Stead Family Department of Pediatrics

Stanley Perlman, MD, PhD

Portrait

Professor of Microbiology
Professor of Pediatrics

Contact Information

Office: 3-712 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Office Phone: 319-335-8549

Lab: 3-730 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Phone: 319-335-7576

Email: stanley-perlman@uiowa.edu
Web: Perlman Lab Website
Web: Faculty Focus: Stanley Perlman, MD, PhD
Web: Interview with KCRG-TV9

Education

AB, Physics, University of Rochester
PhD, Biophysics, Massachusetts Institute of Technology
MD, Medicine, University of Miami School of Medicine

Fellowship, Massachusetts Institute of Technology
Fellowship, Harvard University
Fellowship, University of Edinburgh, Scotland
Fellowship, Brandeis University
Residency, Children's Hospital Medical Center, Boston
Fellowship, Infectious Diseases, Children's Hospital Medical Center, Boston

Licensure and Certifications

Medical License, Iowa
Medical License, Massachusetts
American Board of Pediatrics

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

My laboratory has been interested in the pathogenesis of murine coronavirus infections for several years. Now, we also study three respiratory human coronavirus infections: SARS(Severe Acute Respiratory Syndrome)-coronavirus, human coronavirus-OC43 and human coronavirus-NL63.

Mice infected with mouse hepatitis virus develop a demyelinating disease with many similarities to the human disease, multiple sclerosis. Research in my laboratory is aimed at determining the immunological and viral factors involved in the demyelinating process. Previously, we determined the CD4 and CD8 T cell epitopes recognized in the central nervous system (CNS) of infected mice. We showed that in mice infected chronically with the virus, cytotoxic T cell escape mutants arise. These mutations completely abrogate recognition by CD8 T cells and thereby facilitate persistence. We have also identified mutations in a subdominant epitope that enhance immune recognition by CD8 T cells (heteroclitic epitopes) and are studying the structural basis of heteroclitic effects. We have developed a reverse genetics system for introducing these and other mutations into the murine coronavirus genome. We also study the anti-inflammatory components that are needed to diminish immunopathological disease, with specific focus on regulatory CD4 T cells and IL-10. The ultimate goal of our work is to understand the interplay of pro and anti-inflammatory factors that result in myelin destruction.

The SARS-coronavirus causes the most significant disease of any of the human coronaviruses. The disease is especially severe in aged populations. We are using mice infected with murine adapted strains to understand the basis of this severe disease. We are also developing vaccines that might be useful if SARS were to recur, or more likely, as a model approach if another severe disease caused by a coronavirus were to emerge in human populations.

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases
Helen C. Levitt Center for Viral Pathogenesis
Holden Comprehensive Cancer Center
Institute for Clinical and Translational Science
NIH Vaccine Treatment and Evaluation Unit

All Publications

Hemida M, Perera R, Al Jassim R, Kayali G, Siu L, Wang P, Chu K, Perlman S, Ali M, Alnaeem A, Guan Y, Poon L, Saif L, Peiris M.  Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity.  Euro Surveill.  2014 June 12. 19(23):pi: 20828.
[Link]

Trujillo J, Gras S, Twist K, Croft N, Channappanavar R, Rossjohn J, Purcell A, Perlman S.  Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes.  J Immunol.  2014 June 1. 192(11):5245-56.
[Link]

Barlan A, Zhao J, Sarkar M, Li K, McCray P, Perlman S, Gallagher T.  Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection.  J Virol.  2014 May. 88(9):4953-61.
[Link]

Zhao J, Li K, Wohlford-Lenane C, Agnihothram S, Fett C, Zhao J, Gale M, Baric R, Enjuanes L, Gallagher T, McCray P, Perlman S.  Rapid generation of a mouse model for Middle East respiratory syndrome.  Proc Natl Acad Sci U S A.  2014 April 1. 111(13):4970-5.
[Link]

Lin S, Liu C, Chang Y, Zhao J, Perlman S, Hou M.  Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target.  J Med Chem.  2014 March 27. 57(6):2247-57.
[Link]

Channappanavar R, Zhao J, Perlman S.  T cell-mediated immune response to respiratory coronaviruses.  Immunol Res.  2014. Epub ahead of print.
[Link]

DeDiego M, Nieto-Torres J, Regla-Nava J, Jimenez-Guardeño J, Fernandez-Delgado R, Fett C, Castaño-Rodriguez C, Perlman S, Enjuanes L.  Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival.  J Virol.  2014 January. 88(2):913-24.
[Link]

Zhao J, Fett C, Pewe L, Zhao J, Perlman S.  Development of transgenic mice expressing a coronavirus-specific public CD4 T cell receptor.  J Immunol Methods.  2013 October 31. 396(1-2):56-64.
[Link]

Perlman S.  The middle East respiratory syndrome--how worried should we be?.  MBio.  2013 August 20. 4(4):e00531-13.
[Link]

Perlman S, McCray P.  Person-to-person spread of the MERS coronavirus--an evolving picture. Perlman.  N Engl J Med.  2013 August 1. 369(5):466-7.
[Link]

de Groot R, Baker S, Baric R, Brown C, Drosten C, Enjuanes L, Fouchier R, Galiano M, Gorbalenya A, Memish Z, Perlman S, Poon L, Sinjder E, Stephens G, Woo P, Zaki A, Zambon M, Ziebuhr J.  Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group.  J Virol.  2013 July. 87(14):7790-2.
[Link]

Fett C, DeDiego M, Regla-Nava J, Enjuanes L, Perlman S.  Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein.  J Virol.  2013 June. 87(12):6551-9.
[Link]

Chen I, Yuann J, Chang Y, Lin S, Zhao J, Perlman S, Shen Y, Huang T, Hou M.  Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein.  Biochim Biophys Acta.  2013 June. 1834(6):1054-62.
[Link]

Gallagher T, Perlman S.  Public health: Broad reception for coronavirus.  Nature.  2013 March 14. 495(7440):176-7.
[Link]

