Pharmacology

Rory A. Fisher, PhD

Portrait

Professor of Pharmacology
Professor of Internal Medicine

Contact Information

Primary Office: 2-512 Bowen Science Building
Iowa City, IA 52242
Primary Office Phone: 319-335-8330

Lab: 2-505 Bowen Science Building
Iowa City, IA 52242
Phone: 319-335-8331

Email: rory-fisher@uiowa.edu

Education

Texas A&M University, College Station, TX
BS, Biology, Rockford College, Rockford, IL
PhD, Biochemistry & Biophysics, Iowa State University, Ames, IA, (Major: Molecular Cellular Development Biology)

Postdoctoral Fellow, Dept of Pathology, University of Texas Health Science Center, San Antonio, TX
Postdoctoral Fellow, Dept of Biochemistry, University of Texas Health Science Center, San Antonio, TX

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Molecular and Cellular Biology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Molecular Biology and Signaling of RGS Proteins Cells communicate with the outside world by interactions of molecules with receptors that activate signal transduction pathways, thereby converting extracellular messages into cellular responses. Various hormones, neurotransmitters, autacoids and sensory molecules activate a family of seven- transmembrane-domain receptors that specifically couple to heterotrimeric G proteins, activating specific second messenger systems.. This signaling system is extremely common and important (e.g., the senses of vision, smell and taste all work by these mechanisms), controlling exceptionally diverse physiological and pathophysiological processes. GPCRs and their signaling components enable cells to adjust to their environment rapidly and with exquisite sensitivity and precision. More than half of known drugs target components of this indispensable signaling system in humans. The intensity and duration of G protein signaling via heterotrimeric G proteins is regulated at multiple levels. Recently, a new gene family (RGS proteins) was identified that provides new insights into how G proteins are turned off once activated by receptors. RGS proteins are key negative regulators of G protein signaling by virtue of their GTPase-activating protein (GAP) activity toward G protein subunits. Our laboratory has pioneered the idea that RGS proteins possess activities apart from or in addition to those involved in G protein signaling. Molecular cloning and characterization of new members of the RGS family in our lab revealed surprising diversity in regions not associated with their GAP activity. These and other findings, including evidence that most RGS proteins traffick to and from the nucleus, raised the intriguing possibility that RGS proteins might possess diverse functional activities. In our studies, we have characterized the role of RGS proteins in G protein signaling and determined mechanisms underlying their unique subcellular trafficking in cells, gaining new insights into structural/functional relationships of RGS proteins. We identified the structural organization of genes encoding numerous RGS proteins, revealing exceptional complexity in splicing of some RGS protein transcripts (e.g., 36 splice forms of RGS6) and facilitating gene knock-in and knock-out studies (functional genomics) to determine the role of these proteins in organisms. Our recent studies have revealed novel signaling functions of RGS proteins in the nucleus, in neuronal differentiation and development, and in DNA damage signaling responses. We identified an RGS polymorphism (gene variant) in humans associated with a significant reduction in the risk of cancer, providing the first link between RGS protein expression and cancer. These studies raise questions of considerable interest and importance concerning the role of RGS proteins in cellular regulation by mechanisms both dependent on and independent of their regulatory actions on G proteins. Some current projects include identifying novel RGS protein interaction partners, anti-sense and transgene technologies to probe physiological roles of RGS proteins, defining the role of nuclear RGS proteins and determining the mechansims regulating RGS gene expression.

All Publications

Stewart A, Maity B, Wunsch A, Wemmie J, Fisher R.  Regulator of G protein signaling 6 (RGS6) promotes anxiety and depression through attenuation of serotonin 5-HT1A receptor signaling.  FASEB J.  2014. 
[PubMed]

Huang J, Yang J, Stewart A, Hagen J, Quelle D, Fisher R.  RGS6 Suppresses Ras-induced Cellular Transformation by Facilitating Tip60-mediated Dnmt1 Degradation and Promoting Apoptosis.  Oncogene.  2013 September 2. 
[PubMed]

Maity B, Stewart A, O'Malley Y, Askeland R, Sugg S, Fisher R.  Regulator of G protein signaling 6 is a novel suppressor of breast tumor initiation and progression..  Carcinogenesis.  2013 August. 34(8):1747-55.
[PubMed]

Yang J, Maity B, Huang J, Gao Z, Stewart A, Weiss R, Anderson M, Fisher R.  G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin..  Cancer research.  2013 March. 73(6):1662-7.
[PubMed]

Maity B, Sheff D, Fisher R.  Immunostaining: Detection of Signaling Protein Location in Tissues, Cells and Subcellular Compartments.  Elsevier Inc.  2013. 113:81-105.

