Pharmacology

Kamal Rahmouni, PhD

Portrait

Associate Professor of Pharmacology
Associate Professor of Internal Medicine

Contact Information

Primary Office: 3135C Medical Education Research Facility
Iowa City, IA 52242
Primary Office Phone: 319-353-5256

Lab: 3125 Medical Education Research Facility
Iowa City, IA 52242
Phone: 319-335-7895

Email: kamal-rahmouni@uiowa.edu

Education

BS, Biochemistry, University of Science and Technology, Algiers, Algeria
MS, Pharmacology, Pharmacochemistry, University of Louis Pasteur, Strasbourg, France
PhD, Pharmacology, University of Louis Pasteur, Strasbourg, France

Post Doctoral, University of Iowa, Department of Internal Medicine
Senior Registrar, University of Iowa, Department of Internal Medicine
Fellowship

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

The work in my laboratory is focused on the neurobiology of metabolism, energy homeostasis and cardiovascular function and related disorders such as obesity, diabetes and hypertension. The central nervous system is a major player in the regulation of energy homeostasis as well as cardiovascular system. Our research is aimed at the identification of the neuroanatomical and molecular pathways involved in the regulation of metabolic, autonomic and cardiovascular functions. We also investigate the dysregulation of these pathways in disease condition such us obesity and diabetes. The lab uses multidisciplinary approaches including basic research tools, genetic models and sophisticated physiological techniques that allow us to address physiological questions at the molecular level. There are currently several ongoing studies aimed at elucidating the intracellular pathways involved in the central nervous system control of energy homeostasis and autonomic cardiovascular function by insulin and adipocyte-derived hormone, leptin. Specifically, we are focused at understanding the exact role of the different downstream pathways associated with the insulin and leptin receptors in the regulation of the physiological cues. For these studies, we rely on mouse models that have deletion is specific intracellular signaling pathways. We also use the Cre-LoxP technology to target specific areas in the brain to delineate the neuronal architectural network that control metabolism and autonomic cardiovascular function. Disease mechanisms are investigated in animal models of obesity and diabetes such as diet-induced obesity, but also rare monogenic models including mouse models of Bardet-Biedl Syndrome that mimic the human disorders. The study of monogenic models allow us to elucidate how basic cell biological mechanisms conserved in all organisms (i.e. intracellular transport and cilia function) and complex phenotypes (such as obesity and hypertension) that result when these mechanisms are perturbed.

All Publications

Fernandes-Santos C, Zhang Z, Morgan D, Guo D, Russo A, Rahmouni K.  Amylin acts in the central nervous system to increase sympathetic nerve activity..  Endocrinology.  2013 July. 154(7):2481-8.
[PubMed]

Harlan S, Guo D, Morgan D, Fernandes-Santos C, Rahmouni K.  Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects..  Cell metabolism.  2013 April. 17(4):599-606.
[PubMed]

Beyer A, Guo D, Rahmouni K.  Prolonged treatment with angiotensin 1-7 improves endothelial function in diet-induced obesity..  Journal of hypertension.  2013 April. 31(4):730-8.
[PubMed]

Imbernon M, Beiroa D, Vazquez M, Morgan D, Veyrat-Durebex C, Porteiro B, Diaz-Arteaga A, Senra A, Busquets S, Velasquez D, Al-Massadi O, Varela L, Gandara M, Lopez-Soriano F, Gallego R, Seoane L, Argiles J, Lopez M, Davis R, Sabio G, Rohner-Jeanrenaud F, Rahmouni K, Dieguez C, Nogueiras R.  Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways..  Gastroenterology.  2013 March. 144(3):636-649.e6.
[PubMed]

Harlan S, Rahmouni K.  Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin..  Clinical autonomic research : official journal of the Clinical Autonomic Research Society.  2013 February. 23(1):1-7.
[PubMed]

Chamling X, Seo S, Bugge K, Searby C, Guo D, Drack A, Rahmouni K, Sheffield V.  Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice..  PloS one.  2013. 8(3):e59101.
[PubMed]

Tanida M, Yamamoto N, Shibamoto T, Rahmouni K.  Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation..  PloS one.  2013. 8(2):e56660.
[PubMed]

Grobe J, Rahmouni K, Liu X, Sigmund C.  Metabolic rate regulation by the renin-angiotensin system: brain vs. body..  Pflugers Archiv : European journal of physiology.  2013 January. 465(1):167-75.
[PubMed]

Grobe J, Rahmouni K.  The adipose/circulating renin-angiotensin system cross-talk enters a new dimension..  Hypertension.  2012 December. 60(6):1389-90.
[PubMed]

Lockie S, Heppner K, Chaudhary N, Chabenne J, Morgan D, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker D, DiMarchi R, Rahmouni K, Oldfield B, Tschop M, Perez-Tilve D.  Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling..  Diabetes.  2012 November. 61(11):2753-62.
[PubMed]

Hilzendeger A, Morgan D, Brooks L, Dellsperger D, Liu X, Grobe J, Rahmouni K, Sigmund C, Mark A.  A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity..  American journal of physiology. Heart and circulatory physiology.  2012 July. 303(2):H197-206.
[PubMed]

