Pathology

Sergei I. Syrbu, MD, PhD

Portrait

Medical Director, Immunopathology Laboratory
Clinical Associate Professor of Pathology  - Anatomic Pathology

Contact Information

Primary Office: 6245 Roy Carver Pavilion
Iowa City, IA 52242
Primary Office Phone: 319-356-7372

Email: sergei-syrbu@uiowa.edu

Education

MD, State University of Medicine, Chishinau, Moldova
PhD, All Union Cardiology Research Center, Moscow, USSR

Research Fellow, All Union Cardiology Research Center
Post Doctoral, University of Connecticut Health Center
Residency, Pathology, University of Iowa Carver College of Medicine
Fellowship, Hematopathology, University of Iowa Carver College of Medicine

Licensure and Certifications

Hematology American Board of Pathology
Anatomic and Clinical Pathology American Board of Pathology

Research Summary

Interests Include: Cytologic and histomorphologic correlations of bone marrow and lymph node biopsies with immunohistochemistry and flow cytometric analysis in hematopoietic disorders and lymphomas. Development of new monoclonal antibodies and antigen retrieval procedures for immunohistochemical staining of formalin-fixed, paraffin embedded tissues.

All Publications

Maurer M, Ghesquiere H, Jais J, Witzig T, Thompson C, Delarue R, Micallef I, Peyrade F, Macon W, Molina J, Ketterer N, Syrbu S, Fitoussi O, Kurtin P, Allmer C, Nicolas-Virelizier E, Slager S, Habermann T, Link B, Salles G, Tilly H, Cerhan J.  Event-Free Survival at 24 months Is a Robust End Point for Disease-Related Outcome in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy..  J Clin Oncol.  2014 February 18. 
[PubMed]

Tompkins V, Han S, Oliver A, Syrbu S, Bair T, Button A, Jacobus L, Wang Z, Lifton S, Raychaudhuri P, Morse III H, Weiner G, Link B, Smith B, Janz S.  Identification of Candidate B-Lymphoma Genes by Cross-Species Gene Expression Profiling.  PLos One.  2013 October 09. 8(10).
[PubMed]

Link B, Maurer M, Nowakowski G, Ansell S, Macon W, Syrbu S, Slager S, Thompson C, Inwards D, Johnston P, Colgan J, Witzig T, Habermann T, Cerhan J.  Rates and Outcomes of Follicular Lymphoma Transformation in the Immunochemotherapy Era: A Report From the University of Iowa/Mayo Clinic Specialized Program of Research Excellence Molecular Epidemiology Resource.  J Clin Oncol.  2013 July 29. 
[PubMed]

Fairley J, Bream M, Fullenkamp C, Syrbu S, Chen M, Messingham K.  Missing the target: Characterization of bullous pemphigoid patients who are negative using the BP180 enzyme-linked immunosorbant assay.  J Am Acad Dermatol;  2013. 

Hoover A, Anderson C, Hoffman H, Magalhaes-Silverman M, Syrbu S, C S.  Laryngeal Chloroma Heralding Relapse of Acute Myeloid Leukemia.  J Clin Oncol.  2013. 

Lukas M, Nystrom L, Buckwalter IV J, Syrbu S, Miller B.  Serum Protein Electrophoresis in the Evaluation of Lytic Bone Lesions.  Orthop J.  2013. 33:114-8.
[PubMed]

Gabriel-Griggs S, Bleile M, Bell A, Rosenthal N, Syrbu S.  Annexin A1 (ANXA1), Key Confirmatory Marker Discriminating Hairy Cell Leukemia from Variant Hairy Cell Leukemia and Other Morphologically Similar B-Cell Neoplasms.  Mod Pathol.  2012. 25:335A.

Perepu U, Dogan A, Maurer M, Allmer C, Thompson C, Ansell S, Syrbu S, Slager S, Witzig T, Weiner G, Habermann T, Cerhan J, Link B.  EBV(+) Diffuse Large B Cell Lymphoma Is Infrequent in Upper Central United States and Lacks Unique Clinical Characteristics or Adverse Prognosis Compared to EBV (-) Counterparts: Results From University of Iowa/Mayo Clinic SPORE.  Blood.  2012. 120:1604.