Maity B, Sheff D, Fisher R.  Immunostaining: detection of signaling protein location in tissues, cells and subcellular compartments..  Methods in cell biology.  2013. 113:81-105.
[PubMed]

Yang J, Maity B, Huang J, Gao Z, Stewart A, Weiss R, Anderson M, Fisher R.  Regulator of G protein Signaling 6 (RGS6) Mediates doxorubicin-induced Myocardial Cell Apoptosis and Cardiomyopathy.  FASEB.  2013. 27:1031.7.

Stewart A, Maity B, Wunsch A, Wemmie J, Fisher R.  RGS6 Deficiency Promotes Anxiolytic and Antidepressant Behavior through Potentiation of 5-HT1AR Signaling.  FASEB.  2013. 27:1031.8.

Maity B, Stewart A, O'Malley Y, Askeland R, Sugg S, Fisher R.  RGS6 Functions as a Novel Suppressor of Tumor Initiation and Progression in a Mouse Model of Breast Carcinogenesis.  FASEB.  2013. 27:598.1.

Shim H, Wang C, Chen Y, Chau V, Fu K, Yang J, McQuiston A, Fisher R, Chen C.  Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice..  The Journal of biological chemistry.  2012 April. 287(18):14873-9.
[PubMed]

Maity B, Stewart A, Yang J, Loo L, Sheff D, Shepherd A, Mohapatra D, Fisher R.  Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling..  The Journal of biological chemistry.  2012 February. 287(7):4972-81.
[PubMed]

Stewart A, Fisher R.  Co-Immunoprecipitation: Isolation of Protein Signaling Complexes from Native Tissues.  Elsevier Inc. ISBN: 9780124059146.  2012. 112:33-54.

Stewart A, Maity B, Yang J, Loo L, Shepard A, Mohapatra D, Fisher R.  Regulator of G Protein Signaling 6 (RGS6) ensures coordination of motor movement by modulating GABAB Receptor (GABABR) signaling.  FASEB.  2012. 26:972.

Maity B, Yang J, Huang J, Fisher R.  Regulator of G Protein Signaling 6 (RGS6), A Novel Modulator of Doxorubicin-induced Cardiotoxicity and Apoptosis.  FASEB.  2012. 26:537.

Stewart A, Huang J, Fisher R.  RGS Proteins in Heart: Brakes on the Vagus..  Frontiers in physiology.  2012. 3:95.
[PubMed]

Huang J, Yang J, Maity B, Mayuzumi D, Fisher R.  Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism..  Cancer research.  2011 October. 71(20):6310-9.
[PubMed]

Huang J, Yang J, Hagen J, Quelle D, Fisher R.  A Novel Role of RGS6 In Oncogenic Ras-Induced Cellular Transformation.  FASEB.  2011. 25:498.5.

Chen C, Shim H, Chen Y, Wang C, Chen C, Morhardt D, Yang J, Fisher R.  Involvement of Gbeta5/RGS Proteins in Mammalian Vision.  Society for Neuroscience Meeting.  2011. 

Maity B, Yang J, Huang J, Askeland R, Fisher R.  Regulator of G Protein Signaling 6 (RGS6) Induces Apoptosis in Mammary Tumor Cells via a Mitochondrial-dependent Pathway Not Involving Its GTPase-Activating Protein Activity.  FASEB.  2011. 25:751.7.

Maity B, Yang J, Huang J, Askeland R, Bera S, Fisher R.  Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity..  The Journal of biological chemistry.  2011 January. 286(2):1409-19.
[PubMed]

Yang J, Huang J, Maity B, Gao Z, Lorca R, Gudmundsson H, Li J, Stewart A, Swaminathan P, Ibeawuchi S, Shepherd A, Chen C, Kutschke W, Mohler P, Mohapatra D, Anderson M, Fisher R.  RGS6, a modulator of parasympathetic activation in heart..  Circulation research.  2010 November. 107(11):1345-9.
[PubMed]

Yang J, Huang J, Chatterjee T, Twait E, Fisher R.  A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription..  The Journal of biological chemistry.  2010 September. 285(39):29760-9.
[PubMed]

Freisinger C, Fisher R, Slusarski D.  Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning..  PLoS genetics.  2010 July. 6(7):e1001020.
[PubMed]

Yang J, Ibeawuchi S, Huang J, Stewart A, Chen C, Fisher R.  Identification of Novel Isoforms of Regulator of G-Protein Signaling 6 (RGS6).  FASEB.  2010. 24:587.2.

