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Professor of PharmacologyProfessor of
Primary Office: 2-248 Bowen Science BuildingIowa City, IA 52242
Lab: 2-200 Bowen Science BuildingIowa City, IA 52242
BS, Biochemistry, University of Science and Technology, Algiers, AlgeriaMS, Pharmacology, Pharmacochemistry, University of Louis Pasteur, Strasbourg, FrancePhD, Pharmacology, University of Louis Pasteur, Strasbourg, France
Post Doctorate, University of Iowa, Department of Internal MedicineResidency, University of Iowa, Department of Internal MedicineFellowship, Council for High Blood Pressure Research, American Heart Association
Interdisciplinary Graduate Program in Molecular and Cellular BiologyInterdisciplinary Graduate Program in NeuroscienceInterdisciplinary Graduate Program in Translational BiomedicineMedical Scientist Training Program
The work in my laboratory is focused on the neurobiology of metabolism, energy homeostasis and cardiovascular function and related disorders such as obesity, diabetes and hypertension. The central nervous system is a major player in the regulation of energy homeostasis as well as cardiovascular system. Our research is aimed at the identification of the neuroanatomical and molecular pathways involved in the regulation of metabolic, autonomic and cardiovascular functions. We also investigate the dysregulation of these pathways in disease condition such us obesity and diabetes. The lab uses multidisciplinary approaches including basic research tools, genetic models and sophisticated physiological techniques that allow us to address physiological questions at the molecular level. There are currently several ongoing studies aimed at elucidating the intracellular pathways involved in the central nervous system control of energy homeostasis and autonomic cardiovascular function by insulin and adipocyte-derived hormone, leptin. Specifically, we are focused at understanding the exact role of the different downstream pathways associated with the insulin and leptin receptors in the regulation of the physiological cues. For these studies, we rely on mouse models that have deletion is specific intracellular signaling pathways. We also use the Cre-LoxP technology to target specific areas in the brain to delineate the neuronal architectural network that control metabolism and autonomic cardiovascular function. Disease mechanisms are investigated in animal models of obesity and diabetes such as diet-induced obesity, but also rare monogenic models including mouse models of Bardet-Biedl Syndrome that mimic the human disorders. The study of monogenic models allow us to elucidate how basic cell biological mechanisms conserved in all organisms (i.e. intracellular transport and cilia function) and complex phenotypes (such as obesity and hypertension) that result when these mechanisms are perturbed.
Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin..
Clinical autonomic research : official journal of the Clinical Autonomic Research Society.
2013 February. 23(1):1-7.
Metabolic rate regulation by the renin-angiotensin system: brain vs. body..
Pflugers Archiv : European journal of physiology.
2013 January. 465(1):167-75.
The adipose/circulating renin-angiotensin system cross-talk enters a new dimension..
2012 December. 60(6):1389-90.
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling..
2012 November. 61(11):2753-62.
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity..
American journal of physiology. Heart and circulatory physiology.
2012 July. 303(2):H197-206.
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions..
2012 May. 149(4):871-85.
Metabolic control by S6 kinases depends on dietary lipids..
A guide to analysis of mouse energy metabolism..
2012 January. 9(1):57-63.
Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes..
Proceedings of the National Academy of Sciences of the United States of America.
2011 December. 108(51):20678-83.
Date Last Modified: 07/18/2016 -
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