Maurer M, Ghesquieres H, Witzig T, Thompson C, Micallef N, Macon W, Syrbu S, Kurtin P, Allmer C, Gargi T, Nicolas-Virelizier E, Sebban C, Slager S, Habermann T, Link B, Cerhan J.  Newly Diagnosed Diffuse Large B-Cell Lymphoma Patients Treated with Immunochemotherapy Who Are Alive and Progression Free 12 Months After Diagnosis Have a Subsequent Overall Survival Similar to That of the General Population.  Blood.  2012. 120:1540.

Jacobus L, Lunde J, Maurer M, Dogan A, Syrbu S, Allmer C, Novak A, Cerhan J, Nowakowski G, Slager S, Witzig T, Thompson C, Weiner G, Haberman T, Ansell S, Link B.  Non-Follicular Low Grade B-Cell Lymphomas: Patterns of Presentation and Management with Comparative Prognostic Utility of IPI and FLIPI.  Blood.  2012. 120:1563.

Link B, Maurer M, Nowakowski G, Ansell S, Macon W, Syrbu S, Slager S, Thompson C, Inwards D, Johnston P, Colgan J, Witzig T, Weiner G, Habermann T, Cerhan J.  Rates and Outcomes of Follicular Lymphoma Transformation in the Rituximab Era: A Report From the University of Iowa/Mayo Clinic SPORE Molecular Epidemiology Resource.  Blood.  2012. 120:1546.

Naraev B, Racila E, Goodheart M, Syrbu S, O'Dorisio T, Halfdanarson T.  Status of DNA Repair and Cell Proliferation Markers in High Grade Neuroendocrine Carcinoma of the Uterine Cervix and Small Cell Carcinoma of the Lung.  Pancreas.  2012. 41(2):339.

Fromm J, Sabath D, Wood B, Savage E, Syrbu S, Jensen C.  Diagnostic usefulness of flow cytometry for immunophenotyping classical Hodgkin lymphoma.  Am J Clin Pathol.  2011 July. 136(1):157-8; author reply 158.
[PubMed]

Maurer M, Micallef I, Cerhan J, Katzmann J, Link B, Colgan J, Habermann T, Inwards D, Markovic S, Ansell S, Porrata L, Johnston P, Nowakowski G, Thompson C, Gupta M, Syrbu S, Kurtin P, Macon W, Nikcevich D, Witzig T.  Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphoma.  J Clin Oncol.  2011 April. 29(12):1620-6.
[PubMed]

Syrbu S, COHEN M.  An enhanced antigen retrieval procedure for immunohistochemical staining of formalin-fixed, paraffin-embedded tissue.  Humana Press.  2011 February. 717:101-110.

Savage E, Vanderheyden A, Bell A, Syrbu S, Jensen C.  Independent diagnostic accuracy of flow cytometry obtained from fine-needle aspirates: a 10-year experience with 451 cases.  Am J Clin Pathol.  2011 February. 135(2):304-9.
[PubMed]

Syrbu S, Cohen M.  An enhanced antigen-retrieval protocol for immunohistochemical staining of formalin-fixed, paraffin-embedded tissues.  Methods in Molecular Biology (Clifton, N.J.).  2011. 717:101-110.
[PubMed]

Nasr M, Syrbu S.  CD15 expression in Hodgkin and Reed- Sternberg-like cells in lymph node: Pathologic significance and differential diagnosis.  ASCP Check Sample.  2011. 46(1):1-8.

Bleile M, Syrbu S.  Diffuse Large B-cell Lymphoma, Plasmablastic Variant: Clinical Features and Pathologic Diagnosis.  ASCP Check Sample.  2011. 46(3):19-27.

Maurer M, Cerhan J, Katzmann J, Dogan A, Gupta M, Macon M, Syrbu S, Link B, Micallef I, Witzig T.  Elevated Monoclonal Free Light Chains Are a Serum Marker of ABC Type Diffuse Large B-Cell Lymphoma.  Blood.  2011. 118:1591.

Juweid M, Syrbu S,  A.  Error-prone DNA repair underlying somatic hypermutation/class-switch recombination (SHM/CSR) identified as major contributor of 18F-fluorothymidine (FLT) in low-grade follicular lymphoma (FL).  Society of Nuclear Medicine Annual Meeting.  2010 June. 

