Pathology

Weizhou Zhang, MS, PhD

Portrait

Assistant Professor of Pathology
Assistant Professor of Radiation Oncology

Contact Information

Primary Office: 1020 Medical Laboratories
Iowa City, IA 52242
Primary Office Phone: 319-335-8214

Email: weizhou-zhang@uiowa.edu
Web: Dr. Zhang's Research Laboratory

Education

BS, Microbiology, Nankai University, Tianjin, China
MS, Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
PhD, Microbiology, Mount Sinai School of Medicine, New York University, NY

Post Doctoral, Fellow, Mount Sinai School of Medicine, New York School of Medicine
Post Doctoral, Fellow, Pharmacology, University of California, San Diego

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Molecular and Cellular Biology

Research Summary

Role of inflammation in breast cancer initiation, progression and metastasis.

All Publications

Borcherding N, Kusner D, Liu G, Zhang W.  ROR1, an embryonic protein with an emerging role in cancer biology [ePub ahead of print].  Protein Cell.  2014. 
[PubMed]

Cyr A, Kulak M, Park J, Bogachek M, Spanheimer P, Woodfield G, White-Baer L, O-Malley Y, Sugg S, Olivier A, Zhang W, Domann F, Weigel R.  TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.  Oncogene [epub ahead of print].  2014. 
[PubMed]

Zhang W, Tan W, W X, Poustovoitov M, Strasner A, Li W, Ghassemian M, Koff A, Karin M.  A NIK-IKKα module promotes ErbB2-induced mammary tumorigenesis and tumor initiating cell expansion by stimulating nuclear export of tumor suppressor p27/Kip1.  Cancer Cell.  2013. 23(5):647-59.
[PubMed]

Janowski A, Kolb R, Zhang W, Sutterwala F.  Beneficial and Detrimental Roles of NLRs in Carcinogenesis.  Frontiers in immunology.  2013. 4:370.
[PubMed]

Kolb R, Liu G, Janowski A, Sutterwala F, Zhang W.  Inflammasomes in cancer: a double-edged sword.  Protein and cell [Epub ahead of print].  2013. 
[PubMed]

Guan D, Zhang W, Zhang W, Liu G, Izpisua Belmonte J.  Switching cell fate, ncRNAs coming to play.  Cell Death and Disease.  2013. 4:e464.
[PubMed]

Zhang W, Grivennikov  S.  Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer.  Breast Cancer Research.  2013. 15(5):316.
[PubMed]

Zhang W, Duan S, Li Y, Xu X, Qu J, Zhang W, Liu G.  Converted neural cells: induced to a cure?.  Protein & cell.  2012. 3(2):91-7.
[PubMed]

Kong S, Sartor M, Hu C, Zhang W, Zhang L, Jin S.  Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release.  Acta Biomateriala.  2012. S1742-7061(12):00545-4.
[PubMed]

Zhang W, Guan D, Qu J, Zhang W, Liu G.  Non-viral iPSCs: a safe way for therapy?.  Protein & cell.  2012. 3(4):241-5.
[PubMed]

Xu X, Qu J, Suzuki K, Li M, Zhang W, Liu G, Izpisua Belmonte J.  Reprogramming based gene therapy for inherited red blood cell disorders.  Cell research.  2012. 22(6):941-4.
[PubMed]

Pan H, Zhang W, Zhang W, Liu G.  Find and replace: editing human genome in pluripotent stem cells.  Protein & cell.  2011. 2(12):950-6.
[PubMed]

Tan W, Zhang W, Strasner A, Grivennikov S, Cheng J, Hoffman R, Karin M.  Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.  Nature.  2011. 470(7335):548-53.
[PubMed]

Zhang W, Kater A, Widhopf G, Chuang H, Enzler T, James D, Poustovoitov M, Tseng P, Janz S, Hoh C, Herschman H, Karin M, Kipps T.  B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.  Proceedings of the National Academy of Sciences of the United States of America.  2010. 107(44):18956-60.
[PubMed]

Tseng P, Matsuzawa A, Zhang W, Mino T, Vignali D, Karin M.  Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.  Nature immunology.  2010. 11(1):70-5.
[PubMed]