Whittle A, Carobbio S, Martins L, Slawik M, Hondares E, Vazquez M, Morgan D, Csikasz R, Gallego R, Rodriguez-Cuenca S, Dale M, Virtue S, Villarroya F, Cannon B, Rahmouni K, Lopez M, Vidal-Puig A.  BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions..  Cell.  2012 May. 149(4):871-85.
[PubMed]

Patel P, Ramakrishnan S, Kaw M, Raphael C, Ghosh S, Marino J, Heinrich G, Lee S, Bourey R, Hill J, Jung D, Morgan D, Kim J, Rahmouni K, Rahmouni S, Najjar S.  Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2..  Diabetologia.  2012 March. 55(3):763-72.
[PubMed]

Morgan D, Sheffield V, Rahmouni K.  Bardet Biedl syndrome genes are required for autonomic control of the circulation.  FASEB Journal.  2012. 

Stauss H, Morgan D, Rahmouni K.  Evidence for chemosensitive fibers in the aortic depressor nerve in mice but not in rats.  FASEB Journal.  2012. 

Harlan S, Morgan D, Rahmouni K.  Leptin acts in POMC neurons to increase sympathetic nerve activity.  Hypertension.  2012. 60:A109.

Rahmouni K.  Leptin Signaling in the brain and energy homeostasis.  Academic Press.  2012. 

Harlan S, Morgan D, Rahmouni K.  Leptin-induced arterial pressure increase: key role of the PI3K pathway.  Hypertension.  2012. 60:A21.

Castaneda T, Abplanalp W, Um S, Pfluger P, Schrott B, Brown K, Grant E, Carnevalli L, Benoit S, Morgan D, Gilham D, Hui D, Rahmouni K, Thomas G, Kozma S, Clegg D, Tschop M.  Metabolic control by S6 kinases depends on dietary lipids..  PloS one.  2012. 7(3):e32631.
[PubMed]

Muta K, Grobe J, Sigmund C, Rahmouni K.  mTOR/p70S6K signaling is a novel effector of neuronal action of angiotensin II.  FASEB Journal.  2012. 

Whiteis C, Post C, Morgan D, Rahmouni K, Chapleau M, Abboud F.  Peripheral chemoreceptors contribute significantly to hypertension in Spontaneously Hypertensive Rats (SHR).  FASEB Journal.  2012. 26:703.15.

Tschop M, Speakman J, Arch J, Auwerx J, Bruning J, Chan L, Eckel R, Farese R, Galgani J, Hambly C, Herman M, Horvath T, Kahn B, Kozma S, Maratos-Flier E, Muller T, Munzberg H, Pfluger P, Plum L, Reitman M, Rahmouni K, Shulman G, Thomas G, Kahn C, Ravussin E.  A guide to analysis of mouse energy metabolism..  Nature methods.  2012 January. 9(1):57-63.
[PubMed]

Grobe J, Rahmouni K.  Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic.  American journal of physiology. Regulatory, integrative and comparative physiology.  2012 January. 302(2):R242-3.
[PubMed]

Zhang Q, Nishimura D, Seo S, Vogel T, Morgan D, Searby C, Bugge K, Stone E, Rahmouni K, Sheffield V.  Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes..  Proceedings of the National Academy of Sciences of the United States of America.  2011 December. 108(51):20678-83.
[PubMed]

Rahmouni K, Davisson R, Sigmund C.  Inflaming hypothalamic neurons raises blood pressure..  Cell metabolism.  2011 July. 14(1):3-4.
[PubMed]

Guo D, Rahmouni K.  Molecular basis of the obesity associated with Bardet-Biedl syndrome..  Trends in endocrinology and metabolism: TEM.  2011 July. 22(7):286-93.
[PubMed]

Harlan S, Morgan D, Agassandian K, Guo D, Cassell M, Sigmund C, Mark A, Rahmouni K.  Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation..  Circulation research.  2011 April. 108(7):808-12.
[PubMed]

Zhang Z, Liu X, Morgan D, Kuburas A, Thedens D, Russo A, Rahmouni K.  Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice..  Diabetes.  2011 April. 60(4):1063-71.
[PubMed]

Harlan S, Morgan D, Dellsperger D, Myers M, Mark A, Rahmouni K.  Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor..  Hypertension.  2011 March. 57(3):627-32.
[PubMed]

Guo D, Beyer A, Yang B, Nishimura D, Sheffield V, Rahmouni K.  Inactivation of Bardet-Biedl syndrome genes causes kidney defects..  American journal of physiology. Renal physiology.  2011 February. 300(2):F574-80.
[PubMed]

Hilzendeger A, Morgan D, Rahmouni K, Sigmund C, Mark A.  Brain angiotensin generation contributes to renal sympathetic nerve responses to leptin.  FASEB Journal.  2011. 25:1078.3.

Morgan D, Despas F, Rahmouni K.  Direct sympathetic nerve activity recording in awake mice improves baroreflex sensitivity, but not the responses to leptin.  Hypertension.  2011. 58:e71.

