Stead Family Department of Pediatrics

Aliye Uc, MD


Professor of Pediatrics  - Gastroenterology
Professor of Radiation Oncology

Contact Information

Primary Office: 2865 JPP
Iowa City, IA 52242
Phone: 319-356-2950

Web: INSPPIRE Pediatric Pancreatitis Research Consortium


MD, Medicine, Istanbul University School of Medicine

Residency, Pediatrics, Hacettepe University Children's Hospital
Residency, PL3, Pediatrics, University of Iowa Hospitals and Clinics
Fellowship, Pediatric Gastroenterology, University of Iowa Children's Hospital

Licensure and Certifications

Arkansas Medical License (lapsed)
Turkey Permanent Medical License
Board Certification in Pediatrics, Turkey

Education/Training Program Affiliations

Free Radical and Radiation Biology Graduate Program

Research Summary

Dr. Uc is a Pediatric Gastroenterologist with clinical and research focus in Cystic Fibrosis (CF)-related pancreatic disease, and acute and chronic pancreatitis in children. Her laboratory focuses on dissecting the mechanisms of pancreatic damage and inflammation in CF pigs and development of gene therapies to the pig pancreas. She described that the CF pigs had an increased immune and inflammatory response in their pancreas that could be responsible of ongoing injury. She coauthored publications with Dr. Michael Welsh’s group describing the phenotype of CF pig model. She is collaborating with Drs. Engelhardt and Norris on better understanding the pathogenesis of CF-related diabetes (CFRD) using the CF pig and ferret models. She is also the chair and the founding member of INSPPIRE (International Study Group of Pediatric Pancreatitis: In search for a cure) with the task of studying the epidemiology, etiology, natural history and outcomes of pediatric pancreatitis, a disease without clear diagnostic parameters and treatment alternatives in children. In this context, she is developing a data registry, sample repository, and longitudinal studies on pediatric pancreatitis. University of Iowa is the coordinating center for this NIH-funded multicenter study with 14 other centers providing patients, data and biological samples. This constitutes the first initiative to create a multi-center approach to systematically characterize pancreatitis in children.

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases

Date Last Modified: 04/12/2016 - 14:29:46