Pharmacology

Justin L. Grobe, PhD

Portrait

Assistant Professor of Pharmacology

Contact Information

Primary Office: 2-307 Bowen Science Building
Iowa City, IA 52242
Primary Office Phone: 319-353-5789

Lab: 2-300 Bowen Science Building
Iowa City, IA 52242
Phone: 319-353-5803

Email: justin-grobe@uiowa.edu
Web: Department of Pharmacology

Education

BA, Biology and Chemistry, Hope College, Holland, MI
BS, Biology and Chemistry, Hope College, Holland, MI
PhD, Pharmacodynamics, University of Florida, Gainesville, FL

Postdoctoral Fellow, University of Florida College of Medicine, Gainesville, FL, Physiology and Functional Genomics
Postdoctoral Fellow, University of Iowa Carver College of Medicine, Internal Medicine (8/26-6/10) & Pharmacology (7/10-10/10)

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Pharmacology Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Neuroscience
Medical Scientist Training Program

Research Summary

Obesity is an epidemic in industrialized nations, and current pharmacological interventions are insufficient. While many drugs to combat obesity have been developed, they almost exclusively target food intake behavior or digestive efficiency. Essentially no effective/safe compounds have been developed for increasing energy output, and thus our group’s focus is to identify novel therapeutic targets for increasing resting metabolic rate as an alternative or adjunct to conventional therapies. The renin-angiotensin system (RAS) is well known for its roles in blood pressure and water and electrolyte homeostasis. This hormone system is found in the circulation but also within individual tissues, where it acts as a paracrine/autocrine signaling mechanism. Organs that use the RAS for paracrine signaling include the brain and adipose. We have previously demonstrated important roles for both the brain and adipose RAS in the control of resting metabolic rate, and ongoing work is focused on understanding these mechanisms. Additional research is focused on understanding the contributon of brain RAS to the physiological effects of the metabolic controller, leptin. Our laboratory uses both classic pharmacological and unique transgenic animal models to examine the effects of specific RAS manipulations on physiological processes including blood pressure, fluid and electrolyte turnover, and metabolic rate. Through collaborations with various faculty at the University of Iowa, additional foci of our group include understanding the role of blood pressure and sodium homeostasis on resting metabolism, arginine vasopressin in hypertension and related disorders such as preeclampsia, and the physiological significance of a novel intracellular isoform of the renin enzyme.

Center, Program and Institute Affiliations

Cardiovascular Research Center
Center for Functional Genomics of Hypertension
Fraternal Order of Eagles Diabetes Research Center
Obesity Initiative

All Publications

Muta K, Grobe J, Sigmund C, Rahmouni K.  Essential Role of mTORC1 in the Hypertension Induced by Overactivation of the Brain Renin-Angiotensin System.  EB2014.  2014. 

DeSilva T, Lynch C, Grobe J, Faraci F.  Mild Deoxycorticosterone (DOCA)/salt-induced Hypertension Causes Cerebral Microvascular Dysfunction via a Rho Kinase Dependent Mechanism.  EB2014.  2014. 

Weidemann B, Littlejohn N, Cole R, Grobe J.  The Brain Renin-Angiotensin System Suppresses Digestive Efficiency.  EB2014.  2014. 

Burnett C, Grobe J.  Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice.  Am J Physiol Endocrinol Metab.  2013 October 1. 305(7).
[Link]

Littlejohn N, Siel Jr. R, Ketsawatsomkron P, Pelham C, Pearson N, Hilzendeger A, Buehrer B, Weidemann B, Li H, Davis D, Thompson A, Liu X, Cassell M, Sigmund C, Grobe J.  Hypertension in Mice with Transgenic Activation of the Brain Renin-Angiotensin System is Vasopressin-Dependent.  Am J Physiol Regul Integr Comp Physiol.  2013 May 15. 304(10):R818-R828.
[Link]

Hilzendeger A, Cassell M, Davis D, Stauss H, Mark A, Grobe J, Sigmund C.  Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension.  Hypertension.  2013 March 6. 61(3):716-722.
[Link]

Keen H, Littlejohn N, Liu X, Grobe J, Sigmund C.  Adiopose Angiotensin AT2 Receptors Modulate Thermogenesis though Interactions with Epidermal Growth Factor Signaling.  Hypertension.  2013. 62:A414.

