Pathology

Nitin J. Karandikar, MD, PhD

Portrait

Chair and Department Executive Officer
Dr. Richard G. Lynch Chair in Experimental Pathology
Professor of Pathology

Contact Information

Office: C673 General Hospital
Iowa City, IA 52242
Office Phone: 319-384-9609

Email: nitin-karandikar@uiowa.edu
Web: Dr. Karandikar's Research Laboratory

Education

MBBS, Bachelor of Medicine and Surgery, B.J. Medical College, University of Poona, India
MD, Pathology, B.J. Medical College, University of Poona, India
PhD, Immunology and Molecular Pathogenesis Graduate Program, Northwestern University Medical School

Transitional Internship, B.J. Medical College, University of Poona, India
Residency, Anatomic and Clinical Pathology, B.J. Medical College, University of Poona, India
Residency, Clinical Pathology, University of Texas Southwestern Medical Center, Dallas
Fellowship, Hematopathology, University of Texas Southwestern Medical Center, Dallas
Post Doctoral, Research in Immunology, University of Texas Southwestern Medical Center

Licensure and Certifications

State of Iowa Medical License Iowa Board of Medicine
Educational Commission for Foreign Medical Graduates (ECFMG)
Hematology American Board of Pathology
Clinical Pathology American Board of Pathology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Molecular and Cellular Biology

All Publications

Wang L, Peters J, Li L, Karandikar N, Koduru P, Wang H, Chen W.  Acute Megakaryoblastic Leukemia Associated with Trisomy 21 Demonstrates a Distinct Immunophenotype.  Cytometry B Clin Cytom.  2014 October 10. 
[PubMed]

Rakheja D, Chen K, Liu Y, Shukla A, Schmid V, Chang T, Khokhar S, Wickiser J, Karandikar N, Malter J, Mendell J, Amatruda J.  Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumors.  Nature Communications.  2014 September 5. 2:4802.
[PubMed]

Kashi V, Ortega S, Karandikar N.  Neuroantigen-specific Autoregulatory CD8+ T cells Inhibit Autoimmune Demyelination through Modulation of Dendritic Cell Function.  PLoS ONE;  2014. 

Cunnusamy K, Baughman E, Franco J, Ortega S, Sinha S, Chaudhary P, Greenberg B, Frohman E, Karandikar N.  Disease Exacerbation of Multiple Sclerosis is Characterized by Loss of Terminally Differentiated Autoregulatory CD8+ T cells.  Clinical Immunology.  2014. 152(May-June):115-126.
[Link]

Sinha S, Itani F, Karandikar N.  Immune regulation of multiple sclerosis by CD8+ T cells. .  Immunologic Research.  2014. 

Ortega S, Kashi V, Tyler A, Cunnusamy  K, Mendoza J, Karandikar N.  The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.  Journal of Immunology.  2013 July 1. 191(1):117-26.
[PubMed]

Tyler A, Mendoza J, Firan M, Karandikar N.  CD8+T Cells Are Required For Glatiramer Acetate Therapy in Autoimmune Demyelinating Disease.  PLoS One.  2013 June 21. 8(6):e66772.
[PubMed]

Ayers C, Mendoza J, Sinha S, Cunnusamy K, Greenberg B, Frohman E, Karandikar N.  Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis.  Clinical Immunology.  2013 May. 147(2):105-119.
[PubMed]

Gutierrez T, Mayeux J, Ortega S, Karandikar N, Li Q, Rakheja D, Zhou X, Satterthwaite A.  IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn(-/-) mice.  European journal of immunology.  2013 February. 43(2):382-93.
[PubMed]

Greenberg B, Graves D, Remington G, Hardeman P, Mann M, Karandikar N, Stuve O, Monson N, Frohman E.  Rituximab dosing and monitoring strategies in neuromyelitis optica patients: creating strategies for therapeutic success.  Multiple sclerosis.  2012 July. 18(7):1022-6.
[PubMed]

Morris H, Karandikar N, Balani J, Fuda F, Monaghan S, Emmons J.  A Comparison of Flow Cytometry and Cytologic Evaluation.  2012. 