Huang J, Chatterjee T, Mayuzumi D, Fisher R.  Regulator of G protein Signaling 6 (RGS6) Modulates Doxorubicin-induced DNA Damage Signaling by Regulating ATM Activity.  FASEB.  2010. 24:706.1.

 .  Molecular Biology of RGS Proteins.  2009. 86:115-156.

Huang J, Fisher R.  Nuclear trafficking of regulator of G protein signaling proteins and their roles in the nucleus..  Progress in molecular biology and translational science.  2009. 86:115-56.
[PubMed]

 .  Progress in Molecular Biology and Translational Science.  Elsevier, London, UK.  2009. 86.

Huang J, Chatterjee T, Mayuzumi D, Fisher R.  Regulator of G protein Signaling 6 (RGS6) is Upregulated in Cancer cells by Doxorubicin and Modulates Doxorubicin-induced DNA damage signaling.  FASEB.  2009. 23:701.2.

Huang J, Chatterjee T, Mayuzumi D, Fisher R.  Regulator of G protein Signaling 6 (RGS6) is Upregulated in Cancer cells by Doxorubicin and Modulates Doxorubicin-induced DNA damage signaling.  G Protein Receptor ASPECT Colloquium.  2009. 23:701.2.

Yang J, Huang J, Chatterjee T, Twait E, Fisher R.  Transcriptional Activation of Regulator of G Protein Signaling 4 (RGS4) by Inverted CCAAT Box Element (ICE) Binding Factor NF-YA Attenuates G Protein Signaling.  FASEB.  2009. 23:495.16.

Yang J, Huang J, Chatterjee T, Twait E, Fisher R.  Transcriptional Activation of Regulator of G Protein Signaling 4 (RGS4) by Inverted CCAAT Box Element (ICE) Binding Factor NF-YA Attenuates G Protein Signaling.  G Protein Receptor ASPECT Colloquium.  2009. 23:495.

Fisher R, Singh M, Anderson M, Twait E.  Expression of multiple splice variant forms of RGS6 in mouse ventricular myocytes.  FASEB.  2008. 22:311.

Fisher R, Singh M, Anderson M, Twait E.  Expression of multiple splice variant forms of RGS6 in mouse ventricular myocytes.  G Protein Receptor ASPECT Colloquium.  2008. 

Samuel I, Twait E, Fisher R.  RGS6 Augments CCK-stimulated NF?b Activation via p38 and ERK.  Pancreas.  2007. 35(4):424.

Samuel I, Zaheer A, Fisher R.  In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production..  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.  2006 December. 10(10):1376-83.
[PubMed]

Samuel I, Chaudhary A, Chatterjee T, Fisher R.  Bile-Pancreatic Juice Exclusion Induces Expression of RGS6 in Rat Exocrine Pancreas.  FASEB.  2006. 20:174.5.

Samuel I, Yorek M, Zaheer A, Fisher R.  Bile-pancreatic juice exclusion promotes Akt/NF-kappaB activation and chemokine production in ligation-induced acute pancreatitis..  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.  2006. 10(7):950-9.
[PubMed]

Freisinger C, Westfall T, Fisher R, Slusarski D.  Regulators of G protein signaling function in zebrafish development.  FASEB.  2006. 20:564.6.

Mayuzumi D, Chatterjee T, Fisher R.  RGS6 sensitizes MCF-7 cells to doxorubicin-induced p53 phosphorylation.  FASEB.  2006. 20:593.4.

Samuel I, Chaudhary A, Fisher R, Joehl R.  Exacerbation of acute pancreatitis by combined cholinergic stimulation and duct obstruction..  American journal of surgery.  2005 November. 190(5):721-4.
[PubMed]

Chatterjee T, Fisher R.  Identification and characterization of the human RGS4 promoter: Essential role of an inverted CCAAT box in RGS4 promoter activity.  FASEB.  2005. 19:227.2.

