsaicin in the primate.  Exp Brain Res .  1997 June. 115(1):15-24.
[PubMed]

Sluka K, Willis W.  The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.  Pain .  1997 June. 71(2):165-178.
[PubMed]

Sluka K, Milton M, Westlund K, Willis W.  Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation.  Br J Pharm .  1997 April. 120(7):1263-1273.
[PubMed]

Sluka K, Rees H.  The neuronal response to pain.  Physiother Theory and Practice .  1997. 13(1):3-22.

Sluka K.  The role of the P-type calcium channel in central sensitization of dorsal horn neurons induced by capsaicin injection in rats.  Soc Neurosci Abstr.  1997. 

Rees H, Sluka K, Lu X, Westlund K, Willis W.  Dorsal root reflexes in articular afferents occur bilaterally in a chronic model of arthritis in rats.  J Neurophysiol .  1996 December. 76(6):4190-4193.
[PubMed]

Sluka K.  Pain mechanisms involved in musculoskeletal disorders.  J Orthop Sports Phys Ther .  1996 October. 24(4):240-254.
[PubMed]

Sluka K.  Blockade of calcium channels reduces capsaicin-induced mechanical allodynia and hyperalgesia.  8th World Congress on Pain.  1996 August. 

Chen P, Sluka K, Rees H, Willis W.  α-2 noradrenergic receptor antagonist, idazoxan, blocks anterior pretectal nucleus induced antinociception in rats.  International Association for the Study of Pain, 8th World Congress on Pain.  1996 August. 

Willis W, Sluka K, Rees H, Westlund K.  Cooperative mechanisms of neurotransmitter action in central nervous sensitization.  Prog Brain Res.  1996. 110:151-166.
[PubMed]

Willis W, Sluka K, Rees H, Westlund K.  Cooperative mechanisms of neurotransmitter actions in central sensitization.  Towards the Neurobiology of Chronic Pain, Progress in Brain Research.  1996. 110:151-166.

Sluka K.  The role of the cAMP transduction cascade in mechanical allodynia and hyperalgesia induced by intradermal injection of capsaicin.  Soc Neurosci Abstr.  1996. 

Sluka K, Rees H, Westlund K, Willis W.  Fiber types contributing to dorsal root reflexes induced by joint inflammation in cats and monkeys.  J Neurophysiol .  1995 September. 74(3):981-989.
[PubMed]

Rees H, Sluka K, Westlund K, Willis W.  The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat.  J Physiol .  1995 April. 484:437-445.
[PubMed]

Rees H, Sluka K, Lu Y, Westlund K, Willis W.  Dorsal root reflexes recorded bilaterally from the medial articular nerves in unilateral adjuvant arthritis.  Soc Neurosci Abstr.  1995. 

Sluka K, Milton M, Westlund K, Willis W.  Involvement of neurokinin receptors in the joint inflammation and heat hyperalgesia following acute inflammation in unanaesthetized rats.  J Physiol.  1995. 483P:152-153P.

Rees H, Sluka K, Tsuruoka M, Chen P, Willis W.  The effects of NK1 and NK2 receptor antagonists on the sensitization of STT cells following acute inflammation in the anaesthetized primate.  J Physiol .  1995. 483P:152P.

Sluka K, Willis W, Westlund K.  The role of dorsal root reflexes in neurogenic inflammation.  Pain Forum .  1995. 4:141-149.

Willis W, Sluka K.  The role of G-proteins and protein kinases in allodynia induced by intradermal injection of capsaicin in the rat.  Soc Neurosci Abstr.  1995. 

Sluka K, Rees H, Tsuruoka M, Chen P, Willis W.  The role of G-proteins and protein kinases in the sensitization of spinothalamic neurons induced by intradermal injection of capsaicin in the primate.  Soc Neurosci Abstr.  1995. 

Sluka K, Jordan H, Willis W, Westlund K.  Differential effects of NMDA and non-NMDA receptor antagonists on release of amino acids after development of acute arthritis.  Brain Res .  1994 November 21. 664(1-2):77-84.
[PubMed]

Sluka K, Willis W, Westlund K.  Arthritis induced release of excitatory amino acids is prevented by spinal administration of a GABAA and not by a GABAB receptor antagonist in rats.  J Pharm Exp Ther .  1994 October. 271(1):76-82.
[PubMed]

Sluka K, Jordan H, Westlund K.  Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist.  Pain .  1994 October. 59(1):95-100.

