Pathology

John T. Harty, PhD

Portrait

Professor of Microbiology
Professor of Pathology

Contact Information

Office: 3-530 Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Office Phone: 319-335-9720

Lab: 3-501B Bowen Science Building
51 Newton Rd
Iowa City, IA 52242
Phone: 319-335-9919

Email: john-harty@uiowa.edu
Web: Harty Lab Website

Education

BS, Biology, University of Minnesota
PhD, Microbiology, University of Minnesota

Post Doctoral, Scripps Clinical and Research Foundation, La Jolla, CA
Post Doctoral, Howard Hughes Medical Institute, University of Washington

Education/Training Program Affiliations

Biosciences Graduate Program
Department of Microbiology Graduate Program
Interdisciplinary Graduate Program in Immunology
Interdisciplinary Graduate Program in Translational Biomedicine
Medical Scientist Training Program

Research Summary

In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity against liver-stage malaria infection. Current projects involve:

1. Regulation of memory T cell development

2. Effector mechanisms of CD8 T cells in whole animal models of infectious disease

3. T cell homeostasis in response to infection

4. T cell mediated immunopathology after virus infection

5. CD8 T cell immunity against liver-stage malaria

Center, Program and Institute Affiliations

Center for Immunology and Immune-based Diseases

All Publications

Slütter B, Harty J.  Instructing the instructor: tissue-resident T cells activate innate immunity.  Cell Host Microbe.  2014 October 8. 16(4):421-3.
[Link]

Doll K, Harty J.  Correlates of protective immunity following whole sporozoite vaccination against malaria.  Immunol Res.  2014 August. 59(1-3):166-76.
[Link]

Kim M, Harty J.  Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells.  Front Immunol.  2014 June 19. 5:295.
[Link]

Van Braeckel-Budimir N, Harty J.  CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model.  Front Microbiol.  2014 June 6. 5:272.
[Link]

Brinkhoff B, Ostroumov D, Heemcke J, Woller N, Gürlevik E, Manns M, Longerich T, Zender L, Harty J, Kubicka S, Kühnel F, Wirth T.  Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.  Eur J Immunol.  2014 April. 44(4):1213-24.
[Link]

Gorman J, Starbeck-Miller G, Pham N, Traver G, Rothman P, Harty J, Colgan J.  Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection.  J Immunol.  2014 April 1. 192(7):3133-42.
[Link]

Nolz J, Harty J.  IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking.  J Clin Invest.  2014 March 3. 124(3):1013-26.
[Link]

Doll K, Butler N, Harty J.  CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii.  Vaccine.  2014 January 16. 32(4):483-91.
[Link]

Starbeck-Miller G, Xue H, Harty J.  IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo.  J Exp Med.  2014 January 13. 211(1):105-20.
[Link]

Starbeck-Miller G, Badovinac V, Barber D, Harty J.  Cutting Edge: Expression of FcγRIIB Tempers Memory CD8 T Cell Function In Vivo.  J Immunol.  2014 January 1. 192(1):35-9.
[Link]

Fulton R, Weiss K, Pewe L, Harty J, Varga S.  Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection.  J Virol.  2013 December. 87(23):12694-700.
[Link]

Slütter B, Pewe L, Kaech S, Harty J.  Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.  Immunity.  2013 November 14. 39(5):939-48.
[Link]

Cabrera M, Pewe L, Harty J, Frevert U.  In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.  PLoS One.  2013 August 14. 8(8):e70842.
[Link]

Khanolkar A, Williams M, Harty J.  Antigen experience shapes phenotype and function of memory Th1 cells.  PLoS One.  2013 June 7. 8(6):e65234.
[Link]

Slütter B, Pewe L, Lauer P, Harty J.  Cutting Edge: Rapid Boosting of Cross-Reactive Memory CD8 T Cells Broadens the Protective Capacity of the Flumist Vaccine.  J Immunol.  2013 April 15. 190(8):3854-8.
[Link]

Nolz J, Harty J.  One bug or another: promiscuous T cells form lifelong memory.  Immunity.  2013 February 21. 38(2):207-8.
[Link]

Richer M, Nolz J, Harty J.  Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling.  Immunity.  2013 January 24. 38(1):140-52.
[Link]