Liu Z, Berman D, Fisher R.  RGS6 promotes growth arrest, cell cycle arrest and apoptosis in U2OS cells.  FASEB.  2005. 19:520.4.

Samuel I, Zaheer A, Zaheer S, Fisher R.  Bile-pancreatic juice exclusion increases cholinergic M3 and CCK-A receptor expression and interleukin-6 production in ligation-induced acute pancreatitis..  American journal of surgery.  2004 November. 188(5):511-5.
[PubMed]

Berman D, Wang Y, Liu Z, Dong Q, Burke L, Liotta L, Fisher R, Wu X.  A functional polymorphism in RGS6 modulates the risk of bladder cancer..  Cancer research.  2004 September. 64(18):6820-6.
[PubMed]

Liu Z, Fisher R.  RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity..  The Journal of biological chemistry.  2004 April. 279(14):14120-8.
[PubMed]

Samuel I, Zaheer S, Fisher R, Zaheer A.  Cholinergic receptor induction and JNK activation in acute pancreatitis..  American journal of surgery.  2003 November. 186(5):569-74.
[PubMed]

Chatterjee T, Liu Z, Fisher R.  Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants..  The Journal of biological chemistry.  2003 August. 278(32):30261-71.
[PubMed]

Chatterjee T, Fisher R.  Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins..  The Journal of biological chemistry.  2003 August. 278(32):30272-82.
[PubMed]

Chatterjee T, Fisher R.  Heat stress, proteotoxic stress and inhibition of rDNA transcription promote unique subcellular trafficking and nucleolar localization of RGS proteins.  FASEB.  2003. 17:A1312.

Liu Z, Chatterjee T, Fisher R.  Interaction of human RGS6 with DNA methyltransferase I associated protein (DMAP1).  FASEB.  2003. 17:A1313.

Liu Z, Chatterjee T, Fisher R.  RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6..  The Journal of biological chemistry.  2002 October. 277(40):37832-9.
[PubMed]

Chatterjee T, Fisher R.  RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression..  Molecular and cellular biology.  2002 June. 22(12):4334-45.
[PubMed]

Castro-Fernandez C, Janovick J, Brothers S, Fisher R, Ji T, Conn P.  Regulation of RGS3 and RGS10 palmitoylation by GnRH..  Endocrinology.  2002 April. 143(4):1310-7.
[PubMed]

Liu Z, Chatterjee T, Fisher R.  Interaction of human RGS6 with the neuron-specific growth-associated protein SCG10.  FASEB.  2002. 16:A558.

Samuel I, Zaheer A, Nelson J, Zaheer S, Fisher R.  MAP kinase and CCK-A receptor protein expression increase in parallel in duct ligation-induced acute pancreatitis in rats.  APA.  2002. 

Chatterjee T, Fisher R.  RGS12TS-S is a transcriptional repressor and regulates cell cycle processes.  FASEB.  2002. 16:A167.

Samuel I, Nelson J, Hays D, Thomas J, Elliott D, Fisher R, Weinstock J.  Time course of CCK-A receptor protein and messenger RNA expression in duct ligation induced acute pancreatitis in rats.  Digestive Diseases.  2002. 

Hou J, Carlson S, Liu X, Chatterjee T, Fisher R.  Identification and characterization of a novel splice variant form of rat platelet-activating factor (PAF) receptor.  FASEB.  2001. 15:A178.

Chatterjee T, Fisher R.  RGS12TS is a nuclear protein and colocalizes with PML and PLZF tumor suppressor proteins.  FASEB.  2001. 15:A209.

Chatterjee T, Fisher R.  RGS12TS-S is a nuclear matrix protein: structural requirements for its subnuclear organization, nuclear matrix association and transcriptional regulatory effects.  G Protein Receptor ASPECT Colloquium.  2001. 

Mallis R, Poland B, Chatterjee T, Fisher R, Darmawan S, Honzatko R, Thomas J.  Crystal structure of S-glutathiolated carbonic anhydrase III..  FEBS letters.  2000 October. 482(3):237-41.
[PubMed]

Chatterjee T, Fisher R.  Novel alternative splicing and nuclear localization of human RGS12 gene products..  The Journal of biological chemistry.  2000 September. 275(38):29660-71.
[PubMed]

Chatterjee T, Fisher R.  Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs..  The Journal of biological chemistry.  2000 August. 275(31):24013-21.
[PubMed]

Chatterjee T, Fisher R.  Identification of nuclear and intra-nuclear targeting domains of RGS12.  FASEB.  2000. 14:A1484.