Littlejohn N, Weidemann B, Morgan D, Rahmouni K, Sigmund C, Grobe J.  Adipose Angiotensin AT2 Receptors Inhibit Resting Metabolism.  Hypertension.  2013. 62:A219.

Grobe J, Claflin K.  Angiotensin AT1A Receptos on Leptin Receptor-Expressing Cells are Required for the Blood Pressure and Metabolic Rate Effects of Leptin.  Hypertension.  2013. 62:A25.

Coble J, Cassell M, Grobe J, Sigmund C.  Angiotensin production specifically within the subfornical organ induces polydipsia.  Hypertension.  2013. 62:A174.

Ketsawatsomkron P, Davis D, Hilzendeger A, Grobe J, Sigmund C.  Deoxycorticosterone Acetate (DOCA)-Salt Exacerbates Hypertension and Vascular Dysfunction in Mice Expressing Dominant Negative Peroxisome Proliferator-Activated Receptor-Gamma (PPARG) in Smooth Muscle.  Hypertension .  2013. 62:A310.

 .  Deoxycorticosterone Acetate (DOCA)-Salt Exacerbates Hypertension and Vascular Dysfunction in Mice Expressing Dominant Negative Peroxisome Proliferator-Activated Receptor-Gamma (PPARG) in Smooth Muscle.  FASEB J.  2013. 27:708.10.

Pearson N, Littlejohn N, Lutter M, Grobe J.  Dietary Sodium Suppresses High-Fat Diet Weight Gain in C57Bl/6J Mice.  FASEB J.  2013. 27:1153.3.

Burnett C, Grobe J.  Direct Calorimetry Exposes Inadequacies of Respirometry in the Measurement of Resting Metabolic Rate.  FASEB J.  2013. 27:1202.26.

Weidemann B, Littlejohn N, Sigmund C, Grobe J.  Glycemic Control by the Brain Renin-Angiotensin System: Role for Peripheral AT2 Receptors.  FASEB J.  2013. 27:1120.2.

Claflin K, Hilzendeger A, Sigmund C, Grobe J.  Modulation of the Metabolic Effects of Leptin by the Brain Renin-Angiotensin System.  Hypertension.  2013. 62:A173.

Li W, Peng H, Mehaffey E, Kimball C, Grobe J, van Gool J, Sullivan M, Earley S, Danser A, Ichihara A, Feng Y.  Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension.  Hypertension.  2013. 63(2).
[Link]

Folchert M, Littlejohn N, Liu X, Grobe J, Sigmund C.  Physiological characterization of a selective knockout of the intracellular isoform of renin in the brain in mice.  Hypertension.  2013. 62:A16.

Coble J, Grobe J, Cassell M, Sigmund C.  Production of angiotensin within the SFO is sufficient to increase ERK1/2 and CREB activity in the SFO and PVN.  FASEB J.  2013. 27(1165.11).

Littlejohn N, Keen H, Liu X, Sigmund C, Grobe J.  Regulation of Adipose Thermogenesis by Epidermal Growth Factor and Angiotensin AT2 Receptor.  FASEB J.  2013. 27:696.1.

Jo F, Jo H, Hilzendeger A, Cassell M, Rutkowski D, Davisson R, Grobe J, Sigmund C.  Role of Endoplasmic Reticulum Stress in the SFO in Fluid Balance and Metabolic Effects of Brain Renin-Angiotensin System Activation.  Hypertension.  2013. 62:A176.

Folchert M, Littlejohn N, Liu X, Grobe J, Sigmund C.  Selective Knockout of Novel Intracellular Renin Isoform Results in Reduced Adiposity.  FASEB J.  2013. 27:696.2.

Santillan M, Santillan D, Leslie K, Hunter S, Grobe J.  The Vasopressin Pro-Segment Copeptin: A Novel, First Trimester Predictor of Preeclampsia.  Hypertension.  2013. 62:A9.

Lu K, Weatherford E, Ketsawatsomkron P, Grobe J, Sigmund C.  Transcriptional regulation of renin by nuclear receptors co-regulated with renin.  Hypertension.  2013. 62:A191.

