Pathology

Annette Schlueter, MD, PhD

Portrait

Medical Director, Tissue and Cellular Therapies and Patient services Sections
National Marrow Donor Program (NMDP) Apheresis Center Medical Director
Laboratory Medical Director, Tissue and Cellular Therapies
Assistant Medical Director and Head of Transplant Services
Associate Professor of Pathology  - Transfusion Medicine

Contact Information

Office: C250 General Hospital
Iowa City, IA 52242
Office Phone: 319-356-0370

Email: annette-schlueter@uiowa.edu
Web: Dr. Schlueter's Research Laboratory

Education

BS, Valparaiso University, Valparaiso, IN
MS, University of Illinois at Urbana-Champaign, IL
PhD, University of Illinois at Urbana-Champaign, IL
MD, University of Illinois at Urbana-Champaign, IL

Residency, Clinical Pathology, University of Iowa
Fellowship, Transfusion Medicine, University of Iowa

Licensure and Certifications

State of Iowa Medical License, Iowa Board of Medicine
Diplomate, American Board of Pathology (Transfusion Medicine)
Diplomate, American Board of Pathology (Clinical Pathology)

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Pathology Graduate Program
Interdisciplinary Graduate Program in Immunology
Medical Scientist Training Program

Research Summary

My laboratory studies dendritic cell function in aging, and disease states including alcoholism and graft-versus-host disease. My laboratory is interested in the contribution of dendritic cell (DC) to disease. Specifically, we study the defects induced in DC by chronic ethanol (EtOH) exposure that contribute to increased incidence and severity of infectious disease, and the influence of aging on DC ability to induce more severe graft vs. host disease following allogeneic hematopoietic cell transplant (HCT). It is clear that chronic alcohol abuse results in immunodeficiency, characterized by loss of some lymphocyte subsets and persistent activation of other subsets. Preliminary evidence from a mouse model of alcoholism indicates that chronic ethanol exposure results in decreased numbers of DC in peripheral lymphoid tissue and epidermis. Studies in my laboratory indicate that these losses may be due to defective DC migration in the presence of EtOH. EtOH-exposed DC are also unable to appropriately activate naive T cells, and induce increased numbers of regulatory T cells. We are investigating additional ways in which EtOH exposure in vivo may influence DC function, thereby increasing the susceptibility of alcoholics to infection. My laboratory is also interested in understanding the role DC play in the increased susceptibility of advanced age allogeneic HCT patients to graft-versus host disease (GVHD). It is clear that recipient DC play a key role in the development of GVHD, but nothing is yet known about the mechanism by which this occurs. We are studying the functional characteristics of DC from older and young HCT patients, as well as older and young mice in murine models of HCT. Understanding functional changes in these populations with age will allow us ultimately to design therapeutic interventions that may limit the toxicity of GVHD, and allow this life-saving therapy to be offered to more advanced age patients.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Selected Publications

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Schlueter A, Abusin G, Abu-Arja R, Gingrich R, Silverman M, Zamba G.  An algorithm for utilizing peripheral blood CD34 count as a predictor for the need for perixafor in autologous stem cell mobilization - cost effectiveness analysis.  Journal of Clinical Apheresis.  2013. 

Parlet C, Schlueter A.  Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells.  Alcoholism: Clinical & Experimental Research.  2013. 
[PubMed]

Schlueter A, Stewart A, Collins T, Shetty R, Konkowski B, Holanda D, Nair R, Raife T, Reed A, Thomas C.  Eculizumab rescue of severe hyperacute antibody-mediated rejection after ABO-incompatible kidney transplant.  Transplantation Proceedings.  2012. 
[PubMed]

Chiang H, Steelman V, Pottinger J, Schlueter A, Diekema D, Greenlee J, Howard M, Herwaldt L.  Clinical significance of positive cranial bone flap cultures and associated risk of surgical site infection after craniotomies or craniectomies.  Journal of neurosurgery.  2011 June. 114(6):1746-54.
[PubMed]

Schlueter A, Bhatt A, Neppalli V, Kelley E, Thomas C.  Dextran removal by plasmapheresis in a kidney-pancreas transplant recipient with dextran 40-induced osmotic nephrosis.  American Journal of Kidney Diseases.  2011. 57:621-623.

Fan J, Edsen-Moore M, Turner L, Cook R, Legge K, Waldschmidt T, Schlueter A.  Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.  Alcoholism, clinical and experimental research.  2011 January. 35(1):47-59.
[PubMed]

Chitu V, Ferguson P, de Bruijn R, Schlueter A, Ochoa L, Waldschmidt T, Yeung Y, Stanley E.  Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice.  Blood.  2009 September. 114(12):2497-505.
[PubMed]

Schlueter A, McGill J, Meyer D, Edsen-Moore M, Young B, Coleman R, Waldschmidt T, Legge K, Cook R.  Fetal exposure to ethanol has long-term effects on teh severity of influenza virus infections.  Journal of Immunology.  2009. 182:7803-7808.
[PubMed]

Edsen-Moore M, Fan J, Ness K, Marietta J, Cook R, Schlueter A.  Effects of chronic ethanol feeding on murine dendritic cell numbers, turnover rate, and dendropoiesis.  Alcoholism, clinical and experimental research.  2008 July. 32(7):1309-20.
[PubMed]

Date Last Modified: 07/31/2013 - 10:51:40