Liu Z, Chatterjee T, Fisher R.  Interaction of Gbeta5 with splice variant forms of human RGS6.  FASEB.  2000. 14:A1484.

Chatterjee T, Fisher R.  Molecular cloning and intracellular localization of novel human RGS6 variants: role of G protein gamma subunit-like (GGL) domain and Gbeta5 in intracellular localization.  FASEB.  2000. 14:A1484.

Chatterjee T, Fisher R.  RGS12 promotes migration of Gialpha to the cell nucleus.  FASEB.  1999. 13:A1581.

Chatterjee T, Fisher R.  RGS4 is a nucleo-cytoplasmic shuttle protein.  FASEB.  1999. 13:A1581.

Melliti K, Meza U, Fisher R, Adams B.  Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels..  The Journal of general physiology.  1999 January. 113(1):97-110.
[PubMed]

Carlson S, Chatterjee T, Murphy K, Fisher R.  Mutation of a putative amphipathic alpha-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signaling..  Molecular pharmacology.  1998 March. 53(3):451-8.
[PubMed]

Fisher R, Cui Q, Eapen A, Chatterjee T.  Molecular cloning of a cDNA encoding a novel human protein with a D-AKAP2 sequence at its carboxyl terminal domain.  FASEB.  1998. 12:A1374.

Cui Q, Chatterjee T, Fisher R.  Molecular cloning of cDNAs encoding human RGS5 and RGS13.  FASEB.  1998. 12:A1375.

Chatterjee T, Cui Q, Eapen A, Fisher R.  Molecular cloning of four human RGS12 cDNAs, genomic organization and chromosomal localization of the RGS12 gene and functional analysis of the brain-specific variant of RGS12.  FASEB.  1998. 12:A1374.

Chatterjee T, Eapen A, Kanis A, Fisher R.  Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene..  Genomics.  1997 October. 45(2):429-33.
[PubMed]

Chatterjee T, Eapen A, Fisher R.  A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C..  The Journal of biological chemistry.  1997 June. 272(24):15481-7.
[PubMed]

Chatterjee T, Liu X, Davisson R, Fisher R.  Genomic organization of the rat pituitary adenylate cyclase-activating polypeptide receptor gene. Alternative splicing within the 5'-untranslated region..  The Journal of biological chemistry.  1997 May. 272(18):12122-31.
[PubMed]

Chatterjee T, Fisher R.  A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of MAP kinase, adenylyl cyclase and phosphoinositide phospholipase C.  FASEB.  1997. 11:A1215.

Eapen A, Chatterjee T, Kanis A, Fisher R.  Genomic organization, 5'-flanking region and chromosomal localization of the human RGS3 gene.  FASEB.  1997. 11:A1335.

Chatterjee T, Sharma R, Fisher R.  Molecular cloning of a novel variant of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor that stimulates calcium influx by activation of L-type calcium channels..  The Journal of biological chemistry.  1996 December. 271(50):32226-32.
[PubMed]

Thomas C, Doggett N, Fisher R, Stokes J.  Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel..  The Journal of biological chemistry.  1996 October. 271(42):26062-6.
[PubMed]

Carlson S, Chatterjee T, Fisher R.  The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins. Studies using intracellular domain minigenes and receptor chimeras..  The Journal of biological chemistry.  1996 September. 271(38):23146-53.
[PubMed]

Carlson S, Chatterjee T, Fisher R.  Lack of constitutive activation or inactivation of the platelet-activating factor receptor by glutamate substitution of alanine 230..  Receptors & signal transduction.  1996. 6(2):111-20.
[PubMed]

Hlavaty T, Fisher R, Robbins M, Wheeler J, Funk G, Hussey D.  Radiotherapy for head and neck malignancies is associated with increased salivary platelet-activating factor content.  Intl J Radiation Oncology.  1996. 36(1):236.

Carlson S, Chatterjee T, Fisher R.  Signal transduction by the rat platelet-activating factor (PAF) receptor: Studies using chimeric receptors and cellular expression of cytoplasmic domains of the receptor.  FASEB.  1996. 10:A1389.