Kumar K, Yates S, Sarode V, Karandikar N, Emmons J.  Flow Cytometric Aberrancies and Clinical Outcome in Low Grade, High Proliferation Index Follicular Lymphoma.  2012. 

Hoffhines A, Karandikar N, Fuda F, Monaghan S, Koduru P, Levenson B.  Greater Incidence of Cytogenetic Aberrations in HIV-Positive Non-Hodgkin Lymphoma.  USCAP.  2012. 

Castro-Silva F, Fuda F, Karandikar N.  Increased Bone Marrow Mast Cells, Enumerated by Multiparameter Flow Cytometry, are Associated with Myelodysplastic Syndromes.  USCAP.  2012. 

Olteanu H, Harrington A, Kroft S, Karandikar N, Fuda F.  The Prevalence of CD56 Expression by Flow Cytometry in Acute Promyelocytic Leukemia Patients Treated with All-Trans Retinoic Acid and Anthracycline Drug Combinations.  USCAP.  2012. 

Zaremba C, Oliver D, Cavalier M, Fuda F, Karandikar N, Chen W.  Distinct immunophenotype of early T-cell progenitors in T lymphoblastic leukemia/lymphoma may predict FMS-like tyrosine kinase 3 mutations.  Annals of diagnostic pathology.  2012 January. 16(1):16-20.
[PubMed]

Rakheja D, Konoplev S, Su M, Wheeler D, Muzny D, Ruvolo V, Collins R, Karandikar N, Andreeff M, Medeiros L, Chen W.  High incidence of IDH mutations in acute myeloid leukaemia with cuplike nuclei.  British journal of haematology.  2011 October. 155(1):125-8.
[PubMed]

Biegler B, Yan S, Ortega S, Tennakoon D, Racke M, Karandikar N.  Clonal composition of neuroantigen-specific CD8+ and CD4+ T-cells in multiple sclerosis.  Journal of neuroimmunology.  2011 May. 234(2-Jan):131-40.
[PubMed]

Ayers C, Firan M, Pillai V, Lee W, Karandikar N.  Viral interactions with B-cells contribute to increased regulatory T-cells during chronic HCV infection.  Viral immunology.  2011 April. 24(2):119-29.
[PubMed]

Baughman E, Mendoza J, Ortega S, Ayers C, Greenberg B, Frohman E, Karandikar N.  Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis.  Journal of autoimmunity.  2011 March. 36(2):115-24.
[PubMed]

Willis J, Emmons J, Karandikar N, Fuda F.  Cytochemical and/or Immunohistochemical Staining for Myeloperoxidase are Essential in the Work-up of Mixed Phenotype Acute Leukemia.  USCAP.  2011. 

Willis J, Emmons J, Karandikar N, Fuda F.  Utility of CD117 Expression in the diagnosis of T/Myeloid Mixed Phenotype Acute Leukemia.  USCAP.  2011. 

Harp C, Ireland S, Davis L, Remington G, Cassidy B, Cravens P, Stuve O, Lovett-Racke A, Eagar T, Greenberg B, Racke M, Cowell L, Karandikar N, Frohman E, Monson N.  Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4(+) T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein.  European journal of immunology.  2010 October. 40(10):2942-56.
[PubMed]

York N, Mendoza J, Ortega S, Benagh A, Tyler A, Firan M, Karandikar N.  Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitis.  Journal of autoimmunity.  2010 August. 35(1):33-44.
[PubMed]

Tirado C, Valdez F, Klesse L, Karandikar N, Uddin N, Arbini A, Fustino N, Collins R, Patel S, Smart R, Garcia R, Doolittle J, Chen W.  Acute myeloid leukemia with inv(16) with CBFB-MYH11, 3'CBFB deletion, variant t(9;22) with BCR-ABL1, and del(7)(q22q32) in a pediatric patient: case report and literature review.  Cancer genetics and cytogenetics.  2010 July. 200(1):54-9.
[PubMed]