Doll K, Butler N, Harty J.  Tracking the total CD8 T cell response following whole Plasmodium vaccination.  Methods Mol Biol.  2013. 923:493-504.
[Link]

Pham N, Badovinac V, Harty J.  Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice.  Eur J Immunol.  2012 June. 42(6):1488-99.
[Link]

Butler N, Vaughan A, Harty J, Kappe S.  Whole parasite vaccination approaches for prevention of malaria infection.  Trends Immunol.  2012 May. 33(5):247-54.
[Link]

Nolz J, Rai D, Badovinac V, Harty J.  Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.  Proc Natl Acad Sci U S A.  2012 April 17. 109(16):6199-204.
[Link]

Schmidt N, Khanolkar A, Hancox L, Heusel J, Harty J.  Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection.  Eur J Immunol.  2012 March. 42(3):629-40.
[Link]

Martin M, Condotta S, Harty J, Badovinac V.  Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.  J Immunol.  2012 February 1. 188(3):1255-65.
[Link]

Condotta S, Richer M, Badovinac V, Harty J.  Probing CD8 T cell responses with Listeria monocytogenes infection.  Adv Immunol.  2012. 113:51-80.
[Link]

Butler N, Moebius J, Pewe L, Traore B, Doumbo O, Tygrett L, Waldschmidt T, Crompton P, Harty J.  Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.  Nat Immunol.  2011 December 11. 13(2):188-95.
[Link]

Nolz J, Starbeck-Miller G, Harty J.  Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions.  Immunotherapy.  2011 October. 3(10):1223-33.
[Link]

Martin M, Wirth T, Lauer P, Harty J, Badovinac V.  The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.  J Immunol.  2011 September 15. 187(6):2923-31.
[Link]

Butler N, Nolz J, Harty J.  Immunologic considerations for generating memory CD8 T cells through vaccination.  Cell Microbiol.  2011 July. 13(7):925-33.
[Link]

Butler N, Schmidt N, Vaughan A, Aly A, Kappe S, Harty J.  Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites.  Cell Host Microbe.  2011 June 16. 9(6):451-62.
[Link]

Kashiwada M, Pham N, Pewe L, Harty J, Rothman P.  NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.  Blood.  2011 June 9. 117(23):6193-7.
[Link]

Nolz J, Harty J.  Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection.  Immunity.  2011 May 27. 34(5):781-93.
[Link]

Schmidt N, Butler N, Harty J.  Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.  J Immunol.  2011 May 15. 186(10):5873-84.
[Link]

Wirth T, Martin M, Starbeck-Miller G, Harty J, Badovinac V.  Secondary CD8+ T-cell responses are controlled by systemic inflammation.  Eur J Immunol.  2011 May. 41(5):1321-33.
[Link]

Schmidt N, Harty J.  Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.  J Immunol.  2011 April 1. 186(7):3836-40.
[Link]

Pham N, Badovinac V, Harty J.  Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.  Front Immunol.  2011. 2:4.
[Link]

Nolz J, Harty J.  Strategies and implications for prime-boost vaccination to generate memory CD8 T cells.  Adv Exp Med Biol.  2011. 780:69-83.
[Link]

Zhou X, Yu S, Zhao D, Harty J, Badovinac V, Xue H.  Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.  Immunity.  2010 August 27. 33(2):229-40.
[Link]

Wirth T, Xue H, Rai D, Sabel J, Bair T, Harty J, Badovinac V.  Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation.  Immunity.  2010 July 23. 33(1):128-40.
[Link]

Schmidt N, Butler N, Badovinac V, Harty J.  Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.  PLoS Pathog.  2010 July 15. 6(7):e1000998.
[Link]

Khanolkar A, Fulton R, Epping L, Pham N, Tifrea D, Varga S, Harty J.  T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts.  J Immunol.  2010 July 15. 185(2):1132-41.
[Link]

Pham N, Pewe L, Fleenor C, Langlois R, Legge K, Badovinac V, Harty J.  Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly.  Proc Natl Acad Sci U S A.  2010 July 6. 107(27):12198-203.
[Link]

Wirth T, Harty J, Badovinac V.  Modulating numbers and phenotype of CD8+ T cells in secondary immune responses.  Eur J Immunol.  2010 July. 40(7):1916-26.
[Link]

Butler N, Schmidt N, Harty J.  Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites.  J Immunol.  2010 March 1. 184(5):2528-38.
[Link]

