Pathology

Kevin Legge, PhD

Portrait

Associate Professor of Pathology
Associate Professor of Microbiology

Contact Information

Primary Office: 1028 Medical Laboratories
Iowa City, IA 52242
Primary Office Phone: 319-335-6744

Email: kevin-legge@uiowa.edu
Web: Dr. Legge's Research Laboratory

Education

BS, University of Tennessee, Knoxville, TN
PhD, University of Tennessee, Knoxville, TN

Post Doctoral, Department of Microbiology, University of Tennessee, Knoxville, TN
Post Doctoral, Beirne B. Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, VA

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Department of Pathology Graduate Program
Interdisciplinary Graduate Program in Immunology
Medical Scientist Training Program

Research Summary

Dendritic cell immunobiology and pulmonary immunity.

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases
Holden Comprehensive Cancer Center

All Publications

Boonak K, Vogel L, Feldmann F, Feldmann H, Legge K, Subbarao K.  Lymphopenia associated with highly virulent H5N1 virus infection due to plasmacytoid dendritic cell-mediated apoptosis of T cells.  Journal of immunology.  2014. 192(12):5906-12.
[PubMed]

Hemann E, Legge K.  Peripheral regulation of T cells by dendritic cells during infection.  Immunologic research [Epub ahead of print].  2014. 
[PubMed]

Hemann E, Kang S, Legge K.  Protective CD8 T Cell-Mediated Immunity against Influenza A Virus Infection following Influenza Virus-Like Particle Vaccination.  Journal of Immunology.  2013. 191(5):2486-94.
[PubMed]

Hassan I, Zhang M, Powers L, Shao J, Baltrusaitis J, Rutkowski D, Legge K, Monick M.  Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway.  Journal of Biological Chemistry.  2012. 287(7):4679-89.
[PubMed]

Harwani S, Chapleau M, Legge K, Ballas Z, Abboud F.  Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension.  Circulation research.  2012. 111(9):1190-7.
[PubMed]

Boyden A, Legge K, Waldschmidt T.  Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses.  PloS one.  2012. 7(7):e40733.
[PubMed]

Zhao J, Zhao J, Legge K, Perlman S.  Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice.  Journal of Clinical Investigation.  2011. 121(12):4921-30.
[PubMed]

Case A, McGill J, Tygrett L, Shirasawa T, Spitz D, Waldschmidt T, Legge K, Domann F.  Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.  Free radical biology & medicine.  2011. 50(3):448-58.
[PubMed]

Fan J, Edsen-Moore M, Turner L, Cook R, Legge K, Waldschmidt T, Schlueter A.  Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.  Alcoholism, clinical and experimental research.  2011. 35(1):47-59.
[PubMed]

Alexander C, Tygrett L, Boyden A, Wolniak K, Legge K, Waldschmidt T.  T regulatory cells participate in the control of germinal centre reactions.  Immunology.  2011. 133(4):452-68.
[PubMed]

Brincks E, Gurung P, Langlois R, Hemann E, Legge K, Griffith T.  The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.  Journal of immunology.  2011. 187(9):4581-8.
[PubMed]

Pham N, Pewe L, Fleenor C, Langlois R, Legge K, Badovinac V, Harty J.  Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.  Proceedings of the National Academy of Sciences of the United States of America.  2010. 107(27):12198-203.
[PubMed]

McGill J, Van Rooijen N, Legge K.  IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.  The Journal of experimental medicine.  2010. 207(3):521-34.
[PubMed]

Langlois R, Meyerholz D, Coleman R, Cook R, Waldschmidt T, Legge K.  Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice.  Alcoholism, clinical and experimental research.  2010. 34(8):1425-31.
[PubMed]

Langlois R, Legge K.  Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.  Journal of immunology.  2010. 184(8):4440-6.
[PubMed]

Gurung P, Young B, Coleman R, Wiechert S, Turner L, Ray N, Waldschmidt T, Legge K, Cook R.  Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation.  Journal of leukocyte biology.  2009. 85(1):34-43.
[PubMed]

McGill J, Legge K.  Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection.  Journal of immunology.  2009. 183(7):4177-81.
[PubMed]

McGill J, Meyerholz D, Edsen-Moore M, Young B, Coleman R, Schlueter A, Waldschmidt T, Cook R, Legge K.  Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.  Journal of immunology.  2009. 182(12):7803-8.
[PubMed]

McGill J, Heusel J, Legge K.  Innate immune control and regulation of influenza virus infections.  Journal of leukocyte biology.  2009. 86(4):803-12.
[PubMed]

Brincks E, Katewa A, Kucaba T, Griffith T, Legge K.  CD8 T cells utilize TRAIL to control influenza virus infection.  Journal of immunology.  2008. 181(7):4918-25.
[PubMed]

Meyerholz D, Edsen-Moore M, McGill J, Coleman R, Cook R, Legge K.  Chronic alcohol consumption increases the severity of murine influenza virus infections.  Journal of immunology.  2008. 181(1):641-8.
[PubMed]

Castilow E, Legge K, Varga S.  Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease.  Journal of immunology.  2008. 181(10):6692-6.
[PubMed]

Legge K, Schlueter A.  Dendritic cells in chronic in vivo ethanol exposure models.  Methods in molecular biology.  2008. 447:213-33.
[PubMed]

Brincks E, Kucaba T, Legge K, Griffith T.  Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells.  Human immunology.  2008. 69(10):634-46.
[PubMed]

