Pharmacology

Dawn E. Quelle, PhD

Portrait

Associate Professor of Pharmacology
Associate Professor of Pathology

Contact Information

Primary Office: 2-570 Bowen Science Building
Iowa City, IA 52242
Primary Office Phone: 319-353-5749

Lab: 2-551 Bowen Science Building
Iowa City, IA 52242
Phone: 319-335-7663

Email: dawn-quelle@uiowa.edu

Education

BS, Biochemistry, University of Maine, Orono
PhD, Molecular & Cell Biology, The Pennsylvania State University, University Park

Fellowship, The Pennsylvania State University
Postdoctoral Fellow, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN
Associate, Howard Hughes Medical Institute at St. Jude Children's Research Hospital, Memphis, TN

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Molecular Mechanisms of Tumorigenesis and Cell Cycle Control My research is centered on understanding molecular mechanisms that control cell proliferation and checkpoint responses, and how those processes are disrupted during tumorigenesis. A principal focus of the lab is the ARF tumor suppressor, which is encoded by a gene (INK4a/ARF) that is inactivated in 40-50% of all human cancers. ARF inhibits tumorigenesis through p53-dependent and p53-independent signaling pathways that are complex and only partially defined. That is because ARF functions through numerous binding partners (at least 30) to promote apoptosis or senescence, inhibit migration/invasion and metastasis, sustain cell stress checkpoints and maintain chromosomal stability. Our goal is to define the critical regulators of ARF signaling and determine their significance to tumor suppression using molecular approaches and in vivo models of cancer. In so doing, we will advance our fundamental understanding of ARF-mediated tumor suppression and also identify novel regulators of growth (both positive and negative) whose characterization will likely contribute to new paradigms of carcinogenesis. Such knowledge is essential to providing new markers for tumor detection and developing useful, targeted anticancer strategies.

Selected Publications

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Muniz V, Barnes J, Paliwal S, Zhang X, Tang X, Chen S, Zamba K, Cullen J, Meyerholz D, Meyers S, Davis J, Grossman S, Henry M, Quelle D.  The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis..  Molecular cancer research : MCR.  2011 July. 9(7):867-77.
[PubMed]

di Tommaso A, Hagen J, Tompkins V, Muniz V, Dudakovic A, Kitzis A, Ladeveze V, Quelle D.  Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities..  Experimental cell research.  2009 April. 315(7):1326-35.
[PubMed]

Hagen J, Tompkins V, Dudakovic A, Weydert J, Quelle D.  Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2..  Hybridoma (Larchmt).  2008 June. 27(3):159-66.
[PubMed]

Groskreutz D, Monick M, Yarovinsky T, Powers L, Quelle D, Varga S, Look D, Hunninghake G.  Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells..  Journal of immunology (Baltimore, Md. : 1950).  2007 September. 179(5):2741-7.
[PubMed]

Tompkins V, Hagen J, Frazier A, Lushnikova T, Fitzgerald M, di Tommaso A, Ladeveze V, Domann F, Eischen C, Quelle D.  A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability..  The Journal of biological chemistry.  2007 January. 282(2):1322-33.
[PubMed]

Miller S, Rangwala F, Williams J, Ackerman P, Kong S, Jegga A, Kaiser S, Aronow B, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, Quelle D, Watson M, Perry A, Gutmann D, Ratner N.  Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues..  Cancer research.  2006 March. 66(5):2584-91.
[PubMed]

Datta A, Sen J, Hagen J, Korgaonkar C, Caffrey M, Quelle D, Hughes D, Ackerson T, Costa R, Raychaudhuri P.  ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF..  Molecular and cellular biology.  2005 September. 25(18):8024-36.
[PubMed]

Korgaonkar C, Hagen J, Tompkins V, Frazier A, Allamargot C, Quelle F, Quelle D.  Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function..  Molecular and cellular biology.  2005 February. 25(4):1258-71.
[PubMed]

Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne M, Quelle D.  Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways..  Molecular cancer research : MCR.  2003 January. 1(3):195-206.
[PubMed]

Date Last Modified: 07/31/2013 - 10:51:40