Stead Family Department of Pediatrics

M. Sue O'Dorisio, MD, PhD

Portrait

Pediatric Hematology/Oncology Fellowship Director
Professor of Pediatrics  - Hematology/Oncology

Contact Information

Primary Office: 2526 JCP
Iowa City, IA 52242
Primary Office Phone: 319-356-7873

Email: sue-odorisio@uiowa.edu

Education

BS, Mathematics, cum laude, Creighton University, Omaha, Nebraska
MS, Biochemistry, cum laude, University of Nebraska, Omaha, Nebraska
PhD, Biochemistry, cum laude, University of Nebraska, Omaha, Nebraska
MD, Medicine, cum laude, Ohio State University, Columbus, Ohio

Fellowship, Biochemistry, Ohio State University, Columbus, Ohio
Fellowship, Medicine, Ohio State University, Columbus, Ohio
Residency, Pediatrics, Ohio State University, Columbus, Ohio
Fellowship, Hematology/Oncology, Ohio State University, Columbus, Ohio

Licensure and Certifications

Iowa Medical License
American Board of Pediatrics - General Pediatrics
American Board of Pediatrics - Hematolog/Oncology

Education/Training Program Affiliations

Biosciences Graduate Program
Interdisciplinary Graduate Program in Neuroscience
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Role of neuropeptides in development of neural crest derivatives.

Nervous system tumors are the most common cause of death from pediatric malignancies and rank second only to accidents as a cause of death in this age group. These cancers arise in the developing nervous system during fetal growth or infancy. Neuropeptides are important modulators of neurodevelopment and provide neuroprotection for stem cells and neurons. Vasoactive intestinal peptide is both a differentiation factor and a neuroprotective agent. Somatostatin is a potent modulator of growth factor release and also modulates the signal transduction pathway for multiple growth factors. We are studying the role of vasoactive intestinal peptide and somatostatin in neural development using transgenic and knock out mice. This new understanding of the role of neuropeptides in neural crest development should allow us to develop new diagnostic and therapeutic options for children with neuroblastoma and medulloblastoma.

Date Last Modified: 09/24/2013 - 14:34:27