Seegmiller A, Garcia R, Huang R, Maleki A, Karandikar N, Chen W.  Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas.  Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc.  2010 July. 23(7):909-20.
[PubMed]

Tirado C, Chen W, Valdez F, Karandikar N, Arbini A, Acevedo I, Garcia R, Davila O, Smart R, Matthews E, Kirk A, Collins R.  Unusual presentation of myeloid sarcoma in a case of acute promyelocytic leukemia with a cryptic PML-RARA rearrangement involving multiple sites including the atrium.  Cancer genetics and cytogenetics.  2010 July. 200(1):47-53.
[PubMed]

Wang H, Fuda F, Chen W, Karandikar N.  Notch1 in primary effusion lymphoma: a clinicopathological study.  Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc.  2010 June. 23(6):773-80.
[PubMed]

Olteanu H, Karandikar N, Eshoa C, Kroft S.  Laboratory findings in CD4(+) large granular lymphocytoses.  International journal of laboratory hematology.  2010 February. 32(1 Pt 1):e9-16.
[PubMed]

Pillai V, Karandikar N, Baughman E, Mendoza J, Mohiuddin I.  Activation induced suppressive ability in human T cells revealed by a flow cytometric suppression assay.  Clinical Immunology.  2010. 135(Supplement):S121.

Qian Y, Wei C, Eun-Hyung Lee F, Campbell J, Halliley J, Lee J, Cai J, Kong Y, Sadat E, Thomson E, Dunn P, Seegmiller A, Karandikar N, Tipton C, Mosmann T, Sanz I, Scheuermann R.  Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data.  Cytometry. Part B, Clinical cytometry.  2010. 78 Suppl 1:S69-82.
[PubMed]

Cubillas R, Kintner K, Phillips F, Karandikar N, Thiele D, Brown G.  Tumor necrosis factor receptor 1 expression is upregulated in dendritic cells in patients with chronic HCV who respond to therapy.  Hepatitis research and treatment.  2010. 2010:429243.
[PubMed]

Racke M, Lovett-Racke A, Karandikar N.  The mechanism of action of glatiramer acetate treatment in multiple sclerosis.  Neurology.  2010 January. 74 Suppl 1:S25-30.
[PubMed]

Seegmiller A, Kroft S, Karandikar N, McKenna R.  Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia.  American journal of clinical pathology.  2009 December. 132(6):940-9.
[PubMed]

Fuda F, Karandikar N, Chen W.  Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow.  American journal of clinical pathology.  2009 November. 132(5):733-7.
[PubMed]

Chen Y, Wu H, Wang S, Koito H, Li J, Ye F, Hoang J, Escobar S, Gow A, Arnett H, Trapp B, Karandikar N, Hsieh J, Lu Q.  The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination.  Nature neuroscience.  2009 November. 12(11):1398-406.
[PubMed]

Deisch J, Fuda F, Chen W, Karandikar N, Arbini A, Zhou X, Wang H.  Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study.  Archives of pathology & laboratory medicine.  2009 September. 133(9):1477-82.
[PubMed]

Maleki A, Seegmiller A, Uddin N, Karandikar N, Chen W.  Bright CD38 expression is an indicator of MYC rearrangement.  Leukemia & lymphoma.  2009 June. 50(6):1054-7.
[PubMed]

Seegmiller A, Karandikar N, Kroft S, McKenna R, Xu Y.  Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes.  Cytometry. Part B, Clinical cytometry.  2009 May. 76(3):169-74.
[PubMed]

del Pilar Martin M, Cravens P, Winger R, Frohman E, Racke M, Eagar T, Zamvil S, Weber M, Hemmer B, Karandikar N, Kleinschmidt-DeMasters B, Stüve O.  Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab.  Archives of neurology.  2008 December. 65(12):1596-603.
[PubMed]

Frohman E, Eagar T, Monson N, Stuve O, Karandikar N.  Immunologic mechanisms of multiple sclerosis.  Neuroimaging clinics of North America.  2008 November. 18(4):577-88, ix.
[PubMed]

