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Associate Chair for EducationAssociate Professor of Pharmacology
Primary Office: 2-460 Bowen Science BuildingIowa City, IA 52242
BA, University of California at Los Angeles, Los Angeles, CAMS, University of California at Los Angeles, Los Angeles, CAPhD, Pharmacology, University of California at Los Angeles, Los Angeles, CA
Post Doctorate, University of California at San Diego, La Jolla, CA
Molecular Mechanisms of Hormone-Induced Cell Proliferation Research in my laboratory focuses on the cellular and molecular mechanisms of hormone-induced cell proliferation in reproductive organs. The gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), are thought to provide the main stimuli for steroidogenic and proliferative activity in gonadal cells, whereas steroids themselves are thought to be the primary stimuli for proliferation in most other reproductive organs. Recent evidence suggests that a variety of growth factors and other peptides either mediate or modulate the actions of these hormones. Our investigations are directed toward identifying factors involved in regulating proliferative and activity in prostate, uterus, and ovary, then defining the molecular pathways through which these factors act. Current studies focus on two specific areas: 1. Molecular mechanisms regulating cell proliferation in the prostate. These studies include projects on regulation of cyclin production, characterization and regulation of cyclin-dependent kinase activity, identification of cyclin-dependent kinase targets, and identification of defects in normal regulatory processes resulting in prostate cancer. 2. The actions of leukocyte secretory products (cytokines) on steroidogenic activity in ovarian cells. These studies include projects on receptor interactions, signal transduction pathways, and characterization of novel cytokines in reproductive tissues.
Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase. .
Mol Cell Biol.
1996 February. 16(2):577-583.
Stimulation of rat granulosa cell progesterone production but not other differentiated functions by a splenocyte-derived factor..
J Reprod Fertil .
1995 September. 105(1):125-133.
Identification of vasopressin mRNA in rat aorta. .
1995 May. 25(5):1030-1033.
Arginine vasopressin stimulates protein synthesis but not proliferation of cultured vascular endothelial cells. .
J Cardiovasc Pharmacol .
1995 March. 25(3):368-375.
Induction of rat granulosa cell steroidogenic enzyme activities and their messenger ribonucleic acids by a splenocyte-derived factor..
Mol Cell Endocrinol .
1994 December. 106(1-2):163-170.
Pituitary adenylate cyclase-activating polypeptide stimulates steroidogenesis and adenosine 3',5'-monophosphate accumulation in cultured rat granulosa cells. .
1994 July. 135(1):207-213.
Androgens augment vasoactive intestinal peptide- and growth hormone-releasing hormone-stimulated progestin production by rat granulosa cells. .
1993 February. 132(2):584-590.
Gonadotropin regulation of c-fos and c-jun messenger ribonucleic acids in cultured rat granulosa cells. .
Mol Cell Endocrinol.
1992 December. 90(1):17-25.
Characterization of a vasopressin-like peptide in rat and bovine blood vessels..
Am J Physiol.
1992 March. 262(3 PT. 2):H799-H805.
Central vasopressin raises arterial pressure by sympathetic activation and vasopressin release..
1989 June. 13(6 pt 2):935-940.
Date Last Modified: 08/04/2015 -
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