Trujillo J, Fleming E, Perlman S.  Transgenic CCL2 Expression in the Central Nervous System Results in a Dysregulated Immune Response and Enhanced Lethality after Coronavirus Infection.  J Virol.  2013 March. 87(5):2376-89.
[Link]

Perlman S, Zhao J.  Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus.  MBio.  2013 January 15. 4(1):pii:e00002-13.
[Link]

Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane T, McCray P, Perlman S.  Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections.  J Virol.  2012 November. 86(21):11416-24.
[Link]

Zhao J, Zhao J, Perlman S.  Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.  PLoS One.  2012. 7(9):e46241.
[Link]

Zhao J, Zhao J, Legge K, Perlman S.  Age-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.  J Clin Invest.  2011 December. 121(12):4921-30.
[Link]

DeDiego M, Nieto-Torres J, Jiménez-Guardeño J, Regla-Nava J, Alvarez E, Oliveros J, Zhao J, Fett C, Perlman S, Enjuanes L.  Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.  PLoS Pathog.  2011 October. 7(10):e1002315.
[Link]

Zhao J, Zhao J, Fett C, Trandem K, Fleming E, Perlman S.  IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.  J Exp Med.  2011 August 1. 208(8):1571-7.
[Link]

Trandem K, Jin Q, Weiss K, James B, Zhao J, Perlman S.  Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice.  J Virol.  2011 July. 85(14):6822-31.
[Link]

Trandem K, Zhao J, Fleming E, Perlman S.  Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis.  J Immunol.  2011 March 15. 186(6):3642-52.
[Link]

de Groot R, Baker S, Baric R, Enjuanes L, Gorbalenya A, Holmes K, Perlman S, Poon L, Rottier P, Talbot P, Woo P, Ziebuhr J.  Coronaviridae.  Elsevier Academic Press, San Diego.  2011. 

Shulla A, Heald-Sargent T, Subramanya G, Zhao J, Perlman S, Gallagher T.  A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.  J Virol.  2011 January. 85(2):873-82.
[Link]

Zhou H, Zhao J, Perlman S.  Autocrine interferon priming in macrophages but not dendritic cells results in enhanced cytokine and chemokine production after coronavirus infection.  MBio.  2010 October 19. 1(4):pii: e00219-10.
[Link]

Zhao J, Zhao J, Perlman S.  T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice.  J Virol.  2010 September. 84(18):9318-25.
[Link]

Trandem K, Anghelina D, Zhao J, Perlman S.  Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus.  J Immunol.  2010 April 15. 184(8):4391-400.
[Link]

Zhou H, Ferraro D, Zhao J, Hussain S, Shao J, Trujillo J, Netland J, Gallagher T, Perlman S.  The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication.  J Virol.  2010 April. 84(7):3542-51.
[Link]

Netland J, DeDiego M, Zhao J, Fett C, Alvarez E, Nieto-Torres J, Enjuanes L, Perlman S.  Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease.  Virology.  2010 March 30. 399(1):120-8.
[Link]

Wohlford-Lenane C, Meyerholz D, Perlman S, Zhou H, Tran D, Selsted M, McCray P.  Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.  J Virol.  2009 November. 83(21):11385-90.
[Link]

Zhao J, Zhao J, Perlman S.  De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system.  J Immunol.  2009 October 15. 183(8):5163-70.
[Link]

Zhao J, Zhao J, Van Rooijen N, Perlman S.  Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.  PLoS Pathog.  2009 October. 5(10):e1000636.
[Link]

Perlman S, Netland J.  Coronaviruses post-SARS: update on replication and pathogenesis.  Nat Rev Microbiol.  2009 June. 7(6):439-50.
[Link]

Enquist L, Editors of the Journal of Virology , Perlman S.  Virology in the 21st century.  J Virol.  2009 June. 83(11):5296-308.
[Link]

Anghelina D, Zhao J, Trandem K, Perlman S.  Role of regulatory T cells in coronavirus-induced acute encephalitis.  Virology.  2009 March 15. 385(2):358-67.
[Link]

Zhao J, Falcón A, Zhou H, Netland J, Enjuanes L, Pérez Breña P, Perlman S.  Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication.  J Virol.  2009 March. 83(5):2368-73.
[Link]

Whitman L, Zhou H, Perlman S, Lane T.  IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells.  Virology.  2009 February 5. 384(1):209-15.
[Link]

McIntosh K, Perlman S.  Coronaviridae.  2009. 

Butler N, Theodossis A, Webb A, Nastovska R, Ramarathinam S, Dunstone M, Rossjohn J, Purcell A, Perlman S.  Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant.  PLoS Pathog.  2008 October. 4(10):e1000186.
[Link]

Netland J, Meyerholz D, Moore S, Cassell M, Perlman S.  Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.  J Virol.  2008 August. 82(15):7264-75.
[Link]

Dediego M, Pewe L, Alvarez E, Rejas M, Perlman S, Enjuanes L.  Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice.  Virology.  2008 July 5. 376(2):379-89.
[Link]

Hussain S, Perlman S, Gallagher T.  Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism.  J Virol.  2008 July. 82(14):7212-22.
[Link]

Butler N, Theodossis A, Webb A, Dunstone M, Nastovska R, Ramarathinam S, Rossjohn J, Purcell A, Perlman S.  Structural and biological basis of CTL escape in coronavirus-infected mice.  J Immunol.  2008 March 15. 180(6):3926-37.
[Link]

Templeton S, Perlman S.  Role of IFN-gamma responsiveness in CD8 T-cell-mediated viral clearance and demyelination in coronavirus-infected mice.  J Neuroimmunol.  2008 February. 194(1-2):18-26.
[Link]

Perlman S.  Nidoviruses.  ASM Press, Washington, DC;  2008.

Nicholls J, Peiris M, Perlman S.  Severe Acute Respiratory Syndrome: Epidemiology, pathogenesis and animal models.  ASM Press, Washington, DC.  2008. 

