Pathology

Thomas H. Haugen, MD, PhD

Portrait

Director, Pathology and Laboratory Service, Veterans Administration Medical Center
Associate Professor of Pathology  - Clinical Pathology

Contact Information

Primary Office: 113 Veterans Administration Medical Center
601 Highway 6 West
Iowa City, IA 52246
Primary Office Phone: 319-338-0581

Email: thomas-haugen@uiowa.edu
Web: Dr. Haugen's Research Laboratory

Education

BA, Biochemistry, University of California, Berkeley, CA
PhD, Biochemistry, University of California, Davis, CA
MD, University of Iowa, Iowa City, IA

Residency, Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA
Fellowship, Microbiology, University of Iowa Hospitals and Clinics, Iowa City, IA

Licensure and Certifications

Clinical Pathology American Board of Pathology
Federal Licensing Examination (FLEX) Federation of State Medical Boards

Education/Training Program Affiliations

Department of Pathology Graduate Program

Research Summary

Regulation of human papillomavirus gene expression by viral and cellular factors.

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

All Publications

Lace M, Anson J, Haugen T, Dierdorf J, Turek L.  Interferon treatment of human keratinocytes harboring extrachromosomal, persistent HPV-16 plasmid genomes induces de novo viral integration.  Carcinogenesis.  2014 November 21. 
[PubMed]

Dee F, Haugen T, Kreiter C.  New web-based applications for mechanistic case diagramming.  Med Educ Online;  2014. 

Lace M, Turek L, Anson J, Haugen T.  Analyzing the Human Papillomavirus (HPV) Life Cycle in Primary Keratinocytes with a Quantitative Colony-Forming Assay.  Curr Protoc Microbiol.  2014 May 1. 
[PubMed]

Lace M, Ushikai M, Yamakawa Y, Anson J, Ishiji T, Turek L, Haugen T.  The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products.  Virology.  2012 August. 429(2):99-111.
[PubMed]

Smith E, Rubenstein L, Haugen T, Pawlita M, Turek L.  Complex etiology underlies risk and survival in head and neck cancer human papillomavirus, tobacco, and alcohol: a case for multifactor disease.  Journal of Oncology.  2012. 2012:571862.
[PubMed]

Lace M, Anson J, Klussmann J, Wang D, Smith E, Haugen T, Turek L.  Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers.  Journal of virology.  2011 February. 85(4):1645-54.
[PubMed]

Kreiter C, Haugen T, Leaven T, Goerdt C, Rosenthal N, McGaghie W, Dee F.  A report on the piloting of a novel computer-based medical case simulation for teaching and formative assessment of diagnostic laboratory testing.  Medical education online.  2011. 16.
[PubMed]

Rubenstein L, Smith E, Pawlita M, Haugen T, Hamšíková E, Turek L.  Human papillomavirus serologic follow-up response and relationship to survival in head and neck cancer: a case-comparison study.  Infectious agents and cancer.  2011. 6(1):9.
[PubMed]

Smith E, Rubenstein L, Haugen T, Hamsikova E, Turek L.  Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers.  Cancer causes & control: CCC.  2010 September. 21(9):1369-78.
[PubMed]

Smith E, Pawlita M, Rubenstein L, Haugen T, Hamsikova E, Turek L.  Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer.  International journal of cancer.  2010 July. 127(1):111-7.
[PubMed]

Lace M, Anson J, Haugen T, Turek L.  Interferon regulatory factor (IRF)-2 activates the HPV-16 E6-E7 promoter in keratinocytes.  Virology.  2010 April. 399(2):270-9.
[PubMed]

Smith E, Parker M, Rubenstein L, Haugen T, Hamsikova E, Turek L.  Evidence for vertical transmission of HPV from mothers to infants.  Infectious diseases in obstetrics and gynecology.  2010. 2010:326369.
[PubMed]

Smith E, Rubenstein L, Hoffman H, Haugen T, Turek L.  Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer.  Infectious agents and cancer.  2010. 5:4.
[PubMed]

Lace M, Anson J, Klingelhutz A, Lee J, Bossler A, Haugen T, Turek L.  Human papillomavirus (HPV) type 18 induces extended growth in primary human cervical, tonsillar, or foreskin keratinocytes more effectively than other high-risk mucosal HPVs.  Journal of virology.  2009 November. 83(22):11784-94.
[PubMed]