Kong S, Zhang W, Lee J, Brammer K, Lal R, Karin M, Jin S.  Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release.  Nano letters.  2010. 10(12):5088-92.
[PubMed]

Enzler T, Kater A, Zhang W, Widhopf G, Chuang H, Lee J, Avery E, Croce C, Karin M, Kipps T.  Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression.  Blood.  2009. 114(20):4469-76.
[PubMed]

Cheng G, Park S, Shu S, He L, Kong W, Zhang W, Yuan Z, Wang L, Cheng J.  Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery.  Current cancer drug targets.  2008. 8(1):2-6.
[PubMed]

Matsuzawa A, Tseng P, Vallabhapurapu S, Luo J, Zhang W, Wang H, Vignali D, Gallagher E, Karin M.  Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.  Science.  2008. 321(5889):663-8.
[PubMed]

Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng P, Keats J, Wang H, Vignali D, Bergsagel P, Karin M.  Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.  Nature immunology.  2008. 9(12):1364-70.
[PubMed]

Zhang W, Cheng G, Gong J, Hermanto U, Zong C, Chan J, Cheng J, Wang L.  RACK1 and CIS mediate the degradation of BimEL in cancer cells.  The Journal of biological chemistry.  2008. 283(24):16416-26.
[PubMed]

Cheng G, Zhang W, Wang L.  Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay.  Cancer research.  2008. 68(4):957-60.
[PubMed]

Cheng G, Zhang W, Sun M, Wang Q, Coppola D, Costanzo C, Xu L, Chan J, Cheng J, Wang L.  Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function.  Journal of Biological Chemistry.  2008. 283(21):14665-14673.
[PubMed]

Masker K, Golden A, Gaffney C, Mazack V, Schwindinger W, Zhang W, Wang L, Carey D, Sudol M.  Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src.  Virology.  2007. 364(1):10-20.
[PubMed]

Cheng G, Chan J, Wang Q, Zhang W, Sun C, Wang L.  Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel.  Cancer research.  2007. 67(5):1979-87.
[PubMed]

Zhang W, Zong C, Hermanto U, Lopez-Bergami P, Ronai Z, Wang L.  RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.  Molecular and cellular biology.  2006. 26(2):413-24.
[PubMed]

López-Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang L, Ronai Z.  RACK1 mediates activation of JNK by protein kinase C [corrected].  Molecular cell.  2005. 19(3):309-20.
[PubMed]

Zhao D, Zhang W, Xue Y, Ma Y.  Amphibacillus haojiensis sp. nov.--a novel alkaliphilic and slight halophilic bacterium from Haoji Soda Lake in Inner Mongolia Autonomous Region, China.  Wei sheng wu xue bao = Acta microbiologica Sinica.  2004. 44(6):720-3.
[PubMed]

Ma Y, Zhang W, Xue Y, Zhou P, Ventosa A, Grant W.  Bacterial diversity of the Inner Mongolian Baer Soda Lake as revealed by 16S rRNA gene sequence analyses.  Extremophiles : life under extreme conditions.  2004. 8(1):45-51.
[PubMed]

Zhang W, Xue Y, Ma Y, Grant W, Ventosa A, Zhou P.  Marinospirillum alkaliphilum sp. nov., a new alkaliphilic helical bacterium from Haoji soda lake in Inner Mongolia Autonomous Region of China.  Extremophiles.  2002. 6(1):33-7.
[PubMed]

Zhang W, Xue Y, Ma Y, Zhou P, Ventosa A, Grant W.  Salinicoccus alkaliphilus sp. nov., a novel alkaliphile and moderate halophile from Baer Soda Lake in Inner Mongolia Autonomous Region, China.  International journal of systematic and evolutionary microbiology.  2002. 52(Pt 3):789-93.
[PubMed]

Zhang W, Wenyang M, Xue Y, Ma Y, Zhou P.  The diversity of alkaliphiles from hailaer soda lake, Inner Mongolia.  Biodiversity Science.  2001. 9(1):44-50.

Date Last Modified: 06/07/2014 - 21:56:23