Templeton S, Kim T, O'Malley K, Perlman S.  Maturation and localization of macrophages and microglia during infection with a neurotropic murine coronavirus.  Brain Pathol.  2008 January. 18(1):40-51.
[Link]

Butler N, Dandekar A, Perlman S.  Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus.  J Virol.  2007 December. 81(24):13291-8.
[Link]

Bonthius D, Perlman S.  Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat.  PLoS Pathog.  2007 November. 3(11):e149.
[Link]

Netland J, Ferraro D, Pewe L, Olivares H, Gallagher T, Perlman S.  Enhancement of murine coronavirus replication by severe acute respiratory syndrome coronavirus protein 6 requires the N-terminal hydrophobic region but not C-terminal sorting motifs.  J Virol.  2007 October. 81(20):11520-5.
[Link]

Tangudu C, Olivares H, Netland J, Perlman S, Gallagher T.  Severe acute respiratory syndrome coronavirus protein 6 accelerates murine coronavirus infections.  J Virol.  2007 February. 81(3):1220-9.
[Link]

Lai M, Perlman S, Anderson L.  Chapter 36. Coronaviridae.  2007. 

Templeton S, Perlman S.  Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM.  Immunol Res.  2007. 39(1-3):160-72.
[Link]

McCray P, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia H, Halabi C, Sigmund C, Meyerholz D, Kirby P, LOOK D, Perlman S.  Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.  J Virol.  2007 January. 81(2):813-21.
[Link]

Zhou H, Perlman S.  Mouse hepatitis virus does not induce Beta interferon synthesis and does not inhibit its induction by double-stranded RNA.  J Virol.  2007 January. 81(2):568-74.
[Link]

Kedzierska K, Day E, Pi J, Heard S, Doherty T, Turner S, Perlman S.  Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage.  J Immunol.  2006 November 15. 177(10):6705-12.
[Link]

Anghelina D, Pewe L, Perlman S.  Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis.  Am J Pathol.  2006 July. 169(1):209-22.
[Link]

Butler N, Pewe L, Trandem K, Perlman S.  Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated.  Virology.  2006 April 10. 347(2):410-21.
[Link]

Zhou H, Perlman S.  Preferential infection of mature dendritic cells by mouse hepatitis virus strain JHM.  J Virol.  2006 March. 80(5):2506-14.
[Link]

Pewe L, Zhou H, Netland J, Tangadu C, Olivares H, Shi L, Look D, Gallagher T, Perlman S.  A SARS-CoV-specific protein enhances virulence of an attenuated strain of mouse hepatitis virus.  Adv Exp Med Biol.  2006. 581:493-8.
[Link]

Butler N, Pewe L, Trandem K, Perlman S.  HCoV-OC43-induced encephalitis is in part immune-mediated.  Adv Exp Med Biol.  2006. 581:531-4.
[Link]

Jia H, Look D, Hickey M, Shi L, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray P.  Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization.  Adv Exp Med Biol.  2006. 581:479-84.
[Link]

Zhou H, Perlman S.  Preferential infection of mature dendritic cells by the JHM strain of mouse hepatitis virus.  Adv Exp Med Biol.  2006. 581:411-4.
[Link]

Perlman S.  The Nidoviruses: Toward Control of SARS and other Nidovirus Diseases.  Springer, New York;  2006.

Dandekar A, Perlman S.  Severe Acute Respiratory Syndrome (SARS).  Nature Publishing Group, London.  2006 January. 

Jia H, LOOK D, Shi L, Hickey M, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray P.  ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia.  J Virol.  2005 December. 79(23):14614-21.
[Link]

Perlman S, Dandekar A.  Immunopathogenesis of coronavirus infections: implications for SARS.  Nat Rev Immunol.  2005 December. 5(12):917-27.
[Link]

Pewe L, Zhou H, Netland J, Tangudu C, Olivares H, Shi L, LOOK D, Gallagher T, Perlman S.  A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus.  J Virol.  2005 September. 79(17):11335-42.
[Link]

Dandekar A, O'Malley K, Perlman S.  Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus.  J Virol.  2005 August. 79(15):9388-96.
[Link]

Kim T, Perlman S.  Viral expression of CCL2 is sufficient to induce demyelination in RAG1-/- mice infected with a neurotropic coronavirus.  J Virol.  2005 June. 79(11):7113-20.
[Link]

Kim T, Perlman S.  Virus-specific antibody, in the absence of T cells, mediates demyelination in mice infected with a neurotropic coronavirus.  Am J Pathol.  2005 March. 166(3):801-9.
[Link]

Butler N, Pewe L, Perlman S.  A murine model of human coronavirus infection.  Xth International Nidovirus Symposium, Colorado Springs, CO.  2005. 

Pewe L, Zhou H, Netland J, Tangadu C, Shi L, Look D, Gallagher T, Perlman S.  A SARS-CoV-specific protein enhances virulence of an attenuated murine coronavirus.  Xth International Nidovirus Symposium, Colorado Springs, CO.  2005. 

Dandekar A, Perlman S.  Axons and neurons in coronavirus-induced demyelination.  Springer.  2005. 

Zhou H, Perlman S.  In vitro and in vivo infection of dendritic cells by mouse hepatitis virus strain JHM.  Xth International Nidovirus Symposium, Colorado Springs, CO.  2005. 

Kim T, Perlman S.  The role of T cell epitopes in coronavirus infection.  Springer.  2005. 

Bergmann C, Perlman S, Stohlman S.  The role of T cells in coronavirus induced demyelination.  Springer.  2005. 

Pewe L, Netland J, Heard S, Perlman S.  Very diverse CD8 T cell clonotypic responses after virus infections.  J Immunol.  2004 March 1. 172(5):3151-6.
[Link]

Dandekar A, Anghelina D, Perlman S.  Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis.  Am J Pathol.  2004 February. 164(2):363-9.
[Link]

Dandekar A, Anghelina D, Perlman S.  Interferon-g mediated bystander demyelination in a coronavirus model of multiple sclerosis.  FASEB J.  2004. 18:A457 (335.4).

Kim T, Perlman S.  Interplay of complement and Fc receptors in antibody-induced demyelinating disease in mice infected with a neurotropic coronavirus.  FASEB J.  2004. 18:A1163 (778.3).