Lace M, Yamakawa Y, Ushikai M, Anson J, Haugen T, Turek L.  Cellular factor YY1 downregulates the human papillomavirus 16 E6/E7 promoter, P97, in vivo and in vitro from a negative element overlapping the transcription-initiation site.  The Journal of general virology.  2009 October. 90(Pt 10):2402-12.
[PubMed]

Bruch L, De Young B, Kreiter C, Haugen T, Leaven T, Dee F.  Competency assessment of residents in surgical pathology using virtual microscopy.  Human pathology.  2009 August. 40(8):1122-8.
[PubMed]

Lace M, Anson J, Klingelhutz A, Harada H, Taniguchi T, Bossler A, Haugen T, Turek L.  Interferon-beta treatment increases human papillomavirus early gene transcription and viral plasmid genome replication by activating interferon regulatory factor (IRF)-1.  Carcinogenesis.  2009 August. 30(8):1336-44.
[PubMed]

Lace M, Isacson C, Anson J, Lorincz A, Wilczynski S, Haugen T, Turek L.  Upstream regulatory region alterations found in human papillomavirus type 16 (HPV-16) isolates from cervical carcinomas increase transcription, ori function, and HPV immortalization capacity in culture.  Journal of virology.  2009 August. 83(15):7457-66.
[PubMed]

Lace M, Anson J, Thomas G, Turek L, Haugen T.  The E8E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes.  DNA tumor virus meeting, Oxford, UK.  2009 July. 

Haugen T, Lace M, Ishiji T, Sameshima A, Anson J, Turek L.  Cellular factors are required to activate bovine papillomavirus-1 early gene transcription and to establish viral plasmid persistence but are not required for cellular transformation.  Virology.  2009 June. 389(2-Jan):82-90.
[PubMed]

Lace M, Anson J, Turek L, Haugen T.  Functional mapping of the human papillomavirus type 16 E1 cistron.  Journal of virology.  2008 November. 82(21):10724-34.
[PubMed]

Lace M, Anson J, Thomas G, Turek L, Haugen T.  The E8--E2 gene product of human papillomavirus type 16 represses early transcription and replication but is dispensable for viral plasmid persistence in keratinocytes.  Journal of virology.  2008 November. 82(21):10841-53.
[PubMed]

Smith E, Rubenstein L, Ritchie J, Lee J, Haugen T, Hamsikova E, Turek L.  Does pretreatment seropositivity to human papillomavirus have prognostic significance for head and neck cancers?.  Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.  2008 August. 17(8):2087-96.
[PubMed]

Dee F, Haugen T, Wynn P, Leaven T, Kemp J, Cohen M.  A Web-based database for pathology faculty effort reporting.  Human pathology.  2008 April. 39(4):489-97.
[PubMed]

Smith E, Wang D, Rubenstein L, Morris W, Turek L, Haugen T.  Association between p53 and human papillomavirus in head and neck cancer survival.  Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.  2008 February. 17(2):421-7.
[PubMed]

Smith E, Wang D, Kim Y, Rubenstein L, Lee J, Haugen T, Turek L.  P16INK4a expression, human papillomavirus, and survival in head and neck cancer.  Oral oncology.  2008 February. 44(2):133-42.
[PubMed]

Cook R, Schlueter A, Coleman R, Tygrett L, Ballas Z, Jerrells T, Nashelsky M, Ray N, Haugen T, Waldschmidt T.  Thymocytes, pre-B cells, and organ changes in a mouse model of chronic ethanol ingestion--absence of subset-specific glucocorticoid-induced immune cell loss.  Alcoholism, clinical and experimental research.  2007 October. 31(10):1746-58.
[PubMed]

Smith E, Swarnavel S, Ritchie J, Wang D, Haugen T, Turek L.  Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents.  The Pediatric infectious disease journal.  2007 September. 26(9):836-40.
[PubMed]

Wahls T, Haugen T, Cram P.  The continuing problem of missed test results in an integrated health system with an advanced electronic medical record.  Joint Commission journal on quality and patient safety / Joint Commission Resources.  2007 August. 33(8):485-92.
[PubMed]