Schlub T, Badovinac V, Sabel J, Harty J, Davenport M.  Predicting CD62L expression during the CD8+ T-cell response in vivo.  Immunol Cell Biol.  2010 February. 88(2):157-64.
[Link]

Zhao D, Yu S, Zhou X, Haring J, Held W, Badovinac V, Harty J, Xue H.  Constitutive activation of Wnt signaling favors generation of memory CD8 T cells.  J Immunol.  2010 February 1. 184(3):1191-9.
[Link]

Butler N, Harty J.  The role of inflammation in the generation and maintenance of memory T cells.  Adv Exp Med Biol.  2010. 684:42-56.
[Link]

Rai D, Pham N, Harty J, Badovinac V.  Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts.  J Immunol.  2009 December 15. 183(12):7672-81.
[Link]

Wirth T, Pham N, Harty J, Badovinac V.  High initial frequency of TCR-transgenic CD8 T cells alters inflammation and pathogen clearance without affecting memory T cell function.  Mol Immunol.  2009 November. 47(1):71-8.
[Link]

Schmidt N, Butler N, Harty J.  CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge.  Vaccine.  2009 October 19. 27(44):6103-6.
[Link]

Khanolkar A, Hartwig S, Haag B, Meyerholz D, Epping L, Haring J, Varga S, Harty J.  Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.  J Virol.  2009 September. 83(18):9258-72.
[Link]

Khanolkar A, Hartwig S, Haag B, Meyerholz D, Harty J, Varga S.  Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.  J Virol.  2009 September. 83(17):8946-56.
[Link]

Pham N, Badovinac V, Harty J.  A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation.  J Immunol.  2009 August 15. 183(4):2337-48.
[Link]

Wirth T, Badovinac V, Zhao L, Dailey M, Harty J.  Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes.  J Immunol.  2009 May 15. 182(10):6195-206.
[Link]

Haring J, Harty J.  Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection.  Infect Immun.  2009 May. 77(5):1894-903.
[Link]

Butler N, Harty J.  A "memorable" NK cell discovery.  Cell Res.  2009 March. 19(3):277-8.
[Link]

Wirth T, Harty J.  Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection.  Adv Exp Med Biol.  2009. 633:71-80.
[Link]

Stojakovic M, Salazar-Fontana L, Tatari-Calderone Z, Badovinac V, Santori F, Kovalovsky D, Sant'Angelo D, Harty J, Vukmanovic S.  Adaptable TCR avidity thresholds for negative selection.  J Immunol.  2008 November 15. 181(10):6770-8.
[Link]

Schmidt N, Podyminogin R, Butler N, Badovinac V, Tucker B, Bahjat K, Lauer P, Reyes-Sandoval A, Hutchings C, Moore A, Gilbert S, Hill A, Bartholomay L, Harty J.  Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.  Proc Natl Acad Sci U S A.  2008 September 16. 105(37):14017-22.
[Link]

Xue H, Jing X, Bollenbacher-Reilley J, Zhao D, Haring J, Yang B, Liu C, Bishop G, Harty J, Leonard W.  Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.  Mol Cell Biol.  2008 July. 28(13):4300-9.
[Link]

Elzey B, Schmidt N, Crist S, Kresowik T, Harty J, Nieswandt B, Ratliff T.  Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge.  Blood.  2008 April 1. 111(7):3684-91.
[Link]

Reyes-Sandoval A, Sridhar S, Berthoud T, Moore A, Harty J, Gilbert S, Gao G, Ertl H, Wilson J, Hill A.  Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei.  Eur J Immunol.  2008 March. 38(3):732-41.
[Link]

Haring J, Jing X, Bollenbacher-Reilley J, Xue H, Leonard W, Harty J.  Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.  J Immunol.  2008 March 1. 180(5):2855-62.
[Link]

Harty J, Badovinac V.  Shaping and reshaping CD8+ T-cell memory.  Nat Rev Immunol.  2008 February. 8(2):107-19.
[Link]

Humphreys T, Khanolkar A, Badovinac V, Harty J.  Generation and maintenance of Listeria-specific CD8+ T cell responses in perforin-deficient mice chronically infected with LCMV.  Virology.  2008 January 20. 370(2):310-22.
[Link]

Messingham K, Badovinac V, Jabbari A, Harty J.  A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes.  J Immunol.  2007 August 15. 179(4):2457-66.
[Link]