Dandekar A, Jacobsen G, Waldschmidt T, Perlman S.  Antibody-mediated protection against cytotoxic T-cell escape in coronavirus-induced demyelination.  J Virol.  2003 November. 77(22):11867-74.
[Link]

Ontiveros E, Kim T, Gallagher T, Perlman S.  Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein.  J Virol.  2003 October. 77(19):10260-9.
[Link]

Kim T, Perlman S.  Protection against CTL escape and clinical disease in a murine model of virus persistence.  J Immunol.  2003 August 15. 171(4):2006-13.
[Link]

Haring J, Perlman S.  Bystander CD4 T cells do not mediate demyelination in mice infected with a neurotropic coronavirus.  J Neuroimmunol.  2003 April. 137(1-2):42-50.
[Link]

Dandekar A, Jacobsen G, Waldschmidt T, Perlman S.  Antibody suppression of CTL escape in mice chronically infected with mouse hepatitis virus, strain JHM.  IXth International Symposium on Nidoviruses, Egmond aan Zee, The Netherlands.  2003. 

Ontiveros E, Kim T, Gallagher T, Perlman S.  Enhanced neurovirulence mediated by mouse hepatitis virus-JHM is associated with a S310G change in the spike glycoprotein.  IXth International Symposium on Nidoviruses, Egmond aan Zee, The Netherlands.  2003. 

Kim T, Perlman S.  Selection of CTL escape variants in mice infected with recombinant MHV.  IXth International Symposium on Nidoviruses, Egmond aan Zee, The Netherlands.  2003. 

Dandekar A, Perlman S.  Virus-induced demyelination in nude mice is mediated by gamma delta T cells.  Am J Pathol.  2002 October. 161(4):1255-63.
[Link]

Haring J, Pewe L, Perlman S.  Bystander CD8 T cell-mediated demyelination after viral infection of the central nervous system.  J Immunol.  2002 August 1. 169(3):1550-5.
[Link]

Pewe L, Haring J, Perlman S.  CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus.  J Virol.  2002 July. 76(14):7329-33.
[Link]

Pewe L, Perlman S.  Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus.  J Immunol.  2002 February 15. 168(4):1547-51.
[Link]

Dandekar A, Perlman S.  Demyelination is mediated by gamma-delta T cells in mice infected with a neurotropic coronavirus.  4th International Symposium of NeuroVirology, Dusseldorf, Germany.  2002. 

Ontiveros E, Kuo L, Masters P, Perlman S.  Inactivation of expression of gene 4 of mouse hepatitis virus strain JHM does not affect virulence in the murine CNS.  Virology.  2001 October 25. 289(2):230-8.
[Link]

Haring J, Perlman S.  Mouse hepatitis virus.  Curr Opin Microbiol.  2001 August. 4(4):462-6.
[Link]

Dandekar A, Wu G, Pewe L, Perlman S.  Axonal damage is T cell mediated and occurs concomitantly with demyelination in mice infected with a neurotropic coronavirus.  J Virol.  2001 July. 75(13):6115-20.
[Link]

Haring J, Pewe L, Perlman S.  High-magnitude, virus-specific CD4 T-cell response in the central nervous system of coronavirus-infected mice.  J Virol.  2001 March. 75(6):3043-7.
[Link]

Kolb A, Pewe L, Webster J, Perlman S, Whitelaw C, Siddell S.  Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis.  J Virol.  2001 March. 75(6):2803-9.
[Link]

Ontiveros E, Kuo L, Masters P, Perlman S.  Analysis of MHV-JHM gene 4 KO and CD4 T cell epitope escape recombinants.  20th Ann Meeting of the Amer Soc Virol, Madison, WI.  2001. 

Ontiveros E, Kuo L, Masters P, Perlman S.  Analysis of nonessential gene function in recombinant MHV-JHM.  Coronavirus meeting, Pennsylvania.  2001. 

Ontiveros E, Kuo L, Masters P, Perlman S.  Analysis of nonessential gene function in recombinant MHV-JHM. Gene 4 knockout recombinant virus.  Adv Exp Med Biol.  2001. 494:83-9.
[Link]

Haring J, Pewe L, Perlman S.  Characterization of the CD4 T cell response following CNS infection with MHV-JHM.  20th Ann Meeting of the Amer Soc Virol, Madison, WI.  2001. 

Perlman S, Pewe L.  Demyelination in RAG1 KO mice infected with mouse hepatitis virus.  J Neuroimmunol.  2001. 118:8.

Perlman S, Wu G.  Selection of and evasion from cytotoxic T cell responses in the central nervous system.  Adv Virus Res.  2001. 56:219-42.
[Link]

Dandekar A, Wu G, Pewe L, Perlman S.  T cell mediated axonal damage in a coronavirus-induced demyelinating disease.  20th Ann Meeting of the Amer Soc Virol, Madison, WI.  2001. 

Wu G, Dandekar A, Pewe L, Perlman S.  The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination.  Adv Exp Med Biol.  2001. 494:341-7.
[Link]

Wu G, Dandekar A, Pewe L, Perlman S.  The role of CD4 and CD8 T cells in MHV-JHM-induced demyelination.  Coronavirus meeting, Pennsylvania.  2001. 

Wang G, Deering C, Macke M, Shao J, Burns R, Blau D, Holmes K, Davidson B, Perlman S, McCray P.  Human coronavirus 229E infects polarized airway epithelia from the apical surface.  J Virol.  2000 October. 74(19):9234-9.
[Link]

Wu G, Dandekar A, Pewe L, Perlman S.  CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination.  J Immunol.  2000 August 15. 165(4):2278-86.
[Link]

Wu G, Pewe L, Perlman S.  Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase.  J Virol.  2000 August. 74(16):7683-6.
[Link]

Pewe L, Heard S, Bergmann C, Dailey M, Perlman S.  Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system.  J Immunol.  1999 December 1. 163(11):6106-13.
[Link]

Rakasz E, Mueller A, Perlman S, Lynch R.  Gammadelta T cell response induced by vaginal Herpes simplex 2 infection.  Immunol Lett.  1999 November 1. 70(2):89-93.
[Link]

Wu G, Perlman S.  Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus.  J Virol.  1999 October. 73(10):8771-80.
[Link]

Xue S, Sun N, Van Rooijen N, Perlman S.  Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus.  J Virol.  1999 August. 73(8):6327-34.
[Link]

Pewe L, Perlman S.  Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice.  Virology.  1999 March 1. 255(1):106-16.
[Link]

Perlman S, Lane T, Buchmeier M.  Coronaviruses: Hepatitis, Peritonitis and Central Nervous System Disease.  Lippincott-Raven.  1999. 