Juweid M, Syrbu S, Deyoung B, O'Dorisio M, O'Dorisio T.  Discordant expression of proliferating cell nuclear antigen (PCNA) and Ki-67 Antigen in carcinoid and pancreatic neuroendocrine tumors (C&PET) likely indicates enhanced DNA repair.  Pancreas.  2010. 39(2):279.

Maurer M, Cerhan J, Katzmann J, Link B, Colgan J, Habermann T, Inwards D, Markovic S, Ansell S, Porrata L, Johnston P, Nowakowski G, Thompson C, Gupta M, Syrbu S, Kurtin P, Macon M, Witzig T.  Elevatation of Serum Free Light Chains are Common in Lymphoma and Associated with Poor Event Free Survival and Overall Survival.  Blood.  2010. 116:4136.

Gerhan J, Habermann T, Maurer M, Wooldridge J, Ansell S, Nowakowski G, Micallef I, Thompson C, Wang A, Macon W, Syrbu S, Slager S, Witzig T, Link B.  Genetic Polymorphisms In Genes Involved In R-CHOP Metabolism and Event-Free and Overall Survival In Diffuse Large B-Cell Lymphoma.  Blood.  2010. 116:996.

Racila E, Syrbu S, Nasr M, Juweid M.  Thymidylate Synthase (TS) Expression In Diffuse Large B-Cell Lymphoma (DLBCL): Identification of a Potential Therapeutic Target.  Blood.  2010. 116:5107.

Nasr M, Rosenthal N, Syrbu S.  Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker.  Am J Clin Pathol.  2010 January. 133(1):41-8.
[PubMed]

Thomas D, Syrbu S, Graham M.  Epstein-Barr virus mimicking lymphoma on FDG-PET/CT.  Clin Nucl Med.  2009 December. 34(12):891-3.
[PubMed]

Muirhead D, Stone M, Syrbu S.  The utility of PU 1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin.  Am J Dermatopath.  2009 July. 31(5):432-5.
[PubMed]

Juweid M, Buck A, Pronto L, Mottaghy F, Syrbu S, Moller P, Vose J.  Association of increase in Thymidine uptake relative to tumor cell proliferation in indolent NHLs and DNA Repair.  J Clin Oncol.  2009. 27(15S):11116.

Juweid M, Syrbu S, Bleile M, Buck A, Wondergem M, Vose J.  Association of increased thymidine uptake relative to tumor cell proliferation in low-grade follicular lymphoma and DNA repair.  Blood.  2009. 114:22.

Nasr M, Rosenthal N, Syrbu S.  Expression profiling of transcription factors in B or T-lymphoblastic leukemia/lymphoma and Burkitt lymphoma: Utility of Pax-5 immunostaining as Pan-Pre-B-cell marker.  Mod Pathol.  2009. 22:279A.

Wehbe A, Neppalli N, Syrbu S.  Diffuse follicle center lymphoma presents with high frequency of extranodal disease.  J Clin Oncol.  2008. 26:19511.

Maurer M, Witzig T, Macon W, Syrbu S, Cerhan J, Allmer C, Johnston P, Link B, Habermann T.  Diffuse Large B-Cell Lymphoma (DLBCL) Patients with Composite Histology Have Improved Early Outcome Compared to De Novo DLBCL When Treated with R-CHOP.  Blood.  2008. 112:2819.

Qasem S, COHEN M, Syrbu S.  Cyclin D1 and GATA3 expression correlate with estrogen receptor status in invasive breast carcinoma.  Arch Pathol Lab Med.  2007. 131(9):1448.

Vanderheyden A, Syrbu S, Jensen C.  Independent Diagnostic Accuracy of Flow Cytometry of Fine Needle Aspirates: A 10 year experience with 511 cases.  Mod Pathol.  2007. 21:86A.

Syrbu S, Rokhlin O, COHEN M.  Novel monoclonal antibodies to human kappa and lambda immunoglobulin light chains suitable for immunohistochemical staining and direct immunofluorescence microscopy on formalin-fixed, paraffin-embedded (FFPE) tissues.  Mod Pathol.  2007. 20:261A.