Pezzulo A, Gutierrez J, Duschner K, McConnell K, Taft P, Ernst S, Yahr T, Rahmouni K, Klesney-Tait J, Stoltz D, Zabner J.  Glucose depletion in the airway surface liquid is essential for sterility of the airways..  PloS one.  2011. 6(1):e16166.
[PubMed]

Guo D, Morgan D, Rahmouni K.  Hypothalamic mTOR signaling: a key mediator of the sympathetic and cardiovascular effects of leptin.  Hypertension.  2011. 58:e41.

Harlan S, Fernandes-Santos C, Morgan D, Guo D, Rahmouni K.  PI3K pathway is a critical node for leptin activation of hypothalamic mTOR signaling and renal sympathetic traffic.  Hypertension.  2011. 58:e94.

Beyer A, Guo D, Sheffield V, Rahmouni K.  Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes..  American journal of physiology. Heart and circulatory physiology.  2010 December. 299(6):H1902-7.
[PubMed]

Grobe J, Grobe C, Beltz T, Westphal S, Morgan D, Xu D, de Lange W, Li H, Sakai K, Thedens D, Cassis L, Rahmouni K, Mark A, Johnson A, Sigmund C.  The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance..  Cell metabolism.  2010 November. 12(5):431-42.
[PubMed]

Morgan D, Rahmouni K.  Differential effects of insulin on sympathetic nerve activity in agouti obese mice..  Journal of hypertension.  2010 September. 28(9):1913-9.
[PubMed]

Lopez M, Varela L, Vazquez M, Rodriguez-Cuenca S, Gonzalez C, Velagapudi V, Morgan D, Schoenmakers E, Agassandian K, Lage R, Martinez de Morentin P, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha A, Rahmouni K, Dieguez C, Vidal-Puig A.  Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance..  Nature medicine.  2010 September. 16(9):1001-8.
[PubMed]

Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan D, Mostoslavsky R, Stuart R, Perello M, Vianna C, Nillni E, Rahmouni K, Coppari R.  SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity..  Cell metabolism.  2010 July. 12(1):78-87.
[PubMed]

Rahmouni K.  Leptin-Induced Sympathetic Nerve Activation: Signaling Mechanisms and Cardiovascular Consequences in Obesity..  Current hypertension reviews.  2010 May. 6(2):104-209.
[PubMed]

Rahmouni K.  Obesity, sympathetic overdrive, and hypertension: the leptin connection..  Hypertension.  2010 April. 55(4):844-5.
[PubMed]

Sabharwal R, Morgan D, Whiteis C, Rahmouni K, Chapleau M, Abboud F.  ASIC2 Dependent Activation of the Baroreceptors is Required for the Arterial Baroreflex.  FASEB Journal.  2010. 24:625.1.

Harlan S, Morgan D, Dellsperger D, Myers M, Mark A, Rahmouni K.  Disruption of leptin receptor signaling emanating from Tyr985 enhances the cardiovascular and sympathetic effects of leptin.  Hypertension.  2010. 56:e107-108.

Hilzendeger A, Morgan D, Brooks L, Dellsperger D, Liu X, Rahmouni K, Sigmund C, Mark A.  Evidence for a central neural interaction of leptin and angiotensin.  Hypertension.  2010. 56:e101.

Harlan S, Morgan D, Dellsperger D, Myers M, Mark A, Rahmouni K.  Mutation of Tyr985 of the leptin receptor differentially alters regional sympathetic activation to leptin.  FASEB Journal.  2010. 24:1050.1.

Morgan D, Dellsperger D, Mishimura D, Sheffield V, Rahmouni K.  Obesity, hypertension and sympathetic overdrive in a novel mouse model of Bardet-Biedl syndrome.  Hypertension.  2010. 56:e96.

Tan Z, Morgan D, Whiteis C, Rahmouni K, Chapleau M, Abboud F.  Peripheral Chemoreceptors Enhance Renal Sympathetic Nerve Activity and Hypertension in SHR.  FASEB Journal.  2010. 24:809.22.

Rahmouni K.  Sympathetic tone in the young: the mother weighs in..  Hypertension.  2010 January. 55(1):21-2.
[PubMed]

Lu Y, Ma X, Sabharwal R, Snitsarev V, Morgan D, Rahmouni K, Drummond H, Whiteis C, Costa V, Price M, Benson C, Welsh M, Chapleau M, Abboud F.  The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation..  Neuron.  2009 December. 64(6):885-97.
[PubMed]

Nogueiras R, Perez-Tilve D, Veyrat-Durebex C, Morgan D, Varela L, Haynes W, Patterson J, Disse E, Pfluger P, Lopez M, Woods S, DiMarchi R, Dieguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschop M.  Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2009 May. 29(18):5916-25.
[PubMed]

Seo S, Guo D, Bugge K, Morgan D, Rahmouni K, Sheffield V.  Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling..  Human molecular genetics.  2009 April. 18(7):1323-31.
[PubMed]

Rahmouni K, Sigmund C, Haynes W, Mark A.  Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin..  Diabetes.  2009 March. 58(3):536-42.
[PubMed]

Mark A, Agassandian K, Morgan D, Liu X, Cassell M, Rahmouni K.  Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney..  Hypertension.  2009 February. 53(2):375-80.
[PubMed]

Harlan S, Morgan D, Agassandian K, Cassell M, Mark A, Rahmouni K.  A critical role of leptin receptors in the hypothalamic arcuate nucleus in mediating renal sympathetic activation of leptin.  Hypertension.  2009. 54:e30.

