Patricia A. Kirby, MBBCh


Medical Director, Surgical Pathology and Histology Laboratories
Director, CNS Pathology, Holden Comprehensive Cancer Center
Director, Pediatric Pathology, Holden Comprehensive Cancer Center
Clinical Professor of Pathology  - Anatomic Pathology
Clinical Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 5239D Roy Carver Pavilion
Iowa City, IA 52242
Primary Office Phone: 319-356-4170



MBBCh, University of the Witwatersrand
MMed, University of Stellenbosch Medical School and Tygernerg Hospital

Internship, Kalafong Hospital, Pretoria, South Africa
Internship, McCord Zulu Hospital, Durban, South Africa
Residency, Anatomical Pathology, South African Institute of Medical Research, University of the Witwatersrand, Johannesburg
Residency, Orthopedics, 2 Military Hospital, Wynberg, Cape Town, South Africa
Fellowship, MRCPath, Royal College of Pathologists, London, UK
Fellowship, FRCPath, Royal College of Pathologists, London, UK

Licensure and Certifications

State of Iowa Medical License Iowa Board of Medicine
Neuropathology Royal College of Pathologists
Anatomical Pathology South African Medical & Dental Council
General Med/Surgery General Medical Council (UK)
General Med/Surgery South African Medical & Dental Council

Research Summary

Research Interest include: Correlation of Tumor pathology with neuro-imaging studies (MRI, CT scan and Ultra-sound) Pediatric neuropathology Lateralization gene expression in embryonic mice Distribution of glial tumors in the state of Iowa Correlation of new imaging techniques with tumor therapy response vs. tumor progression. Current Projects Immunohistochemistry in Hirschprung's disease Iowa state Stillbirth registry reviewer.

Selected Publications

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Anderson S, Sato Y, Kirby P, Buatti J, Menezes A.  Disseminated subarachnoid chordoma: long-term favorable follow-up of a pediatric patient.  Pediatric radiology.  2012 July. 42(7):878-80.

Fletcher A, Greenlee J, Chang K, Smoker W, Kirby P, O'Brien E.  Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension.  Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia.  2012 July. 19(7):1048-9.

Jacobus J, Wang B, Maddox C, Esch H, Lehmann L, Robertson L, Wang K, Kirby P, Ludewig G.  3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats.  Environment international.  2010 November. 36(8):970-9.

Walder R, Yang B, STOKES J, Kirby P, Cao X, Shi P, Searby C, Husted R, Sheffield V.  Mice defective in Trpm6 show embryonic mortality and neural tube defects.  Human molecular genetics.  2009 November. 18(22):4367-75.

Maddox C, Wang B, Kirby P, Wang K, Ludewig G.  Mutagenicity of 3-methylcholanthrene, pcb3, and 4-oh-pcb3 in the lung of transgenic bigblue rats.  Environmental toxicology and pharmacology.  2008 March. 25(2):260-6.

Cao X, Lill N, Boase N, Shi P, Croucher D, Shan H, Qu J, Sweezer E, Place T, Kirby P, Daly R, Kumar S, Yang B.  Nedd4 controls animal growth by regulating IGF-1 signaling.  Science signaling.  2008. 1(38):ra5.

Shi P, Cao X, Qu J, Volk K, Kirby P, Williamson R, Stokes J, Yang B.  Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2.  Am J Physiol Renal Physiol.  2007 May. 292(5):F1334-44.

Lehmann L, Esch H, Kirby P, Robertson L, Ludewig G.  4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats.  Carcinogenesis.  2007. 28(2):471-478.

Dokras A, Hoffmann D, Eastvold J, Kienzle M, Gruman L, Kirby P, Weiss R, Davisson R.  Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia.  Biology of reproduction.  2006 December. 75(6):899-907.

Date Last Modified: 05/05/2015 - 09:20:52