Badovinac V, Harty J.  Manipulating the rate of memory CD8+ T cell generation after acute infection.  J Immunol.  2007 July 1. 179(1):53-63.
[Link]

Badovinac V, Haring J, Harty J.  Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.  Immunity.  2007 June. 26(6):827-41.
[Link]

Reyes-Sandoval A, Harty J, Todryk S.  Viral vector vaccines make memory T cells against malaria.  Immunology.  2007 June. 121(2):158-65.
[Link]

Santori F, Popmihajlov Z, Badovinac V, Smith C, Radoja S, Harty J, Vukmanović S.  TCR beta chain that forms peptide-independent alloreactive TCR transfers reduced reactivity with irrelevant peptide/MHC complex.  J Immunol.  2007 May 15. 178(10):6109-14.
[Link]

Messingham K, Harty J.  Adaptive immunity to Listeria monocytogenes.  Springer Science + Business Media, LLC.  2007. 

Khanolkar A, Badovinac V, Harty J.  CD8 T cell memory development: CD4 T cell help is appreciated.  Immunol Res.  2007. 39(1-3):94-104.
[Link]

Harty J.  Dynamics of the CD8 T-cell response revealed by Listeria monocytogenes infection.  ASM Press.  2007. 

Haring J, Harty J.  Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor.  Infect Immun.  2006 November. 74(11):6252-63.
[Link]

Hamilton S, Badovinac V, Khanolkar A, Harty J.  Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity.  J Immunol.  2006 September 15. 177(6):4012-20.
[Link]

Jabbari A, Legge K, Harty J.  T cell conditioning explains early disappearance of the memory CD8 T cell response to infection.  J Immunol.  2006 September 1. 177(5):3012-8.
[Link]

Badovinac V, Messingham K, Griffith T, Harty J.  TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells.  J Immunol.  2006 July 15. 177(2):999-1006.
[Link]

Haring J, Badovinac V, Harty J.  Inflaming the CD8+ T cell response.  Immunity.  2006 July. 25(1):19-29.
[Link]

Jabbari A, Harty J.  The generation and modulation of antigen-specific memory CD8 T cell responses.  J Leukoc Biol.  2006 July. 80(1):16-23.
[Link]

Jabbari A, Harty J.  Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells.  J Immunol Methods.  2006 June 30. 313(1-2):161-8.
[Link]

Badovinac V, Harty J.  Programming, demarcating, and manipulating CD8+ T-cell memory.  Immunol Rev.  2006 June. 211:67-80.
[Link]

Jabbari A, Harty J.  Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.  J Exp Med.  2006 April 17. 203(4):919-32.
[Link]

Porter B, Harty J.  The onset of CD8+-T-cell contraction is influenced by the peak of Listeria monocytogenes infection and antigen display.  Infect Immun.  2006 March. 74(3):1528-36.
[Link]

Jabbari A, Harty J.  Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation.  J Immunol.  2005 October 15. 175(8):4829-33.
[Link]

Haring J, Badovinac V, Olson M, Varga S, Harty J.  In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor.  J Immunol.  2005 September 1. 175(5):3117-22.
[Link]

Badovinac V, Messingham K, Jabbari A, Haring J, Harty J.  Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.  Nat Med.  2005 July. 11(7):748-56.
[Link]

Haring J, Corbin G, Harty J.  Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T cells responding to infection.  J Immunol.  2005 June 1. 174(11):6791-802.
[Link]

Corbin G, Harty J.  T cells undergo rapid ON/OFF but not ON/OFF/ON cycling of cytokine production in response to antigen.  J Immunol.  2005 January 15. 174(2):718-26.
[Link]

Corbin G, Harty J.  Duration of infection and antigen display have minimal influence on the kinetics of the CD4+ T cell response to Listeria monocytogenes infection.  J Immunol.  2004 November 1. 173(9):5679-87.
[Link]

Badovinac V, Porter B, Harty J.  CD8+ T cell contraction is controlled by early inflammation.  Nat Immunol.  2004 August. 5(8):809-17.
[Link]

Tvinnereim A, Hamilton S, Harty J.  Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens.  J Immunol.  2004 August 1. 173(3):1994-2002.
[Link]