Beyer A, Guo D, Rahmouni K.  Angiotensin 1-7 protects against vascular dysfunction associated with diet-induced obesity in mice.  Hypertension.  2009. 54:e38.

Mark A, Brooks L, Morgan D, Sigmund C, Rahmouni K.  Brain angiotensin AT1 receptors mediate sympathetic nerve responses to leptin: evidence for a brain angiotensin-leptin interaction.  Hypertension.  2009. 54:e99.

Beyer A, Morgan D, Anderson M, Rahmouni K.  Increased arterial pressure response to angiotensin II in mice with mutation in the Lysosomal Trafficking Regulator gene.  FASEB Journal.  2009. 23:814.2.

Guo D, Beyer A, HuiPing L, Sigmund C, Sheffield V, Rahmouni K.  Kidney Abnormities in Mouse Models of Bardet-Biedl Syndrome.  Hypertension.  2009. 54:e61.

Rahmouni K, Morgan D, Mark A.  Oxidative stress in the brain mediates thermogenic sympathetic activation to leptin.  FASEB Journal.  2009. 23:1021.6.

Borges G, Morgan D, Ketsawatsomkron P, Rahmouni K, Sigmund C.  Tachycardia caused by interference with PPAR? in vascular smooth muscle in mice is related to autonomic imbalance and baroreflex dysfunction.  Hypertension.  2009. 54:e101.

Morgan D, Thedens D, Weiss R, Rahmouni K.  Mechanisms mediating renal sympathetic activation to leptin in obesity..  American journal of physiology. Regulatory, integrative and comparative physiology.  2008 December. 295(6):R1730-6.
[PubMed]

Rahmouni K, Sigmund C.  Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression..  Circulation research.  2008 September. 103(6):565-7.
[PubMed]

Rahmouni K.  Does genetic variation in the leptin receptor influence the sympathetic tone in obesity?.  Hypertension research : official journal of the Japanese Society of Hypertension.  2008 June. 31(6):1057-9.
[PubMed]

Rahmouni K, Fath M, Seo S, Thedens D, Berry C, Weiss R, Nishimura D, Sheffield V.  Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome..  The Journal of clinical investigation.  2008 April. 118(4):1458-67.
[PubMed]

Beyer A, Didion S, Sheffield V, Rahmouni K.  Altered vascular function in mouse models of Bardet-Biedl syndrome.  Journal of Hypertension.  2008. 21:S224.

Beyer A, Guo D, Didion S, Sheffield V, Rahmouni K.  Bardet-Biedl Syndrome genes are involved in the control of vascular function.  Hypertension.  2008. 52:e37-e38.

Grobe J, Morgan D, Rahmouni K, Sigmund C.  Enhanced sympathetic and HPA-Axis activity contribute to increased metabolic rate in transgenic mice with overactivity of the central renin-angiotensin system.  Hypertension.  2008. 52:e49-e50.

Mark A, Agassandian K, Morgan D, Liu X, Cassell M, Rahmouni K.  Leptin signaling in the nucleus tractus solitarii increases sympathetic outflow to the kidney.  Journal of Hypertension.  2008. 26:S23.

Agassandian K, Morgan D, Cassell M, Rahmouni K, Mark A.  Leptin signaling in the nucleus tractus solitarii increases sympathetic outflow to the kidney.  FASEB Journal.  2008. 22:969.13.

Rahmouni K, Morgan D.  Melanocortin receptors mediate renal sympathetic activation to leptin in obesity.  FASEB Journal.  2008. 22:1167.3.

Rahmouni K, Morgan D, Guo D.  Novel role for hypothalamic mammalian target of rapamycin (mTOR) in sympathetic and circulatory control.  Hypertension.  2008. 52:e40.

Morgan D, Rahmouni K.  Phosphoinositol-3 kinase mediates insulin-induced sympathetic activation in obesity.  Hypertension.  2008. 52:e103-104.

Mark A, Agassandian K, Morgan D, Liu X, Cassell M, Rahmouni K.  Sympathetic responses to microinjection of leptin into the nucleus tractus solitarii: Evidence for a distributed brain network of leptin action.  Hypertension.  2008. 52:e81-e82.

Grobe J, Grobe C, Gall A, Thedens D, Sakai K, Rahmouni K, Blumberg M, Johnson A, Sigmund C.  The brain renin-angiotensin system promotes a negative energy balance in mice.  FASEB Journal.  2008. 22:1167.2.

Beyer A, Trantow C, Anderson M, Rahmouni K.  Vascular defects in mice with mutation in the Lysosomal Trafficking Regulator gene.  FASEB Journal.  2008. 22:1148.14.

