Sergei I. Syrbu, MD, PhD


Associate Professor, Hematopathology and Immunology,
Medical Director, Immunopathology Laboratory
Research Fellow
Clinical Associate Professor of Pathology  - Anatomic Pathology

Contact Information

Primary Office: 6245 Roy Carver Pavilion
Iowa City, IA 52242
Phone: 319-356-7372



MD, State University of Medicine, Chishinau, Moldova
PhD, All Union Cardiology Research Center, Moscow, USSR

Post Doctorate, University of Connecticut Health Center
Residency, Pathology, University of Iowa Carver College of Medicine
Fellowship, Hematopathology, University of Iowa Carver College of Medicine

Licensure and Certifications

Hematology, American Board of Pathology
Anatomic and Clinical Pathology, American Board of Pathology

Research Summary

Interests Include: Cytologic and histomorphologic correlations of bone marrow and lymph node biopsies with immunohistochemistry and flow cytometric analysis in hematopoietic disorders and lymphomas. Development of new monoclonal antibodies and antigen retrieval procedures for immunohistochemical staining of formalin-fixed, paraffin embedded tissues.

Selected Publications

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Mir M, Maurer M, Ziesmer S, Slager S, Habermann T, Macon W, Link B, Syrbu S, Witzig T, Friedberg J, Press O, LeBlanc M, Novak A, Ansell S.  Elevated serum levels of IL-2R, IL-1RA and CXCL9 are associated with a poor prognosis in follicular lymphoma.  Blood Epub ahead of print .  2014 November 24. 

Fairley J, Bream M, Fullenkamp C, Syrbu S, Chen M, Messingham K.  Missing the target: Characterization of bullous pemphigoid patients who are negative using the BP180 enzyme-linked immunosorbant assay.  J Am Acad Dermatol;  2013. 

Maurer M, Micallef I, Cerhan J, Katzmann J, Link B, Colgan J, Habermann T, Inwards D, Markovic S, Ansell S, Porrata L, Johnston P, Nowakowski G, Thompson C, Gupta M, Syrbu S, Kurtin P, Macon W, Nikcevich D, Witzig T.  Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphoma.  J Clin Oncol.  2011 April. 29(12):1620-6.

Savage E, Vanderheyden A, Bell A, Syrbu S, Jensen C.  Independent diagnostic accuracy of flow cytometry obtained from fine-needle aspirates: a 10-year experience with 451 cases.  Am J Clin Pathol.  2011 February. 135(2):304-9.

Nasr M, Syrbu S.  CD15 expression in Hodgkin and Reed- Sternberg-like cells in lymph node: Pathologic significance and differential diagnosis.  ASCP Check Sample.  2011. 46(1):1-8.

Bleile M, Syrbu S.  Diffuse Large B-cell Lymphoma, Plasmablastic Variant: Clinical Features and Pathologic Diagnosis.  ASCP Check Sample.  2011. 46(3):19-27.

Nasr M, Rosenthal N, Syrbu S.  Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker.  Am J Clin Pathol.  2010 January. 133(1):41-8.

Thomas D, Syrbu S, Graham M.  Epstein-Barr virus mimicking lymphoma on FDG-PET/CT.  Clin Nucl Med.  2009 December. 34(12):891-3.

Muirhead D, Stone M, Syrbu S.  The utility of PU 1 as an immunohistochemical marker for histiocytic and dendritic lesions of the skin.  Am J Dermatopath.  2009 July. 31(5):432-5.

McCune R, Syrbu S, Vasef M.  Expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin's and non-Hodgkin's lymphomas: a comparative study using high throughput tissue microarrays.  Mod Pathol.  2006 July. 19(7):1010-8.

Date Last Modified: 08/04/2015 - 09:28:35