Wang H, Karandikar N, Payne D, Maleki A, Schultz B, Collins R, McKenna R.  A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma.  Human pathology.  2008 May. 39(5):781-7.
[PubMed]

Maftoun-Banankhah S, Maleki A, Karandikar N, Arbini A, Fuda F, Wang H, Chen W.  Multiparameter flow cytometric analysis reveals low percentage of bone marrow hematogones in myelodysplastic syndromes.  American journal of clinical pathology.  2008 February. 129(2):300-8.
[PubMed]

Peters J, Karandikar N, Fuda F, Wang H, Arbini A, Chen W.  Acute Megakaryoblastic Leukemia: Immunophenotypic Differences in Patients With and Without Down Syndrome.  USCAP.  2008. 

Kroft S, Karandikar N.  Flow cytometric analysis of acute leukemias, myelodysplastic syndromes and myeloproliferative disorders .  2008. 

Olteanu H, Wang H, Chen W, McKenna R, Karandikar N.  Immunophenotypic studies of monoclonal gammopathy of undetermined significance.  BMC clinical pathology.  2008. 8:13.
[PubMed]

Pillai V, Karandikar N.  Attack on the clones? Human FOXP3 detection by PCH101, 236A/E7, 206D, and 259D reveals 259D as the outlier with lower sensitivity.  Blood.  2008 January. 111(1):463-4; author reply 464-6.
[PubMed]

Wang H, Wilson K, McKenna R, Xu Y, Karandikar N.  An extranodal nasal natural killer/T-cell lymphoma with isochromosome 7q10 as the sole cytogenetic aberration was initially diagnosed via bone marrow biopsy.  Archives of pathology & laboratory medicine.  2007 November. 131(11):1709-14.
[PubMed]

Pillai V, Karandikar N.  Human regulatory T cells: a unique, stable thymic subset or a reversible peripheral state of differentiation?.  Immunology letters.  2007 November. 114(1):15-Sep.
[PubMed]

Sathe A, Ortega S, Mundy D, Collins R, Karandikar N.  In vitro methotrexate as a practical approach to selective allodepletion.  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.  2007 June. 13(6):644-54.
[PubMed]

Pillai V, Lee W, Thiele D, Karandikar N.  Clinical responders to antiviral therapy of chronic HCV infection show elevated antiviral CD4+ and CD8+ T-cell responses.  Journal of viral hepatitis.  2007 May. 14(5):318-29.
[PubMed]

Averill L, Lee W, Karandikar N.  Differential dysfunction in dendritic cell subsets during chronic HCV infection.  Clinical immunology (Orlando, Fla.).  2007 April. 123(1):40-9.
[PubMed]

Pillai V, Ortega S, Wang C, Karandikar N.  Transient regulatory T-cells: a state attained by all activated human T-cells.  Clinical immunology (Orlando, Fla.).  2007 April. 123(1):18-29.
[PubMed]

Seegmiller A, Xu Y, McKenna R, Karandikar N.  Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma.  American journal of clinical pathology.  2007 February. 127(2):176-81.
[PubMed]

Wang H, Xu Y, McKenna R, Karandikar N.  Acute myeloid leukemias with a CD34(-)/HLA-DR(-) immunophenotype encompass a wide range of morphologic subtypes.  USCAP.  2007. 

Karandikar N, Seegmiller A, McKenna R.  Eleven-parameter flow cytometry of lymphoma-infiltrating T lymphocytes: Expansion of memory and suppressor/regulatory T cells.  2007. 