Perlman S, Pewe L.  CTL escape mutants are selected in the presence of a polyclonal T cells response in MHV-infected mice: Demonstration with MHC classI/peptide tetramers.  18th Annual Meeting of the Amer Soc Virol, Amherst, MA.  1999. 

Wu G, Perlman S.  Immune-mediated mechanisms of demyelination following MHV-JHM infection of the murine CNS.  18th Annual Meeting of the Amer Soc Virol, Amherst, MA.  1999. 

Stohlman S, Bergmann C, Perlman S.  Persistent infection by mouse hepatitis virus.  John Wiley & Sons.  1999. 

Pewe L, Xue S, Perlman S.  Infection with cytotoxic T-lymphocyte escape mutants results in increased mortality and growth retardation in mice infected with a neurotropic coronavirus.  J Virol.  1998 July. 72(7):5912-8.
[Link]

LaBrecque F, LaBrecque D, Klinzman D, Perlman S, Cederna J, Winokur P, Han J, Stapleton J.  Recombinant hepatitis A virus antigen: improved production and utility in diagnostic immunoassays.  J Clin Microbiol.  1998 July. 36(7):2014-8.
[Link]

Wu G, Perlman S.  Apoptosis in MHV-infected mice.  International Meeting for Neuroimmunology, Montreal, Canada.  1998. 

Perlman S, Pewe L.  CTL escape mutants cause increased mortality and morbidity in mice infected with mouse hepatitis virus, strain JHM.  Keystone Symposium: Molecular Aspects of Viral Immunity, Tamarron, CO.  1998. 

Perlman S.  Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects.  Adv Exp Med Biol.  1998. 440:503-13.
[Link]

Xue S, Pewe L, Perlman S.  Recognition of additional CTL epitopes and TCR usage in mice infected MHV CTL escape mutants.  17th Meeting of Amer Soc Virol, Vancouver, BC.  1998. 

Perlman S, Pewe L.  Role of CTL mutants in demyelination induced by mouse hepatitis virus, strain JHM.  Adv Exp Med Biol.  1998. 440:515-9.
[Link]

Xue S, Perlman S.  Antigen specificity of CD4 T cell response in the central nervous system of mice infected with mouse hepatitis virus.  Virology.  1997 November 10. 238(1):68-78.
[Link]

Pewe L, Xue S, Perlman S.  Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.  J Virol.  1997 October. 71(10):7640-7.
[Link]

Grzybicki D, Kwack K, Perlman S, Murphy S.  Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection.  J Neuroimmunol.  1997 March. 73(1-2):15-27.
[Link]

Xue S, Perlman S.  Recognition of M and S proteins by CD4 T cells in the CNS of mice infected with mouse hepatitis virus.  16th Ann Meeting of the Amer Soc Virol, Bozeman, MT.  1997. 

Pewe L, Wu G, Barnett E, Castro R, Perlman S.  Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.  Immunity.  1996 September. 5(3):253-62.
[Link]

Sun N, Cassell M, Perlman S.  Anterograde, transneuronal transport of herpes simplex virus type 1 strain H129 in the murine visual system.  J Virol.  1996 August. 70(8):5405-13.
[Link]

Castro R, Perlman S.  Differential antigen recognition by T cells from the spleen and central nervous system of coronavirus-infected mice.  Virology.  1996 August 1. 222(1):247-51.
[Link]

Perlman S, Pewe L.  A high rate of mutation in the dominant CD8+ T cell epitope occurs during the course of the persistent CNS infection caused by mouse hepatitis virus.  Abstr 15th Annu Meet Am Soc Virol.  1996. 

Xue S, Perlman S.  Identification of CD4+ T cell epitopes within the S glycoprotein of mouse hepatitis virus.  Abstr 15th Annu Meet Am Soc Virol, London, Ontario.  1996. 

Castro R, Perlman S.  CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity.  J Virol.  1995 December. 69(12):8127-31.
[Link]

Sun N, Grzybicki D, Castro R, Murphy S, Perlman S.  Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus.  Virology.  1995 November 10. 213(2):482-93.
[Link]

Barnett E, Evans G, Sun N, Perlman S, Cassell M.  Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1.  J Neurosci.  1995 April. 15(4):2972-84.
[Link]

Xue S, Jaszewski A, Perlman S.  Identification of a CD4+ T cell epitope within the M protein of a neurotropic coronavirus.  Virology.  1995 April 1. 208(1):173-9.
[Link]

Sun N, Perlman S.  Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes.  J Virol.  1995 February. 69(2):633-41.
[Link]

Loihl A, Grzybicki D, Kardos S, Perlman S, Murphy S.  Expression of nitric oxide synthase Type II in the CNS during acute and persistent hepatitis virus infection.  Society for Neuroscience.  1995. 

Castro R, Perlman S.  Identification of CTL epitopes within the surface (S) glycoprotein of a mouse neurotropic coronavirus and their possible role in viral demyelinating disease.  J Cell Biochem.  1995. Supple:306, abstr J2-245.

Smith E, Johnson S, Cripe T, Perlman S, McGuinness G, Jiang D, Cripe L, Turek L.  Perinatal transmission and maternal risks of human papillomavirus infection.  Cancer Detect Prev.  1995. 19(2):196-205.
[Link]

Perlman S, Castro R, Sun N.  Role of astrocytes and cytotoxic T cells in mice with chronic demyelination caused by MHV-JHM.  Abstr 14th Annu Meet Am Soc Virol.  1995. 