Davis R, Swiderski R, Rahmouni K, Nishimura D, Mullins R, Agassandian K, Philp A, Searby C, Andrews M, Thompson S, Berry C, Thedens D, Yang B, Weiss R, Cassell M, Stone E, Sheffield V.  A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity..  Proceedings of the National Academy of Sciences of the United States of America.  2007 December. 104(49):19422-7.
[PubMed]

Plum L, Rother E, Munzberg H, Wunderlich F, Morgan D, Hampel B, Shanabrough M, Janoschek R, Konner A, Alber J, Suzuki A, Krone W, Horvath T, Rahmouni K, Bruning J.  Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation..  Cell metabolism.  2007 December. 6(6):431-45.
[PubMed]

Rahmouni K.  Differential Control of the Sympathetic Nervous System by Leptin: Implications for Obesity..  Clinical and experimental pharmacology & physiology. Supplement.  2007 November. 34 Suppl(s1):S8-S10.
[PubMed]

Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh J, Sutton G, Pfluger P, Castaneda T, Neschen S, Hofmann S, Howles P, Morgan D, Benoit S, Szanto I, Schrott B, Schurmann A, Joost H, Hammond C, Hui D, Woods S, Rahmouni K, Butler A, Farooqi I, O'Rahilly S, Rohner-Jeanrenaud F, Tschop M.  The central melanocortin system directly controls peripheral lipid metabolism..  The Journal of clinical investigation.  2007 November. 117(11):3475-88.
[PubMed]

Rahmouni K, Morgan D.  Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin..  Hypertension.  2007 March. 49(3):647-52.
[PubMed]

Dickson M, Zimmerman M, Rahmouni K, Sigmund C.  The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells..  Hypertension.  2007 March. 49(3):631-9.
[PubMed]

Grobe J, Grobe C, Gall A, Sakai K, Rahmouni K, Blumberg M, Johnson A, Sigmund C.  Increased Metabolic Rate in Transgenic Mice Over-Expressing the Central Renin-Angiotensin System.  Hypertension.  2007. 50:e82.

Rahmouni K, Morgan D, Correia M, Haynes W, Mark A.  Intracellular mechanisms mediating sympathetic activation to leptin in obesity hypertension.  Hypertension.  2007. 50:e85.

Rahmouni K, Morgan D, Correia M, Haynes W, Mark A.  Molecular mechanisms of sympathoactivation to leptin in obesity hypertension.  Journal of Hypertension.  2007. 25:S155.

Rahmouni K, Fath M, Morgan D, Correia M, Haynes W, Mark A.  Pathophysiological role of leptin in Bardet-Biedl Syndrome: Evidence from knockout mouse models.  Hypertension.  2007. 50:e84.

Rahmouni K, Correia M, Morgan D, Haynes W, Mark A.  Role of PI3 kinase in mediating renal sympathoactivation to leptin in obesity.  FASEB Journal.  2007. 21:A1193.

Correia M, Morgan D, Rahmouni K, Mark A, Davisson R, Haynes W.  The selectivity of leptin resistance depends on the severity of diet-induced obesity in normotensive and borderline hypertensive mice.  FASEB Journal.  2007. 21:A459.

Correia M, Rahmouni K.  Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome..  Diabetes, obesity & metabolism.  2006 November. 8(6):603-10.
[PubMed]

Rahmouni K, Morgan D.  Cardiovascular and sympathetic responses to direct injection of leptin into the arcuate nucleus of the hypothalamus.  Hypertension.  2006. 48:e32.

Rahmouni K, Morgan D, Morgan G, Correia M, Mark A, Haynes W.  Differential effects of insulin on regional sympathetic nerve activity in obesity.  Journal of Hypertension.  2006. 24:S30.

Rahmouni K, Morgan D.  Injection of leptin into the arcuate nucleus of the hypothalamus increases sympathetic nerve activity and blood pressure.  Journal of Hypertension.  2006. 24:164.

Rahmouni K, Correia M, Haynes W.  Leptin and cardiovascular disease.  Springer.  2006. 

Rahmouni K, Fath M, Andrews M, Sigmund C, Sheffield V.  Pathophysiological mechanisms of obesity and hypertension in mouse models of Bardet-Biedl syndrome.  FASEB Journal.  2006. 20:A1207.

Rahmouni K, Morgan D, Morgan G, Correia M, Mark A, Haynes W.  Regional variation in the sympathetic response to insulin in obesity.  Journal of Hypertension.  2006. 8:A188.

Rahmouni K, Correia M.  Role of leptin and obesity-related leptin resistance in the pathophysiology of metabolic syndrome.  Brazilian Journal of Hypertension.  2006. 13:171-176.

Correia M, Morgan D, Rahmouni K, Davisson R, Haynes W.  Selective leptin resistance in borderline hypertensive BPH5 mice with diet-induced obesity.  Journal of Hypertension.  2006. 24:356.

Correia M, Rahmouni K, Morgan D, Mark A, Haynes W.  Severe visceral obesity attenuates leptin-dependent renal sympathoactivation in C57BJ mice with diet induced obesity.  Obesity.  2006. 14:A208-209.