Chen W, Karandikar N, McKenna R, Kroft S.  Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience.  American journal of clinical pathology.  2007 January. 127(1):39-46.
[PubMed]

Olteanu H, Karandikar N, McKenna R, Xu Y.  Differential usefulness of various markers in the flow cytometric detection of paroxysmal nocturnal hemoglobinuria in blood and bone marrow.  American journal of clinical pathology.  2006 November. 126(5):781-8.
[PubMed]

Biegler B, Yan S, Ortega S, Tennakoon D, Racke M, Karandikar N.  Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis.  Journal of neuroimmunology.  2006 November. 180(2-Jan):159-71.
[PubMed]

Ratts R, Lovett-Racke A, Choy J, Northrop S, Hussain R, Karandikar N, Racke M.  CD28-CD57+ T cells predominate in CD8 responses to glatiramer acetate.  Journal of neuroimmunology.  2006 September. 178(2-Jan):117-29.
[PubMed]

Ratts R, Karandikar N, Hussain R, Choy J, Northrop S, Lovett-Racke A, Racke M.  Phenotypic characterization of autoreactive T cells in multiple sclerosis.  Journal of neuroimmunology.  2006 September. 178(2-Jan):100-10.
[PubMed]

Xu Y, McKenna R, Wilson K, Karandikar N, Schultz R, Kroft S.  Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation.  Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K.  2006 July. 20(7):1321-4.
[PubMed]

Tennakoon D, Mehta R, Ortega S, Bhoj V, Racke M, Karandikar N.  Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis.  Journal of immunology (Baltimore, Md. : 1950).  2006 June. 176(11):7119-29.
[PubMed]

Chen W, Kesler M, Karandikar N, McKenna R, Kroft S.  Flow cytometric features of angioimmunoblastic T-cell lymphoma.  Cytometry. Part B, Clinical cytometry.  2006 May. 70(3):142-8.
[PubMed]

Fuda F, McKenna R,  Y, Karandikar N.  All Cases of Precursor T Acute Lymphoblastic Leukemia/Lymphoma (T-ALL) Exhibit Multiple Immunophenotypic Aberrancies.  USCAP.  2006. 

Chenault C, Karandikar N, Xu Y, Dowell J, Amirkhan R, McKenna R.  Langerhans Cell Histiocytosis (LCH) in Acute Leukemia and MDS in Adult Patients.  USCAP.  2006. 

Xu Y, McKenna R, Karandikar N, Pildain A, Kroft S.  Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis.  American journal of clinical pathology.  2005 November. 124(5):799-806.
[PubMed]

Frohman E, Filippi M, Stuve O, Waxman S, Corboy J, Phillips J, Lucchinetti C, Wilken J, Karandikar N, Hemmer B, Monson N, De Keyser J, Hartung H, Steinman L, Oksenberg J, Cree B, Hauser S, Racke M.  Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions.  Archives of neurology.  2005 September. 62(9):1345-56.
[PubMed]

Frohman E, Filippi M, Stuve O, Waxman S, Corboy J, Phillips J, Lucchinetti C, Wilken J, Karandikar N.  Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions.  Archives of Neurology.  2005. 

Karandikar N, Racke M.  Glatiramer acetate therapy: The plot thickens .  Archives of Neurology .  2005. 

Alfardan J, Kroft S, Fuda F, Xu Y, McKenna R, Karandikar N.  Immunophenotypic comparison of peripheral blood stem cells, normal bone marrow blasts and leukemic myeloid blasts.  Modern Pathology .  2005. 

Fuda F, Kroft S, Alfardan J, Xu Y, McKenna R, Karandikar N.  Myeloperoxidase expression differentiates leukemic from non-leukemic blasts.  Modern Pathology .  2005. 

Karandikar N, Kroft S, Yegappan S, Rogers B, Aquino V, Lee K, Kumar V, Guenaga F, Jaffe E, Douek D, McKenna R.  Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis.  Blood.  2004 October. 104(7):2007-9.
[PubMed]

Kroft S, Asplund S, McKenna R, Karandikar N.  Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients.  British journal of haematology.  2004 July. 126(2):209-12.
[PubMed]

Eagar T, Turley D, Padilla J, Karandikar N, Tan L, Bluestone J, Miller S.  CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.  Journal of immunology (Baltimore, Md. : 1950).  2004 June. 172(12):7442-50.
[PubMed]

Crawford M, Yan S, Ortega S, Mehta R, Hewitt R, Price D, Stastny P, Douek D, Koup R, Racke M, Karandikar N.  High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay.  Blood.  2004 June. 103(11):4222-31.
[PubMed]