Sluka K, Jordan H, Westlund K.  Reduction in joint swelling and hyperalgesia following post-treatment with a non-NMDA glutamate receptor antagonist..  Pain.  1994 October. 59(1):95-100.
[PubMed]

Sluka K, Lawand N, Westlund K.  Joint inflammation is reduced by dorsal rhizotomy and not by sympathectomy or spinal cord transection.  Annals Rheum Dis .  1994 May. 53(5):309-314.
[PubMed]

Sluka K, Lawand N, Westlund K.  Joint inflammation is reduced by dorsal rhizotomy and not by sympathectomy or spinal cord transection. .  Annals Rheum Dis.  1994 May. 53(5):309-314.
[PubMed]

Rees H, Sluka K, Westlund K, Willis W.  Dorsal root reflexes augment peripheral inflammation.  NeuroReport .  1994 March. 5(7):821-824.
[PubMed]

Sluka K, Willis W, Westlund K.  Central control of peripheral joint inflammation and heat hyperalgesia.  IASP Press.  1994. 

Willis W, Rees H, Sluka K, Westlund K.  Dorsal root reflexes augment peripheral inflammation in the anaesthetized rat.  J Physiol.  1994. 

Rees H, Sluka K, Westlund K, Willis W.  Dorsal root reflexes induced by joint inflammation are reduced by dorsal rhizotomy, bicuculline and CNQX.  Soc Neurosci Abstr.  1994. 

Sluka K, Rees H, Westlund K, Willis W.  Fiber types involved in the dorsal root reflexes induced by joint inflammation.  Soc Neurosci Abstr.  1994. 

Willis W, Sluka K, Jordan H, Westlund K.  Post-treatment with either non-NMDA or NMDA receptor antagonists results in differential effects following the development of an acute joint inflammation.  Soc Neurosci Abstr.  1994. 

Sluka K, Westlund K.  Behavioral and immunohistochemical changes in an experimental arthritis model in rats.  Pain .  1993 December. 55(3):367-377.
[PubMed]

Sluka K, Westlund K.  Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation.  Pain .  1993 November. 55(2):217-225.
[PubMed]

Sluka K, Willis W, Westlund K.  Joint inflammation and hyperalgesia are reduced by spinal bicuculline.  NeuroReport .  1993 November. 5(2):109-112.
[PubMed]

Sluka K, Westlund K.  Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists.  Brain Res .  1993 November. 627(1):89-103.
[PubMed]

Sluka K, Westlund K.  Differential effects of non-NMDA and NMDA receptors in the processing of nociceptive information and peripheral joint inflammation.  7th World Congress on Pain.  1993. 

Sluka K, Willis W, Westlund K.  Peripheral joint inflammation and heat hyperalgesia are blocked by spinal administration of A GABAA but not by a GABAB receptor antagonist.  Soc Neurosci Abstr.  1993. 

Westlund K, Willis W, Sluka K.  Peripheral joint inflammation is reduced by spinally administered bicuculline or by unilateral dorsal rhizotomy.  7th World Congress on Pain.  1993. 

Sluka K, Westlund K.  An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn.  Neurosci Lett .  1993 January. 149(1):99-102.
[PubMed]

Sluka K, Westlund K.  An experimental arthritis in rat: dorsal horn aspartate and glutamate increases.  Neurosci Lett .  1992 October 12. 145(2):141-144.
[PubMed]

Sluka K, Westlund K.  Spinal projections of the locus coeruleus and the nucleus subcoeruleus in the Harlan and the Sasco Sprague-Dawley rat.  Brain Res .  1992 May. 579(1):67-73.
[PubMed]

Dougherty P, Sluka K, Sorkin L, Westlund K, Willis W.  Neural changes in acute arthritis in monkeys. I. Parallel enhancement of responses of spinothalamic tract neurons to mechanical stimulation and excitatory amino acids.  Brain Res Rev .  1992 April. 17(1):1-13.
[PubMed]

Westlund K, Sun Y, Sluka K, Dougherty P, Sorkin L, Willis W.  Neural changes in acute arthritis in monkeys. II. Increased glutamate immunoreactivity in the medial articular nerve.  Brain Res Rev .  1992 April. 17(1):15-27.
[PubMed]

