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Director, Molecular Hematology and OncologyAssistant Director, Molecular Pathology Laboratory, University of Iowa Hospitals and ClinicsClinical Associate Professor of Pathology - Clinical Pathology
Primary Office: C614 General HospitalIowa City, IA 52242 Primary Office Phone: 319-356-8616
Email: jon-heusel@uiowa.edu
BS, Biology, University of Nebraska, Lincoln, NEMD, Washington University School of Medicine, St. Louis, MOPhD, Immunology, Washington University, St. Louis, MO
Fellowship, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MOPost Doctoral, Washington University School of Medicine, St. Louis, MOResidency, Washington University School of Medicine and Barnes-Jewish Hospital, St. Louis, MO
Diplomate in Clinical Pathology, American Board of PathologyDiplomate in Molecular Genetic Pathology, American Board of Pathology
Interdisciplinary Graduate Program in ImmunologyMedical Scientist Training Program
Interests: Natural Killer (NK) cell responses in viral infection and malignancy; NK cell alloreactivity in the setting of hematopoietic stem cell transplantation; clinical molecular test development.
Holden Comprehensive Cancer Center
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Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection.. Schmidt N, Khanolkar A, Hancox L, Heusel J, Harty J. European journal of immunology. 2012 March; 42 (3) :629-40. [PubMed] Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H.. Guseva N, Fullenkamp C, Naumann P, Shey M, Ballas Z, Houtman J, Forbes C, Scalzo A, Heusel J. European journal of immunology. 2010 September; 40 (9) :2618-31. [PubMed] Characterization of murine cytomegalovirus m157 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H.. Davis A, Guseva N, Ball B, Heusel J. Journal of immunology (Baltimore, Md. : 1950). 2008 July (3rd Quarter/Summer); 181 (1) :265-75. [PubMed] Recognition of a virus-encoded ligand by a natural killer cell activation receptor.. Smith H, Heusel J, Mehta I, Kim S, Dorner B, Naidenko O, Iizuka K, Furukawa H, Beckman D, Pingel J, Scalzo A, Fremont D, Yokoyama W. Proceedings of the National Academy of Sciences of the United States of America. 2002 June; 99 (13) :8826-31. [PubMed] Vital involvement of a natural killer cell activation receptor in resistance to viral infection.. Brown M, Dokun A, Heusel J, Smith H, Beckman D, Blattenberger E, Dubbelde C, Stone L, Scalzo A, Yokoyama W. Science (New York, N.Y.). 2001 May; 292 (5518) :934-7. [PubMed] Nonstochastic coexpression of activation receptors on murine natural killer cells.. Smith H, Chuang H, Wang L, Salcedo M, Heusel J, Yokoyama W. The Journal of experimental medicine. 2000 April (2nd Quarter/Spring); 191 (8) :1341-54. [PubMed] Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci.. Scalzo A, Brown M, Chu D, Heusel J, Yokoyama W, Forbes C. Immunogenetics. 1999 March; 49 (3) :238-41. [PubMed] Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells.. Ho E, Heusel J, Brown M, Matsumoto K, Scalzo A, Yokoyama W. Proceedings of the National Academy of Sciences of the United States of America. 1998 May; 95 (11) :6320-5. [PubMed] Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.. Shresta S, MacIvor D, Heusel J, Russell J, Ley T. Proceedings of the National Academy of Sciences of the United States of America. 1995 June; 92 (12) :5679-83. [PubMed] Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.. Heusel J, Wesselschmidt R, Shresta S, Russell J, Ley T. Cell. 1994 March; 76 (6) :977-87. [PubMed]
Date Last Modified: 04/25/2013 - 07:50:08