Rawal A, Sarode R, Curtis B, Karandikar N, Friedman K, Rogers Z.  Acquired Glanzmann's thrombasthenia as part of multiple-autoantibody syndrome in a pediatric heart transplant patient.  The Journal of pediatrics.  2004 May. 144(5):672-4.
[PubMed]

Brenchley J, Karandikar N, Betts M, Ambrozak D, Hill B, Crotty L, Casazza J, Kuruppu J, Migueles S, Connors M, Roederer M, Douek D, Koup R.  Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells.  Blood.  2003 April. 101(7):2711-20.
[PubMed]

Karandikar N, Hotchkiss E, Mckenna R, Kroft S.  Transient stress lymphocytosis: an immunophenotypic characterization of the most common cause of newly identified adult lymphocytosis in a tertiary hospital.  American journal of clinical pathology.  2002 May. 117(5):819-25.
[PubMed]

Eagar T, Karandikar N, Bluestone J, Miller S.  The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.  European journal of immunology.  2002 April. 32(4):972-81.
[PubMed]

Douek D, Betts M, Brenchley J, Hill B, Ambrozak D, Ngai K, Karandikar N, Casazza J, Koup R.  A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.  Journal of immunology (Baltimore, Md. : 1950).  2002 March. 168(6):3099-104.
[PubMed]

Karandikar N, Crawford M, Yan X, Ratts R, Brenchley J, Ambrozak D, Lovett-Racke A, Frohman E, Stastny P, Douek D, Koup R, Racke M.  Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis.  The Journal of clinical investigation.  2002 March. 109(5):641-9.
[PubMed]

Racke M, Lovett-Racke A, Karandikar N.  Myelin-reactive T cells and their regulation in multiple sclerosis.  Neuroscience News .  2002. 

Karandikar N, Aquino D, McKenna R, Kroft S.  Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome. An immunophenotypic analysis.  American journal of clinical pathology.  2001 August. 116(2):204-10.
[PubMed]

Karandikar N, Eagar T, Vanderlugt C, Bluestone J, Miller S.  CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis.  Journal of neuroimmunology.  2000 September. 109(2):173-80.
[PubMed]

Karandikar N, Vanderlugt C, Bluestone J, Miller S.  Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.  Journal of neuroimmunology.  1998 August. 89(2-Jan):10-18.
[PubMed]

Karandikar N, Vanderlugt C, Eagar T, Tan L, Bluestone J, Miller S.  Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.  Journal of immunology (Baltimore, Md. : 1950).  1998 July. 161(1):192-9.
[PubMed]

Vanderlugt C, Karandikar N, Lenschow D, Dal Canto M, Bluestone J, Miller S.  Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE.  Journal of neuroimmunology.  1997 November. 79(2):113-8.
[PubMed]

McRae B, Karandikar N, Miller S.  Degenerate antigen recognition by CD4+ effector T cells in experimental autoimmune encephalomyelitis.  Journal of neuroimmunology.  1997 May. 75(2-Jan):156-62.
[PubMed]

Miller S, Vanderlugt C, Karandikar N.  B7-CD28/CTLA-4 costimulatory pathways in the intrinsic and induced regulation of CD4 T cell-mediated autoimmune diseases.  Immune Regulatory Pathways in Autoimmune and Neuroimmunologic Diseases..  1997. 

Karandikar N, Vanderlugt C, Walunas T, Miller S, Bluestone J.  CTLA-4: a negative regulator of autoimmune disease.  The Journal of experimental medicine.  1996 August. 184(2):783-8.
[PubMed]

Miller S, Vanderlugt C, Lenschow D, Pope J, Karandikar N, Dal Canto M, Bluestone J.  Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE.  Immunity.  1995 December. 3(6):739-45.
[PubMed]

Mohiuddin I, Pillai V, Karandikar N.  Activation-induced regulatory T cell function is dependent on strength of activation signal. 

Date Last Modified: 06/07/2014 - 21:56:23