Perlman S, Castro R, Sun N.  Role of astrocytes and cytotoxic T cells in mice with chronic demyelination caused by MHV-JHM.  Abstr 14th Annu Meet Am Soc Virol.  1995. 

Perlman S, Sun N, Barnett E.  Spread of MHV-JHM from nasal cavity to white matter of spinal cord. Transneuronal movement and involvement of astrocytes.  Adv Exp Med Biol.  1995. 380:73-8.
[Link]

Pettit D, Perlman S, Malinow R.  Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons.  Science.  1994 December 16. 266(5192):1881-5.
[Link]

Chung S, Gorczynski R, Cruz B, Fingerote R, Skamene E, Perlman S, Leibowitz J, Fung L, Flowers M, Levy G.  A Th1 cell line (3E9.1) from resistant A/J mice inhibits induction of macrophage procoagulant activity in vitro and protects against MHV-3 mortality in vivo.  Immunology.  1994 November. 83(3):353-61.
[Link]

Castro R, Evans G, Jaszewski A, Perlman S.  Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells.  Virology.  1994 May 1. 200(2):733-43.
[Link]

Barnett E, Jacobsen G, Evans G, Cassell M, Perlman S.  Herpes simplex encephalitis in the temporal cortex and limbic system after trigeminal nerve inoculation.  J Infect Dis.  1994 April. 169(4):782-6.
[Link]

Barnett E, Evans G, Cassell M, Perlman S.  Anterograde viral tracing of trigeminal pain pathways from the tooth pulp to cortex using herpes simplex virus.  Pediatr Res.  1994. 35(4):378A.

Evans G, Barnett E, Jacobsen G, Cassell M, Perlman S.  Trigeminal herpes infection via murine pulp models human herpetic encephalitis.  J Dent Res.  1994. 73(IADR Abstracts):299.

Barnett E, Cassell M, Perlman S.  Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb.  Neuroscience.  1993 December. 57(4):1007-25.
[Link]

Barnett E, Perlman S.  The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM.  Virology.  1993 May. 194(1):185-91.
[Link]

Barnett E, Evans G, Cassell M, Perlman S.  Anterograde transneuronal spread of herpes simplex virus from the murine pulp to two cortical areas associated with jaw movement.  Society for Neuroscience Abstracts.  1993. 19(2):1210.

Gallagher T, Buchmeier M, Perlman S.  Dissemination of MHV4 (strain JHM) infection does not require specific coronavirus receptors.  Adv Exp Med Biol.  1993. 342:279-84.
[Link]

Barnett E, Perlman S.  Herpes simplex encephalitis resulting from trigeminal infection via the toot pulp in Balb/c mice.  American Society for Virology.  1993. 

Jacobsen G, Barnett E, Evans G, Walton R, Perlman S.  Herpes spread from pulp into CNS extensions of trigenimal nerve.  International and American Association for Dental Research.  1993. 

Oleszak E, Perlman S, Parr R, Collisson E, Leibowitz J.  Molecular mimicry between S peplomer proteins of coronaviruses (MHV, BCV, TGEV and IBV) and Fc receptor.  Adv Exp Med Biol.  1993. 342:183-8.
[Link]

Perlman S, Barnett E, Jacobsen G.  Mouse hepatitis virus and herpes simplex virus move along different CNS pathways.  Adv Exp Med Biol.  1993. 342:313-8.
[Link]

Pettit D, Perlman S, Malinow R.  Postsynaptic expression of constitutively active CaMKII occludes LTP in the hippocampal slice.  Neuroscience Abstracts.  1993. 19:703.1.

Castro R, Perlman S.  Primary cytotoxic T lymphocyte activity in mice infected with mouse hepatitis virus strain JHM.  Abstr 12th Annu Meet Am Soci Virol.  1993. 

Chung S, Li C, Fung L, Crow A, Gorczynski R, Cole E, Perlman S, Leibowitz J, Levy G.  Role of macrophage procoagulant activity in mouse hepatitis virus (MHV) infection: studies using T cell MHV-3 clones and monoclonal antibody 3D4.3.  Adv Exp Med Biol.  1993. 342:377-84.
[Link]

Gallagher T, Buchmeier M, Perlman S.  Cell receptor-independent infection by a neurotropic murine coronavirus.  Virology.  1992 November. 191(1):517-22.
[Link]

Denison M, Zoltick P, Hughes S, Giangreco B, Olson A, Perlman S, Leibowitz J, Weiss S.  Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events.  Virology.  1992 July. 189(1):274-84.
[Link]

Mobley J, Evans G, Dailey M, Perlman S.  Immune response to a murine coronavirus: identification of a homing receptor-negative CD4+ T cell subset that responds to viral glycoproteins.  Virology.  1992 April. 187(2):443-52.
[Link]

Page W, Perlman S, Smith F, Segar J, Robillard J.  Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life.  Am J Physiol.  1992 March. 262(3 Pt 2):R459-63.
[Link]

Jacobsen G, Perlman S, Evans G, Barnett E, Walton R.  Herpes spread from pulp to CNS via inferior alveolar nerve.  International Association for Dental Research.  1992. 

Barnett E, Perlman S.  MHV and HSV-1 move along different olfactory pathways after intranasal inoculation.  American Society for Virology.  1992. 

Barnett E, Perlman S.  MHV and HSV-1 move along different olfactory pathways after intranasal inoculation.  Fifth International Coronavirus Symposium, Chantilly, France.  1992. 

Gallagher T, Buchmeier M, Perlman S.  Receptor-independent spread of a neurotropic coronavirus infection.  Fifth International Coronavirus Symposium, Chantilly, France.  1992. 

Chao C, Perlman S, Dailey M.  Regulation of gp90MEL-14 (LECAM-1) mRNA by activated T cells.  FASEB J.  1992. 6:1142.

Robillard J, Page W, Smith F, Segar J, Perlman S.  Renal nerves increase renin gene expression and renin secretion at birth.  Ninth Congress of the International Pediatric Nephrology Association, Jerusalem, Israel.  1992. 

Robillard J, Page W, Smith F, Segar J, Perlman S.  Renal nerves increase renin gene expression and renin secretion at birth.  Pediatr Res.  1992. 31(4, Part 2).