Sluka K, Dougherty P, Sorkin L, Willis W, Westlund K.  Neural changes in acute arthritis in monkeys. III Changes in substance P, calcitonin gene-related peptide and glutamate in the dorsal horn of the spinal cord.  Brain Res Rev .  1992 April. 17(1):29-38.
[PubMed]

Sorkin L, Westlund K, Sluka K, Dougherty P, Willis W.  Neural changes in acute arthritis in monkeys. IV. Time course of amino acid release into the lumbar dorsal horn.  Brain Res Rev.  1992 April. 17(1):39-50.
[PubMed]

Sluka K, Westlund K.  Amino acid release in experimental arthritis and the effects of lidocaine, CNQX, and AP7 pretreatment.  Soc Neurosci Abstr.  1992. 

Westlund K, Sluka K.  Characterization of an arthritis model in rat: temporal changes in paw withdrawal latency and dorsal horn GLU, SP, and CGRP content.  Soc Neurosci Abstr.  1992. 

Westlund K, Sun Y, Sluka K, Dougherty P, Sorkin L, Willis W.  Change in glutamate immunoreactivity in the medial articular nerve of the primate during acute experimental arthritis.  Neurosci Abstr.  1991. 17:1371.

Dougherty P, Sluka K, Sorkin L, Westlund K, Willis W.  Enhancement of responses of monkey spinothalamic cells to excitatory amino acids accompanies the development of acute arthritis.  Neurosci Abstr.  1991. 17:1372.

Sluka K, Dougherty P, Sorkin L, Willis W, Westlund K.  Substance P, calcitonin gene-related peptide and glutamate alterations in the spinal cord of the primate during acute arthritis.  Neurosci Abstr.  1991. 17:1372.

Sorkin L, Westlund K, Sluka K, Dougherty P, Willis W.  Time course of amino acid release into the lumbar dorsal horn of the primate during development of an acute arthritis.  Neurosci Abstr.  1991. 17:1371.

Gong W, Kolker S, Usachev Y, Walder R, Boyle D, Firestein G, Sluka K.  Acid-Sensing Ion Channel 3 decreases phosphorylation of ERK and induces synoviocyte cell death by increasing intracellular calcium. 

Dailey D, Steele A, Sluka K.  Body diagram prediction of pain and quality of life in people in fibromyalgia. 

Brito R, Santos P, Menezes P, Araujo A, de Lucca Junior W, Quintans J, Sluka K, Quintans-Junior L.  Cymbopogon winterianus essential oil complexed in β-cyclodextrin attenuates hyperalgesia in mice. 

Dannecker E, Cook D, Sluka K.  Development of inclusion and exclusion criteria for a preliminary investigation of resistance exercise in fibromyalgia.  Assoc of Rheumatology Health Professionals annual meeting. 

Sluka K.  Global Year Against Musculoskeletal Pain – Exercise http://www.youtube.com/watch?v=CB9FP-EP_EE&feature=channel . 

Sluka K.  Global Year Against Musculoskeletal Pain – Introduction http://www.youtube.com/watch?v=VtV8BZFI12g&feature=channel . 

Sluka K.  Global Year Against Musculoskeletal Pain – Myths http://www.youtube.com/watch?v=nTQQ57P5TxE . 

Hoeger Bement M, Vance C, Sluka K.  Managing Wound Related Pain.  FA Davis Publishers. 

Sluka K.  Pain Mechanisms and Management for the Physical Therapist.  IASP Press; 

McNearney T, Sluka K, Reveille J, Fischbach M, Ahn C, Mayes M.  Plasma endogenous enkephalin levels are associated with anti-topoisomerase I autoantibodies and digital pulp loss in systemic sclerosis (SSc) patients.  ACR. 

Sluka K, Skyba D, Hoeger Bement M, Audette K, Radhakrishnan R.  Second messenger pathways in pain.  Higher Education Press. 

Gong W, Johanek L, Sluka K.  Spinal cord stimulation reduces mechanical hyperalgesia and restores physical activity levels in animals with non-inflammatory muscle pain in a frequency-dependent manner. 

Date Last Modified: 07/29/2014 - 12:37:24