Muirhead D, Stone M, Syrbu S.  The utility of PU 1 as an immunohistochemical marker for histiocyte Lesions of the skin.  Mod Pathol.  2007. 20:96A.

McCune R, Syrbu S, Vasef M.  Expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin's and non-Hodgkin's lymphomas: a comparative study using high throughput tissue microarrays.  Mod Pathol.  2006 July. 19(7):1010-8.
[PubMed]

McCune R, Syrbu S, Vasef M.  Transcription factor PU 1 is a useful marker in distinguishing nodular lymphocyte predominant Hodgkin lymphoma from classical Hodgkin lymphoma.  Mod Pathol.  2006. 18:241A.

Popovici M, Syrbu S, Cobet V, Ivanov V, Popovici I, Ciobanu L.  Serum determination of Ca2+-ATP-ase in the diagnosis of acute myocardial infarction.  Arta Medicala.  2005. 2(11):3-6.

Syrbu S, Jans M, Vasef M.  Expression profiling of transcription factors Pax-5, Oct1, Oct2, BOB.1, and PU.1 in classical Hodgkin and non-Hodgkin lymphomas: a comparative study using high throughout tissue microarrays.  Mod Pathol.  2004. 17:273A.

Syrbu S, Popovici M, Kobets V, Ivanov V, Popovici I, Ciobanu L.  The serum cardiac sarcoplasmic Ca-ATPase immunoassessment: a new diagnostic marker of acute myocardial infarction.  Eur Heart J.  2003. 24:299.

Rokhlin O, Taghiyev A, Guseva N, Glover R, Syrbu S, COHEN M.  TRAIL-DISC formation is androgen-dependent in the human prostatic carcinoma cell line LNCaP.  Cancer Biology & Therapy.  2002. 1(6):631-7.
[PubMed]

Weiner R, Sasso D, Gionfriddo M, Thrall R, Syrbu S, Smilowitz H, Vento J.  Early detection of oleic acid-induced lung injury in rats using (111)In-labeled anti-rat intercellular adhesion molecule-1.  J Nuclear Med.  2001 July. 42(7):1109-15.
[PubMed]

Syrbu S, Zafar N, Vaena D.  Lymphoma of the breast, morphologic and immunologic assessment.  Modern Pathology.  2001. 14(1):180A.

Syrbu S, Waterman W, Molski T, Nagarkatti D, Hajjar J, Sha'afi R.  Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.  J Immunol.  1999 February. 162(4):2334-40.
[PubMed]

Moraru I, Syrbu S, Zecevic N, Hager W, Watras J, Messineo F.  An antibody to annexin V blocks Ca(2+)-dependent ATPase activity of sarcoplasmic reticulum in human failing hearts.  Ann NY Acad Sci.  1998 September. 853:333-7.
[PubMed]

Moraru I, Syrbu S, Michaels K, Kim D, Malchoff D, Watras J.  Pressure overload induces overexpression of annexins II and V in aortic-banded rats.  Ann NY Acad Sci.  1998 September. 853:329-32.
[PubMed]

Weiner R, Sasso D, Gionfriddo M, Syrbu S, Smilowitz H, Vento J, Thrall R.  Early detection of bleomycin-induced lung injury in rat using indium-111-labeled antibody directed against intercellular adhesion molecule-1.  J Nucl Med.  1998 April. 39(4):723-8.
[PubMed]

Cowan A, Syrbu S.  Synthesis and intracellular trafficking of fertilin during guinea pig spermatogenesis.  Mol Biol Cell.  1998. 9:179a.

Syrbu S, Popovici M, Thrall R, Smilowitz H.  Role of inflammatory mediators in oleic acid induced acute lung injury.  Curier Medical.  1997. 3:36-40.

Sasso D, Gionfriddo M, Thrall R, Syrbu S, Smilowitz H, Weiner R.  Biodistribution of indium-111-labeled antibody directed against intercellular adhesion molecule-1.  J Nucl Med.  1996 April. 37(4):656-61.
[PubMed]

Syrbu S, Thrall R, Smilowitz H.  Sequential appearance of inflammatory mediators in rat bronchoalveolar lavage fluid after oleic acid-induced lung injury.  Exp Lung Res.  1996. 22(1):33-49.
[PubMed]

Sasso D, Gionfriddo M, Syrbu S.  Biodistribution of antibody directed against intercellular adhesion molecule-1 in normal rat.  Am J Resp Crit Care Medicine.  1995. 51:A70.