Hamilton S, Porter B, Messingham K, Badovinac V, Harty J.  MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response.  Nat Immunol.  2004 February. 5(2):159-68.
[Link]

Messingham K, Badovinac V, Harty J.  Deficient anti-listerial immunity in the absence of perforin can be restored by increasing memory CD8+ T cell numbers.  J Immunol.  2003 October 15. 171(8):4254-62.
[Link]

Badovinac V, Messingham K, Hamilton S, Harty J.  Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host.  J Immunol.  2003 May 15. 170(10):4933-42.
[Link]

Badovinac V, Hamilton S, Harty J.  Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice.  Immunity.  2003 April. 18(4):463-74.
[Link]

Badovinac V, Harty J.  Memory lanes.  Nat Immunol.  2003 March. 4(3):212-3.
[Link]

Hamilton S, Harty J.  Quantitation of CD8+ T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells.  J Immunol.  2002 November 1. 169(9):4936-44.
[Link]

Badovinac V, Porter B, Harty J.  Programmed contraction of CD8(+) T cells after infection.  Nat Immunol.  2002 July. 3(7):619-26.
[Link]

Harty J, Badovinac V.  Influence of effector molecules on the CD8(+) T cell response to infection.  Curr Opin Immunol.  2002 June. 14(3):360-5.
[Link]

Badovinac V, Harty J.  CD8(+) T-cell homeostasis after infection: setting the 'curve'.  Microbes Infect.  2002 April. 4(4):441-7.
[Link]

Tvinnereim A, Hamilton S, Harty J.  CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection.  Infect Immun.  2002 January. 70(1):153-62.
[Link]

Hamilton S, Tvinnereim A, Harty J.  Listeria monocytogenes infection overcomes the requirement for CD40 ligand in exogenous antigen presentation to CD8(+) T cells.  J Immunol.  2001 November 15. 167(10):5603-9.
[Link]

Wilson R, Tvinnereim A, Jones B, Harty J.  Identification of Listeria monocytogenes in vivo-induced genes by fluorescence-activated cell sorting.  Infect Immun.  2001 August. 69(8):5016-24.
[Link]

Badovinac V, Harty J.  Detection and analysis of antigen-specific CD8+ T cells.  Immunol Res.  2001. 24(3):325-32.
[Link]

Badovinac V, Tvinnereim A, Harty J.  Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.  Science.  2000 November 17. 290(5495):1354-8.
[Link]

Badovinac V, Corbin G, Harty J.  Cutting edge: OFF cycling of TNF production by antigen-specific CD8+ T cells is antigen independent.  J Immunol.  2000 November 15. 165(10):5387-91.
[Link]

White D, Badovinac V, Fan X, Harty J.  Adaptive immunity against Listeria monocytogenes in the absence of type I tumor necrosis factor receptor p55.  Infect Immun.  2000 August. 68(8):4470-6.
[Link]

Grandea A, Golovina T, Hamilton S, Sriram V, Spies T, Brutkiewicz R, Harty J, Eisenlohr L, Van Kaer L.  Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.  Immunity.  2000 August. 13(2):213-22.
[Link]

White D, Badovinac V, Kollias G, Harty J.  Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice.  J Immunol.  2000 July 1. 165(1):5-9.
[Link]

Badovinac V, Harty J.  Adaptive immunity and enhanced CD8+ T cell response to Listeria monocytogenes in the absence of perforin and IFN-gamma.  J Immunol.  2000 June 15. 164(12):6444-52.
[Link]

Myung P, Clements J, White D, Malik Z, Cowdery J, Allen L, Harty J, Kusner D, Koretzky G.  In vitro and in vivo macrophage function can occur independently of SLP-76.  Int Immunol.  2000 June. 12(6):887-97.
[Link]

Badovinac V, Harty J.  Intracellular staining for TNF and IFN-gamma detects different frequencies of antigen-specific CD8(+) T cells.  J Immunol Methods.  2000 April 21. 238(1-2):107-17.
[Link]

Tvinnereim A, Harty J.  CD8(+) T-cell priming against a nonsecreted Listeria monocytogenes antigen is independent of the antimicrobial activities of gamma interferon.  Infect Immun.  2000 April. 68(4):2196-204.
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Wilson R, White D, Harty J.  Transient expression of bacterial gene fragments in eukaryotic cells: implications for CD8(+) T cell epitope analysis.  J Immunol Methods.  2000 February 3. 234(1-2):137-47.
[Link]