McGill J, Van Rooijen N, Legge K.  Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs.  The Journal of experimental medicine.  2008. 205(7):1635-46.
[PubMed]

Meyerholz D, Edsen-Moore M, McGill J, Coleman R, Cook R, Legge K.  Response to Comment on "Chronic alcohol consumption increases the severity of murine influenza virus infections".  Journal of immunology.  2008. 181(9):5813; author reply 5813-4.
[PubMed]

Brincks E, Legge K, Griffith T.  TRAIL deficiency increases the severity of influenza virus.  Options for the Control of Influenza VI.  2008. 
[Link]

Langlois R, Legge K.  Respiratory dendritic cells: mediators of tolerance and immunity.  Immunologic research.  2007. 39(3-Jan):128-45.
[PubMed]

Yoon H, Legge K, Sung S, Braciale T.  Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.  Journal of immunology.  2007. 179(1):391-9.
[PubMed]

Jabbari A, Legge K, Harty J.  T cell conditioning explains early disappearance of the memory CD8 T cell response to infection.  Journal of immunology.  2006. 177(5):3012-8.
[PubMed]

Legge K, Braciale T.  Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.  Immunity.  2005. 23(6):649-59.
[PubMed]

Legge K, Braciale T.  Respiratory dendritic cells: maturation and migration following pulmonary influenza virus infection.  International Congress Series: Options for the Control of Influenza V.  2004. 1236C:149.

Legge K, Braciale T.  Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infection.  Immunity.  2003. 18(2):265-77.
[PubMed]

Legge K, Gregg R, Maldonado-Lopez R, Li L, Caprio J, Moser M, Zaghouani H.  On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity.  The Journal of experimental medicine.  2002. 196(2):217-27.
[PubMed]

Legge K, Bell J, Li L, Gregg R, Caprio J, Zaghouani H.  Multi-modal antigen specific therapy for autoimmunity.  International reviews of immunology.  2001. 20(5):593-611.
[PubMed]

Min B, Legge K, Bell J, Gregg R, Li L, Caprio J, Zaghouani H.  Neonatal exposure to antigen induces a defective CD40 ligand expression that undermines both IL-12 production by APC and IL-2 receptor up-regulation on splenic T cells and perpetuates IFN-gamma-dependent T cell anergy.  Journal of immunology.  2001. 166(9):5594-603.
[PubMed]

Pack C, Cestra A, Min B, Legge K, Li L, Caprio-Young J, Bell J, Gregg R, Zaghouani H.  Neonatal exposure to antigen primes the immune system to develop responses in various lymphoid organs and promotes bystander regulation of diverse T cell specificities.  Journal of immunology.  2001. 167(8):4187-95.
[PubMed]

Li L, Legge K, Min B, Bell J, Gregg R, Caprio J, Zaghouani H.  Neonatal immunity develops in a transgenic TCR transfer model and reveals a requirement for elevated cell input to achieve organ-specific responses.  Journal of immunology.  2001. 167(5):2585-94.
[PubMed]

Legge K, Min B, Bell J, Caprio J, Li L, Gregg R, Zaghouani H.  Coupling of peripheral tolerance to endogenous interleukin 10 promotes effective modulation of myelin-activated T cells and ameliorates experimental allergic encephalomyelitis.  The Journal of experimental medicine.  2000. 191(12):2039-52.
[PubMed]

Min B, Legge K, Caprio J, Li L, Gregg R, Zaghouani H.  Differential control of neonatal tolerance by antigen dose versus extended exposure and adjuvant.  Cellular immunology.  2000. 200(1):45-55.
[PubMed]

Anderson A, Nicholson L, Legge K, Turchin V, Zaghouani H, Kuchroo V.  High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire.  The Journal of experimental medicine.  2000. 191(5):761-70.
[PubMed]

Min B, Legge K, Li L, Caprio J, Pack C, Gregg R, McGavin D, Slauson D, Zaghouani H.  Neonatal tolerant immunity for vaccination against autoimmunity.  International reviews of immunology.  2000. 19(2-3):247-64.
[PubMed]

Legge K, Min B, Pack C, Caprio J, Zaghouani H.  Differential presentation of an altered peptide within fetal central and peripheral organs supports an avidity model for thymic T cell development and implies a peripheral readjustment for activation.  Journal of immunology.  1999. 162(10):5738-46.
[PubMed]

Min B, Legge K, Pack C, Zaghouani H.  Neonatal exposure to a self-peptide-immunoglobulin chimera circumvents the use of adjuvant and confers resistance to autoimmune disease by a novel mechanism involving interleukin 4 lymph node deviation and interferon gamma-mediated splenic anergy.  The Journal of experimental medicine.  1998. 188(11):2007-17.
[PubMed]

Legge K, Min B, Cestra A, Pack C, Zaghouani H.  TCR agonist and antagonist exert in vivo cross-regulation when presented on Igs.  Journal of immunology.  1998. 161(1):106-11.
[PubMed]

Legge K, Min B, Potter N, Zaghouani H.  Presentation of a T cell receptor antagonist peptide by immunoglobulins ablates activation of T cells by a synthetic peptide or proteins requiring endocytic processing.  The Journal of experimental medicine.  1997. 185(6):1043-53.
[PubMed]

Date Last Modified: 08/08/2014 - 07:28:27