Grobe J, Rahmouni K, Liu X, Sigmund C.  Metabolic rate regulation by the renin-angiotensin system: brain vs. body..  Pflugers Arch - European J of Physiology.  2013 January. 465(1):167-175.
[Link]

Grobe J, Rahmouni K.  Editorial Commentary: The adipose-circulating renin-angiotensin system cross-talk enters a new dimension..  Hypertension.  2012 December. 60(6):1389-1390.
[PubMed]

Ketsawatsomkron P, Lorca R, Keen H, Weatherford E, Liu X, Pelham C, Grobe J, Faraci F, England S, Sigmund C.  PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity..  Circ Res.  2012 November 9. 111(11):1446-1458.
[Link]

Pelham C, Ketsawatsomkron P, Groh S, Grobe J, de Lange W, Ibeawuchi S, Keen H, Weatherford E, Faraci F, Sigmund C.  Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase.  Cell Metab.  2012 October 3. 16(4):462-472.
[Link]

Hilzendeger A, Morgan D, Brooks L, Dellsperger D, Liu X, Grobe J, Rahmouni K, Sigmund C, Mark A.  A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.  Am J Physiol Heart Circ Physiol.  2012 July 15. 303(2):H197-H206.
[Link]

Grobe J, Park S, Liu X, Sigmund C.  Angiotensinergic signaling in the brain controls whole-body metabolism: Role of adipose AT2 receptors.  Gordon Research Conference: Angiotensin.  2012 February. 

Grobe J.  Control of Metabolic Rate by Brain Angiotensins.  Gordon Research Conference: Angiotensin.  2012 February. 

Grobe J, Rahmouni K.  Editoral Focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice."..  Am J Physiol Regul Integr Comp Physiol.  2012 January 15. 302(2):R242-R243.
[Link]

Coble J, Grobe J, Cassell M, Sigmund C.  A novel model of conditionally inducible angiotensin production in the brain: investigations of sodium and fluid intake.  The FASEB Journal.  2012. 26:1093.4.

 .  Angiotensin II Type 1a receptor in the subfornical organ is essential for blood pressure regulation and hydromineral effects in mouse models of elevated brain renin-angiotensin system activity.  Hypertension.  2012. 60:A84.

Hilzendeger A, Grobe J, Mark A, Sigmund C.  Angiotensin II Type 1A Receptors in the Subfornical Organ Mediate the Effects of the Brain RAS on Fluid Balance in DOCA-salt model.  The FASEB Journal.  2012. 26:1091.6.

Grobe J, Park S, Littlejohn N, Buehrer B, Weidemann B, Keen H, Liu X, Sigmund C.  Angiotensin suppresses thermogenic capacity through adipose AT2 receptors.  Hypertension.  2012. 60:A20.

Grobe J, Park S, Liu X, Sigmund C.  Angiotensinergic signaling in the brain controls whole-body metabolism: Role of adipose AT2 receptors.  The FASEB Journal.  2012. 26:890.1.

Grobe J, Hilzendeger A, Siel Jr. R, Davis D, Mark A, Sigmund C.  Endoplasmic Reticulum Stress in Cardiovascular and Metabolic Control during DOCA-Salt Treatment.  The FASEB Journal.  2012. 26:703.22.

Grobe J, Hilzendeger A, Davis D, Davisson R, Mark A, Sigmund C.  Endoplasmic Reticulum Stress Mediates Fluid Balance and Metabolic Effects of the Brain Renin-Angiotensin System.  Hypertension.  2012. 60:A409.

Shi P, Desland F, Zhou G, Zhou F, Roper S, Dong Y, Shan Z, Grobe J, Raizada M, Sumners C.  Microglial-neuronal interactions in the paraventricular nucleus (PVN): a potential mechanism underlying neurogenic hypertension.  The FASEB Journal.  2012. 26:891.3.

Muta K, Grobe J, Sigmund C, Rahmouni K.  mTOR/S6K Signaling: A Novel Effector of Neuronal Action of Angiotensin II.  The FASEB Journal.  2012. 26:1093.3.

Grobe J, Park S, Liu X, Sigmund C.  Regulation of Thermogenic Capacity by the Brain Renin-Angiotensin System: Role of Adipose AT2 Receptors.  APS Conference: Autonomic Regulation of Cardiovascular Function in Health and Disease [Presented July 8, 2012 - abstract in press].  2012. 

 .  Selective activation of the renin-angiotensin system in the subfornical organ is sufficient to elicit fluid and sodium intake behaviors.  Hypertension.  2012. 60:A114.