Go L, Watras J, Harnick S, Marx S, Syrbu S, Marks A.  Chamber specific regulation of calcium ATPase messenger RNA and protein during human heart failure.  Circulation.  1995. 92:132.

Sasso D, Gionfriddo M, Syrbu S, Smilowitz H, Thrall R, Weiner R.  Early detection of lung injury using In-111 labeled anti-intercellular adhesion molecule-1 in rat model.  J Nucl Med.  1995. 36:159P.

Syrbu S, Popovici M, Smilowitz H.  Endotoxin and TNF induce upregulation of adhesion molecules on isolated myocardial cells.  Curier Med.  1995. 

Syrbu S, Thrall R, Wisniecki P, Lifchez S, Smilowitz H.  Increased immunoreactive rat lung ICAM-1 in oleic acid-induced lung injury.  Exp Lung Res.  1995. 21(4):599-616.
[PubMed]

Syrbu S, Smilowitz H.  Rapid increase in immunoreactive rat lung ICAM-1 following oleic acid-induced lung injury.  Am J Resp Crit Care Medicine.  1995. 51:A766.

Syrbu S, Smilowitz H.  Sequential appearance of inflammatory mediators in rat broncho-alveolar lavage fluid (BAL) after oleic acid (OA) induced lung injury.  Am J Resp Crit Care Medicine.  1995. 51:A68.

Watras J, Go L, Syrbu S.  Use of endomyocardial biopsies to analyze the sarcoplasmic reticulum calcium pump in patients with heart failure.  Circulation .  1995. 92:I698.

Syrbu S, Thrall R, Wisniecki P, Lifchez S, Smilowitz H.  Increased immunoreactive rat lung ICAM-1 in oleic acid induced lung injury.  Can J Physiol Pharmacol.  1994. 72:275S.

Syrbu S, Popovich M, Loginov V.  Functional states and contents of ion transporting membrane proteins of red cells in hypertensive patients.  Science (Chishinau, Moldova).  1992. 

Popovici M, Costin S, Gudumac V, Syrbu S.  Molecular mechanisms of diastolic stiffness in cardiomyopathies.  Materials of Vth Meeting of Balkan Medical Society. Constancsa (Romania).  1992. 

Topal V, Syrbu S.  Antioxidant treatment of patients with symmetrical lipomatosis (Madelung disease).  Curier MEdical.  1991. 4:12-15.

Popovich M, Cobets V, Kapelko V, Syrbu S.  Functional and energetic myocardial disorders at prolonged adrenergic stimulation and protective effect of taurine.  Materials of IVth Soviet Symposium "Stress, Adaptations and Dysfunction". Chishinau.  1991. 

Topal V, Lysyi L, Syrbu S.  Hormonal metabolic disturbances in patients with symmetrical lipomathosis of the neck.  Curier Medical .  1990. 5:38-41.

Syrbu S, Popovich M, Golikov M, Kapelko V.  Myocardial dysfunction and metabolic disturbances induced by Adriamicine administration in rats.  All Union Symposium of Physiology..  1990. 

Syrbu S, Popovich M, Golikov M, Kapelko V.  Myocardial dysfunction and metabolic disturbances induced by Adriamicine administration in rats.  J Physiology.  1990. 3:103.

Levitsky D, Benevolensky D, Ikemoto N, Syrbu S, Watras J.  Monoclonal antibodies to dog heart sarcoplasmic reticulum as markers of endoplasmic reticulum.  J Mol Cell Cardiol.  1989 February. 21 Suppl 1:55-8.
[PubMed]

Syrbu S, Levitsky D, Popovici M.  Mechanism of inhibiting Ca uptake and ATPase activity of sarcoplasmic reticulum by monoclonal antibodies.  Science (Chishinau, Moldova).  1989. 