Rahmouni K, Haynes W.  Endothelial effects of leptin: implications in health and diseases..  Current diabetes reports.  2005 August. 5(4):260-6.
[PubMed]

Rahmouni K, Jalali A, Morgan D, Haynes W.  Lack of dilator effect of leptin in the hindlimb vascular bed of conscious rats..  European journal of pharmacology.  2005 August. 518(2-3):175-81.
[PubMed]

Rahmouni K, Morgan D, Morgan G, Mark A, Haynes W.  Role of selective leptin resistance in diet-induced obesity hypertension..  Diabetes.  2005 July. 54(7):2012-8.
[PubMed]

Fath M, Mullins R, Searby C, Nishimura D, Wei J, Rahmouni K, Davis R, Tayeh M, Andrews M, Yang B, Sigmund C, Stone E, Sheffield V.  Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome..  Human molecular genetics.  2005 May. 14(9):1109-18.
[PubMed]

Rahmouni K, Haynes W, Sigmund C.  Activation of brain renin-angiotensin system protect against diet-induced obesity.  FASEB Journal.  2005. 19:A1132.

Rahmouni K, Haynes W, Sigmund C.  Activation of brain renin-angiotensin system protect against diet-induced obesity.  FASEB Journal.  2005. 19:A1132.

Rahmouni K, Haynes W, Sigmund C.  Central action of angiotensin II and the development of dietary obesity.  Journal of Hypertension.  2005. 23:S47.

Rahmouni K, Haynes W, Sigmund C.  Central action of angiotensin II and the development of dietary obesity.  Journal of Hypertension.  2005. 23:S47.

Correia M, Walters K, Schroeder K, Morgan D, Rahmouni K, Haynes W, Moore K, Mark A.  Does loss of leptin action lead to intracellular lipid accumulation and lipotoxicity in the kidney?.  FASEB Journal.  2005. 19:A1130.

Correia M, Walters K, Schroeder K, Morgan D, Rahmouni K, Haynes W, Moore K, Mark A.  Does loss of leptin action lead to intracellular lipid accumulation and lipotoxicity in the kidney?.  FASEB Journal.  2005. 19:A1130.

Rahmouni K, Morgan G, Morgan D, Mark A, Haynes W.  Leptin's ability to increases arterial pressure is preserved in obesity.  Journal of Hypertension.  2005. 23:S23.

Rahmouni K, Morgan G, Morgan D, Mark A, Haynes W.  Leptin's ability to increases arterial pressure is preserved in obesity.  Journal of Hypertension.  2005. 23:S23.

Rahmouni K, Sigmund C.  Local production of angiotensinogen: Insights from genetic manipulation of mice.  The Humana Press Inc.  2005. 

Rahmouni K, Sigmund C, Haynes W, Mark A.  Mitogen activated protein kinase: a newly discovered mediator of selective leptin actions.  Hypertension.  2005. 46:867.

Rahmouni K, Morgan G, Morgan D, Mark A, Haynes W.  Preservation of the arterial pressure response to leptin in diet-induced obese mice: a potential mechanism for obesity hypertension.  Journal of Hypertension.  2005. 18(5):203A.

Rahmouni K, Morgan G, Morgan D, Mark A, Haynes W.  Preservation of the arterial pressure response to leptin in diet-induced obese mice: a potential mechanism for obesity hypertension.  American Journal of Hypertension.  2005. 18(5):203A.

Rahmouni K, Correia M, Haynes W, Mark A.  Obesity-associated hypertension: new insights into mechanisms..  Hypertension.  2005 January. 45(1):9-14.
[PubMed]

Rahmouni K, Morgan D, Morgan G, Liu X, Sigmund C, Mark A, Haynes W.  Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin..  The Journal of clinical investigation.  2004 September. 114(5):652-8.
[PubMed]

Rahmouni K, Mark A, Haynes W, Sigmund C.  Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity..  American journal of physiology. Endocrinology and metabolism.  2004 June. 286(6):E891-5.
[PubMed]

Rahmouni K, Morgan D, Morgan G, Mark A, Haynes W.  Diet-induced insulin resistance is associated with dissociation of the metabolic and sympathetic effects of leptin.  Journal of Hypertension.  2004. 22:S362.

Rahmouni K, Morgan D, Morgan G, Liu G, Sigmund C, Mark A, Haynes W.  Intracellular mechanisms involved in regional sympathoactivation to insulin.  Hypertension.  2004. 44:531.

Rahmouni K, Haynes W.  Leptin and the cardiovascular system..  Recent progress in hormone research.  2004. 59:225-44.
[PubMed]

Rahmouni K, Haynes W, Mark A.  Leptin signaling in the central nervous system.  Academic Press.  2004. 

Rahmouni K, Haynes W, Mark A.  Leptin signaling in the central nervous system.  Academic Press.  2004. 

Mark A, Correia M, Rahmouni K, Haynes W.  Loss of leptin actions in obesity: two concepts with cardiovascular implications..  Clinical and experimental hypertension (New York, N.Y. : 1993).  2004. 26(7-8):629-36.
[PubMed]

Rahmouni K, Morgan D, Morgan G, Correia M, Mark A, Haynes W.  Regional variation in leptin-induced sympathaoctivation in diet-induced obesity: evidence for selective leptin resistance.  Journal of Hypertension.  2004. 22:S204.