Folchert M, Liu X, Grobe J, Sigmund C.  Selective Genetic Deletion of the Brain-Specific Intracellular Renin Isoform (Renin-1b) Results in Altered Metabolic and Fluid Balance Regulation.  Hypertension.  2012. 60:A634.

Littlejohn N, Siel Jr. R, Ketsawatsomkron P, Pelham C, Hilzendeger A, Buehrer B, Weidemann B, Li H, Davis D, Thompson A, Liu X, Cassell M, Sigmund C, Grobe J.  Transgenic Hyperactivity of the Brain Renin-Angiotensin System Causes Vasopressin-Dependent Hypertension.  Hypertension.  2012. 60:A126.

Li H, Weatherford E, Davis D, Keen H, Grobe J, Daugherty A, Cassis L, Allen A, Sigmund C.  Renal proximal tubule angiotensin AT1A receptors regulate blood pressure..  Am J Physiol Regul Integr Comp Physiol.  2011 October. 301(4):R1067-R1077.
[Link]

Xu D, Borges G, Davis D, Agassandian K, Sequeira Lopez M, Gomez R, Cassell M, Grobe J, Sigmund C.  Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism.  Physiol Genomics.  2011 March 29. 43(6):286-294.
[Link]

Grobe J, Buehrer B, Hilzendeger A, Liu X, Davis D, Xu D, Sigmund C.  Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice.  Hypertension.  2011 March. 57[Part 2}(3):600-607.
[Link]

Hilzendeger A, Grobe J, Mark A, Sigmund C.  Hydromineral Consequences of DOCA-Salt Treatment: AT1A Receptors in the Brain.  Hypertension.  2011. 58(5):e37.

Sepulveda M, Ketsawatsomkron P, Grobe J, Sigmund C.  Loss of function of peroxisome proliferator-activated receptor gamma (PPARG) in vascular smooth muscle augments angiotensin II (ANG) signaling.  Hypertension.  2011. 58(5):e62.

Grobe J, Buehrer B, Hilzendeger A, Liu X, Davis D, Sigmund C.  Metabolic effects of deoxycorticosterone (DOCA)-salt require the brain renin-angiotensin system.  The FASEB Journal.  2011. 25:648.6.

Shi P, Grobe J, Desland F, Raizada M, Sumners C.  Microglial activation by the brain renin-angiotensin system.  The FASEB Journal.  2011. 25:661.2.

Shi P, Grobe J, Desland F, Rodriguez V, Shan Z, Richards E, Raizada M, Sumners C.  Stimulatory action of the renin-angiotensin-aldosterone system on the production of microglial derived cytokines.  Hypertension.  2011. 58(5):e37.

Grobe J, Ketsawatsomkron P, Pelham C, Siel Jr. R, Davis D, Sigmund C.  Vascular Remodeling and Dysfunction in Response to Elevated Brain Angiotensins.  Hypertension.  2011. 58(5):e43.

Grobe J, Ketsawatsomkron P, Pelham C, Siel Jr. R, Davis D, Sigmund C.  Vascular Remodeling and Dysfunction in Response to Elevated Brain Angiotensins.  Combined Iowa/Nebraska Physiological Societies Meeting.  2011. 

Grobe J, Grobe C, Beltz T, Westphal S, Morgan D, Xu D, de Lange W, Li H, Sakai K, Thedens D, Cassis L, Rahmouni K, Mark A, Johnson A, Sigmund C.  The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.  Cell Metab.  2010 November 3. 12(5):431-442.
[Link]

Grobe J, Dickson M, Park S, Davis D, Born E, Sigmund C.  Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice..  Hypertension.  2010 November. 56(5):981-987.
[Link]

Agassandian K, Grobe J, Liu X, Agassandian M, Sigmund C, Cassell M.  Evidence for intraventricular secretion of angiotensinogen and angiotensin peptides by the subfornical organ.  Hypertension.  2010. 56(5):e102.

Grobe J, Buehrer B, Xu D, Sigmund C.  Metabolic consequences of deoxycorticosterone acetate (DOCA)-salt in mice.  Hypertension.  2010. 56(5):e102.