Pyeon D, Newton M, Lambert P, den Boon J, Sengupta S, Marsit C, Woodworth C, Connor J, Haugen T, Smith E, Kelsey K, Turek L, Ahlquist P.  Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.  Cancer research.  2007 May. 67(10):4605-19.
[PubMed]

Smith E, Ritchie J, Pawlita M, Rubenstein L, Haugen T, Turek L, Hamsikova E.  Human papillomavirus seropositivity and risks of head and neck cancer.  International journal of cancer - Journal international du cancer.  2007 February. 120(4):825-32.
[PubMed]

Parker T, Smith E, Ritchie J, Haugen T, Vonka V, Turek L, Hamsikova E.  Head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors.  Oral oncology.  2006 March. 42(3):288-96.
[PubMed]

Wang D, Ritchie J, Smith E, Zhang Z, Turek L, Haugen T.  Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck.  Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.  2005 March. 14(3):626-32.
[PubMed]

Smith E, Johnson S, Ritchie J, Feddersen D, Wang D, Turek L, Haugen T.  Persistent HPV infection in postmenopausal age women.  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.  2004 November. 87(2):131-7.
[PubMed]

Smith E, Ritchie J, Yankowitz J, Wang D, Turek L, Haugen T.  HPV prevalence and concordance in the cervix and oral cavity of pregnant women.  Infectious diseases in obstetrics and gynecology.  2004 June. 12(2):45-56.
[PubMed]

Smith E, Ritchie J, Summersgill K, Hoffman H, Wang D, Haugen T, Turek L.  Human papillomavirus in oral exfoliated cells and risk of head and neck cancer.  Journal of the National Cancer Institute.  2004 March. 96(6):449-55.
[PubMed]

Smith E, Ritchie J, Summersgill K, Klussmann J, Lee J, Wang D, Haugen T, Turek L.  Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers.  International journal of cancer. Journal international du cancer.  2004 February. 108(5):766-72.
[PubMed]

Smith E, Haugen T, Turek L.  RESPONSE: Human Papillomavirus in Oral Exfoliated Cells and Risk of Head and Neck Cancer.  J Natl Cancer Inst.  2004. 96:1182-1186.

Smith E, Ritchie J, Yankowitz J, Swarnavel S, Wang D, Haugen T, Turek L.  Human papillomavirus prevalence and types in newborns and parents: concordance and modes of transmission.  Sexually transmitted diseases.  2004 January. 31(1):57-62.
[PubMed]

Ritchie J, Smith E, Summersgill K, Hoffman H, Wang D, Klussmann J, Turek L, Haugen T.  Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx.  International journal of cancer - Journal international du cancer.  2003 April. 104(3):336-44.
[PubMed]

Smith E, Ritchie J, Levy B, Zhang W, Wang D, Haugen T, Turek L.  Prevalence and persistence of human papillomavirus in postmenopausal age women.  Cancer detection and prevention.  2003. 27(6):472-80.
[PubMed]

Smith E, Levy B, Ritchie J, Jia J, Wang D, Haugen T, Turek L.  Is use of hormone replacement therapy associated with increased detection of human papillomavirus and potential risk of HPV-related genital cancers?.  European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP).  2002 June. 11(3):295-305.
[PubMed]

Summersgill K, Smith E, Levy B, Allen J, Haugen T, Turek L.  Human papillomavirus in the oral cavities of children and adolescents.  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.  2001 January. 91(1):62-9.
[PubMed]

Smith E, Summersgill K, Allen J, Hoffman H, McCulloch T, Turek L, Haugen T.  Human papillomavirus and risk of laryngeal cancer.  The Annals of otology, rhinology, and laryngology.  2000 November. 109(11):1069-76.
[PubMed]

Kutza J, Smith E, Levy B, Jian J, Haugen T, Turek L.  Use of hormone replacement therapy (Hrt) And detection of human papillomavirus (Hpv) Dna in postmenopausal women.  Annals of epidemiology.  2000 October. 10(7):465-466.
[PubMed]

Summersgill K, Smith E, Kirchner H, Haugen T, Turek L.  p53 polymorphism, human papillomavirus infection in the oral cavity, and oral cancer.  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.  2000 September. 90(3):334-9.
[PubMed]