Rahmouni K, Haynes W, Morgan D, Morgan G, Correia M, Mark A.  Regional variation in leptin-induced sympathoactivation in agouti obese mice.  Journal of Hypertension.  2004. 17(5):217A.

Rahmouni K.  Brain effects of leptin: what intracellular mechanism?.  Current diabetes reports.  2003 December. 3(6):427-9.
[PubMed]

Rahmouni K, Haynes W, Morgan D, Mark A.  Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin..  The Journal of neuroscience : the official journal of the Society for Neuroscience.  2003 July. 23(14):5998-6004.
[PubMed]

Mark A, Rahmouni K, Correia M, Haynes W.  A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat..  Acta physiologica Scandinavica.  2003 March. 177(3):345-9.
[PubMed]

Rahmouni K, Haynes W, Morgan D, Mark A.  Intracellular mechanisms involved in leptin regulation of sympathetic outflow..  Hypertension.  2003 March. 41(3 Pt 2):763-7.
[PubMed]

Rahmouni K, Mark A, Haynes W, Sigmund C.  Adipose tissue-specific increase in human angiotensinogen gene expression in transgenic mice on high fat diet.  FASEB Journal.  2003. 

Rahmouni K, Mark A, Haynes W, Sigmund C.  Differential modulation of angiotensinogen gene expression in obesity-induced by high fat diet.  Hypertension.  2003. 42:423.

Rahmouni K, Jalali A, Morgan D, Haynes W.  Does leptin cause peripheral vasodilatation?.  FASEB Journal.  2003. 

Rahmouni K, Morgan D, Haynes W.  Renal sympathoactivation to insulin is mediated by melanocortin-4 receptors.  American Journal of Hypertension.  2003. 16(5):221A.

Rahmouni K, Morgan D, Haynes W.  Renal sympathoactivation to insulin is mediated by melanocortin-4 receptors.  Journal of Hypertension.  2003. 21:S110.

Rahmouni K, Morgan D, Morgan G, Mark A, Haynes W.  Renal-specific preservation of sympathoexcitatory effect of leptin in diet-induced obese mice.  Hypertension.  2003. 42:421.

Rahmouni K, Morgan D, Morgan G, Mark A, Haynes W.  Selective resistance to central administration of leptin in diet-induced obese mice.  Journal of Hypertension.  2003. 21:S116.

Rahmouni K, Morgan D, Mark A, Haynes W.  Selective resistance to central administration of leptin in diet-induced obese mice.  Journal of Hypertension.  2003. 16(5):35A.

Rahmouni K, G Haynes W.  Leptin and the central neural mechanisms of obesity hypertension..  Drugs of today (Barcelona, Spain : 1998).  2002 December. 38(12):807-17.
[PubMed]

Rahmouni K, Barthelmebs M, Grima M, Imbs J, De Jong W.  Influence of sodium intake on the cardiovascular and renal effects of brain mineralocorticoid receptor blockade in normotensive rats..  Journal of hypertension.  2002 September. 20(9):1829-34.
[PubMed]

Mark A, Correia M, Rahmouni K, Haynes W.  Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications..  Journal of hypertension.  2002 July. 20(7):1245-50.
[PubMed]

Rahmouni K, Haynes W, Mark A.  Cardiovascular and sympathetic effects of leptin..  Current hypertension reports.  2002 April. 4(2):119-25.
[PubMed]

Rahmouni K, Sibug R, De Kloet E, Barthelmebs M, Grima M, Imbs J, De Jong W.  Effects of brain mineralocorticoid receptor blockade on blood pressure and renal functions in DOCA-salt hypertension..  European journal of pharmacology.  2002 February. 436(3):207-16.
[PubMed]

Rahmouni K, Haynes W, Morgan D, Mark A.  Selective resistance to central neural administration of leptin in agouti obese mice..  Hypertension.  2002 February. 39(2 Pt 2):486-90.
[PubMed]

Correia M, Haynes W, Rahmouni K, Morgan D, Sivitz W, Mark A.  The concept of selective leptin resistance: evidence from agouti yellow obese mice..  Diabetes.  2002 February. 51(2):439-42.
[PubMed]

Rahmouni K, Haynes W, Morgan D, Mark A.  Attenuated renal sympathetic nerve responses to stimulation of melanocortin system in absence of leptin receptors.  American Journal of Hypertension.  2002. 15(4):1A.

Rahmouni K, Haynes W, Morgan D, Mark A.  Evidences for interaction between leptin and melanocortin system in the control of renal sympathetic nerve activity.  The Physiologist.  2002. 45(4):79.

Rahmouni K, Haynes W, Morgan D, Mark A.  Interaction between leptin receptors and melanocortin system in the control of renal sympathetic nerve activity.  Journal of Hypertension.  2002. 20:S203.

Rahmouni K, Haynes W, Morgan D, Mark A.  Key intracellular pathways in central neural action of leptin.  Hypertension.  2002. 40:386.