Shenov V, Grobe J, Qi Y, Ferreira A, Fraga-Silva R, Collamat G, Bruce E, Katovich M.  17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats..  Peptides.  2009 December. 30(12):2309-2315.
[Link]

Xu D, Borges G, Grobe J, Pelham C, Yang B, Sigmund C.  Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin.  Hypertension.  2009 December. 54(6):1240-1247.
[Link]

Grobe J, Venegas-Pont M, Sigmund C, Ryan M.  PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake"..  Am J Physiol Regul Integr Comp Physiol.  2009 May. 296(5):R1325-R1326.
[Link]

Grobe J, Grobe C, da Rocha Borges G, Beltz T, Johnson A, Sigmund C.  Adrenal hormones are necessary for the hydromineral phenotypes of transgenic mice with central renin-angiotensin system overactivity.  The FASEB Journal.  2009. 23:967.2.

Grobe J, Grobe C, Beltz T, Borges G, Cassis L, Johnson A, Sigmund C.  Hydromineral phenotypes of transgenic mice with central renin-angiotensin system hyperactivity are dependent upon adrenal steroids.  Hypertension.  2009. 54(4):e96.

Bruce E, Shenoy V, Grobe J, Qi Y, Ferreira A, Collamat G, Katovich M.  Low dose but not high dose of 17â-estradiol prevents cardiac fibrosis in DOCA-salt model of hypertension in rats.  The FASEB Journal.  2009. 23:LB77.

Grobe J, Xu D, Sigmund C.  An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.  Physiology (Bethesda).  2008 August. 23:187-193.
[Link]

Katovich M, Grobe J, Raizada M.  Angiotensin-(1-7) as an antihypertensive, antifibrotic target..  Curr Hypertens Rep.  2008 June. 10(3):227-232.
[PubMed]

Der Sarkissian S, Grobe J, Yuan L, Narielwala D, Walter G, Katovich M, Raizada M.  Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology..  Hypertension.  2008 March. 51(3):712-718.
[Link]

Grobe J, Grobe C, Thedens D, Gall A, Sakai K, Rahmouni K, Blumberg M, Johnson A, Sigmund C.  Negative energy balance in transgenic mice with CNS-specific over-activity of the renin-angiotensin system.  2008 Gordon Research Conference: Angiotensin.  2008 February. 

Grobe J, Morgan D, Rahmouni K, Sigmund C.  Enhanced Sympathetic and HPA-Axis Activity Contribute to Increased Metabolic Rate in Transgenic Mice with Overactivity of the Central Renin-Angiotensin System.  Hypertension.  2008. 52(4):e49.

Grobe J, Grobe C, Gall A, Thedens D, Sakai K, Rahmouni K, Blumberg M, Johnson A, Sigmund C.  The brain renin-angiotensin system promotes a negative energy balance in mice.  The FASEB Journal.  2008. 22:1167.2.

Grobe J, Der Sarkissian S, Stewart J, Meszaros J, Raizada M, Katovich M.  ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts..  Clin Sci (Lond).  2007 October. 113(8):357-364.
[Link]

Li H, Gao Y, Grobe J, Raizada M, Katovich M, Sumners C.  Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor..  Am J Physiol Heart Circ Physiol..  2007 February. 2992(2):H727-H735.
[Link]

Grobe J, Mecca A, Lingis M, Shenoy V, Bolton T, Machado J, Speth R, Raizada M, Katovich M.  Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7)..  Am J Physiol Heart Circ Physiol.  2007 February. 292(2):H736-H742.
[Link]

Grobe J, Mecca A, Lingis M, Shenoy V, Bolton T, Machado J, Speth R, Raizada M, katovich M.  Angiotensin-(1-7) prevents cardiac remodeling during angiotensin II-induced hypertension.  The FASEB Journal.  2007. 21(6):A896.

Shenoy V, Qi Y, Machado J, Bolton T, Grobe J, Katovich M.  Effects of 17-beta-estradiol on cardiac remodeling in the DOCA-salt model of hypertension.  The FASEB Journal.  2007. 21(6):A1364.

Grobe J, Grobe C, Gall A, Sakai K, Rahmouni K, Blumberg M, Johnson A, Sigmund C.  Increased metabolic rate in transgenic mice over-expressing the central renin-angiotensin system.  Hypertension.  2007. 50(4):e82.