Robillard J, Page W, Smith F, Segar J, Perlman S.  Renal nerves increase renin gene expression and renin secretion at birth.  Pediatr Res.  1992. 

Oleszak E, Perlman S, Leibowitz J.  MHV S peplomer protein expressed by a recombinant vaccinia virus vector exhibits IgG Fc-receptor activity.  Virology.  1992 January. 186(1):122-32.
[Link]

Olson A, Robillard J, Kisker C, Smith B, Perlman S.  Negative regulation of angiotensinogen gene expression by glucocorticoids in fetal sheep liver.  Pediatr Res.  1991 September. 30(3):256-60.
[Link]

Oleszak E, Perlman S, Leibowitz J.  Molecular mimicry between Fc gamma receptor and mouse hepatitis virus (MHV) S peplomer protein.  FASEB.  1991. 

Kisker C, Bohlken D, Perlman S, Olson A, Robillard J, Clarke W.  Regulatory mechanisms controlling prothrombin and the development of blood coagulation factors during gestation.  1991. 

Barnett E, Cassell M, Perlman S.  Tracing olfactory pathways in the mouse with a coronavirus.  Society for Neuroscience.  1991. 17(2):1511.

Perlman S, Evans G, Afifi A.  Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain.  J Exp Med.  1990 October 1. 172(4):1127-32.
[Link]

Olson A, Perlman S, Robillard J.  Developmental regulation of angiotensinogen gene expression in sheep.  Pediatr Res.  1990 September. 28(3):183-5.
[Link]

Bale Jr J, O'Neil M, Lyon B, Perlman S.  The pathogenesis of murine cytomegalovirus ocular infection. Anterior chamber inoculation.  Invest Ophthalmol Vis Sci.  1990 August. 31(8):1575-81.
[Link]

Perlman S, Jacobsen G, Olson A, Afifi A.  Identification of the spinal cord as a major site of persistence during chronic infection with a murine coronavirus.  Virology.  1990 April. 175(2):418-26.
[Link]

Olson A, Perlman S, Robillard J.  Development regulation of angiotensinogen (Ao) gene expression in sheep.  Pediatr Res.  1990. 27(4, Part 2):235A.

Robillard J, Kirby R, Page W, Olson A, Perlman S.  Effect of dietary salt manipulation on kidney renin gene expression in artificially-reared newborn WKY rats.  JASN.  1990. 1(4):425.

Robillard J, Kirby R, Page W, Olson A, Perlman S.  Effect of dietary salt manipulation on kidney renin gene expression in artificially-reared newborn WKY rats.  Pediatr Res.  1990. 27(4, Part 2):337A.

Jacobsen G, Perlman S.  Localization of virus and antibody response in mice infected persistently with MHV-JHM.  Adv Exp Med Biol.  1990. 276:573-8.
[Link]

Van Dyke D, Alexander R, Perlman S, Smith W, Dekowski S.  Fusiform bacterial sepsis. Metastases with osteomyelitis and hepatic abscess occurring in a chaotic family.  Clin Pediatr (Phila).  1989 September. 28(9):423-5.
[Link]

Perlman S, Jacobsen G, Afifi A.  Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves.  Virology.  1989 June. 170(2):556-60.
[Link]

Olson A, Perlman S, Kisker C.  Cortisol-stimulated prothrombin gene expression during gestation.  Blood.  1989. 74:290a.

Jacobsen G, Perlman S.  Localization of virus in mice infected persistently with MHV-JHM.  Fourth International Coronavirus Symposium, Cambridge, England.  1989. 

Olson A, Perlman S, Kisker C.  Prothrombin gene transcription rate during gestation: Fetal lamb model.  Pediatr Res.  1989. 25(4):271A.

Kisker C, Olson A, Perlman S.  Prothrombin gene transcription rate during gestation: Fetal lamb model.  Thromb Haemost.  1989. 62:300.

Kisker C, Perlman S, Bohlken D, Wicklund B.  Measurement of prothrombin mRNA during gestation and early neonatal development.  J Lab Clin Med.  1988 October. 112(4):407-12.
[Link]

Perlman S, Jacobsen G, Moore S.  Regional localization of virus in the central nervous system of mice persistently infected with murine coronavirus JHM.  Virology.  1988 October. 166(2):328-38.
[Link]

Denison M, Perlman S, Andersen R.  Misidentification of Neisseria species in a neonate with conjunctivitis.  Pediatrics.  1988 June. 81(6):877-8.
[Link]

Leibowitz J, Perlman S, Weinstock G, DeVries J, Budzilowicz C, Weissemann J, Weiss S.  Detection of a murine coronavirus nonstructural protein encoded in a downstream open reading frame.  Virology.  1988 May. 164(1):156-64.
[Link]

Kisker C, Perlman S, Bohlken D, Wicklund B.  Prothrombin messenger RNA during fetal and neonatal development.  APS/SBR.  1988. 

Kisker C, Perlman S, Bohlken D, Wicklund B.  Prothrombin messenger RNA during fetal and neonatal development.  Pediatr Res.  1988. 23(4).

Perlman S, Ries D.  The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM.  Microb Pathog.  1987 October. 3(4):309-14.
[Link]

Denison M, Perlman S.  Identification of putative polymerase gene product in cells infected with murine coronavirus A59.  Virology.  1987 April. 157(2):565-8.
[Link]

Perlman S, Schelper R, Bolger E, Ries D.  Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody.  Microb Pathog.  1987 March. 2(3):185-94.
[Link]

Bale jr J, O'Neil M, Giller R, Perlman S, Koszinowski U.  Murine cytomegalovirus genomic material in marrow cells: relation to altered leukocyte counts during sublethal infection of mice.  J Infect Dis.  1987 February. 155(2):207-12.
[Link]

Perlman S, Denison M.  Identification of the N-terminal putative polymerase protein of coronavirus MHV A59.  Third International Coronavirus Symposium, Asilomar, CA.  1987. 