Harty J, Tvinnereim A, White D.  CD8+ T cell effector mechanisms in resistance to infection.  Annu Rev Immunol.  2000. 18:275-308.
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Harty J, White D.  A knockout approach to understanding CD8+ cell effector mechanisms in adaptive immunity to Listeria monocytogenes.  Immunobiology.  1999 December. 201(2):196-204.
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Harty J, Bevan M.  Responses of CD8(+) T cells to intracellular bacteria.  Curr Opin Immunol.  1999 February. 11(1):89-93.
[Link]

White D, MacNeil A, Busch D, Pilip I, Pamer E, Harty J.  Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes.  J Immunol.  1999 January 15. 162(2):980-8.
[Link]

Krieg A, Love-Homan L, Yi A, Harty J.  CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge.  J Immunol.  1998 September 1. 161(5):2428-34.
[Link]

Jensen V, Harty J, Jones B.  Interactions of the invasive pathogens Salmonella typhimurium, Listeria monocytogenes, and Shigella flexneri with M cells and murine Peyer's patches.  Infect Immun.  1998 August. 66(8):3758-66.
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Shen H, Miller J, Fan X, Kolwyck D, Ahmed R, Harty J.  Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity.  Cell.  1998 February 20. 92(4):535-45.
[Link]

White D, Harty J.  Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha.  J Immunol.  1998 January 15. 160(2):898-905.
[Link]

Harty J.  Immunity to Listeria monocytogenes infection of the liver.  John Wiley and Sons, Inc., New York, NY.  1998. 

White D, Wilson R, Harty J.  CD8+ T cells in intracellular bacterial infections of mice.  Res Immunol.  1996 October. 147(8-9):519-24.
[Link]

Harty J, Bevan M.  CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes.  Infect Immun.  1996 September. 64(9):3632-40.
[Link]

Harty J, Lenz L, Bevan M.  Primary and secondary immune responses to Listeria monocytogenes.  Curr Opin Immunol.  1996 August. 8(4):526-30.
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Anderson G, Even C, Rowland R, Palmer G, Harty J, Plagemann P.  C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age.  J Neurovirol.  1995 September. 1(3-4):244-52.
[Link]

Harty J, Bevan M.  Specific immunity to Listeria monocytogenes in the absence of IFN gamma.  Immunity.  1995 July. 3(1):109-17.
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Harty J, Pamer E.  CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.  J Immunol.  1995 May 1. 154(9):4642-50.
[Link]

Vukmanović S, Stella G, King P, Dyall R, Hogquist K, Harty J, Nikolić-Zugić J, Bevan M.  A positively selecting thymic epithelial cell line lacks costimulatory activity.  J Immunol.  1994 April 15. 152(8):3814-23.
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Harty J, Schreiber R, Bevan M.  CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion.  Proc Natl Acad Sci U S A.  1992 December 1. 89(23):11612-6.
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Harty J, Bevan M.  CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.  J Exp Med.  1992 June 1. 175(6):1531-8.
[Link]

Plagemann P, Harty J, Even C.  Mode of neutralization of lactate dehydrogenase-elevating virus by polyclonal and monoclonal antibodies.  Arch Virol.  1992. 123(1-2):89-100.
[Link]

Contag C, Harty J, Plagemann P.  Pathogenesis of age-dependent poliomyelitis, viral and immunological factors contributing to fatal paralysis.  Humana Press, Inc..  1992. 

Pamer E, Harty J, Bevan M.  Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes.  Nature.  1991 October 31. 353(6347):852-5.
[Link]

Kuo L, Harty J, Erickson L, Palmer G, Plagemann P.  A nested set of eight RNAs is formed in macrophages infected with lactate dehydrogenase-elevating virus.  J Virol.  1991 September. 65(9):5118-23.
[Link]

Staskus K, Retzel E, Lewis E, Silsby J, Cyr S, Rank J, Wietgrefe S, Haase A, Cook R, Fast D, Geiser P, Harty J, Kong S, Lahti C, Neufeld T, Porter T, Shoop E, Zachow K.  Isolation of replication-competent molecular clones of visna virus.  Virology.  1991 March. 181(1):228-40.
[Link]