Chatterjee T, Liu X, Davisson R, Fisher R.  Structural organization of the rat pituitary adenylate cyclase activating polypeptide (PACAP) receptor gene: Evidence for alternative splicing in the 5'-untranslated region.  FASEB.  1996. 10:A1390.

Chatterjee T, Fisher R.  Multiple affinity and guanine nucleotide sensitive forms of the calcitonin gene related peptide (CGRP) receptor..  Canadian journal of physiology and pharmacology.  1995 July. 73(7):968-73.
[PubMed]

Fisher R.  Book Review, The Tachykinin Receptors.  Endocrine.  1995. 3:185.

Thomas C, Stokes J, Fisher R, Welsh M, Bervig T.  Cloning the 5' flanking region and a regulatory intron of the amiloride-sensitive gamma human epithelial sodium channel (gamma-hENaC) gene.  American Society of Nephrology.  1995. 

Carlson S, Chatterjee T, Fisher R.  Molecular cloning of cDNAs encoding full length and truncated forms of platelet-activating factor (PAF) receptor from rat liver: tissue distribution and functional analysis.  FASEB.  1995. 9:A1450.

Chatterjee T, Sarkar G, Sharma R, Fisher R.  Two novel variants of the rat pituitary adenylate cyclase-activating polypeptide (PACAP) receptor diverging within transmembrane domains 2 and 4 discriminate between cAMP and Ca2+ signaling pathways.  FASEB.  1995. 9:A1411.

Chatterjee T, Fisher R.  Multiple affinity and guanine nucleotide-sensitive forms of the calcitonin gene-related peptide (CGRP) receptor.  Canadian J Physiol & Pharmacol.  1994. 72:28.

Chatterjee T, Sarkar G, Carlson S, Fisher R.  PCR amplification of cDNAs encoding variant forms of pituitary adenylate cyclase-activating polypeptide (PACAP) receptor.  FASEB.  1994. 8:A89.

Chatterjee T, Sarkar G, Bolander M, Fisher R.  Use of PCR for isolation of neuropeptide receptor genes.  Academic Press, Inc.  1994. 26:29-44.

Chatterjee T, Moy J, Cai J, Lee H, Fisher R.  Solubilization and characterization of a guanine nucleotide-sensitive form of the calcitonin gene-related peptide receptor..  Molecular pharmacology.  1993 February. 43(2):167-75.
[PubMed]

Chatterjee T, Fisher R.  Identification and characterization of thromboxane A2 receptors in rat liver sinusoidal cells.  FASEB.  1993. 7:A164.

Hines K, Fisher R.  Stimulation of glycogenolysis and platelet-activating factor (PAF) production during antigen-induced anaphylaxis in the perfused rat liver.  FASEB.  1993. 7:A164.

Hines K, Fisher R.  Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis..  The American journal of physiology.  1992 May. 262(5 Pt 1):G868-77.
[PubMed]

Fisher R, Hines K, Shaffer R, Lewis S.  Measurement of hepatic portal vein blood flow velocity in the rat using an intra-vascular doppler flow probe.  FASEB.  1992. 6:A1470.

Chatterjee T, Moy J, Lee H, Fisher R.  Solubilization and characterization of a guanine nucleotide-sensitive form of the calcitonin gene-related peptide (CGRP) receptor from rat cerebellum.  FASEB.  1992. 6:A1290.

Hines K, Fisher R.  The thromboxane A2 analogue U-46619 increases hepatic portal pressure and blood glucose concentration in vivo.  FASEB.  1992. 

Chatterjee T, Moy J, Fisher R.  Characterization and regulation of high affinity calcitonin gene-related peptide receptors in cultured neonatal rat cardiac myocytes..  Endocrinology.  1991 June. 128(6):2731-8.
[PubMed]

Chatterjee T, Fisher R.  Multiple affinity forms of the calcitonin gene-related peptide receptor in rat cerebellum..  Molecular pharmacology.  1991 June. 39(6):798-804.
[PubMed]

Moy J, Bates J, Fisher R.  Effects of nitric oxide on platelet-activating factor- and alpha-adrenergic-stimulated vasoconstriction and glycogenolysis in the perfused rat liver..  The Journal of biological chemistry.  1991 May. 266(13):8092-6.
[PubMed]

Hines K, Braillon A, Fisher R.  PAF increases hepatic vascular resistance and glycogenolysis in vivo..  The American journal of physiology.  1991 March. 260(3 Pt 1):G471-80.
[PubMed]

Fisher R, Moy J, Chatterjee T.  Characteristics and regulation of high affinity [125I]calcitonin gene-related peptide (*CGRP) binding sites in cultured neonatal rat cardiac myocytes.  FASEB.  1991. 5:A879.

