Stead Family Department of Pediatrics

Paul B. McCray, Jr, MD


Professor of Pediatrics  - Allergy, Immunology, and Pulmonary
Professor of Microbiology

Contact Information

Lab: 6320 PBDB
Iowa City, IA 52242
Phone: 319-335-6844

Web: McCray Laboratory


BA, Biology, St Olaf College
MD, Medicine, University of Iowa

Residency, Pediatrics, County Hospital
Residency, Pediatrics, University of Iowa Hospitals and Clinics
Fellowship, Epithelial Transport, University of Iowa Hospitals and Clinics
Fellowship, Pediatric Allergy and Pulmonology, University of Iowa Hospitals and Clinics

Licensure and Certifications

Medical License, State of Iowa
Medical License, State of California
Federal Licensing Examination (FLEX)
Pediatric Pulmonology, American Board of Pediatrics
American Board of Pediatrics

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics
Interdisciplinary Graduate Program in Human Toxicology
Interdisciplinary Graduate Program in Informatics
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

Our research interests include airway epithelial cell biology and the pathogenesis and treatment of the recessive disease cystic fibrosis. We are using large scale gene expression and genomics approaches to study epithelial cell mRNA and microRNA gene networks regulating biologic processes involved in health and disease. Host-pathogen interactions at the airway surface are studied from the perspectives of disease mechanism and innate immunity. Responses to bacterial and viral respiratory pathogens are under investigation. We wish to apply knowledge from these studies toward new therapies.

Another area of investigation is the development of integrating vector systems for the treatment of inherited diseases. Current projects include gene transfer to airway epithelia for cystic fibrosis and gene transfer to the hepatocytes for the treatment of hemophilia A. The focus of these studies is on the development and optimization of lentivirus and transposon based vectors. A long-term goal is to develop strategies for integrating vector systems that could be successfully used to treat genetic diseases.

PubMed links to publications: term=McCrayPB

Center, Program and Institute Affiliations

Center for Gene Therapy of Cystic Fibrosis and other Genetic Diseases
Cystic Fibrosis Research Center
Iowa Initiative in Human Genetics

Date Last Modified: 04/12/2016 - 14:29:46