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Clinical Professor of Pathology
- Transfusion Medicine
Primary Office: C250 General HospitalIowa City, IA 52242
Primary Office Phone: 319-356-0369
BA, Iowa State UniversityMD, University of Iowa, Iowa City, IA
Residency, University of Iowa Hospitals and ClinicsFellowship, University of Iowa Hospitals and Clinics
Transfusion Medicine/Blood Banking, American Board of PathologyClinical Pathology, American Board of Pathology
Dr. Raife's research focuses on mechanisms of microvascular injury and thrombosis in thrombotic microangiopathic (TM) disorders. TM disorders, including thrombotic thrombocytopenic purpura (TTP) and the hemolytic uremic syndrome (HUS), are rare but serious disorders associated with abnormal blood clotting in the smallest vessels of many organs. Our research projects involve analyses of large repositories of blood samples and patient databases to explore biochemical and genetic abnormalities in patients with TM disorders. We utilize measurements of von Willebrand factor (VWF)-cleaving protease to identify TM patients with defects in VWF proteolysis that may be involved in abnormal platelet clotting. Other studies have focused on identification of genetic thrombotic risk factors in TM patients. We are working in collaboration with investigators at Kansas State University to explore an animal model of shigella toxin-associated HUS, a devastating disease of childhood associated with bacterial contamination of food. These experiments may lead to more effective treatments for a food-borne illness that is becoming and increasingly important world-wide health problem.
Case Report: Eculizumab Rescue of Severe Accelerated Antibody-Mediated Rejection After ABO-Incompatible Kidney Transplant.
Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology.
2011 November. 31(11):2509-17.
An analysis of mobile whole blood collection labor efficiency.
Hematocrit and C-reactive protein predict treatment response times in ADAMTS13-deficient thrombotic microangiopathy.
Journal of clinical apheresis.
ADAMTS13 and thrombotic thrombocytopenic purpura: where we are and where we need to go.
2010 August. 50(8):1640-2.
Severe autoimmunte neutropenia associated with acute autoimmune hepatitis.
International Journal of Hematology.
Successful use of maternal blood in the management of severe hemolytic disease of the newborn due to anti-Kpb.
Transfusion and Apheresis Science.
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site.
2009 August. 114(8):1666-74.
Elevated procalcitonin and C-reactive protein as potential markers of septic inflammation in a subpopulation of thrombotic microangiopathy patients.
Journal of Clinical Apheresis.
Post-donation platelet counts are safe when collecting platelets with a Trima Accel using a post-donation platelet count target of >50,000 platelets/uL.
Journal of Clinical Apheresis.
Date Last Modified: 07/31/2013 -
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