Chatterjee T, Fisher R.  Characterization of [125I]calcitonin gene-related peptide (*CGRP) binding sites in membrane and solubilized preparations of rat cerebellum: Regulation by guanine nucleotides and the existence of multiple affinity binding states.  FASEB.  1991. 5:A1227.

Moy J, Bates J, Fisher R.  Effects of nitric oxide (NO) on platelet-activating factor (PAF)- and alpha-adrenergic-stimulated vasoconstriction and glycogenolysis in the perfused rat liver.  FASEB.  1991. 5:A424.

Hines K, Bates J, Fisher R.  Nitric oxide (NO) inhibits antigen-stimulated increases in vasoconstriction and glycogenolysis in perfused livers derived from sensitized rats.  FASEB.  1991. 5:A907.

Hines K, Fisher R.  Antigen-induced anaphylactic responses in liver: Putative role of platelet-activating factor.  FASEB.  1990. 4:A1875.

Parsons T, Bates J, Fisher R.  Nitrosocysteine inhibits agonist-mediated vasoconstriction in the isolated perfused rat liver.  FASEB.  1990. 4:A1829.

Kester M, Fisher R, Olson M.  Beta-adrenergic inhibition of AGEPC-stimulated Na+/Ca2+ exchange and AGEPC-induced platelet activation..  Biochimica et biophysica acta.  1989 November. 1014(2):195-202.
[PubMed]

Steinhelper M, Fisher R, Revtyak G, Hanahan D, Olson M.  Beta 2-adrenergic agonist regulation of immune aggregate- and platelet-activating factor-stimulated hepatic metabolism..  The Journal of biological chemistry.  1989 July. 264(19):10976-81.
[PubMed]

Fisher R, Sharma R, Bhalla R.  Platelet-activating factor increases inositol phosphate production and cytosolic free Ca2+ concentrations in cultured rat Kupffer cells..  FEBS letters.  1989 July. 251(1-2):22-6.
[PubMed]

Hines K, Fisher R.  Hepatic actions of platelet-activating factor (PAF) in anesthetized rats.  FASEB.  1989. 3:A1222.

Fisher R, Hines K.  Potentiation of calcitonin gene-related peptide-induced cyclic AMP accumulation by phorbol esters in cultured beating rat heart cells.  FASEB.  1989. 3:A286.

Fisher R, Steinhelper M, Olson M.  Regulatory effects of a thromboxane A2 analogue on hepatic glycogenolysis and vasoconstriction.  Plenum Press.  1989. 

Fisher R, Robertson S, Olson M.  Stimulation and homologous desensitization of calcitonin gene-related peptide receptors in cultured beating rat heart cells..  Endocrinology.  1988 July. 123(1):106-12.
[PubMed]

Fisher R, Buxton D, Lapointe D, Hanahan D, Olson M.  AGEPC: A potent calcium-dependent chemical mediator in the liver.  Plenum Press.  1988. 232:203-212.

Harvey S, Fisher R, Maltos D, Olson M.  Cultured neonatal heart cells: Response to platelet activating factor.  FASEB.  1988. 2:A358.

Fisher R, Olson M.  Stimulation and homologous desensitization of calcitonin gene-related peptide receptors in cultured beating rat heart cells.  FASEB.  1988. 2:A358.

Buxton D, Fisher R, Robertson S, Olson M.  Stimulation of glycogenolysis and vasoconstriction by adenosine and adenosine analogues in the perfused rat liver..  The Biochemical journal.  1987 November. 248(1):35-41.
[PubMed]

Buxton D, Fisher R, Briseno D, Hanahan D, Olson M.  Glycogenolytic and haemodynamic responses to heat-aggregated immunoglobulin G and prostaglandin E2 in the perfused rat liver..  The Biochemical journal.  1987 April. 243(2):493-8.
[PubMed]

Fisher R, Robertson S, Olson M.  Stimulation of glycogenolysis and vasoconstriction in the perfused rat liver by the thromboxane A2 analogue U-46619..  The Journal of biological chemistry.  1987 April. 262(10):4631-8.
[PubMed]

Hanahan D, Buxton D, Fisher R, Hill C, Shukla S, Olson M.  Biochemical behavior of AGEPC (platelet activating factor) on interaction with cells.  John Wiley & Sons, Ltd.  1987. 