Rahmouni K, Morgan D, Zhou W, Mark A, Haynes W.  Molecular mechanisms of insulin-induced sympathoexcitation.  American Journal of Hypertension.  2002. 15(4):191A.

Rahmouni K, Haynes W, Morgan D, Mark A.  Pivotal role of phosphoinisitide 3-kinase in leptin signaling in the central nervous system.  Journal of Hypertension.  2002. 20:S255.

Rahmouni K, Haynes W, Morgan D, Mark A.  Pivotal role of phosphoinositide 3-kinase in leptin signaling in the central nervous system.  FASEB Journal.  2002. 16(4):A112.

Rahmouni K, Haynes W.  Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins..  BioEssays : news and reviews in molecular, cellular and developmental biology.  2001 December. 23(12):1095-9.
[PubMed]

Rahmouni K, Barthelmebs M, Grima M, Imbs J, De Jong W.  Involvement of brain mineralocorticoid receptor in salt-enhanced hypertension in spontaneously hypertensive rats..  Hypertension.  2001 October. 38(4):902-6.
[PubMed]

Correia M, Mark A, Morgan D, Rahmouni K, Haynes W.  A new concept of selective leptin resistance: Evidence from agouti yellow obese mice.  Journal of Hypertension.  2001. 19:S95.

Rahmouni K, Yang C, Haynes W, Pessin J, Mark A.  Absence of hypertension and obesity in Syntaxin4 knockout mice with selective insulin resistance.  FASEB Journal.  2001. 15:A469.

Rahmouni K, Haynes W, Morgan D, Mark A.  Control of renal sympathetic outflow by leptin is mediated by melanocortin-4 receptors.  Circulation.  2001. 104(17):II-320.

Rahmouni K, Haynes W, Yang C, Pessin J, Mark A.  Evidence for selective insulin resistance in insulin resistant syntaxin4 knockout mice.  Journal of Hypertension.  2001. 19:S128.

Morgan D, Rahmouni K, Mark A, Haynes W.  Selective leptin resistance during high fat diet in mice: preservation of sympathetic activation despite attenuation of metabolic responses.  Hypertension.  2001. 38:478.

Rahmouni K, Haynes W, Morgan D, Mark A.  Selective resistance to central neural administration of leptin in agouti obese mice.  Circulation.  2001. 104(17):II-278.

Rahmouni K, Haynes W, Morgan D, Mark A.  Selective resistance to central neural administration of leptin in agouti obese mice.  Hypertension.  2001. 38:38.

de Kloet E, Van Acker S, Sibug R, Oitzl M, Meijer O, Rahmouni K, de Jong W.  Brain mineralocorticoid receptors and centrally regulated functions..  Kidney international.  2000 April. 57(4):1329-36.
[PubMed]

Rahmouni K, Barthelmebs M, Grima M, Imbs J, De Jong W.  Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats..  European journal of pharmacology.  1999 December. 385(2-3):199-202.
[PubMed]

Rahmouni K, Barthelmebs M, Grima M, Imbs J, Wybren De J.  Brain mineralocorticoid receptor control of blood pressure and kidney function in normotensive rats..  Hypertension.  1999 May. 33(5):1201-6.
[PubMed]

Rahmouni K, Barthelmebs M, Grima M, Imbs J, De Jong W.  Brain mineralocorticoid receptors and blood pressure control in spontaneously hypertensive rats.  Journal of Hypertension.  1999. 17(3):S43.

Rahmouni K, Barthelmebs M, Imbs J, De Jong W.  [Brain mineralocorticoid receptor and blood pressure control in the conscious normotensive rat]..  Archives des maladies du coeur et des vaisseaux.  1998 August. 91(8):1009-12.
[PubMed]

Rahmouni K, Barthelmebs M, Grima M, Imbs J, De Jong W.  Role of renal nerves in central mineralocorticoid receptor control of blood pressure.  Journal of Hypertension.  1998. 16(2):S115.

Rahmouni K, Barthelmebs M, De Jong W.  Brain mineralocorticoid receptor and blood pressure control-implication of the sympathetic pathway.  Arch Mal Coeur Vaiss.  1997. 90:O65.

Rahmouni K, Barthelmebs M, De Jong W.  Effect of single administration of a mineralocorticoid receptor antagonist (RU28318) on blood pressure and kidney function.  Fundamental and Clinical Pharmacology.  1997. 11:126S.

De Jong W, Rahmouni K, Barthelmebs M.  Brain mineralocorticoid receptor and blood pressure control.  Hypertension.  1996. 28(4):709.

Agassandian K, Patel M, Steren K, Rahmouni K, Sheffield V, Card J.  Ciliopathy in a mouse model of Bardet-Biedl syndrome is pronounced in regions of brain involved in memory and learning. 

Tovar S, Paeger L, Hess S, Morgan D, Redemann N, Bronneke H, Hampel B, Ackermann P, Buning H, Wunderlich F, Rahmouni K, Kloppenburg P, Bruning J.  KATP-channel-dependent glucose sensing in the locus coeruleus controls brown adipose tissue sympathetic nerve activity and energy homeostasis. 

Date Last Modified: 07/31/2013 - 10:51:40