Syrbu S, Popovich M, Levitsky D.  Production and characterization of monoclonal antibodies which inhibit the function of sarcoplasmicreticulum.  J Mol Cell Cardiol.  1989. 21:S32.

Brovkovich V, Syrbu S, benevolensky D, Levitsky D.  Effect of total ischemia on the function of cardiac sarcoplasmic reticulum.  International Symposium on Hypoxia (Berlin): .  1988. 

Syrbu S, Popovici M.  Functional states of Ca pump system of cardiac muscle during prolonged administration of pesticides.  Science (Chishinau, Moldova).  1988. 

Levitsky D, Benevolensky D, Syrbu S.  Monoclonal antibodies to Ca ATPase as a tool for studying structure and function of sarcoplasmic reticulum.  Ind. J. Heart Res.  1988. Suppl IV:S81.

Syrbu S, Levitsky D, Cherepakhin V.  Monoclonal antibodies to Ca ATPase as a tool for studying structure and function of sarcoplasmic reticulum.  Science (Chishinau, Moldova).  1988. 

Levitsky D, Syrbu S, Benevolensky D.  Studies of the structure and function of sarcoplasmic reticulum using monoclonal antibodies against Ca ATPase.  IVth International Congress of Cell Biology (Monreal). .  1988. 

Levitsky D, Syrbu S, Cherepakhin V, Rokhlin O.  Monoclonal antibodies to dog heart sarcoplasmic reticulum. Application of the mAbs for studies of the structure and function of Ca2+-pumps.  Biomedica biochimica acta.  1987 August. 46(9):S382-7.
[PubMed]

Levitsky D, Syrbu S, Cherepakhin V, Rokhlin O.  Monoclonal antibodies to dog heart sarcoplasmic reticulum. Antibodies that inhibit Ca2+-pump systems of cardiac and skeletal muscles.  Eur J Biochem.  1987 April. 164(2):477-84.
[PubMed]

Levitsky D, Brovkovich V, Syrbu S.  Mechanisms of the damage of sarcoplasmic reticulum calcium pump in ischemic myocardium.  J Mol Cell Cardiol.  1987. 19:S213.

Syrbu S, Cherepakhin V, Rokhlin O, Levitsky D.  Monoclonal antibodies to Ca ATPase of cardiac sarcoplasmic reticulum inhibiting Ca pump activity and differentiating fast and slow muscles.  J Mol Cell Cardiol.  1987. 19:S43.

Suhoplechev S, Loginov V, Syrbu S.  Binding of monoclonal antibodies against Ca ATPase with red cells membrane of hypertensive patients.  4th Soviet Congress of Cardiology (Moscow).  1986. 

Syrbu S, Sakharova A, Cherepakhin V.  Monoclonal antibodies against Ca ATPase that discriminate slow and fast muscles.  Materials of III Symposium of Soviet Section of the ISHR (Baku).  1986. 

Levitsky D, Syrbu S, Cherepakhin V, Rokhlin O, Popovich M.  Monoclonal antibodies to sarcoplasmic reticulum membranes that inhibit Ca2+ transport, and Ca2+ ATPase activity.  Biologich Membr.  1986. 3:101-106.

Syrbu S, Levitsky D, Levchenko T.  Production of monoclonal antibodies to dog heart sarcoplasmic reticulum.  Materials of Vth Soviet Congress of Biochemistry(Kiev).  1986. 

Popovich M, Gerasimova T, Syrbu S.  High energy phosphates and myocardial contractile function after prolonged administration of pesticides in rats.  Materials of All Union Symposium "Stress and Adaptation" (Moscow) .  1984. 

Popovich M, Gerasimova T, Syrbu S, Severin V.  Biochemical and physiological alteration of myocardium in rats treated by pesticides.  Materials of International Symposium of Soviet Section of the ISHR (Tashkent).  1983. 

Wondergem M, Syrbu S, Zijlstra J, Hoetjes N, van e Ven P, Hoekstra O, Cillessen S, Moesbergen L, Buck A, Vose J, Juweid M.  Disproportional 18F-Fluorothymidine Uptake Relative to cellular Proliferation in Follicular Lymphoma is Related to Error-Prone DNA Repair.  Clin Can Res. 

Date Last Modified: 06/07/2014 - 21:56:23