Fisher R, Robertson S, Olson M.  Calcium-dependent stimulation of glycogenolysis and vasoconstriction in the perfused rat liver by the thromboxane A2 analogue U-46619.  Cell Calcium Metabolism.  1987. 

Fisher R, Robertson S, Olson M.  SQ 29,548 inhibits the glycogenolytic and vasoconstrictive actions of the thromboxane A2 analogue U-46619 in perfused rat livers.  Fed Proc.  1987. 42:2009.

Fisher R, Kumar R, Hanahan D, Olson M.  Effects of beta-adrenergic stimulation on 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine-mediated vasoconstriction and glycogenolysis in the perfused rat liver..  The Journal of biological chemistry.  1986 July. 261(19):8817-23.
[PubMed]

Kester M, Fisher R, Olson M, Hanahan D.  Isoproterenol inhibits AGEPC-activated Na+/Ca2+ exchange in smooth muscle plasmalemmal vesicles.  Fed Proc.  1986. 45:1571.

Fisher R, Kumar R, Hanahan D, Olson M.  Stimulation of glycogenolysis and platelet activating factor synthesis by zymosan in the perfused rat liver.  Fed Proc.  1986. 45:1838.

Buxton D, Fisher R, Hanahan D, Olson M.  Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver..  The Journal of biological chemistry.  1986 January. 261(2):644-9.
[PubMed]

Fisher R, Tanabe S, Buxton D, Olson M.  The effects of alpha-adrenergic stimulation on the regulation of the pyruvate dehydrogenase complex in the perfused rat liver..  The Journal of biological chemistry.  1985 August. 260(16):9223-9.
[PubMed]

Buxton D, Fisher R, Hanahan D, Olson M.  Adenosine stimulates hepatic glycogenolysis and constriction of the hepatic vasculature via P1 receptors of the A2 subtype.  Fed Proc.  1985. 44:1732.

Fisher R, Tanabe S, Olson M.  The effects of alpha-adrenergic stimulation on regulation of the pyruvate dehydrogenase complex in the perfused rat liver.  Fed Proc.  1985. 44:1405.

Grimm L, Collison M, Fisher R, Thomas J.  Protein mixed-disulfides in cardiac cells. S-thiolation of soluble proteins in response to diamide..  Biochimica et biophysica acta.  1985 January. 844(1):50-4.
[PubMed]

Fisher R, Shukla S, Debuysere M, Hanahan D, Olson M.  The effect of acetylglyceryl ether phosphorylcholine on glycogenolysis and phosphatidylinositol 4,5-bisphosphate metabolism in rat hepatocytes..  The Journal of biological chemistry.  1984 July. 259(14):8685-8.
[PubMed]

Fisher R, Shukla S, DeBuysere M, Hanahan D, Olson M.  AGEPC effects on glycogenolysis and polyphosphoinositides in isolated hepatocytes.  Fed Proc.  1984. 43:1890.

Fisher R, Harary I, Thomas J.  Homologous desensitization of rat heart cells to beta-adrenergic stimulation and the absence of alpha-adrenergic or prostaglandin E1 effects..  Journal of cyclic nucleotide and protein phosphorylation research.  1984. 9(6):449-60.
[PubMed]

Collison M, Fisher R, Loparco F, Thomas J.  Effects of fasting and refeeding on thiolation of cardiac proteins in vivo.  Fed Proc.  1983. 42:2210.

Olson M, Buxton D, Fisher R, Hill K, LaPointe D, Hanahan D.  Platelet activating factor: A potent hepatic glycogenolytic agonist.  Proc Biochem Soc. 

Stewart A, Maity B, Wunsch A, Wemmie J, Fisher R.  RGS6 promotes anxiety and depression through attenuation of serotonin 5-HT1A receptor signaling.  FASEB J (in review). 

Date Last Modified: 06/07/2014 - 21:56:23