Harty J, Plagemann P.  Monoclonal antibody protection from age-dependent poliomyelitis: implications regarding the pathogenesis of lactate dehydrogenase-elevating virus.  J Virol.  1990 December. 64(12):6257-62.
[Link]

Li X, Hu B, Harty J, Even C, Plagemann P.  Polyclonal B cell activation of IgG2a and IgG2b production by infection of mice with lactate dehydrogenase-elevating virus Is partly dependent on CD4+ lymphocytes .  Viral Immunol.  1990. 3(4):273-88.
[Link]

Onyekaba C, Harty J, Plagemann P.  Extensive cytocidal replication of lactate dehydrogenase-elevating virus in cultured peritoneal macrophages from 1-2-week-old mice.  Virus Res.  1989 December. 14(4):327-38.
[Link]

Onyekaba C, Harty J, Even C, Hu B, Plagemann P.  Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses.  Virus Res.  1989 December. 14(4):297-315.
[Link]

Chan S, Onyekaba C, Harty J, Plagemann P.  Persistent infection of mice by lactate dehydrogenase-elevating virus: transient virus replication in macrophages of the spleen.  Virus Res.  1989 December. 14(4):317-26.
[Link]

Contag C, Harty J, Plagemann P.  Dual virus etiology of age-dependent poliomyelitis of mice. A potential model for human motor neuron diseases.  Microb Pathog.  1989 June. 6(6):391-401.
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Harty J, Plagemann P.  Formalin inactivation of the lactate dehydrogenase-elevating virus reveals a major neutralizing epitope not recognized during natural infection.  J Virol.  1988 September. 62(9):3210-6.
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Harty J, Chan S, Contag C, Plagemann P.  Protection of C58 mice from lactate dehydrogenase-elevating virus-induced motor neuron disease by non-neutralizing antiviral antibodies without interference with virus replication.  J Neuroimmunol.  1987 June. 15(2):195-206.
[Link]

Harty J, Chan S, Plagemann P.  Characteristics of monoclonal antibodies to the lactate dehydrogenase-elevating virus.  Intervirology.  1987. 27(1):53-60.
[Link]

Hanto D, Harty J, Hoffman R, Simmons R.  Evidence that secondary mixed leukocyte culture supernatant mediates changes in cellular recruitment, blood flow, and vascular permeability.  Transplantation.  1986 December. 42(6):621-7.
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Cafruny W, Chan S, Harty J, Yousefi S, Kowalchyk K, McDonald D, Foreman B, Budweg G, Plagemann P.  Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus.  Virus Res.  1986 September. 5(4):357-75.
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Keller G, Barke R, Harty J, Humphrey E, Simmons R.  Decreased hepatic glutathione levels in septic shock. Predisposition of hepatocytes to oxidative stress: an experimental approach.  Arch Surg.  1985 August. 120(8):941-5.
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Keller G, West M, Harty J, Wilkes L, Cerra F, Simmons R.  Modulation of hepatocyte protein synthesis by endotoxin-activated Kupffer cells. III. Evidence for the role of a monokine similar to but not identical with interleukin-1.  Ann Surg.  1985 April. 201(4):436-43.
[Link]

Keller G, West M, Harty J, Cerra F, Simmons R.  Modulation of hepatocyte protein synthesis during co-cultivation with macrophage-rich peritoneal cells in vitro.  Arch Surg.  1985 February. 120(2):180-6.
[Link]

Harty J, So S, Keller G, Hoffman R, Ascher N, Simmons R.  Immunospecific lymphocyte-mediated injury of isolated hepatocytes.  Transplant Proc.  1985. 17:606-7.

Hanto D, Harty J, Hoffman R, Simmons R.  Soluble mediators generated by allogeneic stimulation increased lymphocyte recruitment, regional blood flow, and vascular permeability in vitro.  Transplant Proc.  1985. 17:578-81.

Hanto D, Harty J, Simmons R.  Lymphocyte recruitment properties of regional lymph node or spleen cells during skin allograft rejection.  Transplantation.  1983 November. 36(5):578-81.
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Hanto D, Harty J, Hoffman R, Simmons R.  Cyclosporine suppression of lymphocyte recruitment, regional blood flow, and vascular permeability at sites of allogeneic cellular interactions.  Surgery.  1983 August. 94(2):218-24.
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Date Last Modified: 06/07/2014 - 21:56:23