Perlman S, Schelper R, Ries D.  Maternal antibody modulated infection in C57BL/6 and BALB/c mice.  Third International Coronavirus Symposium, Asilomar, CA.  1987. 

Perlman S, Schelper R, Ries D.  Maternal antibody-modulated MHV-JHM infection in C57BL/6 and BALB/c mice.  Adv Exp Med Biol.  1987. 218:297-305.
[Link]

Denison M, Perlman S.  Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells.  Adv Exp Med Biol.  1987. 218:155-6.
[Link]

Perlman S, Ries D, Bolger E, Chang L, Stoltzfus C.  MHV nucleocapsid synthesis in the presence of cycloheximide and accumulation of negative strand MHV RNA.  Virus Res.  1986 December. 6(3):261-72.
[Link]

Denison M, Perlman S.  Translation and processing of mouse hepatitis virus virion RNA in a cell-free system.  J Virol.  1986 October. 60(1):12-8.
[Link]

Murph J, Bale J, Murray J, Stinski M, Perlman S.  Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices.  J Pediatr.  1986 July. 109(1):35-9.
[Link]

Perlman S, Schelper R, Bolger E, Ries D.  Development of subacute demyelinating encephalomyelitis in mice infected with mouse hepatitis virus, strain JHM.  Pediatr Res.  1986. 20:318A.

Denison M, Perlman S.  In vitro translation of virion RNA of mouse hepatitis virus A59, a murine coronavirus.  Pediatr Res.  1986. 20:308A.

Bale Jr J, Perlman S.  Slow Virus Infections Due to Unconventional Agents.  Harper & Row.  1986. 

Bale Jr J, Perlman S.  Viral Encephalitis.  Harper & Row.  1986. 

Perlman S, Bell W.  Viral meningitis/encephalitis.  W.B. Saunders Co., Philadelphia.  1986. 

Broderick A, Perlman S, Dietz F.  Pseudomonas bursitis: inoculation from a catfish.  Pediatr Infect Dis.  1985 November. 4(6):693-4.
[Link]

Denison M, Perlman S.  In vitro translation of coronavirus MHV-A59 virion RNA.  American Society for Virology, Albuquerque, NM.  1985. 

Murph J, Bale, Jr J, Perlman S, Swack N.  The prevalence of cytomegalovirus infection in a midwest day care center.  Pediatr Res.  1985. 19:205A.

Denison M, Perlman S.  Translation of murine coronavirus virion RNA.  Pediatr Res.  1985. 

Perlman S, Bell W.  Viral meningitis/encephalitis.  W.B. Saunders Co., Philadelphia.  1985. 

Perlman S, Carr S.  Citramalic acid in cerebrospinal fluid of patients with bacterial meningitis.  Clin Chem.  1984 July. 30(7):1209-12.
[Link]

Piccoli D, Perlman S, Ephros M.  Transfusion-acquired Plasmodium malariae infection in two premature infants.  Pediatrics.  1983 October. 72(4):560-2.
[Link]

Perlman S, Rosbash M.  Analysis of Xenopus laevis ovary and somatic cell polyadenylated RNA by molecular hybridization.  Dev Biol.  1978 March. 63(1):197-212.
[Link]

Perlman S, Ford P, Rosbash M.  Prescence of tadpole and adult globin RNA sequences in oocytes of Xenopus laevis.  Proc Natl Acad Sci U S A.  1977 September. 74(9):3835-9.
[Link]

Perlman S, Phillips C, Bishop J.  A study of foldback DNA.  Cell.  1976 May. 8(1):33-42.
[Link]

Bishop J, Beckmann J, Campo M, Hastie N, Izquierdo M, Perlman S.  DNA-RNA hybridization.  Philos Trans R Soc Lond B Biol Sci.  1975 November 6. 272(915):147-57.
[Link]

Perlman S.  Effect of cycloheximide on replication and transcription in cells infected with vesicular stomatitiis virus.  Academic Press.  1975. 

Palma E, Perlman S, Huang A.  Ribonucleic acid synthesis of vesicular stomatitis virus. VI. Correlation of defective particle RNA synthesis with standard RNA replication.  J Mol Biol.  1974 May 5. 85(1):127-36.
[Link]

Perlman S, Huang A.  RNA synthesis of vesicular stomatitis virus. V. Interactions between transcription and replication.  J Virol.  1973 December. 12(6):1395-400.
[Link]

Penman S, Abelson H, Hirsch M, Perlman S.  The poly (A)-containing RNA in mitochondria.  International Conference Biogenesis of Mitochondria, Bari, Italy.  1973 June. 

Perlman S, Abelson H, Penman S.  Mitochondrial protein synthesis: RNA with the properties of Eukaryotic messenger RNA.  Proc Natl Acad Sci U S A.  1973 February. 70(2):350-3.
[Link]

Price R, Singer R, Perlman S, Hirsch M, Penman S.  RNA synthesis and processing in the mammalian cell nucleus.  Proc Australian Biochem Soc.  1973. 5:117-32.

Perlman S, Huang A.  Transcription and replication of vesicular stomatitis virus RNA.  Academic Press, New York.  1973. 

Perlman S, Huang A.  Virus-Specific RNA Specified by the Group I and IV Temperature-Sensitive Mutants of Vesicular Stomatitis Virus.  Intervirology.  1973. 2(5-6):312-25.

Perlman S, Hirsch M, Penman S.  Utilization of messenger in adenovirus-2-infected cells at normal and elevated temperatures.  Nat New Biol.  1972 August 2. 238(83):143-4.
[Link]

Zylber E, Perlman S, Penman S.  Mitochondrial RNA turnover in the presence of cordycepin.  Biochim Biophys Acta.  1971 July 29. 240(4):588-93.
[Link]

Perlman S, Penman S.  Mitochondrial protein synthesis: Resistance to emetine and response to RNA synthesis inhibitors.  Biochem Biophys Res Commun.  1970 August 24. 40(4):941-8.
[Link]

Perlman S, Penman S.  Protein-synthesizing structures associated with mitochondria.  Nature.  1970 July 11. 227(5254):133-7.
[Link]

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