Smith E, Hoffman H, Summersgill K, Kirchner H, Turek L, Haugen T.  Human papillomavirus and risk of oral cancer.  The Laryngoscope.  1998 July. 108(7):1098-103.
[PubMed]

Smith E, Johnson S, Figuerres E, Mendoza M, Fedderson D, Haugen T, Turek L.  The frequency of human papillomavirus detection in postmenopausal women on hormone replacement therapy.  Gynecologic oncology.  1997 June. 65(3):441-6.
[PubMed]

Bostik P, Turek L, Haugen T.  Simple method for selective amplification of cDNA from a defined promoter.  BioTechniques.  1997 February. 22(2):300-2, 304, 306.
[PubMed]

Marshall S, Jones R, Wanger A, Washington J, Doern G, Leber A, Haugen T.  Proposed MIC quality control guidelines for National Committee for Clinical Laboratory Standards susceptibility tests using seven veterinary antimicrobial agents: ceftiofur, enrofloxacin, florfenicol, penicillin G-novobiocin, pirlimycin, premafloxacin, and spectinomycin.  Journal of clinical microbiology.  1996 August. 34(8):2027-9.
[PubMed]

Johnson D, Doern G, Haugen T, Hindler J, Washington J, Jones R.  Comparative activity of twelve beta-lactam drugs tested against penicillin-resistant Streptococcus pneumoniae from five medical centers: effects of serum protein and capsular material on potency and spectrum as measured by reference tests.  Diagnostic microbiology and infectious disease.  1996 July. 25(3):137-41.
[PubMed]

Souza I, Nicholson D, Matthey S, Alden B, Haugen T, Trigg M, Bale J.  Rapid epidemiologic characterization of cytomegalovirus strains from pediatric bone marrow transplant patients.  Infection control and hospital epidemiology: the official journal of the Society of Hospital Epidemiologists of America.  1995 July. 16(7):399-404.
[PubMed]

Sommersgill K, Smith E, Hoffman H, Ricks J, Haugen T, Turek L.  The frequency of HPV in the oral cavity of a healthy adult population.  14th International Papillomavirus Workshop.  1995 July. 

Ushikai M, Lace M, Yamakawa Y, Kono M, Anson J, Ishiji T, Parkkinen S, Wicker N, Valentine M, Davidson I, Turek L, Haugen T.  Trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors.  J Virol.  1994 October. 68(10):6655-66.
[PubMed]

Souza I, Nicholson D, Matthey S, Alden B, Haugen T.  Detection of human cytomegalovirus in peripheral blood leukocytes by the polymerase chain reaction and a nonradioactive probe.  Diagnostic microbiology and infectious disease.  1994 September. 20(1):13-9.
[PubMed]

Smith E, Pignatari S, Gray S, Haugen T, Turek L.  Human papillomavirus infection in papillomas and nondiseased respiratory sites of patients with recurrent respiratory papillomatosis using the polymerase chain reaction.  Archives of otolaryngology -- head & neck surgery.  1993 May. 119(5):554-7.
[PubMed]

Haugen T, Alden B, Matthey S, Nicholson D.  Restriction enzyme fragment length polymorphisms of amplified herpes simplex virus type-1 DNA provide epidemiologic information.  Diagnostic microbiology and infectious disease.  1993. 17(2):129-33.
[PubMed]

Perl T, Haugen T, Pfaller M, Hollis R, Lakeman A, Whitley R, Nicholson D, Hunter G, Wenzel R.  Transmission of herpes simplex virus type 1 infection in an intensive care unit.  Annals of internal medicine.  1992 October. 117(7):584-6.
[PubMed]

Ishiji T, Lace M, Parkkinen S, Anderson R, Haugen T, Cripe T, Xiao J, Davidson I, Chambon P, Turek L.  Transcriptional enhancer factor (TEF)-1 and its cell-specific co-activator activate human papillomavirus-16 E6 and E7 oncogene transcription in keratinocytes and cervical carcinoma cells.  The EMBO journal.  1992 June. 11(6):2271-81.
[PubMed]