Grobe J, Mecca A, Mao H, Katovich M.  Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension..  Am J Physiol Heart Circ Physiol..  2006 June. 290(6):H2417-H2423.
[Link]

Grobe J, Katovich M.  Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats.  Regul Pept.  2006 January 15. 133(1-3):62-67.
[Link]

Grobe J, DerSarkissian S, Raizada M, Katovich M.  ACE2 protects cultured cardiac fibroblasts from hypoxia-reperfusion injury.  Hypertension.  2006. 48(4):e79.

Grobe J, Mecca A, Lingis M, Mao H, Katovich M.  Angiotensin 1-7 prevents cardiac fibrosis in angiotensin II and DOCA-salt models of hypertension.  The FASEB Journal.  2006. 20:A305.

Stewart J, Grobe J, Katovich M.  Estrogen modulates ACE2 activity in cardiac myocytes.  The FASEB Journal.  2006. 20:A1189.

Huentelman M, Grobe J, Vazquez J, Stewart J, Mecca A, Katovich M, Ferrario C, Raizada M.  Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats..  Exp Physiol.  2005 September. 90(5):783-790.
[Link]

Katovich M, Grobe J, Huentelman M, Raizada M.  Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension.  Exp Physiol.  2005 May. 90(3):299-305.
[Link]

Li H, Gao Y, Grobe J, Raizada M, Katovich M, Sumners C.  Adenoviral-mediated systemic transduction of the angiotensin II (ang II) type 2 receptor (AT2R) enhances the hypotensive action of losartan.  Molecular Therapy.  2005. 11:S244.

Grobe J, Katovich M.  Effect of sex steroid modulation on vascular reactivity to angiotensin 1-7 in the aorta.  TheFASEB Journal.  2005. 19(5):A126.

Mitra A, Grobe J, Katovich M, Rowland N.  Effects of central and peripheral administration of apelin on food intake, water intake, and blood pressure.  Society for the Study of Ingestive Behavior.  2005. 

Katovich M, Grobe J, Raizada M.  Gene therapy for hypertension: current targets and consideration of novel targets..  Humana Press.  2005. 

Grobe J, Rowland N, Katovich M.  Role of angiotensin II and the subfornical organ in the pharmacological actions of ethanol..  Alcohol Alcohol.  2004 September. 39(5):410-417.
[Link]

Barney C, Kurylo D, Grobe J.  Thermal dehydration-induced thirst in lithium-treated rats..  Pharmacol Biochem Behav..  2003 May. 75(2):341-347.
[Link]

Rowland N, Grobe J, Katovich M.  Effects of subfornical organ lesion on thermal and behavioral responses to ethanol in rats.  The FASEB Journal.  2001. 15(4):A136.

Burnatowska-Hledin M, Zeneberg A, roulo A, Grobe J, Zhao P, Lelkes P, Clare P, Barney C.  Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle.  Endothelium.  2001. 8(1):49-63.
[PubMed]

Grobe J, Barney C, Burnatowska-Hledin M.  Using antibodies to investigate the physiological role of VACM-1.  The FASEB Journal.  2000. 14(4):A676.

Claflin K, Sandgren J, Burnett C, Pearson N, Weidemann B, Voong S, Littlejohn N, Hilzendeger A, Davis D, Stauss H, Morgan D, Rahmouni K, Grobe J.  Angiotensin AT1A receptors expressed on leptin-sensitive cells are required for the resting energy expenditure effects of leptin in mice.  [Intend to submit to Cell Metabolism in January 2013]. 

Santillan M, Santillan D, Scroggins S, Min J, Leslie K, Hunter S, Zamba G, Gibson-Corley K, Grobe J.  Early First Trimester Prediction of Preeclampsia by Copeptin: Is Vasopressin Hypersecretion an Initiating Event in the Pathogenesis of Preeclampsia?.  Under review at New England Journal of Medicine, submitted Nov. 19, 2013. 

Agassandian K, Grobe J, Liu X, Agassandian M, Sigmund C, Cassell M.  Evidence for intraventricular secretion of angiotensinogen and angiotensin peptides by the subfornical organ. 

Li H, Park S, Davis D, Sigmund R, Grobe J, Stokes J, Sigmund C.  Role of Angiotensin II AT1A Receptor in the Renal Thick Ascending Limb of Henle’s Loop and Distal Tubules.  AJP Regulatory. 

Date Last Modified: 01/23/2014 - 09:08:46