Cripe T, Alderborn A, Anderson R, Parkkinen S, Bergman P, Haugen T, Pettersson U, Turek L.  Transcriptional activation of the human papillomavirus-16 P97 promoter by an 88-nucleotide enhancer containing distinct cell-dependent and AP-1-responsive modules.  The New biologist.  1990 May. 2(5):450-63.
[PubMed]

Cripe T, Alderborn A, Haugen T, Anderson R, Parkkinen S, Pettersson U, Turek L.  The binding of a member of the NF-1 protein family is critical but not sufficient for keratinocyte-dependent activation of the HPV-16 E6-E7 gene promoter, P97.  Papillomaviruses - Proceedings of the UCLA Symposium, Taos, NM, March 11-18, 1989, Wiley-Liss New York.  1990. 

Haugen T, Turek L, Mercurio F, Cripe T, Olson B, Anderson R, Seidl D, Karin M, Schiller J.  Sequence-specific and general transcriptional activation by the bovine papillomavirus-1 E2 trans-activator require an N-terminal amphipathic helix-containing E2 domain.  The EMBO journal.  1988 December. 7(13):4245-53.
[PubMed]

Cripe T, Haugen T, Turk J, Tabatabai F, Schmid P, Dürst M, Gissmann L, Roman A, Turek L.  Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.  The EMBO journal.  1987 December. 6(12):3745-53.
[PubMed]

Haugen T, Cripe T, Karin M, Turek L.  A bovine papilloma virus E2 gene function trans-activates the major early viral promoter.  Cancer Cells - Papilloma Viruses, CSH Press, Cold Spring Harbor, NY.  1987. 5:39-46.

Seeberger R, Haugen T, Turek L, Pfister H.  An enhancer of human papillomavirus 8 is trans-activated by the bovine papillomavirus 1 E2-function.  Cancer Cells - Papilloma Viruses, CSH Press, Cold Spring Harbor, NY.  1987. 5:33-38.

Turek L, Haugen T.  Transforming and regulatory functions of bovine papilloma virus-1.  Springer, New York and Berlin.  1987. 

Haugen T, Cripe T, Ginder G, Karin M, Turek L.  Trans-activation of an upstream early gene promoter of bovine papilloma virus-1 by a product of the viral E2 gene.  The EMBO journal.  1987 January. 6(1):145-52.
[PubMed]

Hanley J, Haugen T, Heath E.  Biosynthesis and processing of rat haptoglobin.  The Journal of biological chemistry.  1983 June. 258(12):7858-69.
[PubMed]

Haugen T, Hanley J, Heath E.  Haptoglobin - A novel mode of biosynthesis of a liver secretory glycoprotein.  The Journal of biological chemistry.  1981 February. 256(3):1055-7.
[PubMed]

Haugen T, Heath E.  De novo biosynthesis of an enzymatically active precursor form of bovine pancreatic RNase.  Proceedings of the National Academy of Sciences of the United States of America.  1979 June. 76(6):2689-93.
[PubMed]

Heath E, Brinkley S, Das R, Haugen T.  Biosynthesis and processing of glycoproteins.  Academic Press, Inc. (London).  1979. 

Haugen T, Preiss J.  Biosynthesis of bacterial glycogen - The nature of the binding of substrates and effectors to ADP-glucose synthase.  The Journal of biological chemistry.  1979 January. 254(1):127-36.
[PubMed]

Haugen T, Ishaque A, Preiss J.  Biosynthesis of bacterial glycogen - Characterization of the subunit structure of Escherichia coli B glucose-1-phosphate adenylyltransferase (EC 2.7.7.27).  The Journal of biological chemistry.  1976 December. 251(24):7880-5.
[PubMed]

Haugen T, Ishaque A, Preiss J.  ADPGlucose pyrophosphorylase: evidence for a lysine residue at the activator site of the Escherichia coli B enzyme.  Biochemical and biophysical research communications.  1976 March. 69(2):346-53.
[PubMed]

Haugen T, Ishaque A, Chatterjee A, Preiss J.  Purification of Escherichia coli ADPglucose pyrophosphorylase by affinity chromatography.  FEBS letters.  1974 June. 42(2):205-8.
[PubMed]

Date Last Modified: 06/07/2014 - 21:56:23